Genetics of allergy and asthma

Annals of Allergy, Asthma and Immunology

Volumn 82, Issue 5, 1999, Pages 413-426

  Borish, Larry ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; T LYMPHOCYTE RECEPTOR;

ALLERGIC ASTHMA; ALLERGY; CHROMOSOME 11; CHROMOSOME 5; GENE CLUSTER; GENE LOCATION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 0033016198     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)62715-9     Document Type: Review

References (97)

1. Cooke RA, van der Veer A. Human sensitization. J Immunol 1916;1: 201-205.
2. Coca AF, Cooke RA. On the classification of the phenomenon of hypersensitiveness. J Immunol 1923;8: 163-182.
3. Adkinson J. The behavior of bronchial asthma as an inherited character. Genetics 1920;5:363-418.
4. Lawrence S, Beasley R, Doull I, et al. Genetic analysis of atopy and asthma as quantitative traits and ordered polychromotomies. Ann Hum Genet 1994; 58:359-368.
5. Arshad SH, Stevens M, Hide DW. The effect of genetic and environmental factors on the prevalence of allergic disorders at the age of two years. Clin Exp Allergy 1993;12:504-511.
6. Mrazek DA, Klinnert M, Mrazek P, et al. Early asthma onset. Consideration of parenting issues. J Am Acad Child Adolescent Psych 1991;30:277-282.
7. Klinnert MD, Mrazek P, Mrazek DA. Early asthma onset: the interaction between family stressors and adaptive parenting. Psychiatry 1994;57:51-61.
8. Litonjua AA, Carey VJ, Burge HA, et al. Parental history and the risk for childhood asthma: Does mother confer more risk than father? Am J Respir Crit Care Med 1998;158:176-181.
9. 1 between asthmatic and nonasthmatic families: role of a maternal component. Am J Respir Crit Care Med 1998;158:162-169.
10. Clarke JA, Donnally HH, Coca AF. Studies in specific hypersensitiveness. XXXII. On the influence of heredity in atopy. J Immunol 1928;15:9-11.
11. Edfors-Lubs ML. Allergy in 7000 twin pairs. Acta Allergol 1971;26:249-285.
12. Kjellman N-IM. Atopic disease in seven-year old children. Acta Paediatr Scand 1977;66:465-471.
13. Kuster W, Petersen M, Christopher E, et al. A family study of atopic dermatitis. Arch Dermatol Res 1990;282: 98-102.
14. Falliers CI, de Cardoso RR, Bane HN, et al. Discordant allergic manifestations in monozygotic twins: genetic identity versus clinical, physiologic, and biochemical differences, Allergy 1971;47:207-219.
15. Hanson B, McGue M, Roitman-Johnson B, et al. Atopic disease and immunoglobulin E in twins reared apart and together. Am J Hum Genet 48:873-879.
16. Hopp RJ, Bewtra AK, Watt GD, et al. Genetic analysis of allergic disease in twins. J Allergy Clin Immunol 1984; 73:265-270.
17. Duffy DL, Martin NG, Battistutta D, et al. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis 1990;142:1351-1358.
18. Nieminen MM, Kaprio J, Koskenvuo M. A population-based study of bronchial asthma in twin pairs. Chest 1991; 100:71-75.
19. Lichtenstein P, Svartengren M. Genes, environments, and sex; factors of importance in atopic diseases in 7-9 year-old Swedish twins. Allergy 1997; 52:1079-1086.
20. Harris JR, Magnus P, Samuelsen SO, Tambs K. No evidence for effects of family environment on asthma. A retrospective study of Norwegian twins. Am J Respir Crit Care Med 1997;156: 43-49.
21. Laitinen T, Rasanen M, Kaprio J, et al. Importance of genetic factors in adolescent asthma: a population-based twin-family study. Am J Respir Crit Care Med 1998;157:1073-1078.
