5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: I. Clinical demonstration of acceleration of healing and resolution of pain

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

Volumn 83, Issue 2, 1997, Pages 222-230

  Khandwala, Atul ^a   Van Inwegen, Richard G ^b   Alfano, Michael C ^c  

^a Shaman Pharmaceuticals Inc   (United States)

^b Access Pharmaceuticals Inc   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRIDINE DERIVATIVE; AMLEXANOX; ANTIINFLAMMATORY AGENT; DRUG VEHICLE;

ADULT; ANALYSIS OF VARIANCE; APHTHOUS STOMATITIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG SCREENING; FEMALE; HUMAN; MALE; MULTICENTER STUDY; NONPARAMETRIC TEST; PAIN ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME; VEHICLES;

ADMINISTRATION, TOPICAL; ADULT; AMINOPYRIDINES; ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG EVALUATION; FEMALE; HUMANS; LOGISTIC MODELS; MALE; PAIN MEASUREMENT; STATISTICS, NONPARAMETRIC; STOMATITIS, APHTHOUS; TREATMENT OUTCOME; VEHICLES;

EID: 0031068256     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1079-2104(97)90009-3     Document Type: Article

References (19)

1. Rees TD, Binnie WH. Recurrent aphthous stomatitis. In: Miles DA, Rogers RS, Editors. Dermatologic disorders affecting the oral cavity. Dermatol Clin. Philadelphia: WB Saunders, 1996.
2. Vincent SD, Lilly GE. Clinical, historic, and therapeutic features of aphthous stomatitis: literature review and open clinical trial employing steroids. Oral Surg Oral Med Oral Pathol 1992;74:79-86.
3. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. Philadelphia: WB Saunders Co. 1995:236-55.
4. Drinnan AJ, Fischman SL. Controversies in oral medicine. Dent Clin N Am 1990;34:159-69.
5. Tyldesley WR. Oral medicine for the dental practitioner: 4. recurrent ulcers. Br Dent J 1973;135:537-41.
6. Graykowski EA, Barile MF, Lee WB, Stanley HR. Recurrent aphthous stomatitis. JAMA 1966;196:129-36.
7. Rodu B, Mattingly G. Oral mucosal ulcers: diagnosis and management. J Am Dent Assoc 1992;123:83-6.
8. Regezi JA, Sciubba J, editors. Oral pathology: clinical-pathologic conditions. Second ed. Philadelphia: WB Saunders Co. 1993:52-60.
9. Greer RO, Lindenmuth JE, Juarez T, Khandwala A. A double-blind study of topically applied 5% Amlexanox in the treatment of aphthous ulcers. J Oral Maxillofac Surg 1993; 51:243-8.
10. Saijo T, Kuriki H, Ashida Y, Makino Y, Maki Y. Mechanism of the action of amlexanox (AA-673), an orally active antiallergic agent. Int Archs Allergy Appl Immun 1985;78:43-50.
11. Plemons JM, Rees TD, Binnie WH, Wright JM, Guo I, Hall JE. Evaluation of acemannan in the treatment of recurrent aphthous stomatitis. Wounds 1994;6:40-5.
12. Stoy PJ, The use of topical applications in the treatment of inflammatory conditions of the oral mucosa. Dent Pract 1966; 16:444-7.
13. Browne RM, Fox EC, Anderson RJ. Topical triamcinanole in recurrent aphthous stomatitis. Lancet 1968;(March 16):565-7.
14. Dale RA, Berrong JM, Sandoval VA, Duke ES, Dodge WW. The use of Ora-5 on recurrent aphthous ulcers. Gen Dent 1989;(Nov-Dec):504-7.
15. Poswillo D, Partridge M. Management of recurrent aphthous ulcers. Br Dent J 1984;157:54-7.
16. Revuz J, Guillaume JC, Janier M, Hans P, Marchand C, Souteyrand P, et al. Crossover study of thalidomide vs placebo in severe recurrent aphthous stomatitis. Arch Dermatol 1990;126:923-7.
17. Pedersen A. Acyclovir in the prevention of severe aphthous ulcers. Arch Dermatol 1992;128:119-20.
18. Wormser GP, Mack L, Lenox T, Hewlett D, Goldfarb J, Yarrish PL, et al. Lack of effect of oral acyclovir on prevention of aphthous ulcers. Otolaryngol Head Neck Surg 1988;98;14-7.
19. Colvard M, Kuo P. Managing aphthous ulcers; laser treatment applied. J Am Dent Assoc 1991;122:51-3.