메뉴 건너뛰기




Volumn 33, Issue 12, 2008, Pages 2401-2406

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders

Author keywords

Catenin; Canonical Wnt pathway; Dkk 1; Lithium; Neurodegeneration; Neuronal death

Indexed keywords

AMYLOID BETA PROTEIN; DICKKOPF 1 ANTAGONIST; DICKKOPF 1 PROTEIN; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG; WNT ANTAGONIST; WNT PROTEIN;

EID: 56349085908     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-008-9710-0     Document Type: Review
Times cited : (53)

References (61)
  • 1
    • 0032518695 scopus 로고    scopus 로고
    • Signal transduction by the Wnt family of ligands
    • TC Dale 1998 Signal transduction by the Wnt family of ligands Biochem J 329 209 223
    • (1998) Biochem J , vol.329 , pp. 209-223
    • Dale, T.C.1
  • 2
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way
    • X He M Semenov K Tamai 2004 LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way Development 131 1663 1677
    • (2004) Development , vol.131 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3
  • 3
    • 0033590172 scopus 로고    scopus 로고
    • Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways
    • JR Miller AM Hocking JD Brown 1999 Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways Oncogene 18 7860 7872
    • (1999) Oncogene , vol.18 , pp. 7860-7872
    • Miller, J.R.1    Hocking, A.M.2    Brown, J.D.3
  • 5
    • 0036153448 scopus 로고    scopus 로고
    • The Wnts
    • 1
    • JR Miller 2002 The Wnts Genome Biol 3 1 3001.1 3001.15
    • (2002) Genome Biol , vol.3 , pp. 30011-300115
    • Miller, J.R.1
  • 6
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of Wnt signaling through β-catenin
    • RT Moon B Bowerman M Boutros 2002 The promise and perils of Wnt signaling through β-catenin Science 296 1644 1646
    • (2002) Science , vol.296 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3
  • 7
    • 0036843202 scopus 로고    scopus 로고
    • Planar cell polarization: Do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?
    • M Mlodzik 2002 Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18 564 571
    • (2002) Trends Genet , vol.18 , pp. 564-571
    • Mlodzik, M.1
  • 8
    • 0034214847 scopus 로고    scopus 로고
    • The Wnt/Ca2+pathway: A new vertebrate Wnt signaling pathway takes shape
    • M Kühl LC Sheldahl M Park 2000 The Wnt/Ca2+pathway: a new vertebrate Wnt signaling pathway takes shape Trends Genet 16 279 283
    • (2000) Trends Genet , vol.16 , pp. 279-283
    • Kühl, M.1    Sheldahl, L.C.2    Park, M.3
  • 9
    • 0034727104 scopus 로고    scopus 로고
    • LDL-receptor-related proteins in Wnt signal transduction
    • K Tamai M Semenov Y Kato 2000 LDL-receptor-related proteins in Wnt signal transduction Nature 407 530 535
    • (2000) Nature , vol.407 , pp. 530-535
    • Tamai, K.1    Semenov, M.2    Kato, Y.3
  • 10
    • 0034727099 scopus 로고    scopus 로고
    • Arrow encodes an LDL-receptor-related protein essential for Wingless signalling
    • M Wehrli ST Dougan K Caldwell 2000 Arrow encodes an LDL-receptor-related protein essential for Wingless signalling Nature 407 527 530
    • (2000) Nature , vol.407 , pp. 527-530
    • Wehrli, M.1    Dougan, S.T.2    Caldwell, K.3
  • 11
    • 0037155691 scopus 로고    scopus 로고
    • Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
    • C Liu Y Li M Semenov 2002 Control of β-catenin phosphorylation/ degradation by a dual-kinase mechanism Cell 108 837 847
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3
  • 12
    • 0030978351 scopus 로고    scopus 로고
    • Beta-catenin is a target for the ubiquitin-proteasome pathway
    • H Aberle A Bauer J Stappert 1997 Beta-catenin is a target for the ubiquitin-proteasome pathway EMBO J 16 3797 3804
    • (1997) EMBO J , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3
  • 13
    • 0031888098 scopus 로고    scopus 로고
    • Beta-catenin: A key mediator of Wnt signaling
    • K Willert R Nusse 1998 Beta-catenin: a key mediator of Wnt signaling Curr Opin Genet Dev 8 95 102
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 95-102
    • Willert, K.1    Nusse, R.2
  • 14
    • 33744791463 scopus 로고    scopus 로고
    • Wnt signaling: Is the party in the nucleus?
    • K Willert KA Jones 2006 Wnt signaling: is the party in the nucleus? Genes Dev 20 1394 1404
    • (2006) Genes Dev , vol.20 , pp. 1394-1404
    • Willert, K.1    Jones, K.A.2
  • 15
    • 0032603742 scopus 로고    scopus 로고
    • Wnt factors in axonal remodelling and synaptogenesis
    • PC Salinas 1999 Wnt factors in axonal remodelling and synaptogenesis Biochem Soc Symp 65 101 109
    • (1999) Biochem Soc Symp , vol.65 , pp. 101-109
    • Salinas, P.C.1
  • 16
    • 0242384747 scopus 로고    scopus 로고
    • Beta-catenin is critical for dendritic morphogenesis
    • X Yu RC Malenka 2003 Beta-catenin is critical for dendritic morphogenesis Nat Neurosci 6 1169 1177
    • (2003) Nat Neurosci , vol.6 , pp. 1169-1177
    • Yu, X.1    Malenka, R.C.2
  • 17
    • 0037014456 scopus 로고    scopus 로고
    • Depolarization drives beta-catenin into neuronal spines promoting changes in synaptic structure and function
    • S Murase E Mosser EM Schuman 2002 Depolarization drives beta-catenin into neuronal spines promoting changes in synaptic structure and function Neuron 35 91 105
    • (2002) Neuron , vol.35 , pp. 91-105
    • Murase, S.1    Mosser, E.2    Schuman, E.M.3
  • 18
    • 33845359084 scopus 로고    scopus 로고
    • Function and biological roles of the Dickkopf family of Wnt modulators
    • C Niehrs 2006 Function and biological roles of the Dickkopf family of Wnt modulators Oncogene 25 7469 7481
    • (2006) Oncogene , vol.25 , pp. 7469-7481
    • Niehrs, C.1
  • 19
    • 0032850032 scopus 로고    scopus 로고
    • Functional and structural diversity of the human Dickkopf gene family
    • VE Krupnik JD Sharp C Jiang 1999 Functional and structural diversity of the human Dickkopf gene family Gene 238 301 313
    • (1999) Gene , vol.238 , pp. 301-313
    • Krupnik, V.E.1    Sharp, J.D.2    Jiang, C.3
  • 20
    • 0036337388 scopus 로고    scopus 로고
    • Regulation of Wnt/LRP signalling by distinct domains of Dickkopf proteins
    • BK Brott SY Sokol 2002 Regulation of Wnt/LRP signalling by distinct domains of Dickkopf proteins Mol Cell Biol 22 6100 6110
    • (2002) Mol Cell Biol , vol.22 , pp. 6100-6110
    • Brott, B.K.1    Sokol, S.Y.2
  • 21
    • 7444235421 scopus 로고    scopus 로고
    • Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain
    • DB Diep N Hoen M Backman 2004 Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain Brain Res Dev Brain Res 153 261 270
    • (2004) Brain Res Dev Brain Res , vol.153 , pp. 261-270
    • Diep, D.B.1    Hoen, N.2    Backman, M.3
  • 22
    • 0036500653 scopus 로고    scopus 로고
    • The Wnt antagonist Dickkopf-1 is 675 regulated by Bmp signaling and c-Jun and modulates programmed cell death
    • L Grotewold U Ruther 2002 The Wnt antagonist Dickkopf-1 is 675 regulated by Bmp signaling and c-Jun and modulates programmed cell death EMBO J 21 966 975
    • (2002) EMBO J , vol.21 , pp. 966-975
    • Grotewold, L.1    Ruther, U.2
  • 23
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • A Glinka W Wu H Delius 1998 Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction Nature 391 357 362
    • (1998) Nature , vol.391 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3
  • 24
    • 0035822594 scopus 로고    scopus 로고
    • Wnt signalling: Antagonistic Dickkopfs
    • AM Zorn 2001 Wnt signalling: antagonistic Dickkopfs Curr Biol 11 R592 R595
    • (2001) Curr Biol , vol.11
    • Zorn, A.M.1
  • 25
    • 0037413696 scopus 로고    scopus 로고
    • Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling
    • B Mao C Niehrs 2003 Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling Gene 302 179 183
    • (2003) Gene , vol.302 , pp. 179-183
    • Mao, B.1    Niehrs, C.2
  • 26
    • 0034732151 scopus 로고    scopus 로고
    • Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53
    • J Wang J Shou X Chen 2000 Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53 Oncogene 19 1843 1848
    • (2000) Oncogene , vol.19 , pp. 1843-1848
    • Wang, J.1    Shou, J.2    Chen, X.3
  • 27
    • 2342461756 scopus 로고    scopus 로고
    • To die or not to die: How does p53 decide?
    • EA Slee DJ O'Connor X Lu 2004 To die or not to die: how does p53 decide? Oncogene 23 2809 2818
    • (2004) Oncogene , vol.23 , pp. 2809-2818
    • Slee, E.A.1    O'Connor, D.J.2    Lu, X.3
  • 28
    • 0028642274 scopus 로고
    • Calcium and excitotoxic neuronal injury
    • DW Choi 1994 Calcium and excitotoxic neuronal injury Ann N Y Acad Sci 747 162 171
    • (1994) Ann N Y Acad Sci , vol.747 , pp. 162-171
    • Choi, D.W.1
  • 29
    • 0033782480 scopus 로고    scopus 로고
    • Neuronal apoptosis after CNS injury: The roles of glutamate and calcium
    • GJ Zipfel DJ Babcock JM Lee 2000 Neuronal apoptosis after CNS injury: the roles of glutamate and calcium J Neurotrauma 17 857 869
    • (2000) J Neurotrauma , vol.17 , pp. 857-869
    • Zipfel, G.J.1    Babcock, D.J.2    Lee, J.M.3
  • 30
    • 0034852645 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs
    • V Bruno G Battaglia A Copani 2001 Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs J Cereb Blood Flow Metab 21 1013 1033
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1013-1033
    • Bruno, V.1    Battaglia, G.2    Copani, A.3
  • 31
    • 20144367724 scopus 로고    scopus 로고
    • Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death
    • I Cappuccio A Calderone CL Busceti 2005 Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death J Neurosci 25 2647 2657
    • (2005) J Neurosci , vol.25 , pp. 2647-2657
    • Cappuccio, I.1    Calderone, A.2    Busceti, C.L.3
  • 32
    • 0042379932 scopus 로고    scopus 로고
    • Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes
    • RS Jope 2003 Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes Trends Pharmacol Sci 24 441 443
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 441-443
    • Jope, R.S.1
  • 33
    • 33749994957 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1
    • C Scali F Caraci M Gianfriddo 2006 Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1 Neurobiol Dis 24 254 265
    • (2006) Neurobiol Dis , vol.24 , pp. 254-265
    • Scali, C.1    Caraci, F.2    Gianfriddo, M.3
  • 34
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • S Oddo A Caccamo M Kitazawa 2003 Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease Neurobiol Aging 24 1063 1070
    • (2003) Neurobiol Aging , vol.24 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3
  • 35
    • 33846047004 scopus 로고    scopus 로고
    • Pathways by which Abeta facilitates tau pathology
    • M Blurton-Jones FM Laferla 2006 Pathways by which Abeta facilitates tau pathology Curr Alzheimer Res 3 437 448
    • (2006) Curr Alzheimer Res , vol.3 , pp. 437-448
    • Blurton-Jones, M.1    Laferla, F.M.2
  • 36
    • 0031695652 scopus 로고    scopus 로고
    • Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons
    • A Takashima T Honda K Yasutake 1998 Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons J Neurosci Res 31 317 323
    • (1998) J Neurosci Res , vol.31 , pp. 317-323
    • Takashima, A.1    Honda, T.2    Yasutake, K.3
  • 37
    • 33747425620 scopus 로고    scopus 로고
    • GSK-3 is essential in the pathogenesis of Alzheimer's disease
    • A Takashima 2006 GSK-3 is essential in the pathogenesis of Alzheimer's disease J Alzheimers Dis 9 309 317
    • (2006) J Alzheimers Dis , vol.9 , pp. 309-317
    • Takashima, A.1
  • 38
    • 0030788767 scopus 로고    scopus 로고
    • Presenilin 1 interaction in the brain with a novel member of the Armadillo family
    • J Zhou U Liyanage M Medina 1997 Presenilin 1 interaction in the brain with a novel member of the Armadillo family NeuroReport 8 1489 1494
    • (1997) NeuroReport , vol.8 , pp. 1489-1494
    • Zhou, J.1    Liyanage, U.2    Medina, M.3
  • 39
    • 13144265717 scopus 로고    scopus 로고
    • Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
