Mucoadhesive polymers for delivery of drugs to the oral cavity

Recent Patents on Drug Delivery and Formulation

Volumn 2, Issue 2, 2008, Pages 108-119

  Mizrahi, Boaz ^a   Domb, Abraham J ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Aphthous stomatitis; Buccal; Mucoadhesive; Oral infections; Polymers

Indexed keywords

ACRYLIC ACID; ALGINIC ACID; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; CARBOMER; CARBOXYMETHYLCELLULOSE; CARRAGEENAN; CELLULOSE DERIVATIVE; CHITOSAN; COPOLYMER; DRUG CARRIER; GELLAN; HYDROXYMETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; IODINE; MACROGOL; METHYLCELLULOSE; MICONAZOLE; PECTIN; PEPTIDE DERIVATIVE; POLYACRYLIC ACID; POLYCARBOPHIL; POLYMACON; POLYMER; POLYMETHACRYLIC ACID; POLYVINYL ALCOHOL; POVIDONE; PYRROLE DERIVATIVE; UNINDEXED DRUG; XANTHAN;

AQUEOUS SOLUTION; ARTICLE; BIODEGRADABILITY; CROSS LINKING; DENTAL CARIES; DRUG ABSORPTION; DRUG DECOMPOSITION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG RESEARCH; DRUG SAFETY; DRUG SOLUBILITY; EMULSION; GEL; GINGIVITIS; HALITOSIS; HUMAN; HYDROLYSIS; HYDROPHOBICITY; LOZENGE; MOUTH INFECTION; MOUTH MUCOSA; MOUTH ULCER; MOUTHWASH; MYCOSIS; NONHUMAN; OINTMENT; PARTICLE SIZE; PATENT; PERIODONTITIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET FORMULATION; TISSUE STRUCTURE; WETTABILITY; XEROSTOMIA;

ADHESIVES; ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, BUCCAL; DELAYED-ACTION PREPARATIONS; DOSAGE FORMS; DRUG DELIVERY SYSTEMS; HUMANS; MOUTH MUCOSA; PATENTS AS TOPIC; PHARMACEUTICAL PREPARATIONS; POLYMERS;

EID: 55849119893     PISSN: 18722113     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221108784534126     Document Type: Article

References (97)

1. Lee JW, Park JH, Robinson JR. Bioadhesive-based dosage forms: the next generation. J Pharm Sci 2000; 89(7): 850-866.
2. Eveson JW, Scully C. Color atlas of oral pathology. London: Mosby-Wolfe 1995.
3. Kambara M, Norde W. Influence of fluoride applications on some physicochemical surface-properties of synthetic hydroxyapatite and human dental enamel and its consequences for protein adsorption. Caries Res 1995; 29(3): 210-217.
4. VanMoer C, Sabzevar MM, Adriaens PA. Anti-gingivitis effect of chlorhexidine chewing gum in periodontal maintenance patients. J Dental Res 1996; 75: 1820-1829.
5. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005; 366(9499): 1809-1820.
6. Drisko CH. Nonsurgical periodontal therapy. Periodontol 2000 2001; 25 77-88.
7. Hung HC, Douglass CW. Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss. J Clin Periodontol 2002; 29(11): 975-986.
8. Akpan A, Morgan R. Oral candidiasis. Postgrad Med J 2002; 78(922): 455- 459.
9. Epstein S. Restorative dentistry for hospitalized patient. J Am Dent Assoc 1966; 72(1): 83-86.
10. Kelly HM, Deasy PB, Busquet M, Torrance AA. Bioadhesive, rheological, lubricant and other aspects of an oral gel formulation intended for the treatment of xerostomia. Int J Pharm 2004; 278(2): 391-406.
11. Stone OJ. Aphthous stomatitis (canker sores) - a consequence of high oral submucosal viscosity (the role of extracellular-matrix and the possible role of lectins). Med Hypotheses 1991; 36(4): 341-344.
12. Khandwala A, VanInwegen RG, Alfano MC. 5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers. 1. Clinical demonstration of acceleration of healing and resolution of pain. Oral Surgery Oral Med Oral Pathol Oral Radiol Endod 1997; 83(2): 222-230.
13. Joiner A. The bleaching of teeth: A review of the literature. J Dent 2006; 34(7): 412-419.
14. Laurie SA, Licitra L. Systemic therapy in the palliative management of advanced salivary gland cancers. J Clin Oncol 2006; 24(17): 2673-2678.
15. Reid V, Yu ZK, Schuman T, et al. Herpes oncolytic therapy of salivary gland carcinomas. Int J Cancer 2008; 122: 202-208.
16. Steinberg D, Friedman M. Dental drug-delivery devices: Local and sustained-release applications. Crit Rev in Therapeutic Drug Carrier Sys 1999; 16(5): 425-459.
17. Harris D, Robinson JR. Drug delivery via the mucous-membranes of the oral cavity. J Pharm Sci 1992; 81(1): 1-10.
18. Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev 2005; 57(11): 1666-1691.
19. Samaranayake LP, Ferguson MM. Delivery of antifungal agents to the oral cavity. Adv Drug Deliv Rev 1994; 13(1-2): 161-179.
20. Smart JD. Drug-delivery using buccal-adhesive systems. Adv Drug Deliv Rev 1993; 11(3): 253-270.
21. Weatherell JA, Robinson C, Rathbone MJ. Site-specific differences in the salivary concentrations of substances in the oral cavity-implications for the etiology of oral-disease and local-drug delivery. Adv Drug Deliv Rev 1994; 13(1-2): 23-42.
22. Kutcher MJ, Ludlow JB, Samuelson AD, Campbell T, Pusek SN. Evaluation of a bioadhesive device for the management of aphthous ulcers. J Am Dent Assoc 2001; 132(3): 368-376.
23. Yamamura K, Yotsuyanagi T, Okamoto T, Nabeshima T. Pain relief of oral ulcer by dibucaine-film. Pain 1999; 83(3): 625-626.
24. Longer MA, Robinson JR. Fundamental-aspects of bioadhesion. Pharm Int 1986; 7(5): 114-117.
25. Dodou D, Breedveld P, Wieringa PA. Mucoadhesives in the gastrointestinal tract: revisiting the literature for novel applications. Eur J Pharm Biopharm 2005; 60(1): 1-16.
26. Dubolazov AV, Nurkeeva ZS, Mun GA, Khutoryanskiy VV. Design of mucoadhesive polymeric films based on blends of poly(acrylic acid) and (hydroxypropyl)cellulose. Biomacromolecules 2006; 7(5): 1637-1643.
27. Bruschi ML, de Freitas O. Oral bioadhesive drug delivery systems. Drug Dev Ind Pharm 2005; 31(3): 293-310.
