Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury

Experimental Neurology

Volumn 196, Issue 2, 2005, Pages 352-364

  Chan, Carmen C M ^a   Khodarahmi, Kourosh ^a   Liu, Jie ^a   Sutherland, Darren ^a   Oschipok, Loren W ^a   Steeves, John D ^a   Tetzlaff, Wolfram ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Axonal regeneration; Behavior; CNS injury; Corticospinal tract; Dorsal column tract; Rho GTPases

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PHOSPHATE BUFFERED SALINE; RHO KINASE INHIBITOR;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CERVICAL SPINE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; FOOD; FOREFOOT; GRAY MATTER; HISTOPATHOLOGY; INSTRUMENTATION; INTERMETHOD COMPARISON; LOW DRUG DOSE; MALE; NERVE FIBER REGENERATION; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; RAT; ROTATION; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; STATISTICAL SIGNIFICANCE; TIME SERIES ANALYSIS; WALKING;

ACTIN DEPOLYMERIZING FACTORS; AMIDES; ANALYSIS OF VARIANCE; ANIMALS; AXONS; BEHAVIOR, ANIMAL; BIOTIN; BLOTTING, WESTERN; CHOLERA TOXIN; DEXTRANS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOTOR ACTIVITY; MYOSIN-LIGHT-CHAIN PHOSPHATASE; NERVE REGENERATION; PAIN MEASUREMENT; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PSYCHOMOTOR PERFORMANCE; PYRIDINES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECOVERY OF FUNCTION; ROTAROD PERFORMANCE TEST; SPINAL CORD INJURIES;

EID: 27744532683     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2005.08.011     Document Type: Article

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