Bioadhesive, rheological, lubricant and other aspects of an oral gel formulation intended for the treatment of xerostomia

International Journal of Pharmaceutics

Volumn 278, Issue 2, 2004, Pages 391-406

  Kelly, H M ^a   Deasy, P B ^a   Busquet, M ^a   Torrance, A A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Bioadhesion; Carbopol 974P; Excipients; Lubricity; Rheology; Saliva substitute; Xerostomia

Indexed keywords

ADHESIVE AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CARBOPOL 974P; ELECTROLYTE; EXCIPIENT; FLAVORING AGENT; FLUORIDE; LUBRICATING AGENT; POLYMER; SWEETENING AGENT; TRICLOSAN; VEGETABLE OIL; ZINC;

ADHESION; ARTICLE; CROSS LINKING; DENTAL CARIES; DRUG FORMULATION; FLOW KINETICS; FRICTION; GEL; LUBRICATION; MOUTH MUCOSA; MUCOSA; PALATABILITY; PRIORITY JOURNAL; PROPHYLAXIS; SALIVA LEVEL; SALIVATION; SIMULATION; STIMULATION; TASTE; TOOTH DEVELOPMENT; XEROSTOMIA;

ACRYLATES; ADHESIVENESS; EXCIPIENTS; MUCOUS MEMBRANE; RHEOLOGY; SALIVA, ARTIFICIAL; XEROSTOMIA;

EID: 2942516875     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.03.022     Document Type: Article

References (29)

1. Blanco-Fuente H., Villa-Dorrio B., Anguiano-Igea S., Otero-Espinar F.J., Blanco-Mendez J. Tanned leather: a good model for determining hydrogels bioadhesion. Int. J. Pharm. 138:1996;103-112
2. Bhargave H.N., Leonar P.A. Triclosan - applications and safety. Am. J. Infect. Control. 24:1996;209-218
3. British National Formulary, 2002. The Pharmaceutical Press, London.
4. Brown L.R., Dreizen S., Handler S., Johnston D.A. Effect of radiation-induced xerostomia on human oral microflora. J. Dent. Res. 54:1975;740-750
5. Chaushu G., Bercovici M., Dori S., Waller A., Taicher S., Kronenburg J., Talmi Y. Salivary flow and its relation with oral symptoms in terminally ill patients. Cancer. 88:2000;984-987
6. De Vries M.E., Boddé H.E. Hydrogels for buccal drug delivery: properties relevant for mucoadhesion. J. Biomed. Mater. Res. 22:1998;1023-1032
7. Duxbury A.J., Thakker N.S., Wastell D.G. A double-blind cross-over trial of a mucin containing artificial saliva. Br. Dent. J. 166:1989;115-120
8. Edgar W.M. Saliva - its secretion, composition and functions. Br. Dent. J. 172:1992;305-312
9. Ettinger R.L. Review: xerostomia: a symptom which acts like a disease. Age Ageing. 25:1996;409-412
10. Furomoto E.K., Carter-Hanson C. Subjective and clinical evaluation of oral lubricants in xerostomic patients. Spec. Care Dent. 18:1998;113-118
11. Gaffar A., Scheri D., Afflitto J., Coleman E.J. The effect of triclosan on mediators of gingival inflammation. J. Clin. Periodontol. 22:1995;480-484
12. Hägerström H., Paulsson M., Edsman K. Evaluation of mucoadhesion for two polyelectrolyte gels in simulated physiological conditions using a rheological method. Eur. J. Pharm. Sci. 9:2000;301-309
13. Hamlet S., Faull J., Klein B., Aref A., Fontanesi J., Stachler R., Shamsa F., Jones L., Simpson M. Mastication and swallowing in patients with postirradiation xerostomia. Int. J. Rad. Oncol. Biol. Phys. 37:1997;789-796
14. Harrap G.J., Saxton C.A., Best J.S. Inhibition of plaque growth by zinc salts. J. Periodontol. Res. 18:1983;634-642
15. Horrobin D.F. Essential fatty acid metabolism in diseases of connective tissue with special reference to scleroderma and to Sjögrens syndrome. Med. Hypotheses. 14:1984;233-247
16. Jones D.S., Woolfson A.D., Djokic J., Coulter W.A. Development and mechanical characterisation of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases. Pharm. Res. 13:1996;1734-1738
17. Levine M.J., Aguirre A., Hatton M.N., Tabak L.A. Artificial salivas: present and future. J. Dent. Res. 66:1987;693-698
18. Mortazavi S.A., Carpenter B.G., Smart J.D. A comparative study on the role played by mucus glycoproteins in the rheological behaviour of the mucoadhesive/mucosal interface. Int. J. Pharm. 94:1993;195-201
19. Mortazavi S.A., Smart J.D. Factors influencing gel strengthening at the mucoadhesive-mucus interface. J. Pharm. Pharmacol. 46:1994;86-90
20. Mossman K.L., Henkin R.I. Radiation-induced changes in taste acuity in cancer patients. Int. J. Rad. Oncol. Biol. Phys. 4:1978;663-670
21. Olsson H., Axéll T. Objective and subjective efficacy of saliva substitutes containing mucin and carboxymethylcellulose. Scand. J. Dent. Res. 99:1991;316-319
22. Plankhurst, C.L., Dunne, S.M., Rogers, J.O., 1996. Restorative dentistry in the patient with dry mouth. Part 2. Problems and solutions. Oral Med. Dental Update.
23. Rosling B., Dahlén G., Volpe A., Furuichi Y., Ramberg P., Lindhe J. Effect of triclosan on the subgingival microbiota of periodontitis- susceptible subjects. J. Clin. Periodontol. 24:1997;881-887
24. Schiødt M., Dodd C.C., Greenspan D., Daniels T.E., Chernoff D., Hollander H., Wara D., Greenspan J.S. Natural history of HIV associated salivary gland disease. Oral Surg. Oral Med. Oral Pathol. 74:1992;326-331
25. Sweeney M.P., Bagg J., Baxter W.P., Aitchison T.C. Clinical trial of a mucin containing oral spray for the treatment of xerostomia in hospice patients. Palliative Med. 11:1997;225-232
26. Svatun B., Saxton C.A., van der Ouderaa F., Rolla G. The influence of a dentrifice containing a zinc salt and a nonionic antimicrobial agent on the maintenance of gingival health. J. Clin. Periodontol. 14:1987;457-461
27. Waaler S.M., Rölla G., Skjörland K., Ögaard B. Effects of oral rinsing with triclosan and sodium lauryl sulphate on plaque formation: a pilot study. Scand. J. Dent. Res. 101:1993;92-105
28. Weisenfeld D., Stewart A.M., Mason D.K. A critical assessment of oral lubricants in patients with xerostomia. Br. Dent. J. 10:1983;155-157
29. Whelton, H., 1996. In: Edgar, W., O'Mullane, D.M. (Eds.), Saliva and Oral Health, second ed. British Dental Association. pp. 1-9 (Chapter 1).