28. Smart JD. Lectin-mediated drug delivery in the oral cavity. Adv Drug Deliv Rev 2004; 56(4): 481-489.
29. Smart JD. Recent developments in the use of bioadhesive systems for delivery of drugs to the oral cavity. Crit Rev Ther Drug Carrier Sys 2004; 21(4): 319-344.
30. Collins LMC, Dawes C. The surface-area of the adult human mouth and thickness of the salivary film covering the teeth and oral-mucosa. J Dent Res 1987; 66(8): 1300-1302.
31. Gandhi RB, Robinson JR. Oral cavity as a site for bioadhesive drug-delivery. Adv Drug Deliv Rev 1994; 13(1-2): 43-74.
32. Bradway SD, Bergey EJ, Jones PC, Levine MJ. Oral mucosal pellicle - adsorption and transpeptidation of salivary components to buccal epithelial-cells. Biochem J 1989; 261(3): 887-896.
33. Addy M. Local-delivery of antimicrobial agents to the oral cavity. AdvDrug Deliv Rev 1994; 13(1-2): 123-134.
34. Nagai T, Machida Y. Advances in drug delivery - mucosal adhesive dosage forms. Pharm Int 1985; 6(8): 196-200.
35. Robinson JR, Yang X. AeIJSaJCB, Editors, Encyclopedia of Technology vol. 18, Marcel Dekker Inc, New York (1999), pp. 1-27.
36. Mizrahi BAJD. Mucoadhesive tablet releasing iodine for treating oral infections. J Pharm Sci 2007; 96(11): 3144-3150.
37. Alur H.H. TPJaAKM, Encyclopedia of Pharmaceutical Technology. In: J. Superbrick and J.C. Boylan, Editors, Peptides and Proteins: Buccal Absorption 20(3), Marcel Dekker Inc., New York 2001; 193-218.
38. Heller J DCW. Penhale,Use of bioerodible polymers in, self-regulated drug delivery systems iPIL, W.R. Good (Eds.),, Controlled Release Technology PA, Washington, DC ASS 1997; 76: 281-282.
39. Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery - A promising option for orally less efficient drugs. J Controll Release 2006; 114(1): 15-40.
40. Woodley J. Bioadhesion - New possibilities for drug administration? Clin Pharmacokinet 2001; 40(2): 77-84.
41. Senel S, Hincal A.A. Drug permeation enhancement via buccal route: possibilities and limitations. J Control Release 2001; 72 (1-3): 133-144.
42. Ishida M, Machida Y, Nambu N, Nagai T. Pharmaceutical interactions in dosage forms and processing 21. New mucosal dosage form of insulin. Chem Pharma Bull 1981; 29(3): 810-816.
43. Shojaei AH, Paulson J, Honary S. Evaluation of poly(acrylic acid-co-ethylhexyl acrylate) films for mucoadhesive transbuccal drug delivery: factors affecting the force of mucoadhesion. J Control Release 2000; 67(2-3): 223-232.
44. Chng HS, Park H, Kelly P, Robinson JR. Bioadhesive polymers as platforms for oral controlled drug delivery. 2. Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J Pharm Sci 1985; 74(4): 399-405.
45. Ahuja A, Khar RK, Ali J. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm 1997; 23(5): 489-515.
46. Wallace JW. Cellulose derivatives and natural products utilized, in Encyclopedia of Pharmaceutical Technology, M. Dekker. Marcel Dekker: New York Editor 1990; 319-337.
47. Kumar V, Banker GS. Chemically-modified cellulosic polymers. Drug Dev Ind Pharm 1993; 19(1-2): 1-31.
48. Dhawan S, Singla AK, Sinha VR. Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods. Aaps Pharmscitech 2004; 5(4): article 67.
49. Ali J, Khar RK, Ahuja A. Formulation and characterisation of a buccoadhesive erodible tablet for the treatment of oral lesions. Pharmazie 1998; 53(5): 329-334.
50. Robinson JR, Longer M, Veillard M. Bioadhesive polymer for controlled drug delivery. Ann N Y Acad Sci 1987; 507:307-314
51. Ishida M, Nambu N, Nagai T. Pharmaceutical interactions in dosage forms and processing. 42. Highly viscous gel ointment containing carbopol for application to the oral-mucosa. Chem Pharm Bull 1983; 31(12): 4561-4564.
52. Rathbone MJ, Drummond BK, Tucker IG. The oral cavity as a site for systemic drug-delivery. Adv Drug Deliv Rev 1994; 13(1-2): 1-22.
