Lack of spontaneous and radiation-induced chromosome breakage at interstitial telomeric sites in murine scid cells

Cytogenetic and Genome Research

Volumn 104, Issue 1-4, 2004, Pages 131-136

  Wong, H P ^a   Mozdarani, H ^b   Finnegan, C ^b   McIlrath, J ^a,c   Bryant, P E ^b   Slijepcevic, P ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOUBLE STRANDED DNA; PROTEIN KINASE C;

ANIMAL CELL; CHROMATIN CONDENSATION; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; CHROMOSOME CONDENSATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA REPAIR; GENETIC SUSCEPTIBILITY; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIVITY; SCID MOUSE; TELOMERE;

ANIMALS; CELLS, CULTURED; CHROMOSOME BREAKAGE; CHROMOSOME PAINTING; CHROMOSOMES; CHROMOSOMES, HUMAN, PAIR 8; DNA; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; HUMANS; MICE; MICE, SCID; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; REPETITIVE SEQUENCES, NUCLEIC ACID; SEVERE COMBINED IMMUNODEFICIENCY; TELOMERE;

MAMMALIA; MURINAE;

EID: 2642564384     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077477     Document Type: Conference Paper

References (21)

1. Alvarez L, Evans JW, Wilks R, Lucas JN, Brown M, Giacia AJ: Chromosomal radiosensitivity at intrachromosomal telomeric sites. Genes Chrom Cancer 8:8-14 (1993).
2. Bailey SM, Meyne J, Chen DJ, Kurimasa A, Li GC, Lehnert BE, Goodwin EH: DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc natl Acad Sci, USA 96:14899-14904 (1999).
3. Balajee AS, Oh HJ, Natarajan AT: Analysis of restriction enzyme-induced chromosome aberrations in the interstitial telomeric repeat sequences of CHO and CHE cells by FISH. Mutat Res 307:307-313 (1994).
4. n sequences in gene amplification and chromosome stability. Genomics 24:53-62 (1994).
5. Bouffler S, Silver A, Papworth D, Coates J, Cox R: Murine radiation myeloid leukaemogenesis: relationship between interstitial telomere-like sequences and chromosome 2 fragile sites. Genes Chrom Cancer 6:98-106 (1993).
6. Bryant PE: Enzymatic restriction of mammalian cell DNA using PvuII and BamH1: evidence for the double strand break origin of chromosomal aberrations. Int J Radiat Biol 46:57-65 (1984).
7. Folle GA, Obe G: Localization of chromosome breakpoints induced by AluI and BamHI in Chinese hamster ovary cells treated in the G1 phase of the cell cycle. Int J Radiat Biol 68:437-445 (1995).
8. Folle GA, Obe G: Intrachromosomal localization of breakpoints induced by the restriction endonucleases AluI and BamHI in Chinese hamster ovary cells treated in S phase of the cell cycle. Int J Radiat Biol 69:447-457 (1996).
9. Goytisolo FA, Samper E, Edmonson S, Taccioli GE, Blasco MA: The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol 21:3642-3651 (2001).
10. Kilburn AE, Shea MJ, Sargent RG, Wilson JH: Insertion of a telomere repeat sequence into a mammalian gene causes chromosome instability. Mol Cell Biol 21:126-135 (2001).
11. Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettinger MA, Brown JM: DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267:1178-1183 (1995).
12. Natarajan AT, Obe G: Molecular mechanisms involved in the production of chromosomal aberrations. Chromosoma 90:120-127 (1984).
13. Samper E, Goytisolo AF, Slijepcevic P, Van Buul PW, Blasco MA: Mammalian Ku86 protein prevents telomeric fusion independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep 1:244-252 (2000).
14. Schubert I, Rieger R, Fuchs J: Alteration of basic chromosome number by fusion fission cycles. Genome 38:1289-1292 (1995).
15. Slijepcevic P: Telomeres and mechanisms of Robertsonian fusion. Chromosoma 107:136-140 (1998).
16. 2 chromatid damage among Chinese hamster chromosomes: influence of chromatin conformation. Mutat Res 323:113-119 (1994a).
17. 1 exchange and terminal deletion breakpoints in Chinese hamster chromosomes as detected by G-banding. Int J Radiat Biol 66:747-755 (1994b).
18. Slijepcevic P, Xiao Y, Dominguez I, Natarajan AT: Spontaneous and radiation induced chromosomal breakage at interstitial telomeric sites. Chromosoma 104:596-604 (1996).
19. Slijepcevic P, Hande MP, Bouffler SD, Lansdorp P, Bryant PE: Telomere length, chromatin structure and chromosome fusigenic potential. Chromosoma 106:413-421 (1997).
20. Smith GC, Jackson SP: The DNA-dependent protein kinase. Genes Dev 13:916-934 (1999).
21. Surralles J, Sebastian S, Natarajan AT: Chromosomes with high gene density are preferentially repaired in human cells. Mutagenesis 12:437-442 (1997).