Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model

International Journal of Cancer

Volumn 72, Issue 1, 1997, Pages 95-101

  Lubet, Ronald A ^a   Steele, Vernon E ^a   Eto, Isao ^b   Margaret Juliana, M ^c   Kelloff, Gary J ^a   Grubbs, Clinton J ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANETHOLE TRITHIONE; CARCINOGEN; CYTOCHROME P450; DIMETHYLBENZ[A]ANTHRACENE; MICONAZOLE; OLTIPRAZ; PHENETHYL ISOTHIOCYANATE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER INCIDENCE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ACETYLCYSTEINE; ANETHOLE TRITHIONE; ANIMALS; ANTICARCINOGENIC AGENTS; BODY WEIGHT; FEMALE; ISOTHIOCYANATES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICONAZOLE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0030745630     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970703)72:1<95::AID-IJC14>3.0.CO;2-9     Document Type: Article

References (26)

1. ADAM-RODWELL , G., MORSE, M. and STONER, G.D., The effects of phenethylisothiocyanate on benzo(a)pyrene induced tumors and DNA adducts in A/J mouse lung. Cancer Lett., 71, 35-42 (1993).
2. ARMITAGE, P., The chi-square test for heterogenity of proportion after adjustment for stratification. J.R. Statist. Soc. B, 28, 150-163 (1966).
3. BRODIE, R.R., CHASSEAUD, L.F. and WALMSLEY, W.H., High performance liquid chromatographic determination of the antimycotic compound econazole in plasma. J. Chromatogr., 155, 209-213 (1976).
4. CORNWELL, P.E., MORGAN, S.L. and VAUGHN, W.H., Modification of a high-performance liquid chromatographic method for assay of homocysteine in human plasma. J. Chromatogr., 617, 136-139 (1993).
5. DEFLORA, S., ASTENGO, M., SERRA, D. and BENNICELLI, C., Inhibition of urethan induced lung tumors in mice by dietary N-acetylcysteine. Cancer Lett., 32, 235-241 (1986).
6. DUNNICK, J.K., PREJEAN, J.D., HASEMAN, J., THOMPSON, R.B., GILES, H.D. and McCONNELL, E.E., Carcinogenesis bioassay of allyl isothiocyanate. Fund. appl. Toxicol., 2, 114-120 (1982).
7. GRUBBS, C.J., STEELE, V.E., CASEBOLT, T., JULIANA, M.M., ETO, I., WHITAKER, L.M., DRAGNEV, K.H., KELLOFF, G.J. and LUBET, R.L., Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol. Anticancer Res., 15, 709-716 (1995).
8. GUO, Z.G., SMITH, T.J., WANG, E., SADRICH, N., MA, Q., THOMAS, P.E. and YANG, C.S., Effects of phenethylisothiocyanante, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosoamine metabolism in rats. Carcinogenesis. 13, 2205-2210 (1992).
9. IZZOTTI, A., D'AGOSTINI, F., BAGNASCO, M., SCATOLINI, L., ROUIDA, A., BALANSKY, R.M., CESARONE, C.F. and DEFLORA, S., Chemoprevention of carcinogen DNA adducts and chronic degenerative diseases. Cancer Res. (Suppl.), 54, 1994S-1998S (1994).
10. KENSLER, T.W., EGNER, P.A., DOLA, P.M., GROOPMAN, J.D. and ROEBUCK, J.D., Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2 dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thione and 1,2-dithiol-3-ones. Cancer Res., 47, 4271-4277 (1987).
11. KEY, T.J. and PIKE, M.C., The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer. Europ. J. Cancer clin. Oncol., 24, 29-34 (1988).
12. LUBET, R.A., STEELE, V.E., CASEBOLT, T.L., ETO, I., KELLOFF, G.J. and GRUBBS, C.J., Chemopreventive effects of the aromatase inhibitors vorozole (R83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats. Carcinogenesis, 15, 2775-2780 (1994).
13. MASOUND, A.N. and BUEDING, E., Identification and quantitation of metabolites of anethole dithiolthione in rat and mouse urine using high-performance liquid chromatography. J. Chromatocr., 276, 111-119 (1983).
14. MIKI, Y., SWENSEN, J., SHATTUCK-EIDENS, D., FUTREAL, P.A., HARSHMAN, K., TAVTIGIAN, S., LIU, Q., COCHRAN, C., BENNETT, L.M. and DING, W., A strong candidate for the breast and ovarian cancer susceptibility gene BRCA 1. Science, 266, 66-71 (1994).
15. MILLER, E.G., MILLER, J.A., BROWN, R.R. and MACDONALD, J.C., On the protective effect of polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene. Cancer Res., 18, 469-477 (1958).
16. MORSE, M.A., EKLIND, K.I., HECHT, S.S., JORDAN, K.G., CHOI, C.-I., DESAI, D.H., AMIN, S.G. and CHUNG, F.-L., Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res., 51, 1846-1850 (1991).
17. PETO, J., The calculation and interpretation of survival curves. In: Buyse, M.E. (ed.), Cancer clinical trials: methods and practice, pp. 361-380, Oxford University Press, Oxford (1988).
18. PRESTERA, T., HOLTZCLAW, W.D., ZHANG, Y. and TALALAY, P., Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc. nat. Acad. Sci. (Wash.), 90, 2965-2969 (1993).
19. REDDY, B.S., RAO, C.V., RIVENSON, A. and KELLOFF, G.J., Chemoprevention of colon carcinogenesis by organosulfur compounds. Cancer Res., 53, 3493-3498(1993).
20. RODRIGUES, A.D., LEWIS, D.F., IOANNIDES, C. and PARKE, D.B., Spectral and kinetic studies of the interaction of imadazole anti-fungal agents with microsomal cytochromes P450. Xenobiotica. 67, 1315-1327 (1987).
21. TALALAY, P., DELONG, M.J. and PROCHASKA, H.J., Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc. nat. Acad. Sci. (Wash.), 85, 8261-8266 (1988).
22. WATTENBERG, L.W., Chemoprevention of cancer. Cancer Res., 45, 1-8 (1985).
23. WATTENBERG, L.W. and LOUB, W.D., Inhibition of polycyclic hydrocarbon induced neoplasia by naturally occurring indoles. Cancer Res., 38, 1410-1413 (1978).
24. WOLFF, M.S., TONIOLO, P.G., LEE, E.W., RIVERA, M. and DUBIN, N., Blood levels of organochlorine residues and risk of breast cancer. J. nat. Cancer Inst., 85, 648-652 (1993).
25. YAMAMOTO, T., FUKUOKA, M., YASAMURA, T. and OKADA, H., In vivo and in vitro effects of the antifungal agent miconazole on estrogen biosynthesis in human breast cancer. Europ. J. Cancer clin. Oncol., 25, 1493-1497 (1989).
26. ZHANG, Y., TALALAY, P., CHO, C.G. and POSNER, G., A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. nat. Acad. Sci. (Wash.). 89, 2399-2403 (1992).