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Volumn 112, Issue 9, 2008, Pages 3856-3866

Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73

Author keywords

[No Author keywords available]

Indexed keywords

LATS2 PROTEIN; PROTEIN P21; PROTEIN P73; PUMA PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA BINDING PROTEIN; LATS1 PROTEIN, HUMAN; LATS2 PROTEIN, HUMAN; MESSENGER RNA; NUCLEAR PROTEIN; ONCOPROTEIN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; RNA; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR SUPPRESSOR PROTEIN P73; YAP1 PROTEIN, HUMAN;

EID: 55749104705     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-09-111773     Document Type: Article
Times cited : (54)

References (83)
  • 1
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    • Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 1995;9:534-546.
    • (1995) Genes Dev , vol.9 , pp. 534-546
    • Justice, R.W.1    Zilian, O.2    Woods, D.F.3    Noll, M.4    Bryant, P.J.5
  • 2
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase
    • Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development. 1995;121:1053-1063.
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.1    Wang, W.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5
  • 3
    • 31044440368 scopus 로고    scopus 로고
    • From cell structure to transcription: Hippo forges a new path
    • Edgar BA. From cell structure to transcription: Hippo forges a new path. Cell. 2006;124:267-273.
    • (2006) Cell , vol.124 , pp. 267-273
    • Edgar, B.A.1
  • 4
    • 33847206401 scopus 로고    scopus 로고
    • The Salvador-Warts-Hippo pathway: An emerging tumour-suppressor network
    • Harvey K, Tapon N. The Salvador-Warts-Hippo pathway: an emerging tumour-suppressor network. Nat Rev Cancer. 2007;7:182-191.
    • (2007) Nat Rev Cancer , vol.7 , pp. 182-191
    • Harvey, K.1    Tapon, N.2
  • 5
    • 34247191134 scopus 로고    scopus 로고
    • Hippo signaling in organ size control
    • Pan D. Hippo signaling in organ size control. Genes Dev. 2007;21:886-897.
    • (2007) Genes Dev , vol.21 , pp. 886-897
    • Pan, D.1
  • 6
    • 0042733354 scopus 로고    scopus 로고
    • The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    • Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell. 2003;114:457-467.
    • (2003) Cell , vol.114 , pp. 457-467
    • Harvey, K.F.1    Pfleger, C.M.2    Hariharan, I.K.3
  • 7
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    • Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122:421-434.
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 8
    • 0037162714 scopus 로고    scopus 로고
    • salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    • Tapon N, Harvey KF, Bell DW, et al. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell. 2002;110:467-478.
    • (2002) Cell , vol.110 , pp. 467-478
    • Tapon, N.1    Harvey, K.F.2    Bell, D.W.3
  • 9
    • 0042232429 scopus 로고    scopus 로고
    • hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • Wu S, Huang J, Dong J, Pan D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell. 2003;114:445-456.
    • (2003) Cell , vol.114 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3    Pan, D.4
  • 10
    • 24344463858 scopus 로고    scopus 로고
    • Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases
    • He Y, Emoto K, Fang X, et al. Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases. Mol Biol Cell. 2005;16:4139-4152.
    • (2005) Mol Biol Cell , vol.16 , pp. 4139-4152
    • He, Y.1    Emoto, K.2    Fang, X.3
  • 11
    • 14844297327 scopus 로고    scopus 로고
    • Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
    • Lai ZC, Wei X, Shimizu T, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell. 2005;120:675-685.
    • (2005) Cell , vol.120 , pp. 675-685
    • Lai, Z.C.1    Wei, X.2    Shimizu, T.3
  • 12
    • 34247182696 scopus 로고    scopus 로고
    • Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila
    • Wei X, Shimizu T, Lai ZC. Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J. 2007;26:1772-1781.
    • (2007) EMBO J , vol.26 , pp. 1772-1781
    • Wei, X.1    Shimizu, T.2    Lai, Z.C.3
  • 13
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu F, Willecke M, Kango-Singh M, et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006;8:27-36.
