Telomere length in lymphoblast cell lines derived from clinically radiosensitive cancer patients

Cancer Biology and Therapy

Volumn 7, Issue 5, 2008, Pages 638-644

  Sprung, Carl N ^a,b   Davey, Deborah S P ^a   Withana, Nimali P ^a   Distel, Luitpold V ^c   McKay, Michael J ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Lymphoblast cell line; Radiosensitivity; Radiotherapy; Telomerase; Telomere length

Indexed keywords

TELOMERE BINDING PROTEIN; DNA; RESTRICTION ENDONUCLEASE;

ADULT; ARTICLE; ATAXIA TELANGIECTASIA; BREAST CANCER; CANCER CONTROL; CANCER PATIENT; CANCER RADIOTHERAPY; CELL LINE; CHROMOSOME SIZE; CLINICAL ARTICLE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; LYMPHOBLAST; NIJMEGEN BREAKAGE SYNDROME; PATIENT IDENTIFICATION; RADIATION DOSE; RADIOSENSITIVITY; RISK REDUCTION; TELOMERE; TISSUE REACTION; COHORT ANALYSIS; FLOW CYTOMETRY; GENETICS; LYMPHOCYTE; METABOLISM; METHODOLOGY; NEOPLASM; TUMOR CELL LINE; ULTRASTRUCTURE;

ATAXIA TELANGIECTASIA; CELL LINE, TUMOR; COHORT STUDIES; DNA; DNA RESTRICTION ENZYMES; FLOW CYTOMETRY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; NEOPLASMS; NIJMEGEN BREAKAGE SYNDROME; TELOMERE;

EID: 56149092751     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.5.5762     Document Type: Article

References (58)

