Study of gene - Gene interactions for endophenotypic quantitative traits in chinese asthmatic children

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 63, Issue 8, 2008, Pages 1031-1039

  Chan, I H S ^a   NLSTang, ^a   Leung, T F ^a   Huang, W ^a   Lam, Y Y O ^a   Li, C Y ^a   Wong, C K ^a   Wong, G W K ^a   Lam, C W K ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

Asthma; Eosinophils; Gene gene interactions; Immunoglobulin e; Quantitative traits

Indexed keywords

DEOXYRIBONUCLEASE; IMMUNOGLOBULIN E; RSA1 ENZYME; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG; CCL17 PROTEIN, HUMAN; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 4 RECEPTOR ALPHA; MS4A2 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CHILD; CHINESE; CONTROLLED STUDY; EOSINOPHIL COUNT; GENE INTERACTION; GENE LOCUS; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; CASE CONTROL STUDY; CHINA; EOSINOPHILIA; FEMALE; GENETICS; HOSPITALIZATION; MALE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SPIROMETRY;

ADOLESCENT; ASTHMA; CASE-CONTROL STUDIES; CHEMOKINE CCL17; CHILD; CHILD, PRESCHOOL; CHINA; EOSINOPHILIA; FEMALE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT; MALE; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, IGE; SEVERITY OF ILLNESS INDEX; SPIROMETRY;

EID: 56149094769     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2008.01639.x     Document Type: Article

References (52)