53. Mizrahi B, Domb AJ. Mucoadhesive tablet releasing iodine for treating oral infections. J Pharm Sci 2007; 96(11): 3144-3150.
54. Aiache, J.-M., Costantini, D., Chaumont, C.: US20050208129 (2005).
55. Acharya, R.N., Baker, J.L.: US20016210699 (2001).
56. Timpe, C., Dittgen, M., Grawe, D., Schumacher, J., Zimmermann, H., Hoffmann, H.: US20006063404 (2000).
57. Muzio LL, della Valle A, Mignogna MD, et al. The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients. J Oral Path Med 2001; 30(10): 611-617.
58. Mizrahi B, Golenser J, Wolnerman JS, Domb AJ. Adhesive tablet effective for treating canker sores in humans. J Pharm Sci 2004; 93(12): 2927-2935.
59. Domb, A.J., Wolnerman, J.S.: US20070104783 (2007).
60. Levine, W., Satter, A.: US20060228427 (2006).
61. Peh KK, Wong CF. Polymeric films as vehicle for buccal delivery: Swelling, mechanical, and bioadhesive properties. J Pharm Pharm Sci 1999; 2(2): 53-61.
62. Perioli L, Ambrogi A, Angelici F, et al. Development of mucoadhesive patches for buccal administration of ibuprofen. J Control Release 2004; 99(1): 73-82.
63. Albert, H., Chapdelaine, D.J.Z., Michael, R.D.: US20046740332 (2004).
64. Xu, G., Reci, M., Blackwell, B.L., Robinson, R.S., Viscio, D.B., Curtis, J.P.: US20026419903 (2002).
65. Yu Shaohua, L.: CN1706269 (2005).
66. Sanvordeker, D.R., Leung, S.-H.S.: US5047244 (1991).
67. Sanvordeker, D. R., Leung, S.-H.S.: WO006270 (1991).
68. Mizobuchi, T.O.A., Sakoh, S., Muguruma, Y.: US4876092 (1989).
69. Zerbe, H.G., Guo, J.-H., Serino, A.: US20016284264 (2001).
70. Zerbe, H.G., Guo, J.-H., Serino, A.: US2004630562 (2004).
71. Zerbe, H.G., Guo, J.-H., Serino, A: US20026592887 (2002).
72. Krumme, M.: US20060039957 (2006).
73. Moro, D.G.C., Ernest, H. Jr., Nowotnik, D.P.: US20040062724 (2004).
74. Rencher, W.F.: US5192802 (1993).
75. Rencher, W.F.: US5314915 (1994).
76. Akemi, H.K.T., Otsuka, S., Hosaka, Y., Nakano, Y.: US5298258 (1994).
77. Yamashita, M.K.T., Hashiguchi, M.: US20067056961 (2006).
78. Nakatsuka, K.O.K.: US20056939901 (2005).
79. He H, Cao X, Lee LJ. Design of a novel hydrogel-based intelligent system for controlled drug release. J Control Release 2004; 95(3): 391-402.
80. Mantelle, J.H.D., Kanios, D.: US20036562363 (2003).
81. 2 as antibacterial and anti-inflammatory agents. J Periodont 2006; 77(6): 963-968.
82. Vyas SP, Sihorkar V, Mishra V. Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases. J Clin Pharm Therapeut 2000; 25(1): 21-42.
83. Frank, K.:US20067074426 (2006).
84. Friedman, D., Schwarz, J., Amselem, S.: US5993846 (1999).
85. Smita, N.: US5989535 (1999).
86. Shefer, A., Shefer, A., Shefer, S.D.: US20046790460 (2004).
87. Howard, B.F., Malitz, H.: US20070248548 (2007).
88. Francesco, D.V., Silvana, L., Roberto, C., Gabrle, M.: WO9603973 (1996).
89. Kawa, G.U.S., Urquhart, D.: WO06013081 (2006).
90. Joseph, D.D.: WO000010530 (2000).
91. Bottoni, G., Maffei, P., Sforzini, A., Federici, M., Caramella, C., Rossi S, Viscomi, G.C.: WO06131262 (2006).
92. Urakawa H, Mimura M, Kajiwara K. Diversity and versatility of plant seed xyloglucan. Trends Glycosci Glycotechnol 2002; 14(80): 355-376.
93. MiwazakiI, S.M., Yamatoya, K.: WO9729777 (1997).
94. Bravo-Osuna I, Vauthier C, Farabollini A, Palmieri GF, Ponchel G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles. Biomaterials 2007; 28(13): 2233-2243.
95. Bernkop-Schnurch A, Pinter Y, Guggi D, et al. The use of thiolated polymers as carrier matrix in oral peptide delivery - Proof of concept. J Control Release 2005; 106(1-2): 26-33.
96. Yin YS, Chen DW, Qiao MX, Lu Z, Hu HY. Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin. J Control Release 2006; 116(3): 337-345.
97. Sanford BA, Thomas VL, Ramsay MA. Binding of Staphylococci to mucus in vivo and in vitro. Infect Immun1989; 57(12): 3735-3742.