1. Peters L, McKay M. Predictive assays: will they ever have a role in the clinic? Int J Radiat Oncol Biol Phys 2001; 49:501-4.
2. Brock WA, Tucker SL, Geara FB, Turesson I, Wike J, Nyman J, Peters LJ. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. Int J Radiat Oncol Biol Phys 1995; 32:1371-9.
3. Burnet NG, Nyman J, Turesson I, Wurm R, Yarnold JR, Peacock JH. The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules. Radiother Oncol 1994; 33:228-38.
4. Johansen J, Bentzen SM, Overgaard J, Overgaard M. Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiother Oncol 1996; 40:101-9.
5. Geara FB, Peters LJ, Ang KK, Wike JL, Brock WA. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys 1993; 27:1173-9.
6. van Gent DC, Hoeijmakers JH, Kanaar R. Chromosomal stability and the DNA doublestranded break connection. Nat Rev Genet 2001; 2:196-206.
7. Gatti RA. The inherited basis of human radiosensitivity. Acta Oncol 2001; 40:702-11.
8. Sprung CN, Mathews LJ, McKay MJ. DNA repair deficiencies: connecting carcinogenesis and sensitivity to ionising radiation. Today's Life Science 2002; 14:40-4.
9. Tucker SL, Turesson I, Thames HD. Evidence for individual differences in the radiosensitivity of human skin. Eur J Cancer 1992; 28:1783-91.
10. Gotoff SP, Amirmokri E, Liebner EJ. Ataxia telangiectasia. Neoplasia, untoward response to x-irradiation, and tuberous sclerosis. Am J Dis Child 1967; 114:617-25.
11. Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA, Kysela B. Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity. J Biol Chem 2001; 276:31124-32.
12. Varon R, Seemanova E, Chrzanowska K, Hnateyko O, Piekutowska Abramczuk D, Krajewska Walasek M, Sykut Cegielska J, Sperling K, Reis A. Clinical ascertainment of Nijmegen breakage syndrome (NBS) and prevalence of the major mutation, 657del5, in three Slav populations. Eur J Hum Genet 2000; 8:900-2.
13. Greider CW, Blackburn EH. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989; 337:331-7.
14. Murnane JP, Sabatier L, Marder BA, Morgan WF. Telomere dynamics in an immortal human cell line. Embo J 1994; 13:4953-62.
15. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. Embo J 1995; 14:4240-8.
16. Slijepcevic P. Is there a link between telomere maintenance and radiosensitivity? Radiat Res 2004; 161:82-6.
17. Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 2005; 6:611-22.
18. Goytisolo FA, Blasco MA. Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene 2002; 21:584-91.
19. Genesca A, Martin M, Latre L, Soler D, Pampalona J, Tusell L. Telomere dysfunction: a new player in radiation sensitivity. Bioessays 2006; 28:1172-80.
20. Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG, Benchimol S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. Embo J 1997; 16:6018-33.
21. Metcalfe JA, Parkhill J, Campbell L, Stacey M, Biggs P, Byrd PJ, Taylor AM. Accelerated telomere shortening in ataxia telangiectasia. Nat Genet 1996; 13:350-3.
22. Bianchi A, de Lange T. Ku binds telomeric DNA in vitro. J Biol Chem 1999; 274:21223-7.
23. Hsu HL, Gilley D, Galande SA, Hande MP, Allen B, Kim SH, Li GC, Campisi J, Kohwi Shigematsu T, Chen DJ. Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev 2000; 14:2807-12.
24. Song K, Jung D, Jung Y, Lee SG, Lee I. Interaction of human Ku70 with TRF2. FEBS Lett 2000; 481:81-5.
25. Bianchi A, Stansel RM, Fairall L, Griffith JD, Rhodes D, de Lange T. TRF1 binds a bipartite telomeric site with extreme spatial flexibility. Embo J 1999; 18:5735-44.
26. Hsu HL, Gilley D, Blackburn EH, Chen DJ. Ku is associated with the telomere in mammals. Proc Natl Acad Sci USA 1999; 96:12454-8.
27. Tsukamoto Y, Taggart AK, Zakian VA. The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres. Curr Biol 2001; 11:1328-35.
28. Ranganathan V, Heine WF, Ciccone DN, Rudolph KL, Wu X, Chang S, Hai H, Ahearn IM, Livingston DM, Resnick I, Rosen F, Seemanova E, Jarolim P, DePinho RA, Weaver DT. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol 2001; 11:962-6.
29. Bradshaw PS, Stavropoulos DJ, Meyn MS. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nat Genet 2005; 37:193-7.
30. Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T. Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 2000; 20:1659-68.
31. Neuhof D, Ruess A, Wenz F, Weber KJ. Induction of telomerase activity by irradiation in human lymphoblasts. Radiat Res 2001; 155:693-7.
32. Goytisolo FA, Samper E, Martin Caballero J, Finnon P, Herrera E, Flores JM, Bouffler SD, Blasco MA. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med 2000; 192:1625-36.
33. Wong HP, Mozdarani H, Finnegan C, McIlrath J, Bryant PE, Slijepcevic P. Lack of spontaneous and radiation-induced chromosome breakage at interstitial telomeric sites in murine scid cells. Cytogenet Genome Res 2004; 104:131-6.
34. Xiong J, Fan S, Meng Q, Schramm L, Wang C, Bouzahza B, Zhou J, Zafonte B, Goldberg ID, Haddad BR, Pestell RG, Rosen EM. BRCA1 inhibition of telomerase activity in cultured cells. Mol Cell Biol 2003; 23:8668-90.
35. French JD, Dunn J, Smart CE, Manning N, Brown MA. Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines. Genes Chromosomes Cancer 2006; 45:277-89.
36. Stavropoulos DJ, Bradshaw PS, Li X, Pasic I, Truong K, Ikura M, Ungrin M, Meyn MS. The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis. Hum Mol Genet 2002; 11:3135-44.
37. Leteurtre F, Li X, Guardiola P, Le Roux G, Sergere JC, Richard P, Carosella ED, Gluckman E. Accelerated telomere shortening and telomerase activation in Fanconi's anaemia. Br J Haematol 1999; 105:883-93.
38. Ball SE, Gibson FM, Rizzo S, Tooze JA, Marsh JC, Gordon-Smith EC. Progressive telomere shortening in aplastic anemia. Blood 1998; 91:3582-92.
39. Tahara H, Tokutake Y, Maeda S, Kataoka H, Watanabe T, Satoh M, Matsumoto T, Sugawara M, Ide T, Goto M, Furuichi Y, Sugimoto M. Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus. Oncogene 1997; 15:1911-20.
40. Tarsounas M, Munoz P, Claas A, Smiraldo PG, Pittman DL, Blasco MA, West SC. Telomere maintenance requires the RAD51D recombination/repair protein. Cell 2004; 117:337-47.
41. Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol 2004; 24:8437-46.
42. Jaco I, Munoz P, Goytisolo F, Wesoly J, Bailey S, Taccioli G, Blasco MA. Role of mammalian Rad54 in telomere length maintenance. Mol Cell Biol 2003; 23:5572-80.
43. McIlrath J, Bouffler SD, Samper E, Cuthbert A, Wojcik A, Szumiel I, Bryant PE, Riches AC, Thompson A, Blasco MA, Newbold RF, Slijepcevic P. Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res 2001; 61:912-5.
44. Severin DM, Leong T, Cassidy B, Elsaleh H, Peters L, Venter D, Southey M, McKay M. Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients. Int J Radiat Oncol Biol Phys 2001; 50:1323-31.
45. Leong T, Whitty J, Keilar M, Mifsud S, Ramsay J, Birrell G, Venter D, Southey M, McKay M. Mutation analysis of BRCA1 and BRCA2 cancer predisposition genes in radiation hypersensitive cancer patients. Int J Radiat Oncol Biol Phys 2000; 48:959-65.
46. Distel L, Neubauer S, Varon R, Holter W, Grabenbauer G. Fatal toxicity following radioand chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome. Med Pediatr Oncol 2003; 41:44-8.
47. Sprung CN, Afshar G, Chavez EA, Lansdorp P, Sabatier L, Murnane JP. Telomere instability in a human cancer cell line. Mutat Res 1999; 429:209-23.
48. Sprung CN, Sabatier L, Murnane JP. Telomere dynamics in a human cancer cell line. Exp Cell Res 1999; 247:29-37.
49. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992; 89:10114-8.
50. Rufer N, Dragowska W, Thornbury G, Roosnek E, Lansdorp PM. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol 1998; 16:743-7.
51. Henson JD, Neumann AA, Yeager TR, Reddel RR. Alternative lengthening of telomeres in mammalian cells. Oncogene 2002; 21:598-610.
52. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266:2011-5.
53. Ayouaz A, Raynaud C, Heride C, Revaud D, Sabatier L. Telomeres: hallmarks of radiosensitivity. Biochimie 2008; 90:60-72.
54. de Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE. Structure and variability of human chromosome ends. Mol Cell Biol 1990; 10:518-27.
55. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990; 346:866-8.
56. Sprung CN, Reynolds GE, Jasin M, Murnane JP. Chromosome healing in mouse embryonic stem cells. Proc Natl Acad Sci USA 1999; 96:6781-6.
57. Cabuy E, Newton C, Joksic G, Woodbine L, Koller B, Jeggo PA, Slijepcevic P. Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines. Radiat Res 2005; 164:53-62.
58. Barwell J, Pangon L, Georgiou A, Docherty Z, Kesterton I, Ball J, Camplejohn R, Berg J, Aviv A, Gardner J, Kato BS, Carter N, Paximadas D, Spector TD, Hodgson S. Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity? Br J Cancer 2007; 97:1696-700.