Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters

Cancer Letters

Volumn 153, Issue 1-2, 2000, Pages 211-218

  Son, Hwa Young ^a   Nishikawa, Akiyoshi ^a   Furukawa, Fumio ^a   Kasahara, Ken ichiro ^a   Miyauchi, Makoto ^a   Nakamura, Hideaki ^a   Ikeda, Takako ^a   Hirose, Masao ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Hamster; Modification; N nitrosobis(2 oxopropyl)amine; Oltipraz; Tumorigenesis

Indexed keywords

BIS(2 OXOPROPYL)NITROSAMINE; CARCINOGEN; OLTIPRAZ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GALLBLADDER CANCER; HAMSTER; HISTOPATHOLOGY; KIDNEY CANCER; LIVER ADENOMA; LUNG CANCER; NONHUMAN; ORGAN WEIGHT; PANCREAS CANCER; PRIORITY JOURNAL;

ANIMALS; ANTICARCINOGENIC AGENTS; BODY WEIGHT; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; CRICETINAE; FEMALE; MESOCRICETUS; NEOPLASMS, EXPERIMENTAL; NITROSAMINES; ORGAN SIZE; PYRAZINES;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0034729356     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00373-6     Document Type: Article

References (50)

1. Kensler T.W., Groopman J.D., Roebuck B.D. Chemoprotection by Oltipraz and other dithiolethiones. Wattenberg L., Lipkin M., Boone C.W., Kelloff G.J. Cancer Chemoprevention. 1992;205-226 CRC Press, Boca Raton, FL.
2. Ansher S.S., Dolan P., Bueding E. Biochemical effects of dithiolthiones. Food Chem. Toxicol. 24:1986;405-415.
3. Bertram J.S., Kolonel L.N., Meyskens F.L. Jr. Rationale and strategies for chemoprevention of cancer in humans. Cancer Res. 47:1987;3012-3031.
4. Zhang Y., Talalay P., Cho C.G., Posner G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA. 89:1992;2399-2403.
5. Kensler T.W., Helzlsouer K.J. Oltipraz: clinical opportunities for cancer chemoprevention. J. Cell Biochem. 22:(Suppl.):1995;101-107.
6. Nishikawa A., Tanakamura Z., Furukawa F., Lee I.S., Kasahara K., Ikezaki S., Takahashi M. Chemopreventive activity of oltipraz against induction of glandular stomach carcinogenesis in rats by N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis. 19:1998;365-368.
7. Gupta E., Olopade O.I., Ratain M.J., Mick R., Baker T.M., Berezin F.K., Benson A.B. III, Dolan M.E. Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent. Clin. Cancer Res. 1:1995;1133-1138.
8. Benson A.B. III. Oltipraz: a laboratory and clinical review. J. Cell Biochem. 17F:(Suppl.):1993;278-291.
9. Jacobson L.P., Zhang B.C., Zhu Y.R., Wang J.B., Wu Y., Zhang Q.N., Yu L.Y., Qian G.S., Kuang S.Y., Li Y.F., Fang X., Zarba A., Chen B., Enger C., Davidson N.E., Gorman M.B., Gordon G.B., Prochaska H.J., Egner P.A., Groopman J.D., Munoz A., Helzlsouer K.J., Kensler T.W. Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes. Cancer Epidemiol. Biomarkers Prev. 6:1997;257-265.
10. Kensler T.W., He X., Otieno M., Egner P.A., Jacobson L.P., Chen B., Wang J.S., Zhu Y.R., Zhang B.C., Wang J.B., Wu Y., Zhang Q.N., Qian G.S., Kuang S.Y., Fang X., Li Y.F., Yu L.Y., Prochaska H.J., Davidson N.E., Gordon G.B., Gorman M.B., Zarba A., Enger C., Munoz A., Helzlsouer K.J., Groopman J.D. Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers. Cancer Epidemiol. Biomarkers Prev. 7:1998;127-134.
11. 1 by oltipraz in residents of Qidong, People's Republic of China. J. Natl. Cancer Inst. 91:1999;347-354.
12. Pepin P., Bouchard L., Nicole P., Castonguay A. Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis. 13:1992;341-348.
