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Volumn 10, Issue 3, 2008, Pages 143-151

HIV coreceptor phenotyping in the clinical setting

Author keywords

Coreceptor; HIV; Phenotype; Trofile; Tropism

Indexed keywords

ANTIRETROVIRUS AGENT; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; VIRUS RECEPTOR;

EID: 55049107630     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (31)

References (121)
  • 1
    • 0025866185 scopus 로고
    • Conformational changes induced in the HIV envelope glycoprotein by soluble CD4 binding
    • Sattentau Q. Moore J. Conformational changes induced in the HIV envelope glycoprotein by soluble CD4 binding. J Exp Med. 1991; 174:407-15.
    • (1991) J Exp Med , vol.174 , pp. 407-415
    • Sattentau, Q.1    Moore, J.2
  • 2
    • 0025304589 scopus 로고
    • HIV envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells
    • Ashorn P, Berger E, Moss B. HIV envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells. J Virol. 1990;64: 2149-56.
    • (1990) J Virol , vol.64 , pp. 2149-2156
    • Ashorn, P.1    Berger, E.2    Moss, B.3
  • 4
    • 0027283312 scopus 로고
    • The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s)
    • Broder C, Dimitrov D, Blumenthal R, Berger E. The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s). Virology. 1993;193:483-91.
    • (1993) Virology , vol.193 , pp. 483-491
    • Broder, C.1    Dimitrov, D.2    Blumenthal, R.3    Berger, E.4
  • 5
    • 0025021452 scopus 로고
    • Failure of HIV entry and infection in CD4-positive human brain and skin cells
    • Chesebro B, Buller R, Portis J, Wehrly K. Failure of HIV entry and infection in CD4-positive human brain and skin cells, J Virol. 1990; 64:215-21.
    • (1990) J Virol , vol.64 , pp. 215-221
    • Chesebro, B.1    Buller, R.2    Portis, J.3    Wehrly, K.4
  • 6
    • 0025731030 scopus 로고
    • Specific cell surface requirements for the infection of CD4-positive cells by HIV types 1 and 2 and by SIV
    • Clapham P, Blanc D, Weiss R, Specific cell surface requirements for the infection of CD4-positive cells by HIV types 1 and 2 and by SIV. Virology. 1991;181:703-15.
    • (1991) Virology , vol.181 , pp. 703-715
    • Clapham, P.1    Blanc, D.2    Weiss, R.3
  • 7
    • 0026654559 scopus 로고
    • Complementation of murine cells for HIV envelope/CD4-mediated fusion in human/murine heterokaryons
    • Dragic T, Charneau P, Clavel F, Alizon M. Complementation of murine cells for HIV envelope/CD4-mediated fusion in human/murine heterokaryons. J Virol. 1992;66:4794-802.
    • (1992) J Virol , vol.66 , pp. 4794-4802
    • Dragic, T.1    Charneau, P.2    Clavel, F.3    Alizon, M.4
  • 8
    • 0028885228 scopus 로고
    • Proteinase-resistant factors in human erythrocyte membranes mediate CD4-dependent fusion with cells expressing HIV-1 envelope glycoproteins
    • Dragic T, Picard L, Alizon M. Proteinase-resistant factors in human erythrocyte membranes mediate CD4-dependent fusion with cells expressing HIV-1 envelope glycoproteins. J Virol. 1995; 69:1013-18.
    • (1995) J Virol , vol.69 , pp. 1013-1018
    • Dragic, T.1    Picard, L.2    Alizon, M.3
  • 9
    • 0027321495 scopus 로고
    • Cofactor requirement for HIV-1 entry into a CD4-expressing human cell line
    • Harrington R, Geballe A. Cofactor requirement for HIV-1 entry into a CD4-expressing human cell line. J Virol. 1993;67:5939-47,
    • (1993) J Virol , vol.67 , pp. 5939-5947
    • Harrington, R.1    Geballe, A.2
  • 11
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng Y, Broder C, Kennedy P, Berger E. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 1996:272:872-7.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.2    Kennedy, P.3    Berger, E.4
  • 12
    • 0029775576 scopus 로고    scopus 로고
    • The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    • Bleul C. Farzan M, Choe H, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature, 1996; 382:829-33.
    • (1996) Nature , vol.382 , pp. 829-833
    • Bleul, C.1    Farzan, M.2    Choe, H.3
  • 13
    • 16044370087 scopus 로고    scopus 로고
    • The CXC chemolkine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
    • Oberlin E, Amara A. Bachelerie F, et al. The CXC chemolkine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature, 1996;382:833-5.
    • (1996) Nature , vol.382 , pp. 833-835
    • Oberlin, E.1    Amara, A.2    Bachelerie, F.3
  • 14
    • 0026442236 scopus 로고
    • An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of HIV-1
    • Collman R, Balliet J, Gregory S, et al, An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of HIV-1. J Virol. 1992;66:7517-21.
    • (1992) J Virol , vol.66 , pp. 7517-7521
    • Collman, R.1    Balliet, J.2    Gregory, S.3
  • 15
    • 0031954686 scopus 로고    scopus 로고
    • Effects of CCR5 and CD4 cell surface concentrations on infections by macrophage tropic isolates of HIV-1
    • Platt E, Wehrly K, Kuhmann SE, Chesebro B, Kabat D. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophage tropic isolates of HIV-1. J Virol. 1998;72:2855-64.
    • (1998) J Virol , vol.72 , pp. 2855-2864
    • Platt, E.1    Wehrly, K.2    Kuhmann, S.E.3    Chesebro, B.4    Kabat, D.5
  • 16
    • 0033609149 scopus 로고    scopus 로고
    • Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
    • Lee B, Sharron M, Montaner L, Weissman D, Doms R. Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc Natl Acad Sci USA. 1999;96:5215-20.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5215-5220
    • Lee, B.1    Sharron, M.2    Montaner, L.3    Weissman, D.4    Doms, R.5
  • 17
    • 0023896246 scopus 로고
    • Differential syncytium-inducing capacity of HIV isolates: Frequent detection of syncytium-inducing isolates in patients with AIDS and AIDS-related complex
    • Tersmette M, de Goede R, Al B, et al. Differential syncytium-inducing capacity of HIV isolates: Frequent detection of syncytium-inducing isolates in patients with AIDS and AIDS-related complex. J Virol. 1988;62:2026-32.
    • (1988) J Virol , vol.62 , pp. 2026-2032
    • Tersmette, M.1    de Goede, R.2    Al, B.3
  • 18
    • 0024536114 scopus 로고
    • Evidence for a role of virulent HIV variants in the pathogenesis of AIDS: Studies on sequential HIV isolates
    • Tersmette M. Gruters R, de Wolf F, et al. Evidence for a role of virulent HIV variants in the pathogenesis of AIDS: Studies on sequential HIV isolates. J Virol. 1989;63:2118-25.
    • (1989) J Virol , vol.63 , pp. 2118-2125
    • Tersmette, M.1    Gruters, R.2    de Wolf, F.3
  • 19
    • 0026070668 scopus 로고
    • Monocytotropic HIV-1 variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture
    • Schuitemaker H. Kootstra N, de Goede R, de Wolf F, Miedema F, Tersmette M. Monocytotropic HIV-1 variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. J Virol. 1991;65:356-63.
    • (1991) J Virol , vol.65 , pp. 356-363
    • Schuitemaker, H.1    Kootstra, N.2    de Goede, R.3    de Wolf, F.4    Miedema, F.5    Tersmette, M.6
  • 20
    • 0026533899 scopus 로고
    • HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 co-cultivation assay
    • Koot M, Vos A, Keet R, et al. HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 co-cultivation assay. AIDS. 1992;6:49-54.
    • (1992) AIDS , vol.6 , pp. 49-54
    • Koot, M.1    Vos, A.2    Keet, R.3
  • 21
    • 0026475031 scopus 로고
    • HIV-1 biological phenotype and the development of zidovudine resistance in relation to disease progression in asymptomatic individuals during treatment
    • Boucher C, Lange J, Miedema F. et al. HIV-1 biological phenotype and the development of zidovudine resistance in relation to disease progression in asymptomatic individuals during treatment. AIDS. 1992; 6:1259-64.
    • (1992) AIDS , vol.6 , pp. 1259-1264
    • Boucher, C.1    Lange, J.2    Miedema, F.3
  • 22
    • 0027955291 scopus 로고
    • MT-2 cell tropism as prognostic marker for disease progression in HIV-1 infection
    • Karlsson A, Parsmyr K, Sandstrom E, Fenyo E, Albert J, MT-2 cell tropism as prognostic marker for disease progression in HIV-1 infection. J Clin Microbiol. 1994;32:364-70.
    • (1994) J Clin Microbiol , vol.32 , pp. 364-370
    • Karlsson, A.1    Parsmyr, K.2    Sandstrom, E.3    Fenyo, E.4    Albert, J.5
  • 23
    • 0023989956 scopus 로고
    • Biologic features of HIV-1 that correlate with virulence in the host
    • Cheng-Mayer C. Seto D, Tateno M, Levy JA. Biologic features of HIV-1 that correlate with virulence in the host. Science. 1988; 240(4848):80-82
    • (1988) Science , vol.240 , Issue.4848 , pp. 80-82
    • Cheng-Mayer, C.1    Seto, D.2    Tateno, M.3    Levy, J.A.4
  • 24
    • 0025652444 scopus 로고
    • Interactions between HIV and the host immune system in the pathogenesis of AIDS
    • Tersmette M, Miedema F. Interactions between HIV and the host immune system in the pathogenesis of AIDS. AIDS. 1990;4(Suppl 1):S57-66.
    • (1990) AIDS , vol.4 , Issue.SUPPL. 1
    • Tersmette, M.1    Miedema, F.2
  • 25
    • 0028027078 scopus 로고
    • The impact of the syncytium-inducing phenotype of HIV on disease progression
    • Richman D, Bozzette S. The impact of the syncytium-inducing phenotype of HIV on disease progression. J Infect Dis. 1994;169:968-74.
    • (1994) J Infect Dis , vol.169 , pp. 968-974
    • Richman, D.1    Bozzette, S.2
  • 26
    • 0033934948 scopus 로고    scopus 로고
    • Strong association between failure of T-cell homeostasis and the syncytium-inducing phenotype among HIV-1-infected men in the Amsterdam cohort study
    • Maas J, Gange S, Schuitemaker H, Coutinho R, van Leeuwen R, Margolick J. Strong association between failure of T-cell homeostasis and the syncytium-inducing phenotype among HIV-1-infected men in the Amsterdam cohort study. AIDS. 2000;14:1155-61.
    • (2000) AIDS , vol.14 , pp. 1155-1161
    • Maas, J.1    Gange, S.2    Schuitemaker, H.3    Coutinho, R.4    van Leeuwen, R.5    Margolick, J.6
  • 27
    • 0027537480 scopus 로고
    • Prognostic value of HIV-1 syncoum-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS
    • Koot M, Keet I. Vos A. et al. Prognostic value of HIV-1 syncoum-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med. 1993;118:681-8.
    • (1993) Ann Intern Med , vol.118 , pp. 681-688
    • Koot, M.1    Keet, I.2    Vos, A.3
  • 28
    • 0026600926 scopus 로고
    • Biological phenotype of HIV-1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
    • Schuitemaker H, Koot M, Kootstra N, et al. Biological phenotype of HIV-1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J Virol. 1992;66:1354-60.
    • (1992) J Virol , vol.66 , pp. 1354-1360
    • Schuitemaker, H.1    Koot, M.2    Kootstra, N.3
  • 29
    • 16444381128 scopus 로고    scopus 로고
    • Short communication: HIV type 1 phenotype, tropism, and sequence patterns: Association and preference
    • Dong X, Chen X, Chen Y, et al. Short communication: HIV type 1 phenotype, tropism, and sequence patterns: Association and preference. AIDS Res Hum Retrovinuses. 2005;21:234-8.