22. Sibbald B, Horn MEC, Brain EA, Gregg I. Genetic factors in childhood asthma. Thorax 1980;35:671-674.
23. Townley RG, Bewtra AK, Nair NM, et al. Methacholine inhalation challenge studies. J Allergy Clin Immunol 1979; 64:569-574.
24. Townley RG, Bewtra A, Wilson AF, et al. Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma. J Allergy Clin Immunol 1986; 77:101-107.
25. Konig P, Godfrey S. Prevalence of exercise-induced bronchial lability in families of children with asthma. Arch Dis Child 1973;48:513-518.
26. König P, Godfrey S. Exercise-induced bronchial lability in monozygotic (identical) and dizygotic (nonidentical) twins. J Allergy Clin Immunol 1974; 54:280-287.
27. Bazarel M, Orgel HA, Hamburger RN. Genetics of IgE and allergy: serum IgE levels in twins. J Allergy Clin Immunol 1974;54:288-304.
28. Sistonen P, Johnsson V, Koskenvuo M, et al. Serum IgE levels in twins. Hum Hered 1980;30:155-158.
29. Lee SK, Metrakos JD, Tanaka KR, et al. Genetic influence on serum IgE levels. Pediatr Res 1980;14:60-63.
30. Cookson WO, Hopkin JM. Dominant inheritance of atopic immunoglobulin E responsiveness. Lancet 1988;1: 86-88.
31. Meyers DA, Beaty TH, Freidhoff LF, et al. Inheritance of total serum IgE (basal levels) in man. Am J Hum Genet 1987;41:51-62.
32. Meyers DA, Marsh DG. Report on a National Institute of Allergy and Infectious Diseases sponsored workshop on the genetics of total immunoglobulin E levels in humans. J Allergy Clin Immunol 1981;67:167-170.
33. Gerrard JW, Rao DC, Morton NE. A genetic study of immunoglobulin E. Am J Hum Genet 1978;30:46-58.
34. Parks T, Felix K, Rice T, et al. A genetic study of immunoglobulin E and atopic disease based on families ascertained through asthmatic children. Hum Hered 1990;40:69-76.
35. Blumenthal MN, Namboodiri K, Mendell N, et al. Genetic transmission of serum IgE levels. Am J Med Genet 1981;10:219-228.
36. Young RP, Hart BJ, Merrett TG, et al. House dust mite sensitivity; interaction of genetics and allergen dosage. Clin Exp Allergy 1992;22:205-211.
37. Diepgen TL, Blettner M. Analysis of familial aggregation of atopic eczema and other atopic diseases by odds ratio regression models. J Invest Dermatol 1996;106:977-981.
38. Schultz Larsen F, Holm NV. Genetic heterogeneity in atopic dermatitis elucidated by a twin-family study [Abstract]. Ann Allergy 1985;55:266.
39. Schultz Larsen F, Holm NV, Henningsen K. Atopic dermatitis. A genetic-epidemiologic study in a population-based twin sample. J Am Acad Dermatol 1986;15:487-494.
40. Beaty JS, West KA, Nepom GT. Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1. Mol Cell Biol 1995;15:4771-4782.
41. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52:506-516.
42. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996;273:1516-1517.
43. Lander ES, Green P, Abrahamson J, et al. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1987;1:174-181.
44. DeSanctis GT, Merchant M, Beier DR, et al. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nature Genetics 1995;11:150-154.
45. Cookson WO, Sharp PA, Faux JA, et al. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1989;1:1292-1295.
46. Moffatt MF, Sharp PA, Faux JA, et al. Factors confounding genetic linkage between atopy and chromosome 11q. Clin Exp Allergy 1992;22:1046-1051.
47. Lympany P, Welsh K, MacCochrane G, et al. Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine. J Allergy Clin Immunol 1992;89:619-628.
48. Hizawa N, Yamaguchi E, Ohe M, et al. Lack of linkage between atopy and locus 11q13. Clin Exp Allergy 1992; 22:1065-1069.
