Mass spectrometric studies of potent inhibitors of farnesyl protein transferase - Detection of pentameric noncovalent complexes

Journal of Mass Spectrometry

Volumn 43, Issue 10, 2008, Pages 1393-1401

  Mirza, Urooj A ^a   Chen, Guodong ^a   Liu, Yan Hui ^a   Doll, Ronald J ^a   Girijavallabhan, Viyyoor M ^a   Ganguly, Ashit K ^a   Pramanik, Birendra N ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Electrospray ionization time of flight mass spectrometry (ESI TOF MS); Farnesyl protein transferase; Noncovalent complex; Protein inhibitor complex

Indexed keywords

BINDING ENERGY; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DESALINATION; ENZYMES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDUCTIVELY COUPLED PLASMA; IONIZATION; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; NEGATIVE IONS; SIZE EXCLUSION CHROMATOGRAPHY; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; ZINC;

ANTI CANCER AGENTS; ANTICANCER THERAPIES; CLINICAL TRIALS; DIRECT DETECTIONS; ELECTROSPRAY IONIZATION MASS SPECTROMETRIES; FARNESYL PROTEIN TRANSFERASE; FARNESYL PYROPHOSPHATES; INHIBITOR COMPLEXES; NONCOVALENT BINDINGS; NONCOVALENT COMPLEX; NONCOVALENT COMPLEXES; ORALLY ACTIVES; PENTAMERIC COMPLEXES; POTENT INHIBITORS; PROMISING APPROACHES; PROTEIN INHIBITOR COMPLEX; PROTEIN SAMPLES; SIZE EXCLUSIONS; TIME OF FLIGHTS;

ELECTROSPRAY IONIZATION;

FARNESYL DIPHOSPHATE; LONAFARNIB; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; ZINC;

ARTICLE; DRUG BINDING; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; GEL PERMEATION CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY;

ALKYL AND ARYL TRANSFERASES; CHROMATOGRAPHY, GEL; ENZYME INHIBITORS; MASS SPECTROMETRY; MOLECULAR WEIGHT; PIPERIDINES; PROTEIN DENATURATION; PYRIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 55249101240     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1417     Document Type: Article

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