Local lymph node assay (LLNA): Comparison of different protocols by testing skin-sensitizing epoxy resin system components

Regulatory Toxicology and Pharmacology

Volumn 52, Issue 3, 2008, Pages 290-298

  Gamer, Armin O ^a   Nies, Eberhard ^b   Vohr, Hans Werner ^c  

^a BASF SE   (Germany)

^b INSTITUT FÜR ARBEITSSCHUTZ DER DEUTSCHEN GESETZLICHEN UNFALLVERSICHERUNG IFA   (Germany)

^c BAYER PHARMA AG   (Germany)

Author keywords

Epoxy resin system components; Local lymph node assay variants; Potency ranking of sensitizers; Quantification of lymph node stimulation; Vehicle effect

Indexed keywords

1,2 DIAMINOCYCLOHEXANE; 1,6 HEXANEDIOL DIGLYCIDYL ETHER; 2,2 BIS(4 GLYCIDYLOXYPHENYL)PROPANE; 3 XYLYLENEDIAMINE; 4 TERT BUTYLPHENYL GLYCIDYL ETHER; ACETONE; ALPHA HEXYLCINNAMALDEHYDE; AMINOETHYLETHANOLAMINE; BISPHENOL F DIGLYCIDYL ETHER; DIPROPYLENETRIAMINE; EPOXY RESIN; ISOPHORONE DIAMINE; OLIVE OIL; THYMIDINE; TRIMETHYL 1,6 HEXANEDIAMINE; TRIMETHYLOLPROPANE TRIGLYCIDYL ETHER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; LOCAL LYMPH NODE ASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SKIN IRRITATION; SKIN SENSITIZATION;

ADMINISTRATION, TOPICAL; ALLERGENS; ANIMALS; CELL PROLIFERATION; EAR AURICLE; EPOXY RESINS; FALSE POSITIVE REACTIONS; FEMALE; IMMUNIZATION; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MODELS, ANIMAL; PATCH TESTS; PINUS; RADIOACTIVE TRACERS; STATISTICS, NONPARAMETRIC; TOXICITY TESTS;

EID: 56249092468     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.08.018     Document Type: Article

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