    • (2006) Nat Cell Biol , vol.8 , pp. 27-36
    • Hamaratoglu, F.1    Willecke, M.2    Kango-Singh, M.3
  • 14
    • 33750611115 scopus 로고    scopus 로고
    • Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/ Hippo signaling pathway
    • Bennett FC, Harvey KF. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/ Hippo signaling pathway. Curr Biol. 2006;16: 2101-2110.
    • (2006) Curr Biol , vol.16 , pp. 2101-2110
    • Bennett, F.C.1    Harvey, K.F.2
  • 16
    • 33750624298 scopus 로고    scopus 로고
    • The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway
    • Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol. 2006;16:2081-2089.
    • (2006) Curr Biol , vol.16 , pp. 2081-2089
    • Silva, E.1    Tsatskis, Y.2    Gardano, L.3    Tapon, N.4    McNeill, H.5
  • 17
    • 33750614445 scopus 로고    scopus 로고
    • The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    • Willecke M, Hamaratoglu F, Kango-Singh M, et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol. 2006;16:2090-2100.
    • (2006) Curr Biol , vol.16 , pp. 2090-2100
    • Willecke, M.1    Hamaratoglu, F.2    Kango-Singh, M.3
  • 18
    • 0034702214 scopus 로고    scopus 로고
    • Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor
    • Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. Oncogene. 2000; 19:3101-3109.
    • (2000) Oncogene , vol.19 , pp. 3101-3109
    • Hori, T.1    Takaori-Kondo, A.2    Kamikubo, Y.3    Uchiyama, T.4
  • 19
    • 0034094293 scopus 로고    scopus 로고
    • Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts
    • Yabuta N, Fujii T, Copeland NG, et al. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics. 2000;63: 263-270.
    • (2000) Genomics , vol.63 , pp. 263-270
    • Yabuta, N.1    Fujii, T.2    Copeland, N.G.3
  • 20
    • 0038381486 scopus 로고    scopus 로고
    • Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor
    • Kamikubo Y, Takaori-Kondo A, Uchiyama T, Hori T. Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor. J Biol Chem. 2003; 278:17609-17614.
    • (2003) J Biol Chem , vol.278 , pp. 17609-17614
    • Kamikubo, Y.1    Takaori-Kondo, A.2    Uchiyama, T.3    Hori, T.4
  • 21
    • 0041302154 scopus 로고    scopus 로고
    • Lats2, a putative tumor suppressor, inhibits G1/S transition
    • Li Y, Pei J, Xia H, Ke H, Wang H, Tao W. Lats2, a putative tumor suppressor, inhibits G1/S transition. Oncogene. 2003;22:4398-4405.
    • (2003) Oncogene , vol.22 , pp. 4398-4405
    • Li, Y.1    Pei, J.2    Xia, H.3    Ke, H.4    Wang, H.5    Tao, W.6
  • 22
    • 3242726756 scopus 로고    scopus 로고
    • Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)
    • Ke H, Pei J, Ni Z, et al. Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). Exp Cell Res. 2004;298: 329-338.
    • (2004) Exp Cell Res , vol.298 , pp. 329-338
    • Ke, H.1    Pei, J.2    Ni, Z.3
  • 23
    • 33749334018 scopus 로고    scopus 로고
    • A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
    • Aylon Y, Michael D, Shmueli A, Yabuta N, Nojima H, Oren M. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 2006;20:2687-2700.
    • (2006) Genes Dev , vol.20 , pp. 2687-2700
    • Aylon, Y.1    Michael, D.2    Shmueli, A.3    Yabuta, N.4    Nojima, H.5    Oren, M.6
  • 24
    • 0034680044 scopus 로고    scopus 로고
    • Isolation and characterization of sixteen novel p53 response genes
    • Kostic C, Shaw PH. Isolation and characterization of sixteen novel p53 response genes. Oncogene. 2000;19:3978-3987.
    • (2000) Oncogene , vol.19 , pp. 3978-3987
    • Kostic, C.1    Shaw, P.H.2
  • 25
    • 33745997665 scopus 로고    scopus 로고
    • Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage
    • Colombani J, Polesello C, Josue F, Tapon N. Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr Biol. 2006;16:1453-1458.