13. Morse M.A., Zu H., Kresty L.A., Stoner G.D. Failure of dietary oltipraz to inhibit benzo[a]pyrene-induced lung tumorigenesis in strain a mice. Cancer Lett. 91:1995;133-138.
14. 1-induced preneoplastic foci in a rat model of hepatic tumorigenesis. Carcinogenesis. 14:1993;2423-2425.
15. Clapper M.L., Wood M., Leahy K., Lang D., Miknyoczki S., Ruggeri B.A. Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters. Carcinogenesis. 16:1995;2159-2165.
16. Pour P.M., Althoff K., Kruger F.W., Mohr U. A potent pancreatic carcinogen in Syrian hamsters; N-nitrosobis(2-oxopropyl)amine. J. Natl. Cancer Inst. 58:1977;1449-1453.
17. Nishikawa A., Furukawa F., Uneyama C., Ikezaki S., Tanakamaru Z., Chung F.L., Takahashi M., Hayashi Y. Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N-nitrosobis(2-oxopropyl)amine-treated hamsters. Carcinogenesis. 17:1996;1381-1384.
18. Nishikawa A., Furukawa F., Kasahara K., Tanakamaru Z., Miyauchi M., Nakamura H., Ikeda T., Imazawa T., Hirose M. Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase. Cancer Lett. 141:1999;109-115.
19. Hoffmann D., Revienson A., Hecht S.S., Hilfroch J., Kobayashi N., Wynder E.L. Model studies in tobacco carcinogenesis with the Syrian golden Hamster. Homburger F. The Syrian Hamster in Toxicology and Carcinogenesis Research, Progress in Experimental Tumor Research. Vol. 24:1979;370-390 Karger, Basel.
20. Takahashi M., Furukawa F., Toyoda K., Sato H., Hasegawa R., Imaida K., Hayashi Y. Effects of various prostaglandin synthesis inhibitors on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine. Carcinogenesis. 11:1990;393-395.
21. Steele V.E., Moon R.C., Lubet R.A., Grubbs C.J., Reddy B.S., Wargovich M., McCormick D.L., Pereira M.A., Crowell J.A., Bagheri D., Sigman C.C., Boone C.W., Kelloff G.J. Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: methods and results from the NCI Chemoprevention Drug Development Program. J. Cell Biochem. 20:(Suppl.):1994;32-54.
22. O'Dwyer P.J., Clayton M., Halbherr T., Myers C.B., Yao K.S. The chemopreventive agent oltipraz stimulates repair of damaged DNA. Cancer Res. 57:1997;1050-1053.
23. Clapper M.L., Everley L.C., Strobel L.A., Townsend A.J., Engstrom P.F. Coordinate induction of glutathione S-transferase alpha, mu, and pi expression in murine liver after a single administration of oltipraz. Mol. Pharmacol. 45:1994;469-474.
24. Clapper M.L. Chemopreventive activity of oltipraz. Pharmacol. Ther. 78:1998;17-27.
25. Egner P.A., Kensler T.W., Prestera T., Talalay P., Libby A.H., Joyner H.H., Curphey T.J. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones. Carcinogenesis. 15:1994;177-181.
26. Nare B., Smith J.M., Prichard R.K. Mechanisms of inactivation of Schistosoma mansoni and mammalian glutathione S-transferase activity by the antischistosomal drug oltipraz. Biochem. Pharmacol. 43:1992;1345-1351.
27. 1 metabolism in human hepatocytes in primary culture. Cancer Res. 55:1995;5574-5579.
28. Chi W.J., Doong S.L., Lin-Shiau S.Y., Boone C.W., Kelloff G.J., Lin J.K. Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein. Carcinogenesis. 19:1998;2133-2138.
29. O'Dwyer P.J., Szarka C.E., Yao K.S., Halbherr T.C., Pfeiffer G.R., Green F., Gallo J.M., Brennan J., Frucht H., Goosenberg E.B., Hamilton T.C., Litwin S., Balshem A.M., Engstrom P.F., Clapper M.L. Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz. J. Clin. Invest. 98:1996;1210-1217.
30. Boone C.W., Kelloff G.J., Malone W.E. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review. Cancer Res. 50:1990;2-9.
