Differential effects of oltipraz on CYP1A and CYP2B in rat lung

Carcinogenesis

Volumn 22, Issue 1, 2001, Pages 49-55

  Le Ferrec, Eric ^a   Ilyin, Guennady ^b   Mahéo, Karine ^a   Bardiau, Caroline ^a   Courtois, Arnaud ^a   Guillouzo, André ^a   Morel, Fabrice ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; APOPROTEIN; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2B; ENDOTOXIN; ENZYME; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; OLTIPRAZ; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOSOL; DIET; DRUG EFFECT; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE EXPRESSION; HEPATITIS; KIDNEY; LUNG; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

ESCHERICHIA COLI;

EID: 0035135934     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.1.49     Document Type: Article

References (51)

1. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review
2. Inhibition of 2-amino-1-methyl-6-phenylimidazol[4,5]pyridine-induced lymphoma formation by oltipraz
3. Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1, 2-dithiol-3-thione (oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard
4. Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats
5. Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): Predictive role for short-term molecular dosimetry
6. Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2- [N-(4- methylthiazol-2-yl) carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice
7. Chemopreventive activity of oltipraz against N-nitrosobis (2-oxopropyl) amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters
8. Oltipraz: Clinical opportunities for cancer chemoprevention
9. Antioxidant-inducible genes
10. Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture
11. Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture
12. Quantitation of tissue-and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones
13. Endotoxin suppresses the oltipraz-mediated induction of major hepatic glutathione transferases and cytochromes P450 in the rat
14. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma
15. Ulcerative colitis and colorectal cancer. A population-based study
16. Helicobacter pylori infection and the risk of gastric carcinoma
17. Factors affecting drug biotransformation
18. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
19. Genomic sequencing
20. Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1β in rat hepatocytes in primary culture
21. Tissue distribution of rat glutathione transferase subunit 7, a hepatoma marker
22. cDNA clones for liver cytochrome P-450s from individual Aroclor-treated rats: Constitutive expression of a new P-450 gene related to phenobarbital inducible forms
23. Mechanism of induction of cytochrome P-450 by phenobarbital
24. The nucleotide sequence of a rat 18S ribosomal ribonucleic acid gene and a proposal for the secondary structure of 18S ribosomal ribonucleic acid
25. Glutathione S-transferases (rat and human)
26. Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its N-alkyl ethers (alkoxyresorufins)
27. Induction of CYP2B1 mediated pentoxyresorufin O-dealkylase activity in different species, sex and tissue by prototype 2B1-inducers
28. Tissue-specific expression of rat mRNAs homologous to cytochromes P-450b and P-450e
29. The acute phase response
30. Role of the proteasome complex in degradation of human CYP2E1 in transfected HepG2 cells
31. Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes
32. Proteolytic degradation of heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination, and the 26S proteasome?
33. Rapid detection of inducers of enzymes that protect against carcinogens
34. Detoxication enzymes and chemoprevention
35. A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture
36. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones
37. Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver
38. Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz
39. Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver
40. Hormone-and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes
41. Acetone-regulated synthesis and degradation of cytochrome P450E1 and cytochrome P4502B1 in rat liver
42. Purification and characterization of two membrane bound serine proteinases from rat liver microsomes active in degradation of cytochrome P450
43. Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1
44. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
45. Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: Characterization of the proteolytic system
46. Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis
47. Expression of CYP2B1 in freshly isolated and proliferating cultures of epithelial rat lung cells
48. DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes
49. DUB-1, a deubiquitinating enzyme with growth-suppressing activity
50. Deubiquitinating enzymes: A new class of biological regulators
51. Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane