Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging

Experimental Dermatology

Volumn 14, Issue 8, 2005, Pages 609-618

  Jensen, Jens Michael ^a   Förl, Michael ^a   Winoto Morbach, Supandi ^a   Seite, Sophie ^b   Schunk, Michael ^a   Proksch, Ehrhardt ^a   Schütze, Stefan ^a,c  

^a UNIVERSITY OF KIEL   (Germany)

^b L ORÉAL RECHERCHE   (France)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Aging; Ceramidase; Ceramide; Ceramide synthase; Sphingomyelinase

Indexed keywords

ACYLSPHINGOSINE DEACYLASE; CERAMIDE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE ACYLTRANSFERASE;

AGE DETERMINATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; CUTANEOUS PARAMETERS; ENZYME ACTIVITY; ENZYME LOCALIZATION; EPIDERMIS; HOMEOSTASIS; MOUSE; NONHUMAN; NUDE MOUSE; PERMEABILITY BARRIER; PROTEIN DETERMINATION; PROTEIN FUNCTION;

EID: 22744447509     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0906-6705.2005.00342.x     Document Type: Article

References (74)

1. Denda M, Koyama J, Hori J et al. Age- and sex-dependent change in stratum corneum sphingolipids. Arch Dermatol Res 1993: 285: 415-417.
2. Rogers J, Harding C, Mayo A, Banks J, Rawlings A. Stratum corneum lipids: the effect of aging and the seasons. Arch Dermatol Res 1996: 288: 765-770.
3. Ghadially R, Brown B E, Sequeira-Martin S M, Feingold K R, Elias P M. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 1995: 95: 2281-2290.
4. Ghadially R, Brown B E, Hanley K, Reed J T, Feingold K R, Elias P M. Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice. J Invest Dermatol 1996: 106: 1064-1069.
5. Holleran W M, Feingold K R, Man M Q, Gao W N, Lee J M, Elias P M. Regulation of epidermal sphingolipid synthesis by permeability barrier function. J Lipid Res 1991: 32: 1151-1158.
6. Uchida Y, Nardo A D, Collins V, Elias P M, Holleran W M. De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes. J Invest Dermatol 2003: 120: 662-669.
7. Holleran W M, Takagi Y, Menon G K, Legler G, Feingold K R, Elias P M. Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. J Clin Invest 1993: 91: 1656-1664.
8. Holleran W M, Ginns E I, Menon G K et al. Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest 1994: 93: 1756-1764.
9. Holleran W M, Takagi Y, Menon G K et al. Permeability barrier requirements regulate epidermal beta-glucocerebrosidase. J Lipid Res 1994: 35: 905-912.
10. Jensen J M, Schütze S, Förl M, Krönke M, Proksch E. Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest 1999: 104: 1761-1770.
11. Schmuth M, Man M Q, Weber F et al. Permeability barrier in Niemann-Pick disease: sphingomyelin-to-ceramide processing required for normal barrier homeostasis. J Invest Dermatol 2000: 115: 459-466.
12. Wertz P W, Downing D T. Ceramidase activity in porcine epidermis. FEBS Lett 1990: 268: 110-112.
13. Yada Y, Higuchi K, Imokawa G. Purification and biochemical characterization of membrane-bound epidermal ceramidases from guinea pig skin. J Biol Chem 1995: 270: 12677-12684.
14. Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G. High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest Dermatol 2000: 115: 406-413.
15. Heller R A, Krönke M. Tumor necrosis factor receptor-mediated signaling pathways. J Cell Biol 1994: 126: 5-9.
16. Kolesnick R N, Krönke M. Regulation of ceramide production and apoptosis. Annu Rev Physiol 1998: 60: 643-665.
17. Perry D K, Hannun Y A. The role of ceramide in cell signaling. Biochim Biophys Acta 1998: 1436: 233-243.
18. Heinrich M, Wickel M, Schneider-Brachert W et al. Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J 1999: 18: 5252-5263.
19. Egberts F, Heinrich M, Jensen J M et al. Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. J Cell Sci 2004: 117: 2295-2307.
20. Cifone M G, Roncatoli P, De Maria R et al. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J 1995: 14: 5859-5868.
21. Santana P, Pena L A, Haimovitz-Friedman A et al. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 1996: 86: 189-199.
22. De Maria R, Testi R. Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity. Immunol Today 1998: 19: 121-125.
23. Kirschnek S, Paris F, Weller M et al. CD95-mediated apoptosis in vivo requires acid sphingomyelinase. J Biol Chem 2000: 275: 27316-27323.
24. Lin T, Genistier L, Pinkoski M J et al. Role of acidic sphingomyelinase in Fas/CD95-mediated cell death. J Biol Chem 2000: 275: 8657-8663.
25. Lozano J, Menendez S, Morales A et al. Cell autonomous defects in acid sphingomyelinase knockout fibroblasts. J Biol Chem 2001: 276: 442-448.
26. Garcia-Ruiz C, Colell A, Mari M et al. Defective TNF-alpha-mediated hepatocellular apotosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest 2003: 111: 197-208.
27. Sikora J, Pavlu-Pereira H, Elleder M, Roelofs H, Wevers R A. Seven novel acid sphingomyelinase gene mutations in Niemann-Pick type A and B patients. Ann Hum Genet 2003: 67: 63-70.
28. Yamamura T, Tezuka T. Change in sphingomyelinase activity in human epidermis during aging. J Dermatol Sci 1990: 1: 79-83.
29. Venable M E, Lee J Y, Smyth M, Bielawska A, Obeid L M. Role of ceramide in cellular senescence. J Biol Chem 1995: 270: 30701-30708.
30. Venable M E, Obeid L M. Phospholipase D in cellular senescence. Biochim Biophys Acta 1999: 1439: 291-298.
31. Lecka-Czernik B, Moerman E J, Jones R A, Goldstein S. Identification of gene sequences overexpressed in senescent and Werner syndrome human fibroblasts. Exp Gerontol 1996: 31: 159-174.
32. Lightle S A, Oakley J I, Nikolova-Karakashian M N. Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging. Mech Ageing Dev 2000: 120: 111-125.
33. Ghadially R. Aging and the epidermal permeability barrier: implications for contact dermatitis. Am J Contact Dermat 1998: 9: 162-169.
34. Engelke M, Jensen J M, Ekanayake-Mudiyanselage S, Proksch E. Effects of xerosis and aging on epidermal proliferation and differentiation. Br J Dermatol 1997: 137: 219-225.
35. Harvell J D, Maibach H I. Percutaneous absorption and inflammation in aged skin: a review. J Am Acad Dermatol 1994: 31: 1015-1021.
36. Akimoto K, Yoshikawa N, Higaki Y, Kawashima M, Imokawa G. Quantitative analysis of stratum corneum lipids in xerosis and asteatotic eczema. J Dermatol 1993: 20: 1-6.
37. Jensen J M, Fölster-Holst R, Baranowsky A et al. Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J Invest Dermatol 2004: 122: 1423-1431.
38. Gray G M, King I A, Yardley H J. The plasma membrane of granular cells from pig epidermis: isolation and lipid and protein composition. J Invest Dermatol 1980: 71: 131-135.
39. Freinkel R K, Traczyk T N. Lipid composition and acid hydrolase content of lamellar granules of fetal rat epidermis. J Invest Dermatol 1985: 85: 295-298.
40. Grayson S, Johnson-Winegar A G, Wintroub B U, Isseroff R R, Epstein E H Jr, Elias P M. Lamellar body-enriched fractions from neonatal mice: preparative techniques and partial characterization. J Invest Dermatol 1985: 85: 289-294.
41. Bowser P A, Gray P M. Sphingomyelinase in pig and human epidermis. J Invest Dermatol 1978: 70: 331-335.
42. Freinkel R K, Traczyk T N. Acid hydrolases of the epidermis: subcellular localization and relationship to cornification. J Invest Dermatol 1983: 80: 441-446.
43. Menon G K, Grayson S, Elias P M. Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis. J Invest Dermatol 1986: 86: 591-597.
44. Kusuda S, Chang-Yi C, Takahashi M, Tezuka T. Localization of sphingomyelinase in lesional skin of atopic dermatitis patients. J Invest Dermatol 1998: 111: 733-738.
45. Robson K J, Stewart M E, Michelsen S, Lazo N D, Downing D T. 6-Hydroxy-4-sphingenine in human epidermal ceramides. J Lipid Res 1994: 35: 2060-2068.
46. Ponec M, Weerheim A, Lankhorst P, Wertz P. New acylceramide in native and reconstructed epidermis. J Invest Dermatol 2003: 120: 581-588.
47. Madison K C. Barrier function of the skin: 'la raison d'etre' of the epidermis. J Invest Dermatol 2003: 121: 231-241.
48. Elias P M, Menon G K. Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 1991: 24: 1-26.
49. Wertz P W, Miethke MC, Long S A, Strauss J S, Downing D T. The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol 1985: 84: 410-412.
50. Stewart M E, Downing D T. A new 6-hydroxy-4-sphingenine-containing ceramide in human skin. J Lipid Res 1999: 40: 1434-1439.
51. Uchida Y, Hara M, Nishio H et al. Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res 2000: 41: 2071-2082.
52. Vicanova J, Boyce S T, Harriger M D, Weerheim A M, Bouwstra J A, Ponec M. Stratum corneum lipid composition and structure in cultured skin substitutes is restored to normal after grafting onto athymic mice. J Investig Dermatol Symp Proc 1998: 3: 114-120.
53. Adam-Klages S, Adam A, Wiegmann K et al. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell 1996: 86: 937-947.
54. Kreder D, Krut O, Adam-Klages S et al. Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice. EMBO J 1999: 18: 2472-2479.
55. Elias P M, Fritsch P, Tappeiner G, Mittermayer H, Wolff K. Experimental staphylococcal toxic epidermal necrolysis (TEN) in adult humans and mice. J Lab Clin Med 1974: 84: 414-424.
56. Proksch E, Elias P M, Feingold K R. Localization and regulation of epidermal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by barrier requirements. Biochim Biophys Acta 1991: 1083: 71-79.
57. Liao W C, Haimovitz-Friedman A, Persaud R S et al. Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. J Biol Chem 1999: 274: 17908-17917.
58. Herget T, Esdar C, Oehrlein S A et al. Production of ceramides causes apoptosis during early neural differentiation in vitro. J Biol Chem 2000: 275: 30344-30354.
59. Strelow A, Bernardo K, Adam-Klages S et al. Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. J Exp Med 2000: 192: 601-612.
60. Smith P K, Krohn R I, Hermanson G T et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985: 150: 76-85.
61. Hinkovska-Galcheva V, Boxer L, Mansfield P J, Schreiber A D, Shayman J A. Enhanced phagocytosis through inhibition of de novo ceramide synthesis. J Biol Chem 2003: 278: 974-982.
62. Gilhar A, Ullmann Y, Karry R et al. Aging of human epidermis: reversal of aging changes correlates with reversal of keratinocyte fas expression and apoptosis. J Gerontol A Biol Sci Med Sci 2004: 59: 411-415.
63. Gilchrest B A. A review of skin ageing its medical therapy. Br J Dermatol 1996: 135: 867-875.
64. Gause-Nilsson I, Dey D K. Percent body fat estimation from skin fold thickness in the elderly. J Nutr Health Aging 2005: 9: 19-24.
65. Ohkawa S, Odamaki M, Ikegaya N, Hibi I, Miyaji K, Kumagai H. Association of age with muscle mass, fat mass and fat distribution in non-diabetic haemodialysis patients. Nephrol Dial Transplant 2005: 20: 945-951.
66. Di Marzio L, Cinque B, De Simone C, Cifone M G. Effect of the lactic acid bacterium Streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo. J Invest Dermatol 1999: 113: 98-106.
67. Wilhelm K P, Cua A B, Maibach H I. Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content. Arch Dermatol 1991: 127: 1806-1809.
68. Berardesca E, Maibach H I. Transepidermal water loss and skin surface hydration in the non invasive assessment of stratum corneum function. Derm Beruf Umwelt 1990: 38: 50-53.
69. Rodrigues L M, Pinto P C, Magro J M, Fernandes M, Alves J. Exploring the influence of skin perfusion on transepidermal water loss. Skin Res Technol 2004: 10: 257-262.
70. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 1991: 96: 523-526.
71. Branchet MC, Boisnic S, Frances C, Robert A M. Skin thickness changes in normal aging skin. Gerontology 1990: 36: 28-35.
72. Jin K, Higaki Y, Takagi Y et al. Analysis of beta-glucocerebrosidase and ceramidase activities in atopic and aged dry skin. Acta Derm Venereol 1994: 74: 337-340.
73. Ohnishi Y, Okino N, Ito M, Imayama S. Ceramidase activity in bacterial skin flora as a possible cause of ceramide deficiency in atopic dermatitis. Clin Diagn Lab Immunol 1990: 6: 101-104.
74. Murata Y, Ogata J, Higaki Y et al. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? J Invest Dermatol 1996: 106: 1242-1249.