31. Wattenberg L.W., Bueding E. Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard. Carcinogenesis. 7:1986;1379-1381.
32. Moon R.C., Rao K.V.N., Detrisac C.J., Kelloff G.J., Steele V.E., Doody L.A. Chemoprevention of respiratory tract neoplasia in the hamster by oltipraz, alone and in combination. Int. J. Oncol. 4:1994;661-667.
33. 1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer Res. 51:1991;5501-5506.
34. 1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione. Carcinogenesis. 6:1985;759-763.
35. 14C-oltipraz in animals. Pharmacokinetics in mice, rats and monkeys. Comparison of the biotransformation in the infected mouse and in the schistosomes. Arzneimittelforschung. 35:1985;1431-1436.
36. Kensler T.W. Chemoprevention by inducers of carcinogen detoxication enzymes. Environ. Health Perspect. 105:(Suppl. 4):1997;965-970.
37. Rao C.V., Rivenson A., Katiwalla M., Kelloff G.J., Reddy B.S. Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats. Cancer Res. 53:1993;2502-2506.
38. 7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases. Cancer Res. 46:1986;3924-3931.
39. Guttenplan J.B., Guttenplan J.B., Kokkinakis D. High mutagenic activity of N-nitrosobis(2-oxopropyl)amine and N-nitrosobis(2-hydroxypropyl)amine in the host-mediated assay in hamsters: evidence for premutagenic methyl and hydroxylpropyl adducts. Carcinogenesis. 14:1993;1621-1625.
40. Kokkinakis D.M. Alkylation of rodent tissue DNA induced by N-nitrosobis(2-hydroxypropyl)amine. Carcinogenesis. 13:1992;759-765.
41. Bax J., Schippers-Gillissen C., Woutersen R.A., Scherer E. Cell specific DNA alkylation in target and non-target organs of N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis in hamster and rat. Carcinogenesis. 12:1991;583-590.
42. Tsujiuchi T., Mizumoto K., Tsutsumi M., Denda A., Amanuma T., Kondoh S., Konishi Y. Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters. Cancer Lett. 61:1991;61-66.
43. Cerny W.L., Mangold K.A., Scarpelli D.G. K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster. Cancer Res. 52:1992;4507-4513.
44. Ohgaki H., Furukawa F., Takahashi M., Kleihues P. K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine. Carcinogenesis. 14:1993;1471-1473.
45. Yamanaka S., Tomioka T., Tajima Y., Okada K., Shiku H., Kanematsu T. K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters. J. Surg. Oncol. 66:1997;97-103.
46. Mori Y., Yamazaki H., Toyoshi K., Denda A., Konishi Y. Mutagenic activation of carcinogenic N-nitrosopropylamines by liver S9 fractions from mice, rats and hamsters: evidence for a cytochrome P-450-dependent reaction. Carcinogenesis. 7:1986;375-379.
47. Langouët S., Maheo K., Berthou F., Morel F., Lagadic-Gossman D., Glaise D., Coles B., Ketterer B., Guillouzo A. Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture. Carcinogenesis. 18:1997;1343-1349.
48. Buetler T.M., Gallagher E.P., Wang C., Stahl D.L., Hayes J.D., Eaton D.L. Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. Toxicol. Appl. Pharmacol. 135:1995;45-57.
49. Buetler T.M., Bammler T.K., Hayes J.D., Eaton D.L. Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention. Cancer Res. 56:1996;2306-2313.
50. Maheo K., Morel F., Antras-Ferry J., Langouët S., Desmots F., Corcos L., Guillouzo A. Endotoxin suppresses the oltipraz-mediated induction of major hepatic glutathione transferases and cytochromes P450 in the rat. Hepatology. 28:1998;1655-1662.