Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?

British Journal of Cancer

Volumn 97, Issue 12, 2007, Pages 1696-1700

  Barwell, J ^a   Pangon, L ^a   Georgiou, A ^a   Docherty, Z ^a   Kesterton, I ^a   Ball, J ^a   Camplejohn, R ^b   Berg, J ^c   Aviv, A ^d   Gardner, J ^d   Kato, B S ^e   Carter, N ^a   Paximadas, D ^e   Spector, T D ^e   Hodgson, S ^f  

^a GUY S HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^e ST THOMAS HOSPITAL   (United Kingdom)

^f ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Apoptosis; Breast cancer susceptibility; Chromosome; Radiosensitivity; Telomere

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; APOPTOSIS; ARTICLE; BODY MASS; BREAST CANCER; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MAMMOGRAPHY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIOSENSITIVITY; TELOMERE;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; BREAST NEOPLASMS; CHROMOSOMES, HUMAN; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LYMPHOCYTES; MIDDLE AGED; RADIATION TOLERANCE; TELOMERE;

EID: 37049018196     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604085     Document Type: Article

References (20)

1. Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A (2001) Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 37(2 Part 2): 381-385
2. Bisoffi M, Heaphy CM, Griffith JK (2006) Telomeres: prognostic markers for solid tumors. Int J Cancer 119(10): 2255-2260
3. Blackburn EH (2001) Switching and signaling at the telomere. Cell 106(6): 661-673
4. Bouffler SD, Blasco MA, Cox R, Smith PJ (2001) Telomeric sequences, radiation sensitivity and genomic instability. Int J Radiat Biol 77(10): 995-1005
5. Camplejohn RS, Gilchrist R, Easton D, McKenzie-Edwards E, Barnes DM, Eccles DM, Ardern-Jones A, Hodgson SV, Duddy PM, Eeles RA (2003) Apoptosis, ageing and cancer susceptibility. Br J Cancer 88(4): 487-490
6. Camplejohn RS, Perry P, Hodgson SV, Turner G, Williams A, Upton C, MacGeoch C, Mohammed S, Barnes DM (1995) A possible screening test for inherited p53-related defects based on the apoptotic response of peripheral blood lymphocytes to DNA damage. Br J Cancer 72(3): 654-662
7. Docherty Z, Georgiou A, Langman C, Kesterton I, Rose S, Camplejohn R, Ball J, Barwell J, Gilchrist R, Pangon L, Berg J, Hodgson S (2007) Is chromosome radiosensitivity and apoptotic response to irradiation correlated with cancer susceptibility? Int J Radiat Biol 83(1): 1-12
8. Fordyce CA, Heaphy CM, Bisoffi M, Wyaco JL, Joste NE, Mangalik A, Baumgartner KB, Baumgartner RN, Hunt WC, Griffith JK (2006) Telomere content correlates with stage and prognosis in breast cancer. Breast Cancer Res Treat 99(2): 193-202
9. Goytisolo FA, Samper E, Martin-Caballero J, Finnon P, Herrera E, Flores JM, Bouffler SD, Blasco MA (2000) Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med 192(11): 1625-1636
10. Howell RT, Taylor AMR (1992) Chromosome instability syndrome. In Human Cytogenetics A Practical Approach. Volume II: Malignancy and Acquired Abnormalities, Rooney DE and Czepulkowski BH (eds) (2nd edn), pp 209-234. Oxford: IRL Press, Oxford University Press
11. Kim SH, Karmiker P, Campisi J (2002) Telomeres, aging and cancer: in search of a happy ending. Oncogene 21: 503-511
12. Lo AW, Sprung CN, Fouladi B, Pedram M, Sabatier L, Ricoul M, Reynolds GE, Murnane JP (2002) Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol Cell Biol 22(13): 4836-4850
13. McIlrath J, Bouffler SD, Samper E, Cuthbert A, Wojcik A, Szumiel I, Bryant PE, Riches AC, Thompson A, Blasco MA, Newbold RF, Slijepcevic P (2001) Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res 61(3): 912-915
14. Meeker AK, Argani P (2004) Telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation? J Mammary Gland Biol Neoplasia 9(3): 285-296
15. Murnane JP (2006) Telomeres and chromosome instability. DNA Repair (Amst) 5(9-10): 1082-1092
16. Preto A, Singhrao SK, Haughton MF, Kipling D, Wynford-Thomas D, Jones CJ (2004) Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy. Oncogene 23(23): 4136-4145
17. Slijepcevic P (2004) Is there a link between telomere maintenance and radiosensitivity? Radiat Res 161(1): 82-86
18. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD (2005) Obesity, cigarette smoking, and telomere length in women. Lancet 366(9486): 662-664
19. Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA (2000) Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet 26(1): 85-88
20. Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK, Spitz MR (2003) Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 95(16): 1211-1218