    • (2006) Curr Biol , vol.16 , pp. 1453-1458
    • Colombani, J.1    Polesello, C.2    Josue, F.3    Tapon, N.4
  • 26
    • 20844449390 scopus 로고    scopus 로고
    • Lats2/ Kpm is required for embryonic development, proliferation control and genomic integrity
    • McPherson JP, Tamblyn L, Elia A, et al. Lats2/ Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 2004;23:3677-3688.
    • (2004) EMBO J , vol.23 , pp. 3677-3688
    • McPherson, J.P.1    Tamblyn, L.2    Elia, A.3
  • 27
    • 34547103279 scopus 로고    scopus 로고
    • Lats2 is an essential mitotic regulator required for the coordination of cell division
    • Yabuta N, Okada N, Ito A, et al. Lats2 is an essential mitotic regulator required for the coordination of cell division. J Biol Chem. 2007;282: 19259-19271.
    • (2007) J Biol Chem , vol.282 , pp. 19259-19271
    • Yabuta, N.1    Okada, N.2    Ito, A.3
  • 29
    • 0028283579 scopus 로고
    • Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product
    • Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene. 1994;9:2145-2152.
    • (1994) Oncogene , vol.9 , pp. 2145-2152
    • Sudol, M.1
  • 30
    • 0028997651 scopus 로고
    • Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain
    • Sudol M, Bork P, Einbond A, et al. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995;270: 14733-14741.
    • (1995) J Biol Chem , vol.270 , pp. 14733-14741
    • Sudol, M.1    Bork, P.2    Einbond, A.3
  • 31
    • 0037138411 scopus 로고    scopus 로고
    • WW and SH3 domains, two different scaffolds to recognize proline-rich ligands
    • Macias MJ, Wiesner S, Sudol M. WW and SH3 domains, two different scaffolds to recognize proline-rich ligands. FEBS Lett. 2002;513:30-37.
    • (2002) FEBS Lett , vol.513 , pp. 30-37
    • Macias, M.J.1    Wiesner, S.2    Sudol, M.3
  • 32
    • 0035873391 scopus 로고    scopus 로고
    • Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 2001;15:1229-1241.
    • Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 2001;15:1229-1241.
  • 33
    • 0042858208 scopus 로고    scopus 로고
    • WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
    • Komuro A, Nagai M, Navin NE, Sudol M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem. 2003; 278:33334-33341.
    • (2003) J Biol Chem , vol.278 , pp. 33334-33341
    • Komuro, A.1    Nagai, M.2    Navin, N.E.3    Sudol, M.4
  • 34
    • 23044492008 scopus 로고    scopus 로고
    • WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function
    • Aqeilan RI, Donati V, Palamarchuk A, et al. WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res. 2005;65: 6764-6772.
    • (2005) Cancer Res , vol.65 , pp. 6764-6772
    • Aqeilan, R.I.1    Donati, V.2    Palamarchuk, A.3
  • 35
    • 0033522472 scopus 로고    scopus 로고
    • AWW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator
    • Yagi R, Chen LF, Shigesada K, Murakami Y, Ito Y. AWW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 1999;18:2551-2562.
    • (1999) EMBO J , vol.18 , pp. 2551-2562
    • Yagi, R.1    Chen, L.F.2    Shigesada, K.3    Murakami, Y.4    Ito, Y.5
  • 36
    • 1842457741 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
    • Zaidi SK, Sullivan AJ, Medina R, et al. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J. 2004;23:790-799.
    • (2004) EMBO J , vol.23 , pp. 790-799
    • Zaidi, S.K.1    Sullivan, A.J.2    Medina, R.3
  • 37
    • 33747591465 scopus 로고    scopus 로고
    • Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
    • Overholtzer M, Zhang J, Smolen GA, et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A. 2006;103:12405-12410.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12405-12410
    • Overholtzer, M.1    Zhang, J.2    Smolen, G.A.3
  • 38
    • 33745253109 scopus 로고    scopus 로고
    • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    • Zender L, Spector MS, Xue W, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 2006;125:1253-1267.