1. Wiesch DG, Meyers DA, Bleecker ER. Genetics of asthma. J Allergy Clin Immunol 1999;104:895-901.
2. Szefler SJ, Apter A. Advances in pedi- atric and adult asthma. J Allergy Clin Immunol 2005;115:470-477.
3. Liu X, Beaty TH, Deindl P, Huang SK, Lau S, Sommerfeld C et al. Associations between specific serum IgE response and variants within the genes IL4, IL13, and IL4RA in German children: The German Multicenter Atopy Study. J Allergy Clin Immunol 2004;113:489-495.
4. Ober C, Thompson EE. Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol 2005;17:670-678.
5. Bochner BS, Busse WW. Allergy and asthma. J Allergy Clin Immunol 2005;115:953-959.
6. Vercelli D. Genetic regulation of IgE responses: achilles and the tortoise. J Allergy Clin Immunol 2005;116: 60-64.
7. Hahn LW, Ritchie MD, Moore JH. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 2003;19:376-382.
8. Chan IH, Leung TF, Tang NLS, Li CY, Sung YM, Wong GWK et al. Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children. J Allergy Clin Immunol 2006;117:127-133.
9. Battle NC, Choudhry S, Tsai HJ, Eng C, Kumar G, Beckman KB et al. Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma. Am J Respir Crit Care Med 2007;175:881- 887.
10. Moore JH, Williams SM. New strategies for identifying gene-gene interactions in hypertension. Ann Med 2002;34:88-95.
11. Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF et al. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 2001;69:138-147.
12. Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC et al. A generalized combinatorial approach for detecting gene- by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet 2007; 80:1125-1137.
13. American Thoracic Society. Medical section of the American Lung Association. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225-244.
14. Leung TF, Tang NL, Chan IH, Li AM, Ha G, Lam CW. A polymorphism in the coding region of IL-13 gene is associated with atopy but not asthma in Chinese children. Clin Exp Allergy 2001;31: 1515-1521.
15. Ip MS, Karlberg EM, Karlberg JP, Luk KD, Leong JC. Lung function reference values in Chinese children and adolescents in Hong Kong. I. Spirometric values and comparison with other populations. Am J Respir Crit Care Med 2000;162:424-429.
16. Palmer LJ, Cookson WO, James AL, Musk AW, Burton PR. Gibbs sampling-based segregation analysis of asthma- associated quantitative traits in a population-based sample of nuclear families. Genet Epidemiol 2001;20:356-372.
17. Howard TD, Koppelman GH, Xu J, Zheng SL, Postma DS, Meyers DA et al. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet 2002; 70:230-236.
18. Hunninghake GM, Soto-Quiros ME, Avila L, Su J, Murphy A, Demeo DL et al. Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol 2007;120:84-90.
19. Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T et al. Ile50Val variant of IL4Ra upregulates IgE synthesis and associates with atopic asthma. Nat Genet 1998;19:119-120.
20. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 1997;337:1720-1725.
21. Leung TF, Tang NL, Li CY, Lam CW, Wong GW, Fok TF. Association between TARC C-431T and atopy and asthma in children. J Allergy Clin Immunol 2004;114:199-202.
22. Palmer LJ, Rye PJ, Gibson NA, Moffatt MF, Goldblatt J, Burton PR et al. Association of FcepsilonR1-beta polymorphisms with asthma and associated traits in Australian asthmatic families. Clin Exp Allergy 1999;29:1555-1562.
23. van Hage-Hamsten M, Johansson E, Kronqvist M, Loughry A, Cookson WO, Moffatt MF. Associations of Fc epsilon R1-beta polymorphisms with immunoglobin E antibody responses to common inhalant allergens in a rural population. Clin Exp Allergy 2002;32: 838-842.
24. Bloemen K, Verstraelen S, Van Den Heuvel R, Witters H, Nelissen I, Schoeters G. The allergic cascade: Review of the most important molecules in the asthmatic lung. Immunol Lett 2007;113:6-18.
25. Holt PG. Antigen presentation in the lung. Am J Respir Crit Care Med 2000;162:S151-S156.
26. Bochner BS, Busse WW. Advances in mechanisms of allergy. J Allergy Clin Immunol 2004;113:868-875.
27. Nakae S, Ho LH, Yu M, Monteforte R, Iikura M, Suto H et al. Mast cell derived TNF contributes to airway hyperreactivity, inflammation, and T(H)2 cytokine production in an asthma model in mice. J Allergy Clin Immunol 2007;120:48-55.
28. Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ. cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. J Biol Chem 1996;271:29265-29270.
29. Gauchat JF, Schlagenhauf E, Feng NP, Moser R, Yamage M, Jeannin P et al. A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. Eur J Immunol 1997;27:971-978.
30. Arima K, Umeshita-Suyama R, Sakata Y, Akaiwa M, Mao XQ, Enomoto T et al. Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J Allergy Clin Immunol 2002;109:980- 987.
31. Risma KA, Wang N, Andrews RP, Cunningham CM, Ericksen MB, Bernstein JA et al. V75R576 IL-4 receptor α is associated with allergic asthma and enhanced IL-4 receptor function. J Immunol 2002;169:1604-1610.
32. Zurawski SM, Vega F Jr, Huyghe B, Zurawski G. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 1993; 12:2663-2670.
33. Guéant-Rodriguez RM, Romano A, Béri-Dexheimer M, Viola M, Gaeta F, Guéant JL. Gene-gene interactions of IL13 and IL4RA variants in immediate allergic reactions to betalactam antibiotics. Pharmacogenet Genomics 2006;16:713-719.
34. Humbert M, Ying S, Corrigan C, Menz G, Barkans J, Pfister R et al. Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophilactive cytokines interleukin (IL)-5, granulocyte macrophage-colony- stimulating factor, and IL-3. Am J Respir Cell Mol Biol 1997;16:1-8.
35. Bochner BS, Hudson SA, Xiao HQ, Liu MC. Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. J Allergy Clin Immunol 2003;112:930-934.
36. Leung TF, Wong CK, Chan IH, Ip WK, Lam CW, Wong GW. Plasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthma. J Allergy Clin Immunol 2002;110:404-409.
37. Leung TF, Wong CK, Lam CW, Li AM, Ip WK, Wong GW et al. Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children. Eur Respir J 2003;21:616-620.
38. Romagnani S. The role of lymphocytes in allergic disease. J Allergy Clin Immunol 2000;105:399-408.
39. Tsunemi Y, Komine M, Sekiya T, Saeki H, Nakamura K, Hirai K et al. The - 431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients. Exp Dermatol 2004;13:715-719.
40. Sekiya T, Tsunemi Y, Miyamasu M, Ohta K, Morita A, Saeki H et al. Variations in the human Th2-specific chemokine TARC gene. Immunogenetics 2003;54:742-745.
41. Djukanovic' R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF et al. The effects of anti-IgE (omalizumab) treatment on airways inflammation in allergic asthma. Am J Respir Crit Care Med 2004;170:583-593.
42. Plewako H, Arvidsson M, Petruson K, Oancea I, Holmberg K, Adelroth E et al. The effect of omalizumab on nasal allergic inflammation. J Allergy Clin Immunol 2002;110:68-71.
43. Holgate S, Casale T, Wenzel S, Bousquet J, Deniz Y, Reisner C. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. J Allergy Clin Immunol 2005;115:459-465.
44. Korzycka-Zaborowska B, Hopkin JM, Górski P. Genetic variants of FcepsilonRIbeta and Il-4 and atopy in a Polish population. Allergol Immunopathol (Madr) 2004;32:53-58.
45. Borish L. Genetics of allergy and asthma. Ann Allergy Asthma Immunol 1999;82:413-424.
46. Martinez FD, Solomon S, Holberg CJ, Graves PE, Baldini M, Erickson RP. Linkage of circulating eosinophils to markers on chromosome 5q. Am J Respir Crit Care Med 1998;158:1739-1744.
47. Rioux JD, Stone VA, Daly MJ, Cargill M, Green T, Nguyen H et al. Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33. Am J Hum Genet 1998; 63:1086-1094.
48. Adamko D, Lacy P, Moqbel R. Eosin- ophil function in allergic inflammation: from bone marrow to tissue response. Curr Allergy Asthma Rep 2004;4:149-158.
49. Rohrbach M, Frey U, Kraemer R, Liechti-Gallati S. A variant in the gene for GM-CSF, I117T, is associated with atopic asthma in a Swiss population of asthmatic children. J Allergy Clin Immunol 1999;104: 247-248.
50. Park BL, Kim LH, Choi YH, Lee JH, Rhim T, Lee YM et al. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. J Hum Genet 2004;49:517-527.
51. Hong SJ, Lee SY, Kim HB, Kim JH, Kim BS, Choi SO et al. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. J Allergy Clin Immunol 2005;115:758-763.
52. Kabesch M, Depner M, Dahmen I, Weiland SK, Vogelberg C, Niggemann B et al. Polymorphisms in eosinophil pathway genes, asthma and atopy. Allergy 2007;62:423-428.