Do proteins denature during droplet evolution in electrospray ionization?

International Journal of Mass Spectrometry and Ion Processes

Volumn 162, Issue 1-3, 1997, Pages 173-181

  Mirza, Urooj A ^a   Chait, Brian T ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Denaturation; Droplet evolution; Electrospray ionization; Protein

Indexed keywords

EID: 0001555550     PISSN: 01681176     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0168-1176(96)04517-x     Document Type: Article

References (29)

1. S.K. Chowdhury, V. Katta and B.T. Chait, J. Am. Chem. Soc., 112 (1990) 9012.
2. J.A. Loo, C.G. Edmonds, H.R. Udseth and R.D. Smith, Anal. Chem., 62 (1990) 693.
3. J.A. Loo, R.R.O. Loo, H.R. Udseth, C.G. Edmonds and R.D. Smith, Rapid. Commun. Mass. Spectrom., 5 (1991) 101.
4. R.D. Smith, J.A. Loo, R.R.O. Loo, M. Busman and H.R. Udseth, Mass Spectrom. Rev., 10 (1990) 693.
5. V. Katta and B.T. Chait, Rapid Commun. Mass Spectrom., 5 (1991) 214. V. Katta and B.T. Chait, J. Am. Chem. Soc., 115 (1993) 6317.
6. V. Katta and B.T. Chait, Rapid Commun. Mass Spectrom., 5 (1991) 214. V. Katta and B.T. Chait, J. Am. Chem. Soc., 115 (1993) 6317.
7. J.C.Y. LeBlanc, D. Beuchemin, K.W. Siu, R. Guevremont and S.S. Berman, Org. Mass Spectrom., 21 (1993) 831.
8. U.A. Mirza, S.L. Cohen and B.T. Chait, Anal. Chem., 65 (1993) 1.
9. V. Katta and B.T. Chait, J. Am. Chem. Soc., 113 (1991) 8534.
10. R. Feng and Y. Konishi, J. Am. Soc. Mass Spectrom., 4 (1990) 638.
11. D.L. Smith and Z. Zhang, Mass Spectrom. Rev., 13 (1994) 411.
12. M. Dole, L.L. Mach, R.L. Hines, R.C. Mobley, L.P. Ferguson and M.B. Alice, J. Chem. Phys., 49 (1968) 2240.
13. J.V. Iribarne and B.A. Thomson, J. Chem. Phys., 64 (1976) 2287.
14. J.B. Fenn, J. Am. Soc. Mass Spectrom., 4 (1993) 524.
15. P. Kebarle and L. Tang, Anal. Chem., 65 (1993) 972A.
16. M.G. Ikonomou and P. Kebarle, J. Am. Soc. Mass Spectrom., 5 (1994) 791.
17. C.L. Gatlin and F. Turecek, Anal. Chem., 66 (1994) 712.
18. S.K. Chowdhury, V. Katta and B.T. Chait, Rapid Commun. Mass Spectrom., 4 (1990) 81.
19. M. Pirani and J. Yarwood, Principles of Vacuum Engineering, Chapman and Hall, London, 1961.
20. T.E. Creighton, Biochem. J., 270 (1990) 1.
21. U.A. Mirza and B.T. Chait, Anal. Chem., 66 (1994) 2898.
22. D. Suckau, Y. Shi, S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler III and F.W. McLafferty, Proc. Natl. Acad. Sci. USA, 90 (1993) 790. B.E. Winger, K.J. Light-Wahl, A.L. Rockwood and R.D. Smith, J. Am. Chem. Soc., 114 (1992) 5897. T.R. Covey and D.J. Douglas, J. Am. Soc. Mass Spectrom., 4 (1993) 616. R.R.O. Loo and R.D. Smith, J. Am. Soc. Mass Spectrom., 5 (1994) 207. Y. Konishi and R. Feng, Biochemistry, 33 (1994) 9706. D.E. Clemmer, R.R. Hudgins and M.F. Jarrold, J. Am. Chem. Soc., 117 (1995) 10 141.