    • (2006) Cell , vol.125 , pp. 1253-1267
    • Zender, L.1    Spector, M.S.2    Xue, W.3
  • 39
    • 0035957958 scopus 로고    scopus 로고
    • Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains
    • Espanel X, Sudol M. Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. J Biol Chem. 2001;276:14514-14523.
    • (2001) J Biol Chem , vol.276 , pp. 14514-14523
    • Espanel, X.1    Sudol, M.2
  • 40
    • 17944379798 scopus 로고    scopus 로고
    • ASPP proteins specifically stimulate the apoptotic function of p53
    • Samuels-Lev Y, O'Connor DJ, Bergamaschi D, et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell. 2001;8:781-794.
    • (2001) Mol Cell , vol.8 , pp. 781-794
    • Samuels-Lev, Y.1    O'Connor, D.J.2    Bergamaschi, D.3
  • 42
    • 14644420898 scopus 로고    scopus 로고
    • Downregulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
    • Takahashi Y, Miyoshi Y, Takahata C, et al. Downregulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin Cancer Res. 2005; 11:1380-1385.
    • (2005) Clin Cancer Res , vol.11 , pp. 1380-1385
    • Takahashi, Y.1    Miyoshi, Y.2    Takahata, C.3
  • 43
    • 28544433969 scopus 로고    scopus 로고
    • Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia
    • Jime'nez-Velasco A, Roman-Gomez J, Agirre X, et al. Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia. Leukemia. 2005;19:2347-2350.
    • (2005) Leukemia , vol.19 , pp. 2347-2350
    • Jime'nez-Velasco, A.1    Roman-Gomez, J.2    Agirre, X.3
  • 44
    • 0018940849 scopus 로고
    • An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1)
    • Koeffler HP, Billing R, Lusis AJ, Sparkes R, Golde DW. An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1). Blood. 1980;56:265-273.
    • (1980) Blood , vol.56 , pp. 265-273
    • Koeffler, H.P.1    Billing, R.2    Lusis, A.J.3    Sparkes, R.4    Golde, D.W.5
  • 45
    • 0023597217 scopus 로고
    • Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia
    • Maeda M, Arima N, Daitoku Y, et al. Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia. Blood. 1987;70: 1407-1411.
    • (1987) Blood , vol.70 , pp. 1407-1411
    • Maeda, M.1    Arima, N.2    Daitoku, Y.3
  • 46
    • 0024402245 scopus 로고
    • Acute transformation of chronic large granular lymphocyte leukemia associated with additional chromosome abnormality
    • Ohno Y, Amakawa R, Fukuhara S, et al. Acute transformation of chronic large granular lymphocyte leukemia associated with additional chromosome abnormality. Cancer. 1989;64:63-67.
    • (1989) Cancer , vol.64 , pp. 63-67
    • Ohno, Y.1    Amakawa, R.2    Fukuhara, S.3
  • 47
    • 33749606409 scopus 로고    scopus 로고
    • Identification of HLA class I-restricted tumor-associated antigens in adult T cell leukemia cells by mass spectrometric analysis
    • Kawahara M, Hori T, Matsubara Y, Okawa K, Uchiyama T. Identification of HLA class I-restricted tumor-associated antigens in adult T cell leukemia cells by mass spectrometric analysis. Exp Hematol. 2006;34:1496-1504.
    • (2006) Exp Hematol , vol.34 , pp. 1496-1504
    • Kawahara, M.1    Hori, T.2    Matsubara, Y.3    Okawa, K.4    Uchiyama, T.5
  • 48
    • 33748641213 scopus 로고    scopus 로고
    • Delineation of immunoregulatory properties of adult T-cell leukemia cells
    • Matsubar Y, Hori T, Morita R, Sakaguchi S, Uchiyama T. Delineation of immunoregulatory properties of adult T-cell leukemia cells. Int J Hematol. 2006;84:63-69.