    • (2005) AIDS Res Hum Retrovinuses , vol.21 , pp. 234-238
    • Dong, X.1    Chen, X.2    Chen, Y.3
  • 30
    • 0031794425 scopus 로고    scopus 로고
    • CCR5- and CXCR4-utilizing strains of HIV-1 exhibit differential tropism and pathogenesis in vivo
    • Berkowitz R, Alexander S, Bare C, et al. CCR5- and CXCR4-utilizing strains of HIV-1 exhibit differential tropism and pathogenesis in vivo. J Virol. 1998;72:10108-17.
    • (1998) J Virol , vol.72 , pp. 10108-10117
    • Berkowitz, R.1    Alexander, S.2    Bare, C.3
  • 31
    • 0031936306 scopus 로고    scopus 로고
    • Neutralization sensitivity of HIV-1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage
    • Trkola A. Ketas T. Kewalramani V, et al. Neutralization sensitivity of HIV-1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage. J Virol. 1998;72:1876-85.
    • (1998) J Virol , vol.72 , pp. 1876-1885
    • Trkola, A.1    Ketas, T.2    Kewalramani, V.3
  • 33
    • 33846623260 scopus 로고    scopus 로고
    • Development and characterization of a novel single-cycle recombinant-virus assay to determine HIV-1 coreceptor tropism
    • Whitcomb J, Huang W, Fransen S. et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine HIV-1 coreceptor tropism. Antimicrob Agents Chemother. 2007;51:566-75.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 566-575
    • Whitcomb, J.1    Huang, W.2    Fransen, S.3
  • 34
    • 0034749279 scopus 로고    scopus 로고
    • Determination of coreceptor usage of HIV-1 from patient plasma samples by using a recombinant phenotypic assay
    • Trouplin V, Salvatori F, Cappello F, et al. Determination of coreceptor usage of HIV-1 from patient plasma samples by using a recombinant phenotypic assay. J Virol. 2001;75:251-9.
    • (2001) J Virol , vol.75 , pp. 251-259
    • Trouplin, V.1    Salvatori, F.2    Cappello, F.3
  • 35
    • 55049118433 scopus 로고    scopus 로고
    • Gonzalez N, Perez-Olmeda M, Garcia-Perez J, et al. Evaluation of HIV-1 tropism using a new and sensitive system based on recombinant viruses. Antiviral Therapy. 2008; 13(Suppl 3):Al 19 [abstract].
    • Gonzalez N, Perez-Olmeda M, Garcia-Perez J, et al. Evaluation of HIV-1 tropism using a new and sensitive system based on recombinant viruses. Antiviral Therapy. 2008; 13(Suppl 3):Al 19 [abstract].
  • 36
    • 55049109820 scopus 로고    scopus 로고
    • Direct sequencing of V3 could be a valuable alternative to phenotypic assays for the routine assessment of HIV-1 tropism
    • abstract
    • Raymond S, Delobel P. Mavignier M, et al. Direct sequencing of V3 could be a valuable alternative to phenotypic assays for the routine assessment of HIV-1 tropism. Antiviral Therapy. 2008;13(Suppl 3):A114 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Raymond, S.1    Delobel, P.2    Mavignier, M.3
  • 37
    • 0032789087 scopus 로고    scopus 로고
    • Characterization of V3 sequence heterogeneity in subtype C HIV-1 isolates from Malawi: Underrepresentation of X4 variants
    • Ping L, Nelson J, Hoffman I, et al. Characterization of V3 sequence heterogeneity in subtype C HIV-1 isolates from Malawi: Underrepresentation of X4 variants. J Virol. 1999;73:6271-81.
    • (1999) J Virol , vol.73 , pp. 6271-6281
    • Ping, L.1    Nelson, J.2    Hoffman, I.3
  • 38
    • 34547128097 scopus 로고    scopus 로고
    • Coreceptor tropism in HIV-1 subtype D: High prevalence of CXCR4 tropism and heterogeneous composition of viral populations
    • Huang W, Eshleman S, Toma J, et al. Coreceptor tropism in HIV-1 subtype D: high prevalence of CXCR4 tropism and heterogeneous composition of viral populations. J Virol. 2007;81:7885-93.
    • (2007) J Virol , vol.81 , pp. 7885-7893
    • Huang, W.1    Eshleman, S.2    Toma, J.3
  • 39
    • 33846623260 scopus 로고    scopus 로고
    • Development and characterization of a novel single-cycle recombinant-virus assay to determine HIV-type 1 coreceptor tropism
    • Whitcomb J, Huang W, Fransen S, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine HIV-type 1 coreceptor tropism. Antimicrob Agents Chernother. 2007; 51:566-75.
    • (2007) Antimicrob Agents Chernother , vol.51 , pp. 566-575
    • Whitcomb, J.1    Huang, W.2    Fransen, S.3
  • 41
    • 55049137682 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/ 3 Study in the USA and Canada
    • Lalezari J, Goodrich J, DeJesus E, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/ 3 Study in the USA and Canada. 14th CROI, Los Angeles, California, USA, February 2007;104bLB [abstract].
    • 14th CROI, Los Angeles, California, USA, February 2007;104bLB [abstract]
    • Lalezari, J.1    Goodrich, J.2    DeJesus, E.3
  • 42
    • 33749839996 scopus 로고    scopus 로고
    • Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experiences subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial
    • Mayer H, Van der Ryst E, Saag M, et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experiences subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial. XVI International AIDS Conference, Toronto, Canada, August 2006;THLB0215 [abstract].
    • XVI International AIDS Conference, Toronto, Canada, August 2006;THLB0215 [abstract]
    • Mayer, H.1    Van der Ryst, E.2    Saag, M.3
  • 43
    • 55049138615 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia, and North America: 24-week results
    • Nelson M, Fäatkenheuer G, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia, and North America: 24-week results. 14th CROI, Los Angeles, USA, February 2007;104aLB [abstract].
    • 14th CROI, Los Angeles, USA, February 2007;104aLB [abstract]
    • Nelson, M.1    Fäatkenheuer, G.2    Konourina, I.3
  • 44
    • 33847053906 scopus 로고    scopus 로고
    • Determining HIV coreceptor use in a clinical setting: Degree of correlation between two phenotypic assays and a boinformatic model
    • Skrabal K. Low A, Dong W, et al. Determining HIV coreceptor use in a clinical setting: Degree of correlation between two phenotypic assays and a boinformatic model. J Clin Microbiol. 2007;45:279-84.
    • (2007) J Clin Microbiol , vol.45 , pp. 279-284
    • Skrabal, K.1    Low, A.2    Dong, W.3
  • 45
    • 55049089635 scopus 로고    scopus 로고
    • Enhancements to the Trofile HIV Coreceptor Tropism Assay enable reliable detection of CXCR4-using subpopulations at less than 1%
    • Reeves J. Han D, Liu Y. et al. Enhancements to the Trofile HIV Coreceptor Tropism Assay enable reliable detection of CXCR4-using subpopulations at less than 1%, 47th ICAAC. Chicago, USA, September 2007;H-1026 [abstract].
    • 47th ICAAC. Chicago, USA, September 2007;H-1026 [abstract]
    • Reeves, J.1    Han, D.2    Liu, Y.3
  • 46
    • 55049106689 scopus 로고    scopus 로고
    • Technical validation of an enhanced sensitivity Trofile HIV coreceptor tropism assay for selecting patients for therapy with entry inhibitors targeting CCR5
    • abstract
    • Trinh L, Han D, Huang W, et al, Technical validation of an enhanced sensitivity Trofile HIV coreceptor tropism assay for selecting patients for therapy with entry inhibitors targeting CCR5. Antiviral Therapy. 2008;13(Suppl 3):A128 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Trinh, L.1    Han, D.2    Huang, W.3
  • 47
    • 55049102344 scopus 로고    scopus 로고
    • Response to vicriviroc in HIV-infected, treatment experienced individuals using an enhanced version of the Trofile HIV coreceptor tropism assay [Trofile (ES)]: Reanalysis of ACTG 5211 results
    • abstract
    • Su Z, Reeves J, Krambrink A, et al. Response to vicriviroc in HIV-infected, treatment experienced individuals using an enhanced version of the Trofile HIV coreceptor tropism assay [Trofile (ES)]: reanalysis of ACTG 5211 results. Antiviral Therapy. 2008;13(Suppl 3):A98 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Su, Z.1    Reeves, J.2    Krambrink, A.3
  • 48
    • 0025004459 scopus 로고
    • Viral determinants of HIV-1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation
    • Cheng-Mayer C, Quiroga M. Tung J, Dina D, Levy J. Viral determinants of HIV-1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation. J Virol. 1990;64:4390-8.
    • (1990) J Virol , vol.64 , pp. 4390-4398
    • Cheng-Mayer, C.1    Quiroga, M.2    Tung, J.3    Dina, D.4    Levy, J.5
  • 49
    • 0026501677 scopus 로고
    • HIV-1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity
    • de Jong J, Goudsmit J, Keulen W, et al. HIV-1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity. J Virol. 1992;66:757-65.
    • (1992) J Virol , vol.66 , pp. 757-765
    • de Jong, J.1    Goudsmit, J.2    Keulen, W.3
  • 50
    • 0025065099 scopus 로고
    • HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain
    • O'Brien W, Koyanagi Y, Namazie A. et al. HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain. Nature. 1990;348:69-73.
    • (1990) Nature , vol.348 , pp. 69-73
    • O'Brien, W.1    Koyanagi, Y.2    Namazie, A.3
  • 51
    • 0026089184 scopus 로고
    • Macrophage and T cell-line tropisms of HIV-1 are determined byspecific regionsofthe envelope gp120 gene
    • Shioda T, Levy J, Cheng-Mayer C. Macrophage and T cell-line tropisms of HIV-1 are determined byspecific regionsofthe envelope gp120 gene. Nature, 1991;349:167-9.
    • (1991) Nature , vol.349 , pp. 167-169
    • Shioda, T.1    Levy, J.2    Cheng-Mayer, C.3
  • 52
    • 0026591753 scopus 로고
    • Macrophage tropism determinants of HIV-1 in vivo
    • Westervelt P, Trowbridge D, Epstein L, et al. Macrophage tropism determinants of HIV-1 in vivo. J Virol, 1992;66:2577-82.
    • (1992) J Virol , vol.66 , pp. 2577-2582
    • Westervelt, P.1    Trowbridge, D.2    Epstein, L.3
  • 53
    • 0028057280 scopus 로고
    • Persistence of multiple maternal genotypes of HIV-1 in infants infected by vertical transmission
    • Lamers S, Sleasman J, She J, et al. Persistence of multiple maternal genotypes of HIV-1 in infants infected by vertical transmission. J Clin Invest. 1994;93:380-90.
    • (1994) J Clin Invest , vol.93 , pp. 380-390
    • Lamers, S.1    Sleasman, J.2    She, J.3
  • 54
    • 0026702003 scopus 로고
    • Minimal requirements for the HIV-1 V3 domain to support the syncytium-inducing phenotype: Analysis by single amino acid substitution
    • De Jong J, De Ronde A, Keulen W, Tersmette M, Goudsmit J. Minimal requirements for the HIV-1 V3 domain to support the syncytium-inducing phenotype: Analysis by single amino acid substitution. J Virol. 1992;66:6777-80.
    • (1992) J Virol , vol.66 , pp. 6777-6780
    • De Jong, J.1    De Ronde, A.2    Keulen, W.3    Tersmette, M.4    Goudsmit, J.5
  • 55
    • 0025961011 scopus 로고
    • Identification of the principal neutralizing determinant of HIV-1 as a fusion domain
    • Freed E, Myers D, Risser R. Identification of the principal neutralizing determinant of HIV-1 as a fusion domain. J Virol. 1991; 65:190-4.
    • (1991) J Virol , vol.65 , pp. 190-194
    • Freed, E.1    Myers, D.2    Risser, R.3
  • 56
    • 0028877422 scopus 로고
    • Syncytium induction in primary CD4+ T-cell lines from normal donors by HIV-1 isolates with non-syncytium-inducing genotype and phenotype in MT-2 cells
    • Todd B, Kedar P, Pope J. Syncytium induction in primary CD4+ T-cell lines from normal donors by HIV-1 isolates with non-syncytium-inducing genotype and phenotype in MT-2 cells. J Virol. 1995;69:7099-105.
    • (1995) J Virol , vol.69 , pp. 7099-7105
    • Todd, B.1    Kedar, P.2    Pope, J.3
  • 57
    • 0028073184 scopus 로고
    • Exploration of antigenic variation in gp120 from clades A through F of HIV-1 by using monoclonal antibodies
    • Moore J, McCutchan F, Poon S, et al. Exploration of antigenic variation in gp120 from clades A through F of HIV-1 by using monoclonal antibodies. J Virol. 1994;68:8350-64.
    • (1994) J Virol , vol.68 , pp. 8350-8364
    • Moore, J.1    McCutchan, F.2    Poon, S.3
  • 59
    • 0038637409 scopus 로고    scopus 로고
    • Predicting HIV-1 coreceptor usage with sequence analysis
    • Jensen M, van 't Wout A. Predicting HIV-1 coreceptor usage with sequence analysis. AIDS Rev. 2003;5:104-12.
    • (2003) AIDS Rev , vol.5 , pp. 104-112
    • Jensen, M.1    van 't Wout, A.2
  • 60
    • 22544456536 scopus 로고    scopus 로고
    • Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals
    • Brumme Z, Goodrich J, Mayer H, et al. Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals. J Infect Dis. 2005;192:466-74.
    • (2005) J Infect Dis , vol.192 , pp. 466-474
    • Brumme, Z.1    Goodrich, J.2    Mayer, H.3
  • 61
    • 0035884899 scopus 로고    scopus 로고
    • Improved success of phenotype prediction of the HIV-1 from envelope variable loop 3 sequence using neural networks
    • Resch A Hoffman N, Swanstrom R. Improved success of phenotype prediction of the HIV-1 from envelope variable loop 3 sequence using neural networks. Virology. 2001;288:51-62.
    • (2001) Virology , vol.288 , pp. 51-62
    • Resch, A.1    Hoffman, N.2    Swanstrom, R.3
  • 62
    • 12144291059 scopus 로고    scopus 로고
    • Clinical and immunologic impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy
    • Brumme Z, Dong W, Yip B, et al. Clinical and immunologic impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy. AIDS. 2004;18:F1-9.
    • (2004) AIDS , vol.18
    • Brumme, Z.1    Dong, W.2    Yip, B.3
  • 63
    • 3042666256 scopus 로고    scopus 로고
    • MUSCLE: Multiple sequence alignment with high accuracy and high throughput
    • Edgar R. MUSCLE: Multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004;32:1792-7.
    • (2004) Nucleic Acids Res , vol.32 , pp. 1792-1797
    • Edgar, R.1
  • 64
    • 55049114814 scopus 로고    scopus 로고
    • Improvement of genotypic algorithms to predict HIV-1 tropism in treatment-experienced patients - correlation with Trofile results
    • abstract
    • Poveda E, Seclen E, Gonzalez M, et al. Improvement of genotypic algorithms to predict HIV-1 tropism in treatment-experienced patients - correlation with Trofile results. Antiviral Therapy, 2008;13 (Suppl 3):A109 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Poveda, E.1    Seclen, E.2    Gonzalez, M.3
  • 65
    • 0026089184 scopus 로고
    • Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene
    • Shioda T, Levy J, Cheng-Mayer C. Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene. Nature. 1991;349:167-9.
