A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children

Clinical and Experimental Allergy

Volumn 31, Issue 10, 2001, Pages 1515-1521

  Leung, T F ^a   Tang, N L S ^a   Chan, I H S ^a   Li, A M ^a   Ha, G ^a   Lam, C W K ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Aeroallergens; Asthma; Chinese; IL 13; Immunoglobulin E; R130Q polymorphism

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13;

ADOLESCENT; ALLELE; ARTICLE; ASTHMA; ATOPY; CHINESE; COCKROACH; CONTROLLED STUDY; DISEASE MARKER; DISEASE SEVERITY; DOG; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HONG KONG; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOGLOBULIN BLOOD LEVEL; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MICROPARTICLE ENZYME IMMUNOASSAY; PRIORITY JOURNAL; RADIOALLERGOSORBENT TEST; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; SPIROMETRY;

ADOLESCENT; ALLERGENS; ANIMALS; ASIAN CONTINENTAL ANCESTRY GROUP; ASTHMA; CATS; CHILD; CHILD WELFARE; CHILD, PRESCHOOL; DOGS; EPITOPES; FEMALE; GENETIC CODE; GENOTYPE; HONG KONG; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; INTERLEUKIN-13; MALE; PHENOTYPE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROMOTER REGIONS (GENETICS); SEVERITY OF ILLNESS INDEX; SPIROMETRY;

EID: 0034797233     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2001.01212.x     Document Type: Article

References (41)

1. Asthma epidemiology in the Far East
2. Prevalence and etiology of asthma
3. Prevalence of asthma and allergy in Hong Kong schoolchildren: An ISAAC study
4. Association of asthma with serum IgE levels and skin-test reactivity to allergens
5. Ile50Val variant of IL-4R alpha upregulates IgE synthesis and associates with atopic asthma
6. Association between FcεRI-β and atopic disorder in a Japanese population
7. A genome wide search for quantitative trait loci underlying asthma
8. β2-adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma
9. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations
10. A genome-wide search for asthma susceptibility loci in ethnically diverse populations
11. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations
12. Allelic association of gene markers on chromosome 5q and 11q with atopy and bronchial hyperresponsiveness
13. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population
14. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5
15. The role of lymphocytes in allergic disease
16. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells
17. Differential regulation of IL-13 and IL-4 production by human CD8+ and CD4+ Th0, Th1 and Th2 T cell clones and EBV-transformed B cells
18. Interleukin-13 is produced by activated human CD45RA+ and CD45RO+ T cells: Modulation by interleukin-4 and interleukin-12
19. Functional screening of an asthma QTL in YAC transgenic mice
20. Requirement for IL-13 independently of IL-4 in experimental asthma
21. An IL-13 promoter polymorphism associated with increased risk of allergic asthma
22. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children
23. Genetic variants of IL-13 signalling and human asthma and atopy
24. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma
25. Assessment of airway hyperresponsiveness in chronic stable asthma
26. Standardization of spirometry, 1994 update
27. Predictive normograms for forced expiratory volume, forced vital capacity, and peak expiratory flow rate, in Chinese adults and children
28. The R576 IL-4 receptor α allele correlates with asthma severity
29. Eosinophilic inflammation in asthma
30. Interleukin-13: Central mediator of allergic asthma
31. The role of IL-13 in IgE synthesis by allergic asthma patients
32. Asthma, atopy and genetic variants of IL-4 and IL-13 signalling
33. Association of FcεRI-β polymorphisms with asthma and associated traits in Australian asthmatic families
34. Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: Positive association of a T924C polymorphism in the thromboxane A2 receptor gene
35. Epidemiology natural history of asthma
36. Sensitization to inhaled allergens as a risk factor for asthma and allergic diseases in Chinese population
37. Genetics and pulmonary medicine: Asthma
38. Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Health Survey
39. Effect of allergen avoidance in infancy on allergic manifestations at age two years
40. Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital
41. Mite and cat allergen levels in homes and severity of asthma