    • (2006) Int J Hematol , vol.84 , pp. 63-69
    • Matsubar, Y.1    Hori, T.2    Morita, R.3    Sakaguchi, S.4    Uchiyama, T.5
  • 49
    • 0033517321 scopus 로고    scopus 로고
    • New p73 variants with altered Cterminal structures have varied transcriptional activities
    • Ueda Y, Hijikata M, Takagi S, Chiba T, Shimotohno K. New p73 variants with altered Cterminal structures have varied transcriptional activities. Oncogene. 1999;18:4993-4998.
    • (1999) Oncogene , vol.18 , pp. 4993-4998
    • Ueda, Y.1    Hijikata, M.2    Takagi, S.3    Chiba, T.4    Shimotohno, K.5
  • 50
    • 61849177571 scopus 로고    scopus 로고
    • National Center for Biotechnology Information. BLASTN. http://www.ncbi.nlm.nih.gov/blast/ Blast.cgi?PAGENucleotides&PROGRAM=blastn. Accessed on March 11, 2005.
    • National Center for Biotechnology Information. BLASTN. http://www.ncbi.nlm.nih.gov/blast/ Blast.cgi?PAGENucleotides&PROGRAM=blastn. Accessed on March 11, 2005.
  • 51
    • 30344450404 scopus 로고    scopus 로고
    • p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
    • Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell. 2006;9:45-56.
    • (2006) Cancer Cell , vol.9 , pp. 45-56
    • Rocco, J.W.1    Leong, C.O.2    Kuperwasser, N.3    DeYoung, M.P.4    Ellisen, L.W.5
  • 52
    • 33646056975 scopus 로고    scopus 로고
    • A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors
    • Voorhoeve PM, le Sage C, Schrier M, et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell. 2006;124:1169-1181.
    • (2006) Cell , vol.124 , pp. 1169-1181
    • Voorhoeve, P.M.1    le Sage, C.2    Schrier, M.3
  • 53
    • 0031048884 scopus 로고    scopus 로고
    • Radiation-enhanced expression of interferon-inducible genes in the KG1a primitive hematopoietic cell line
    • Clave E, Carosella ED, Gluckman E, Socie G. Radiation-enhanced expression of interferon-inducible genes in the KG1a primitive hematopoietic cell line. Leukemia. 1997;11:114-119.
    • (1997) Leukemia , vol.11 , pp. 114-119
    • Clave, E.1    Carosella, E.D.2    Gluckman, E.3    Socie, G.4
  • 54
    • 0347628818 scopus 로고    scopus 로고
    • p21Waf1/Cip1 as a therapeutic target in breast and other cancers
    • Weiss RH. p21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell. 2003;4: 425-429.
    • (2003) Cancer Cell , vol.4 , pp. 425-429
    • Weiss, R.H.1
  • 55
    • 0142227023 scopus 로고    scopus 로고
    • No PUMA, no death: Implications for p53-dependent apoptosis
    • Yu J, Zhang L. No PUMA, no death: implications for p53-dependent apoptosis. Cancer Cell. 2003; 4:248-249.
    • (2003) Cancer Cell , vol.4 , pp. 248-249
    • Yu, J.1    Zhang, L.2
  • 56
    • 33751513394 scopus 로고    scopus 로고
    • Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
    • Kim H, Rafiuddin-Shah M, Tu HC, et al. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol. 2006; 8:1348-1358.
    • (2006) Nat Cell Biol , vol.8 , pp. 1348-1358
    • Kim, H.1    Rafiuddin-Shah, M.2    Tu, H.C.3
  • 57
    • 3042660431 scopus 로고    scopus 로고
    • The inhibitor of apoptosis protein family (IAPs): An emerging therapeutic target in cancer
    • Nachmias B, Ashhab Y, Ben-Yehuda D. The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer. Semin Cancer Biol. 2004;14:231-243.
    • (2004) Semin Cancer Biol , vol.14 , pp. 231-243
    • Nachmias, B.1    Ashhab, Y.2    Ben-Yehuda, D.3
  • 58
    • 29644436953 scopus 로고    scopus 로고
    • p73, a sophisticated p53 family member in the cancer world
    • Ozaki T, Nakagawara A. p73, a sophisticated p53 family member in the cancer world. Cancer Sci. 2005;96:729-737.
    • (2005) Cancer Sci , vol.96 , pp. 729-737
    • Ozaki, T.1    Nakagawara, A.2
  • 59
    • 33751019980 scopus 로고    scopus 로고
    • Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma
    • Jiang Z, Li X, Hu J, et al. Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res. 2006;56:450-458.
    • (2006) Neurosci Res , vol.56 , pp. 450-458
    • Jiang, Z.1    Li, X.2    Hu, J.3
  • 60
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 1995; 9:1149-1163.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 61
    • 0036674502 scopus 로고    scopus 로고
    • Vousden KH. p73: Friend or foe in tumorigenesis. Nat Rev Cancer
    • Melino G, De Laurenzi V, Vousden KH. p73: friend or foe in tumorigenesis. Nat Rev Cancer. 2002;2:605-615.
    • (2002) , vol.2 , pp. 605-615
    • Melino, G.1    Laurenzi, D.2
  • 62
    • 0033611565 scopus 로고    scopus 로고
    • p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent
    • Ichimiya S, Nimura Y, Kageyama H, et al. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. Oncogene. 1999;18:1061-1066.
    • (1999) Oncogene , vol.18 , pp. 1061-1066
    • Ichimiya, S.1    Nimura, Y.2    Kageyama, H.3
  • 65
    • 2942657482 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of p73 is inhibited by PML
    • Bernassola F, Salomoni P, Oberst A, et al. Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med. 2004;199:1545-1557.
    • (2004) J Exp Med , vol.199 , pp. 1545-1557
    • Bernassola, F.1    Salomoni, P.2    Oberst, A.3
  • 66
    • 15444367709 scopus 로고    scopus 로고
    • The ubiquitin-protein ligase Itch regulates p73 stability
    • Rossi M, De Laurenzi V, Munarriz E, et al. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 2005;24:836-848.
    • (2005) EMBO J , vol.24 , pp. 836-848
    • Rossi, M.1    De Laurenzi, V.2    Munarriz, E.3
  • 67
    • 0242664079 scopus 로고    scopus 로고
    • p73alpha regulation by Chk1 in response to DNA damage
    • Gonzalez S, Prives C, Cordon-Cardo C. p73alpha regulation by Chk1 in response to DNA damage. Mol Cell Biol. 2003;23:8161-8171.
    • (2003) Mol Cell Biol , vol.23 , pp. 8161-8171
    • Gonzalez, S.1    Prives, C.2    Cordon-Cardo, C.3
  • 68
    • 10644270921 scopus 로고    scopus 로고
    • p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2
    • Urist M, Tanaka T, Poyurovsky MV, Prives C. p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev. 2004;18:3041-3054.
    • (2004) Genes Dev , vol.18 , pp. 3041-3054
    • Urist, M.1    Tanaka, T.2    Poyurovsky, M.V.3    Prives, C.4
  • 69
    • 0034609798 scopus 로고    scopus 로고
    • Role for the p53 homologue p73 in E2F-1-induced apoptosis
    • Irwin M, Marin MC, Phillips AC, et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 2000;407:645-648.
    • (2000) Nature , vol.407 , pp. 645-648
    • Irwin, M.1    Marin, M.C.2    Phillips, A.C.3
  • 70
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53-homologue p73 in E2F1-induced apoptosis
    • Stiewe T, Putzer BM. Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat Genet. 2000; 26:464-469.
    • (2000) Nat Genet , vol.26 , pp. 464-469
    • Stiewe, T.1    Putzer, B.M.2
  • 71
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis
    • Agami R, Blandino G, Oren M, Shaul Y. Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature. 1999;399:809-813.
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 72
    • 0033600234 scopus 로고    scopus 로고
    • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    • Gong JG, Costanzo A, Yang HQ, et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature. 1999;399:806-809.
