A neurotoxic dose of 3, 4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long term defect in thermoregulation

Psychopharmacology

Volumn 155, Issue 4, 2001, Pages 413-418

  Mechan, Annis O ^a   O'Shea, Esther ^b   Elliott, J Martin ^a   Colado, Maria ^c   Green, A Richard ^a  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

3, 4 Methylenedioxymethamphetamine; 5 HT; 8 OH DPAT; Ecstasy; Hyperthermia; MDMA; Neurodegeneration; Thermoregulation

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; 5 HYDROXYINDOLEACETIC ACID; SEROTONIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; HYPERTHERMIA; HYPOTHALAMUS; MALE; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; SEROTONIN BRAIN LEVEL; SEROTONINERGIC NERVE CELL; THERMOREGULATION;

AMPHETAMINES; ANIMALS; BODY TEMPERATURE; BODY TEMPERATURE REGULATION; BRAIN CHEMISTRY; HALLUCINOGENS; HYDROXYINDOLEACETIC ACID; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEUROTOXICITY SYNDROMES; PIPERAZINES; RATS; SEROTONIN; SEROTONIN AGONISTS;

EID: 0035010140     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100735     Document Type: Article

References (35)

1. 1A receptor density and 8-OH-DPAT-induced hypothermia - Blockade by drugs preventing 5-hydroxytryptamine depletion
2. Age-dependent sensitivity of rats to the long term effects of the serotonergic neurotoxicant (±)-3, 4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response
3. Multiple severe complications from recreational ingestion of MDMA ("Ecstasy")
4. Ecstasy, 3, 4-methylenedioxymethamphetamine (MDMA), a fatality associated with coagulopathy and hyperthermia
5. 5-HT loss in rat brain following 3, 4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine
6. The hyperthermic and neurotoxic effects of "ecstasy" (MDMA) and 3, 4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype
7. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ("ecstasy") and p-chloroamphetamine but not the degeneration following fenfluramine
8. Role of hyperthermia in the protective action of clomethiazole against MDMA ("ecstasy")-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR
9. Dopamine
10. Effects of ambient temperature on hyperthermia and hyperkinesis induced by 3, 4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats
11. Hyperthermia following MDMA administration in rats: Effects of ambient temperature, water consumption and chronic dosing
12. Persistent loss of thermoregulation in the rat induced by 3, 4-methylenedioxymethamphetamine (MDMA or "Ecstasy") but not fenfluramine
13. Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments with 3, 4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX
14. Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Effects with methamphetamine, p-chloramphetamine, fenfluramine, dizocilpine and dextromethorphan
15. The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino) tetraline (8-OH-DPAT)
16. Effect of 3, 4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat
17. Ecstasy and neurodegeneration
18. Review of the pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA or "Ecstasy")
19. Toxicity and deaths from 3, 4-methylenedioxymethamphetamine ("ecstasy")
20. 5-Hydroxytryptamine
21. Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat
22. 2A/2C receptor antagonists
23. Neurotoxic effects in human brains after use of 3, 4-methylenedioxymethamphetamine ("Ecstasy") viewed by positron emission tomography
24. Altered neuroendocrine and behavioral responses to m-chlorophenylpiperazine in 3, 4-methylenedioxymethamphetamine (MDMA) users
25. Some behavioural and neurochemical aspects of subacute (±)3, 4-methylenedioxymethamphetamine administration in rats
26. Neurotoxicity of MDMA and related compounds: Anatomic studies
27. Hypothalamic control of thermoregulation; neurochemical mechanisms
28. Elevation of serum prolactin and corticosterone concentrations after administration of 3, 4-methylenedioxymethamphetamine
29. Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence
30. The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ("ecstasy")
31. Ecstasy-fueled "rave" parties become dances of death for English youths
32. 2A receptors in rat thermoregulatory mechanisms
33. No evidence of neurotoxicity exists
34. A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration
35. Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy")