Studies on Ternary Metallo-β Lactamase-Inhibitor Complexes Using Electrospray Ionization Mass Spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 17, Issue 7, 2006, Pages 1000-1004

  Selevsek, Nathalie ^a   Tholey, Andreas ^a   Heinzle, Elmar ^a   Liénard, Benoît M R ^b   Oldham, Neil J ^b   Schofield, Christopher J ^b   Heinz, Uwe ^c   Adolph, Hans Werner ^a   Frère, Jean Marie ^d  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

IONIZATION MASS SPECTROMETRY; LACTAMASE-INHIBITOR COMPLEXES; METALLO-Β-LACTAMASES (MBL); OPTIMAL METAL STOICHIOMETRIES;

ANTIBIOTICS; BACTERIA; BIOASSAY; CATALYSIS; COMPLEXATION; ENZYME INHIBITION; IONIZATION; MASS SPECTROMETRY;

TERNARY SYSTEMS;

CARBOXYLIC ACID DERIVATIVE; ENZYME; ENZYME INHIBITOR; METAL ION; METALLO BETA LACTAMASE; ZINC;

ARTICLE; ASSAY; BINDING AFFINITY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; METAL BINDING; STOICHIOMETRY;

BACTERIAL PROTEINS; BETA-LACTAMASES; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; METALS; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; ZINC;

BACTERIA (MICROORGANISMS);

EID: 33745255068     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2006.03.010     Document Type: Article

References (20)

1. Rasmussen B.A., and Bush K. Carbapenem-hydrolyzing β-lactamases. Antimicrob. Agents Chemother. 41 (1997) 223-232
2. Felici A., Perilli M., Segatore B., Franceschini N., Setacci D., Oratore A., Stefani S., Galleni M., and Amicosante G. Interactions of biapenem with active-site serine and metallo-β-lactamases. Antimicrob. Agents Chemother. 39 (1995) 1300-1305
3. Livermore D.M., and Woodford N. Carbapenemases. A problem in waiting?. Curr. Opin. Microbiol. 3 (2000) 489-495
4. Heinz U., and Adolph H.W. Metallo-β-lactamases. Two binding sites for one catalytic metal ion?. Cell. Mol. Life. Sci. 61 (2004) 2827-2839
5. Wommer S., Rival S., Heinz U., Galleni M., Frère J.M., Franceschini N., Amicosante G., Rasmussen B., Bauer R., and Adolph H.W. Substrate-activated zinc binding of metallo-β-lactamases. J. Biol. Chem. 277 (2002) 24142-24147
6. Hernandez-Valladares M., Felici A., Weber G., Adolph H.W., Zeppezauer M., Rossolini G.M., Amicosante G., Frère J.M., and Galleni M. Zn(II) dependence of the Aeromonas hydrophila AE036 metallo-β-lactamase activity and stability. Biochemistry 36 (1997) 11534-11541
7. Mollard C., Moali C., Papamicael C., Damblon C., Vessilier S., Amicosante G., Schofield C.J., Galleni M., Frère J.M., and Roberts G.C. Thiomandelic acid, a broad spectrum inhibitor of zinc-β-lactamases. Kinetic and spectroscopic studies. J. Biol. Chem. 6 (2001) 45015-45023 27
8. Damblon C., Jensen M., Ababou A., Barsukov I., Papamicael C., Schofield C.J., Olsen L., Bauer R., and Roberts G.C. The inhibitor thiomandelic acid binds to both metal ions in metallo-β-lactamase and induces positive cooperativity in metal binding. J. Biol. Chem. 278 (2003) 29240-29251
9. Concha N.O., Janson C.A., Rowling P., Pearson S., Cheever C.A., Clarke B.P., Lewis C., Galleni M., Frère J.M., Payne D.J., Bateson J.H., and Abdel-Meguid S.S. Crystal structure of the IMP-1 metallo β-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor. Binding determinants of a potent, broad-spectrum inhibitor. Biochemistry 39 (2000) 4288-4298
10. Cheng X., Chen R., Bruce J.E., Schwartz B.L., Anderson G.A., Hofstadler S.A., Gale D.C., and Smith R.D. Using electrospray ionization FTICR mass spectrometry to study competitive binding of inhibitors to carbonic anhydrase. J. Am. Chem. Soc. 117 (1995) 8859-8860
11. Gao J., Cheng X., Chen R., Sigal G.B., Bruce J.E., Schwartz B.L., Hofstadler S.A., Anderson G.A., Smith R.D., and Whitesides G.M. Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization-mass spectrometry. J. Med. Chem. 39 (1996) 1949-1955
12. Wu Q., Gao J., Joseph-McCarthy D., Sigal G.B., Bruce J.E., Whitesides G.M., and Smith R.D. Carbonic anhydrase-inhibitor binding. From solution to the gas phase. J. Am. Chem. Soc. 119 (1997) 1157-1158
13. Feng R., Castelhano A.L., Biuedeau R., and Yuan Z. Study of noncovalent enzyme-inhibitor complexes and metal binding stoichiometry of matrilysin by electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom. 6 (1995) 1105-1111
14. Paul-Soto R., Bauer R., Frère J.M., Galleni M., Meyer-Klaucke W., Nolting H., Rossolini G.M., de Seny D., Hernandez-Valladares M., Zeppezauer M., and Adolph H.W. Mono- and binuclear Zn2+ β-lactamase. Role of the conserved cysteine in the catalytic mechanism. J. Biol. Chem. 274 (1999) 13242-13249
15. Hernandez-Valladares M., Galleni M., Frère J.M., Felici A., Perilli M., Franceschini N., Rossolini G.M., Oratore A., and Amicosante G. Overproduction and purification of the Aeromonas hydrophila CphA metallo-β-lactamase expressed in Escherichia coli. Microb. Drug Resist. 2 (1996) 253-256
16. De Seny D., Prosperi-Meys C., Bebrone C., Rossolini G.M., Page M.I., Noel P., Frère J.M., and Galleni M. Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-β-lactamase. Biochem. J. 363 (2002) 687-696
17. Toney J.H., Hammond G.G., Fitzgerald P.M.D., Sharma N., Balkove J.M., Rouen G.P., Olson S.H., Hammond M.L., Greenlee M.L., and Gao Y.-D. Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-β-lactamase. J. Biol. Chem. 276 (2001) 31913-31918
18. Carfi A., Pares S., Duee E., Galleni M., Duez C., Frère J.M., and Dideberg O. The 3-D structure of a zinc metallo-β-lactamase from Bacillus cereus reveals a new type of protein fold. EMBO J. 14 (1995) 4914-4921
19. Zhang S., Van Pelt C.K., and Wilson D.B. Quantitative determination of noncovalent binding interactions using automated nanoelectrospray mass spectrometry. Anal. Chem. 75 (2003) 3010-3018
20. Hernandez-Valladares M., Kiefer M., Heinz U., Paulo-Soto R.P., Meyer-Klaucke W., Nolting H.F., Zeppezauer M., Galleni M., Frère J.M., Rossolini G.M., Amicosante G., and Adolph H.W. Kinetic and spectroscopic characterization of native and metal-substituted β-lactamase from Aeromonas hydrophila AE036. FEBS Lett. 467 (2000) 221-225