    • A Takashima M Murayama O Murayama 1998 Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau Proc Natl Acad Sci USA 95 9637 9641
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9637-9641
    • Takashima, A.1    Murayama, M.2    Murayama, O.3
  • 40
    • 0037145062 scopus 로고    scopus 로고
    • Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis
    • DE Kang S Soriano X Xia 2002 Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 110 751 762
    • (2002) Cell , vol.110 , pp. 751-762
    • Kang, D.E.1    Soriano, S.2    Xia, X.3
  • 41
    • 0032531793 scopus 로고    scopus 로고
    • Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
    • Z Zhang H Hartmann VM Do 1998 Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis Nature 395 698 702
    • (1998) Nature , vol.395 , pp. 698-702
    • Zhang, Z.1    Hartmann, H.2    Do, V.M.3
  • 42
    • 33845350346 scopus 로고    scopus 로고
    • The ups and downs of Wnt signaling in prevalent neurological disorders
    • GV De Ferrari RT Moon 2006 The ups and downs of Wnt signaling in prevalent neurological disorders Oncogene 25 7545 7553
    • (2006) Oncogene , vol.25 , pp. 7545-7553
    • De Ferrari, G.V.1    Moon, R.T.2
  • 44
    • 0037220599 scopus 로고    scopus 로고
    • Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils
    • GV De Ferrari MA Chacón MI Barría 2003 Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils Mol Psychiatry 8 195 208
    • (2003) Mol Psychiatry , vol.8 , pp. 195-208
    • De Ferrari, G.V.1    Chacón, M.A.2    Barría, M.I.3
  • 45
    • 0032787503 scopus 로고    scopus 로고
    • Mitotic signaling by beta-amyloid causes neuronal death
    • A Copani F Condorelli A Caruso 1999 Mitotic signaling by beta-amyloid causes neuronal death FASEB J 13 2225 2234
    • (1999) FASEB J , vol.13 , pp. 2225-2234
    • Copani, A.1    Condorelli, F.2    Caruso, A.3
  • 46
    • 33947185406 scopus 로고    scopus 로고
    • The nature of the cell cycle in neurons: Focus on a "non- canonical" pathway of DNA replication causally related to death
    • A Copani F Caraci JJ Hoozemans 2007 The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death Biochim Biophys Acta 1772 409 412
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 409-412
    • Copani, A.1    Caraci, F.2    Hoozemans, J.J.3
  • 47
    • 3042834662 scopus 로고    scopus 로고
    • Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
    • A Caricasole A Copani F Caraci 2004 Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain J Neurosci 24 6021 6027
    • (2004) J Neurosci , vol.24 , pp. 6021-6027
    • Caricasole, A.1    Copani, A.2    Caraci, F.3
  • 48
    • 34547191230 scopus 로고    scopus 로고
    • Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease
    • GV De Ferrari A Papassotiropoulos T Biechele 2007 Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease Proc Natl Acad Sci USA 104 9434 9439
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9434-9439
    • De Ferrari, G.V.1    Papassotiropoulos, A.2    Biechele, T.3
  • 49
    • 56349137912 scopus 로고    scopus 로고
    • Induction of transient focal brain ischemia induces the expression of the Wnt inhibitor, Dickkopf-1, in neurons of the perifocal regions in rats
    • Biagioni F, Mastroiacovo F, Busceti CL et al (2007) Induction of transient focal brain ischemia induces the expression of the Wnt inhibitor, Dickkopf-1, in neurons of the perifocal regions in rats. Soc Neurosci Abstr Program No. 493.22
    • (2007) Soc Neurosci Abstr Program No. 493.22
    • Biagioni, F.1    Mastroiacovo, F.2    Busceti, C.L.3
  • 51
    • 34247114226 scopus 로고    scopus 로고
    • Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy
    • CL Busceti F Biagioni E Aronica 2007 Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy Epilepsia 48 694 705
    • (2007) Epilepsia , vol.48 , pp. 694-705
    • Busceti, C.L.1    Biagioni, F.2    Aronica, E.3
  • 52
    • 56349114013 scopus 로고    scopus 로고
    • 3,4-Methylendioxymethamphetamine (ecstasy) induces the expression of the wnt inhibitor, dickkopf-1, and tau protein phosphorylation in the mouse hippocampus
    • Busceti CL, Biagioni F, Riozzi et al (2007) 3,4- Methylendioxymethamphetamine (ecstasy) induces the expression of the wnt inhibitor, dickkopf-1, and tau protein phosphorylation in the mouse hippocampus. Soc Neurosci Abstr Program No. 66.4
    • (2007) Soc Neurosci Abstr Program No. 66.4
    • Busceti, C.L.1    Biagioni, F.2    Riozzi3
  • 53
    • 33645853196 scopus 로고    scopus 로고
    • Memory impairment in now abstinent MDMA users and continued users: A longitudinal follow-up
    • KK Zakzanis Z Campbell 2006 Memory impairment in now abstinent MDMA users and continued users: a longitudinal follow-up Neurology 66 740 741
    • (2006) Neurology , vol.66 , pp. 740-741
    • Zakzanis, K.K.1    Campbell, Z.2
  • 54
    • 56349132966 scopus 로고    scopus 로고
    • Compositions and methods for bone formation and remodeling
    • US Patent 2005/0196349
    • Wu D, Zhang Y, Liu P et al (2005) Compositions and methods for bone formation and remodeling. US Patent 2005/0196349
    • (2005)
    • Wu, D.1    Zhang, Y.2    Liu, P.3
  • 55
    • 0035843148 scopus 로고    scopus 로고
    • Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
    • C Desbois-Mouthon A Cadoret MJ Blivet-Van Eggelpoël 2001 Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation Oncogene 20 252 259
    • (2001) Oncogene , vol.20 , pp. 252-259
    • Desbois-Mouthon, C.1    Cadoret, A.2    Blivet-Van Eggelpoël, M.J.3
  • 56
    • 56349094978 scopus 로고    scopus 로고
    • A dual mechanism of neuroprotection by transforming growth factor-β1 against β-amyloid neurotoxicity
    • Caraci F, Copani A, Battaglia G et al (2006) A dual mechanism of neuroprotection by transforming growth factor-β1 against β-amyloid neurotoxicity. Soc Neurosci Abstr Program No. 171.4
    • (2006) Soc Neurosci Abstr Program No. 171.4
    • Caraci, F.1    Copani, A.2    Battaglia, G.3
  • 57
    • 33644806375 scopus 로고    scopus 로고
    • Role of insulin-like growth factors in neuronal plasticity and neuroprotection
    • I Torres Aleman 2005 Role of insulin-like growth factors in neuronal plasticity and neuroprotection Adv Exp Med Biol 567 243 258
    • (2005) Adv Exp Med Biol , vol.567 , pp. 243-258
    • Torres Aleman, I.1
  • 58
    • 30944440647 scopus 로고    scopus 로고
    • Transforming growth factor-beta signalling in brain disorders
    • D Vivien C Ali 2006 Transforming growth factor-beta signalling in brain disorders Cytokine Growth Factor Rev 17 121 128
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 121-128
    • Vivien, D.1    Ali, C.2
  • 59
    • 33750894549 scopus 로고    scopus 로고
    • Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease
    • HC Huang PS Klein 2006 Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease Curr Drug Targets 7 1389 1397
    • (2006) Curr Drug Targets , vol.7 , pp. 1389-1397
    • Huang, H.C.1    Klein, P.S.2
  • 60
    • 29144471908 scopus 로고    scopus 로고
    • Lithium: Potential therapeutics against acute brain injuries and chronic neurodegenerative diseases
    • A Wada H Yokoo T Yanagita 2005 Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases J Pharmacol Sci 99 307 321
    • (2005) J Pharmacol Sci , vol.99 , pp. 307-321
    • Wada, A.1    Yokoo, H.2    Yanagita, T.3
  • 61
    • 34147210411 scopus 로고    scopus 로고
    • Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder
    • PV Nunes OV Forlenza WF Gattaz 2007 Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder Br J Psychiatry 190 359 360
    • (2007) Br J Psychiatry , vol.190 , pp. 359-360
    • Nunes, P.V.1    Forlenza, O.V.2    Gattaz, W.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.