49. Rich SS, Roitman-Johnson B, Greenberg B, et al. Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97. Clin Exp Allergy 1992;22:1070-1076.
50. Brereton HM, Ruffin RE, Thompson PJ, Turner DR. Familial atopy in Australian pedigrees: adventitious linkage to chromosome 8 is not confirmed nor is there evidence of linkage to the high affinity IgE receptor. Clin Exp Allergy 1994;24:868-877.
51. Thomas NS, Wilkinson J, Holgate ST. The candidate region approach to the genetics of asthma and allergy. Am J Respir Crit Care Med 1997;156: S144-S151.
52. Shirakawa T, Mao X-Q, Sasaki S, et al. Association between atopic asthma and a coding variant of FceRI-β in a Japanese population. Hum Mol Genet 1996;5:1129-1130.
53. Collee JM, ten Kate LP, de Vries HG, et al. Allele sharing on chromosome 11q13 in sibs with asthma. Lancet 1993;342:936.
54. van Herwerden L, Harrap SB, Wong ZYH, et al. Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. Lancet 1995;346:1262-1265.
55. Shirakawa T, Li A, Dubowitz M, et al. Association between atopy and variants of the β subunit of the high-affinity immunoglobulin E receptor. Nat Genet 1994;7:125-130.
56. Hay JG, Danel C, Chu CS, et al. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease. Am J Physiol 1995;268:L565-L575.
57. Laing IA, Goldblatt J, Eber E, et al. A polymorphism of the CC16 gene is associated with an increased risk of asthma. J Med Genet 1998;35: 463-467.
58. Gao PS, Mao XQ, Kawai M, et al. Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations. Hum Genet 1998;103: 57-59.
59. Collaborative Study on the Genetics of Asthma (CSGA). A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997;15:389-392.
60. Ober C, Cox NJ, Abney M, et al. Genome-wide search for asthma susceptibility loci in a founder population. Hum Mol Genetics 1998;7:1393-1398.
61. Daniels SE, Bhattacharrya S, James A. et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 1996;383:247-250.
62. Wilkinson J, Holgate ST. Candidate gene loci in asthmatic and allergic inflammation. Thorax 1996;51:3-8.
63. Chandrasekharappa SC, Rebelsky MS, Firak TA, et al. A long-range restriction map of the interleukin-4 and interleukin-5 linkage group on chromosome 5. Genomics 1990;6: 94-99.
64. Marsh DG, Neely JD, Breazeale DR, et al. Linkage analysis of IL-4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994;264:1152-1156.
65. Meyers DA, Postma DS, Panhuysen CIM, et al. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994;23: 464-470.
66. Postma DS, Bleecker ER, Amelung PJ, et al. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995;333:894-900.
67. Noguchi E, Shibasaki M, Arinami T, et al. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population. Am J Respir Crit Care Med 1997;156:1390-1393.
68. Kamitani A, Wong ZY, Dickson P, et al. Absence of genetic linkage of chromosome 5q31 with asthma and atopy in the general population. Thorax 1997;52:816-817.
69. Mansur AH, Bishop DT, Markham AF, et al. Association study of asthma and atopy traits and chromosome 5q cytokine cluster markers. Clin Exp Allergy 1998;28:141-150.
70. Barnes KC, Neely JD, Duffy DL, et al. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and Caucasian populations. Genomics 1996;37:41-50.
71. Nickel R, Wahn U, Hizawa N, et al. Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German multicenter allergy study. Genomics 1997;46:159-162.
72. Wilkinson J, Thomas NS, Lio P, et al. Evidence for linkage between markers on chromosome 12q and asthma and atopy in 191 families. Am J Respir Crit Care Med 1997;155:A257.
