Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients

International Journal of Radiation Oncology Biology Physics

Volumn 50, Issue 5, 2001, Pages 1323-1331

  Severin, Diane Marie ^a   Leong, Trevor ^a   Cassidy, Barry ^b   Elsaleh, Hany ^b   Peters, Lester ^a   Venter, Deon ^a   Southey, Melissa ^a   McKay, Michael ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b SIR CHARLES GAIRDNER HOSPITAL   (Australia)

Author keywords

Cancer; hHR21; Radiation sensitivity; Radiotherapy

Indexed keywords

BIOASSAY; BLOOD; CELLS; GENES; RADIOTHERAPY; TUMORS;

RADIOSENSITIVITY;

DNA SEQUENCES;

ADENINE; ARGININE; DOUBLE STRANDED DNA; GENE PRODUCT; GLYCINE; GUANINE;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CANCER PATIENT; CELL GROWTH; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA SEQUENCE; DNA STRAND BREAKAGE; GENE AMPLIFICATION; GENE MUTATION; GENETIC SCREENING; HETEROZYGOTE; HUMAN; HUMAN CELL; HYPERSENSITIVITY; LYMPHOBLASTOID CELL; MOLECULAR EVOLUTION; NORTHERN BLOTTING; PRIORITY JOURNAL; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SISTER CHROMATID;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BLOTTING, NORTHERN; CELL LINE, TRANSFORMED; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEOPLASM PROTEINS; NEOPLASMS; NUCLEAR PROTEINS; OPEN READING FRAMES; PHOSPHOPROTEINS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RADIATION INJURIES; RADIATION TOLERANCE; RADIOTHERAPY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0035424764     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(01)01608-X     Document Type: Article

References (33)

1. Tolerance of normal tissue to therapeutic irradiation
2. Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene
3. Nijmegen breakage syndrome
4. Genetic determinants of radiation response
5. Synergistic actions of Rad51 and Rad52 in recombination and DNA repair
6. Stimulation by Rad52 of yeast Rad51-mediated recombination
7. Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: Evidence for functional conservation
8. Cloning the RAD51 homologue of Schizosaccharomyces pombe
9. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA
10. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
11. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
12. Association of BRCA1 with RAD51 in mitotic and meiotic cells
13. DNA breakage and repair
14. Cloning and characterization of rad21 an essential gene of Schizosaccharomyces pombe involved in DNA double-strand-break repair
15. Sequence conservation of the rad 21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse
16. A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
17. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids
18. Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans
19. Molecular cloning
20. A routine method for the establishment of permanent growing lymphoblastoid cell lines
21. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity
22. A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype
23. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
24. 0) T-lymphocytes, T-lymphocyte lines, lymphoblastoid cell lines and fibroblasts from normal donors, from ataxia-telangiectasia patients and from ataxia-telangiectasia heterozygotes
25. Fragments of ATM which have dominant-negative or complementing activity
26. Defective control of apoptosis and mitotic spindle checkpoint in heterozygous carriers of ATM mutations
27. Enhanced radiation late effects and cellular radiation sensitivity in an ATM heterozygous breast cancer patient
28. Normal tissue radiosensitivity - How important is it?
29. Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia and skin erythema after radiotherapy
30. Invited review: Intrinsic radiosensitivity as a predictor of patient response to radiotherapy
31. A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T heterozygotes
32. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients