Knockout of ERK5 causes multiple defects in placental and embryonic development

BMC Developmental Biology

Volumn 3, Issue , 2003, Pages 1-21

  Yan, Lijun ^a   Carr, Julia ^a   Ashby, Peter R ^a   Murry Tait, Victoria ^a   Thompson, Calum ^a   Arthur, J Simon C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 7; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONGENITAL MALFORMATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ENZYME ANALYSIS; FEMALE; GENE INACTIVATION; GENE TARGETING; HEAD; HEART DEVELOPMENT; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE MALFORMATION; KNOCKOUT MOUSE; MALE; MESENCHYME; MOUSE; NONHUMAN; ORGAN DISTRIBUTION; PHENOTYPE; PLACENTA DISORDER; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRUNK; WILD TYPE; YOLK SAC;

ANIMALIA;

EID: 2942717178     PISSN: 1471213X     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-213X-3-11     Document Type: Article

References (48)

1. Kato Y, Tapping RI, Huang S, Watson MH, Ulevitch RJ, Lee JD: Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature 1998, 395(6703):713-6.
2. Abe J, Kusuhara M, Ulevitch RJ, Berk BC, Lee JD: Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem 1996, 271(28):16586-90.
3. Abe J, Takahashi M, Ishida M, Lee JD, Berk BC: c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1. J Biol Chem 1997, 272(33):20389-94.
4. Chao TH, Hayashi M, Tapping RI, Kato Y, Lee JD: MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. J Biol Chem 1999, 274(51):36035-8.
5. Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL: MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. J Biol Chem 2001, 276(7):5093-100.
6. Kamakura S, Moriguchi T, Nishida E: Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem 1999, 274(37):26563-71.
7. Mody N, Leitch J, Armstrong C, Dixon J, Cohen P: Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway. FEBS Lett 2001, 502(1-2):21-4.
8. Nicol RL, Frey N, Pearson G, Cobb M, Richardson J, Olson EN: Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. Embo J 2001, 20(11):2757-67.
9. Dinev D, Jordan BW, Neufeld B, Lee JD, Lindemann D, Rapp UR, Ludwig S: Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells. EMBO Rep 2001, 2(9):829-34.
10. Zhao M, Liu Y, Bao M, Kato Y, Han J, Eaton JW: Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases. Arch Biochem Biophys 2002, 400(2):199-207.
11. Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J: Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation. J Biol Chem 2003, 278(20):18682-8.
12. Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA: Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. Nucleic Acids Res 1998, 26(20):4771-7.
13. Kato Y, Kravchenko VV, Tapping RI, Han J, Ulevitch RJ, Lee JD: BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. Embo J 1997, 16(23):7054-66.
14. Kasler HG, Victoria J, Duramad O, Winoto A: ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain. Mol Cell Biol 2000, 20(22):8382-9.
15. Lin Q, Schwarz J, Bucana C, Olson EN: Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 1997, 276(5317):1404-7.
16. Yang J, Boerm M, McCarty M, Bucana C, Fidler IJ, Zhuang Y, Su B: Mekk3 is essential for early embryonic cardiovascular development. Nat Genet 2000, 24(3):309-13.
17. Kolodziejczyk SM, Wang L, Balazsi K, DeRepentigny Y, Kothary R, Megeney LA: MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr Biol 1999, 9(20):1203-6.
18. Yang SH, Galanis A, Sharrocks AD: Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol Cell Biol 1999, 19(6):4028-38.
19. Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J: Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol 1999, 19(1):21-30.
20. Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ: Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 1997, 386(6622):296-9.
21. Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR: Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 2000, 6(1):109-16.
22. Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 2000, 102(2):221-31.
23. Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, Shen MM: Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A 2000, 97(19):10454-9.
24. Lescisin KR, Varmuza S, Rossant J: Isolation and characterization of a novel trophoblast-specific cDNA in the mouse. Genes Dev 1988, 2(12A):1639-46.
25. Regan CP, Li W, Boucher DM, Spatz S, Su MS, Kuida K: Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A 2002, 99(14):9248-53.
26. Sohn SJ, Sarvis BK, Cado D, Winoto A: ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem 2002, 277(45):43344-51.
27. Rossant J, Cross JC: Placental development: lessons from mouse mutants. Nat Rev Genet 2001, 2(7):538-48.
28. Hemberger M, Cross JC: Genes governing placental development. Trends Endocrinol Metab 2001, 12(4):162-8.
29. Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J: Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol 1999, 9(7):369-72.
30. Ware CB, Horowitz MC, Renshaw BR, Hunt JS, Liggitt D, Koblar SA, Gliniak BC, McKenna HJ, Papayannopoulou T, Thoma B et al.: Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development 1995, 121(5):1283-99.
31. Sibilia M, Steinbach JP, Stingl L, Aguzzi A, Wagner EF: A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. Embo J 1998, 17(3):719-31.
32. Ohlsson R, Falck P, Hellstrom M, Lindahl P, Bostrom H, Franklin G, Ahrlund-Richter L, Pollard J, Soriano P, Betsholtz C: PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta. Dev Biol 1999, 212(1):124-36.
33. Ogura Y, Takakura N, Yoshida H, Nishikawa SI: Essential role of platelet-derived growth factor receptor alpha in the development of the intraplacental yolk sac/sinus of Duval in mouse placenta. Biol Reprod 1998, 58(1):65-72.
34. Sachs M, Brohmann H, Zechner D, Muller T, Hulsken J, Walther I, Schaeper U, Birchmeier C, Birchmeier W: Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol 2000, 150(6):1375-84.
35. Qian X, Esteban L, Vass WC, Upadhyaya C, Papageorge AG, Yienger K, Ward JM, Lowy DR, Santos E: The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. Embo J 2000, 19(4):642-54.
36. Chen J, Kubalak SW, Chien KR: Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development 1998, 125(10):1943-9.
37. Mehta PB, Jenkins BL, McCarthy L, Thilak L, Robson CN, Neal DE, Leung HY: MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Oncogene 2003, 22(9):1381-9.
38. Shalizi A, Lehtinen M, Gaudilliere B, Donovan N, Han J, Konishi Y, Bonni A: Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neurosci 2003, 23(19):7326-36.
39. Liu L, Cavanaugh JE, Wang Y, Sakagami H, Mao Z, Xia Z: ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc Natl Acad Sci U S A 2003, 100(14):8532-7.
40. Arthur JS, Cohen P: MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. FEBS Lett 2000, 482(1-2):44-8.
41. Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS: MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol 2002, 22(8):2871-81.
42. Wilkinson DG: In situ hybridization. A Practical Approach IRL Press/Oxford University Press; 1992.
43. Mark M, Lufkin T, Vonesch JL, Ruberte E, Olivo JC, Dolle P, Gorry P, Lumsden A, Chambon P: Two rhombomeres are altered in Hoxa-1 mutant mice. Development 1993, 119(2):319-38.
44. Bancroft JDSA: Theory and practice of histological techniques Churchill/Livinstone; 1997.
45. Gundersen HJ, Jensen EB: The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987, 147(Pt 3):229-63.
46. Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, Gridley T, Wolburg H, Risau W, Qin Y: Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 1995, 376(6535):70-4.
47. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996, 87(7):1171-80.
48. Esparis-Ogando A, Diaz-Rodriguez E, Montero JC, Yuste L, Crespo P, Pandiella A: Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2. Mol Cell Biol 2002, 22(1):270-85.