73. Marsh GD, Meyers DA, Bias W. The epidemiology and genetics of atopic allergy. N Engl J Med 1981;305: 1551-1559.
74. Blumenthal M, Marais-Bagley D, Awden Z, et al. HLA-DR2 {HLA-B7, SC31, DR2} and {HLA-B8, SC)1,DR3} haplotypes distinguish subjects with asthma from with rhinitis only in ragweed pollen allergy. J Immunol 1992;148:411-416.
75. Blumenthal M, Mendell N, Yunis E. Immunogenetics of atopic disease. J Allergy Clin Immunol 1980;65: 403-405.
76. Marsh DG, Hsu SH, Roebber M, et al. HLA-Dw2 - A genetic marker for human immune response to short ragweed allergen RAS. 1. Response resulting primarily from natural antigenic exposure. J Exp Med 1982; 155:1439-1451.
77. Freidhoff LR, Ehrlich-Kautzky E, Meyers DA, et al, Association of HLA-DR3 with human immune response to Lol p I and Lol p II antigens in allergic subjects. Tissue Antigens 1988;31:211-219.
78. Verhoef A, Higgins JA, Thorpe CJ, et al. Clonal analysis of the atopic immune response to the group 2 allergens of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T cell epitopes. Int Immunol 1993;5: 1589-1597.
79. + T cell-clones. J Immunol 1992;148:738-745.
80. van Metre TE, Jr, Marsh DG, Adkinson NF, Jr, et al. Dose of cat (Felis domesticus) allergen (Fel d I) that induces asthma. J Allergy Clin Immunol 1986;78:62-75.
81. Pollart SM, Reid MJ, Fling JA, et al. Epidemiology of emergency room asthma in northern California: association with IgE antibody to rye grass pollen. J Allergy Clin Immunol 1988; 82:224-230.
82. Lau S, Falkenhorst G, Weber A, et al. High mite-allergen exposure increases the risk of sensitization in atopic children and young adults. J Allergy Clin Immunol 1989;84:718-725.
83. Carrington M, Colonna M, Spies T, et al. Haplotypic variation of the transporter associated with antigen processing (TAP) genes and their extension of HLA class II region haplotypes. Immunogenetics 1993;37:266-273.
84. Powis SH, Tonks S, Mockridge I, et al. Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. Immunogenetics 1993;38: 345-350.
85. Kuwata S, Yanagisawa M, Saeki H, et al. Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis. J Allergy Clin Immunol 1995; 96:1051-1060.
86. Moffatt MF, Hill MR, Cornelis F, et al. Genetic linkage of T-cell receptor α/β complex to specific IgE responses. Lancet 1994;343:1597-1600.
87. Deichmann KA, Heinzmann A, Forster J, et al. Linkage and allelic association of atopy and markers flanking the IL4-receptor gene. Clin Exp Allergy 1998;28:151-155.
88. Hershey GKK, Friedrich MF, Esswein LA, et al. The association of atopy with a gain-of-function mutation in the subunit of the interleukin-4 receptor. N Engl J Med 1997;337:1720-1725.
89. Angott E, Mele E, Costanzo F, et al. A polymorphism (G-A transition) in the -78 position of the apoliproprotein A-I promoter increases transcription efficiency. J Biol Chem 1994;269: 1731-1734.
90. Jeunemaitre X, Soubrier F, Kotelevtsev YV, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992;71:169-180.
91. Song Z, Caslaro V, Chen R, et al. Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene. J Immunol 1996;156:424-429.
92. Rosenwasser LJ, Klemm DJ, Dresback JK, et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995;25(Suppl 2):74-78.
93. Rosenwasser LJ, Borish L. Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). Am J Respir Crit Care Med 1997;156:S152-155.
94. Walley AJ, Cookson WOCM. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet 1996; 33:689-692.
95. In KH, Asano K, Beier D, et al. Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. J Clin Invest 1997;99:1130-1137.
96. 4 synthase promoter polymorphism and risk of aspirin-induced asthma. Lancet 1997;350: 1599-1600.
97. 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993;8:334-339.