Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark

Journal of Neuroscience

Volumn 27, Issue 33, 2007, Pages 8805-8815

  Woodruff, Michael L ^a   Olshevskaya, Elena V ^b   Savchenko, Andrey B ^b   Peshenko, Igor V ^b   Barrett, Ronald ^c   Bush, Ronald A ^d   Sieving, Paul A ^d   Fain, Gordon L ^a,e   Dizhoor, Alexander M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PENNSYLVANIA COLLEGE OF OPTOMETRY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL EYE INSTITUTE   (United States)

^e JULES STEIN EYE INSTITUTE   (United States)

Author keywords

Calcium; cGMP; Degeneration; GCAP; Guanylyl cyclase; Retina; Rod

Indexed keywords

ASPARTIC ACID; CALCIUM ION; CYCLIC GMP; GLYCINE; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; GUANYLYL CYCLASE ACTIVATING PROTEIN 1; PHOSPHODIESTERASE; RHODOPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; DARKNESS; ELECTRORETINOGRAM; ENZYME ACTIVITY; GENE MUTATION; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PHOTORECEPTOR; PHOTOTRANSDUCTION; PRIORITY JOURNAL; RETINA DEGENERATION; RETINA ROD; TRANSGENE;

ADAPTATION, OCULAR; ANIMALS; ASPARTIC ACID; CALCIUM; CYCLIC GMP; CYSTEINE; DARK ADAPTATION; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; GENE EXPRESSION REGULATION; GLYCINE; GUANYLATE CYCLASE-ACTIVATING PROTEINS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; PHYSICAL STIMULATION; RETINA; RETINAL DEGENERATION; RHODOPSIN; RODS (RETINA); TYROSINE;

EID: 34548087004     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2751-07.2007     Document Type: Article

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