23. D. Suckau, Y. Shi, S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler III and F.W. McLafferty, Proc. Natl. Acad. Sci. USA, 90 (1993) 790. B.E. Winger, K.J. Light-Wahl, A.L. Rockwood and R.D. Smith, J. Am. Chem. Soc., 114 (1992) 5897. T.R. Covey and D.J. Douglas, J. Am. Soc. Mass Spectrom., 4 (1993) 616. R.R.O. Loo and R.D. Smith, J. Am. Soc. Mass Spectrom., 5 (1994) 207. Y. Konishi and R. Feng, Biochemistry, 33 (1994) 9706. D.E. Clemmer, R.R. Hudgins and M.F. Jarrold, J. Am. Chem. Soc., 117 (1995) 10 141.
24. D. Suckau, Y. Shi, S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler III and F.W. McLafferty, Proc. Natl. Acad. Sci. USA, 90 (1993) 790. B.E. Winger, K.J. Light-Wahl, A.L. Rockwood and R.D. Smith, J. Am. Chem. Soc., 114 (1992) 5897. T.R. Covey and D.J. Douglas, J. Am. Soc. Mass Spectrom., 4 (1993) 616. R.R.O. Loo and R.D. Smith, J. Am. Soc. Mass Spectrom., 5 (1994) 207. Y. Konishi and R. Feng, Biochemistry, 33 (1994) 9706. D.E. Clemmer, R.R. Hudgins and M.F. Jarrold, J. Am. Chem. Soc., 117 (1995) 10 141.
25. D. Suckau, Y. Shi, S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler III and F.W. McLafferty, Proc. Natl. Acad. Sci. USA, 90 (1993) 790. B.E. Winger, K.J. Light-Wahl, A.L. Rockwood and R.D. Smith, J. Am. Chem. Soc., 114 (1992) 5897. T.R. Covey and D.J. Douglas, J. Am. Soc. Mass Spectrom., 4 (1993) 616. R.R.O. Loo and R.D. Smith, J. Am. Soc. Mass Spectrom., 5 (1994) 207. Y. Konishi and R. Feng, Biochemistry, 33 (1994) 9706. D.E. Clemmer, R.R. Hudgins and M.F. Jarrold, J. Am. Chem. Soc., 117 (1995) 10 141.
26. D. Suckau, Y. Shi, S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler III and F.W. McLafferty, Proc. Natl. Acad. Sci. USA, 90 (1993) 790. B.E. Winger, K.J. Light-Wahl, A.L. Rockwood and R.D. Smith, J. Am. Chem. Soc., 114 (1992) 5897. T.R. Covey and D.J. Douglas, J. Am. Soc. Mass Spectrom., 4 (1993) 616. R.R.O. Loo and R.D. Smith, J. Am. Soc. Mass Spectrom., 5 (1994) 207. Y. Konishi and R. Feng, Biochemistry, 33 (1994) 9706. D.E. Clemmer, R.R. Hudgins and M.F. Jarrold, J. Am. Chem. Soc., 117 (1995) 10 141.
27. D. Suckau, Y. Shi, S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler III and F.W. McLafferty, Proc. Natl. Acad. Sci. USA, 90 (1993) 790. B.E. Winger, K.J. Light-Wahl, A.L. Rockwood and R.D. Smith, J. Am. Chem. Soc., 114 (1992) 5897. T.R. Covey and D.J. Douglas, J. Am. Soc. Mass Spectrom., 4 (1993) 616. R.R.O. Loo and R.D. Smith, J. Am. Soc. Mass Spectrom., 5 (1994) 207. Y. Konishi and R. Feng, Biochemistry, 33 (1994) 9706. D.E. Clemmer, R.R. Hudgins and M.F. Jarrold, J. Am. Chem. Soc., 117 (1995) 10 141.
28. M. Wilm and M. Mann, Int. J. Mass Spectrom. Ion Processes, 136 (1994) 167. M. Wilm and M. Mann, Anal. Chem., 68 (1996) 1.
29. M. Wilm and M. Mann, Int. J. Mass Spectrom. Ion Processes, 136 (1994) 167. M. Wilm and M. Mann, Anal. Chem., 68 (1996) 1.