    • (1999) Nature , vol.399 , pp. 806-809
    • Gong, J.G.1    Costanzo, A.2    Yang, H.Q.3
  • 73
    • 0033600235 scopus 로고    scopus 로고
    • p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
    • Yuan ZM, Shioya H, Ishiko T, et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature. 1999;399:814--817.
    • (1999) Nature , vol.399 , pp. 814-817
    • Yuan, Z.M.1    Shioya, H.2    Ishiko, T.3
  • 74
    • 0034193343 scopus 로고    scopus 로고
    • A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents
    • Sanchez-Prieto R, Rojas JM, Taya Y, Gutkind JS. A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res. 2000;60:2464-2472.
    • (2000) Cancer Res , vol.60 , pp. 2464-2472
    • Sanchez-Prieto, R.1    Rojas, J.M.2    Taya, Y.3    Gutkind, J.S.4
  • 75
    • 18244408596 scopus 로고    scopus 로고
    • DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
    • Costanzo A, Merlo P, Pediconi N, et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell. 2002;9:175-186.
    • (2002) Mol Cell , vol.9 , pp. 175-186
    • Costanzo, A.1    Merlo, P.2    Pediconi, N.3
  • 76
    • 2942547565 scopus 로고    scopus 로고
    • Pin1 links the activities of c-Abl and p300 in regulating p73 function
    • Mantovani F, Piazza S, Gostissa M, et al. Pin1 links the activities of c-Abl and p300 in regulating p73 function. Mol Cell. 2004;14:625-636.
    • (2004) Mol Cell , vol.14 , pp. 625-636
    • Mantovani, F.1    Piazza, S.2    Gostissa, M.3
  • 77
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    • Basu S, Totty NF, Irwin MS, Sudol M, Downward J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell. 2003; 11:11-23.
    • (2003) Mol Cell , vol.11 , pp. 11-23
    • Basu, S.1    Totty, N.F.2    Irwin, M.S.3    Sudol, M.4    Downward, J.5
  • 78
    • 21044442524 scopus 로고    scopus 로고
    • The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage
    • Strano S, Monti O, Pediconi N, et al. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage. Mol Cell. 2005;18:447-459.
    • (2005) Mol Cell , vol.18 , pp. 447-459
    • Strano, S.1    Monti, O.2    Pediconi, N.3
  • 79
    • 34748812613 scopus 로고    scopus 로고
    • RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
    • Matallanas D, Romano D, Yee K, et al. RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell. 2007;27:962-975.
    • (2007) Mol Cell , vol.27 , pp. 962-975
    • Matallanas, D.1    Romano, D.2    Yee, K.3
  • 80
    • 34548636132 scopus 로고    scopus 로고
    • Elucidation of a universal size-control mechanism in Drosophila and mammals
    • Dong J, Feldmann G, Huang J, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell. 2007;130:1120-1133.
    • (2007) Cell , vol.130 , pp. 1120-1133
    • Dong, J.1    Feldmann, G.2    Huang, J.3
  • 81
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007;21:2747-2761.
    • (2007) Genes Dev , vol.21 , pp. 2747-2761
    • Zhao, B.1    Wei, X.2    Li, W.3
  • 82
    • 14744301343 scopus 로고    scopus 로고
    • JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
    • Yoshida K, Yamaguchi T, Natsume T, Kufe D, Miki Y. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol. 2005;7: 278-285.
    • (2005) Nat Cell Biol , vol.7 , pp. 278-285
    • Yoshida, K.1    Yamaguchi, T.2    Natsume, T.3    Kufe, D.4    Miki, Y.5
  • 83
    • 22944479314 scopus 로고    scopus 로고
    • JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3
    • Sunayama J, Tsuruta F, Masuyama N, Gotoh Y. JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol. 2005;170: 295-304.
    • (2005) J Cell Biol , vol.170 , pp. 295-304
    • Sunayama, J.1    Tsuruta, F.2    Masuyama, N.3    Gotoh, Y.4


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