    • (1991) Nature , vol.349 , pp. 167-169
    • Shioda, T.1    Levy, J.2    Cheng-Mayer, C.3
  • 66
    • 0029987361 scopus 로고    scopus 로고
    • Mapping of independent V3 envelope determinants of HIV-1 macrophage tropism and syncytium formation in lymphocytes
    • Chesebro B, Wehrly K, Nishio J, Perryman S. Mapping of independent V3 envelope determinants of HIV-1 macrophage tropism and syncytium formation in lymphocytes. J Virol. 1996;70:9055-9.
    • (1996) J Virol , vol.70 , pp. 9055-9059
    • Chesebro, B.1    Wehrly, K.2    Nishio, J.3    Perryman, S.4
  • 67
    • 0033541941 scopus 로고    scopus 로고
    • Identification of determinants of interaction between CXCR4 and gp120 of adual-tropic HIV-1DH12 isolate
    • Lee M, Heaton J, Cho M. Identification of determinants of interaction between CXCR4 and gp120 of adual-tropic HIV-1DH12 isolate. Virology. 1999;257:290-6.
    • (1999) Virology , vol.257 , pp. 290-296
    • Lee, M.1    Heaton, J.2    Cho, M.3
  • 68
    • 0031978550 scopus 로고    scopus 로고
    • Determinants of entry cofactor utilization and tropism in a dual-tropic HIV-1 primary isolate
    • Smyth R, Yi Y, Singh A, Collman R. Determinants of entry cofactor utilization and tropism in a dual-tropic HIV-1 primary isolate. J Virol. 1998;72:4478-84.
    • (1998) J Virol , vol.72 , pp. 4478-4484
    • Smyth, R.1    Yi, Y.2    Singh, A.3    Collman, R.4
  • 69
    • 0035000767 scopus 로고    scopus 로고
    • Cooperation of the V1/V2 and V3 domains of HIV-1 gp120 for interaction with the CXCR4 receptor
    • Labrosse B, Treboute C, Brelot A. Alizon M. Cooperation of the V1/V2 and V3 domains of HIV-1 gp120 for interaction with the CXCR4 receptor. J Virol. 2001;75:5457-64.
    • (2001) J Virol , vol.75 , pp. 5457-5464
    • Labrosse, B.1    Treboute, C.2    Brelot, A.3    Alizon, M.4
  • 70
    • 0034523325 scopus 로고    scopus 로고
    • Envelope V3 amino acid sequence predicts HIV-1 phenotype (coreceptor usage and tropism for macrophages)
    • Briggs D, Tuttle D, Sleasman J, Goodenow M. Envelope V3 amino acid sequence predicts HIV-1 phenotype (coreceptor usage and tropism for macrophages). AIDS. 2000;14:2937-9.
    • (2000) AIDS , vol.14 , pp. 2937-2939
    • Briggs, D.1    Tuttle, D.2    Sleasman, J.3    Goodenow, M.4
  • 71
    • 10744231634 scopus 로고    scopus 로고
    • Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of HIV-1 env V3 loop sequences
    • Jensen M, Li F, van 't Wout A, et al. Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of HIV-1 env V3 loop sequences. J Virol, 2003;77:13376-88.
    • (2003) J Virol , vol.77 , pp. 13376-13388
    • Jensen, M.1    Li, F.2    van 't Wout, A.3
  • 73
    • 55049135265 scopus 로고    scopus 로고
    • Immunologic and virologic parameters improve genotypic prediction of HIV-1 coreceptor usage
    • Bethesda, USA, December, abstract 30
    • Sing T, Lengauer T, Beerenwinkel N, et al. Immunologic and virologic parameters improve genotypic prediction of HIV-1 coreceptor usage. 1st Int. Workshop on Targeting HIV Entry, Bethesda, USA, December, 2000 [abstract 30].
    • (2000) 1st Int. Workshop on Targeting HIV Entry
    • Sing, T.1    Lengauer, T.2    Beerenwinkel, N.3
  • 74
    • 55049125807 scopus 로고    scopus 로고
    • Improved detection of X4 virus by V3 genotyping: Application to plasma RNA and proviral DNA
    • abstract
    • Moores A, Thielen A, Dong W, et al. Improved detection of X4 virus by V3 genotyping: application to plasma RNA and proviral DNA. Antiviral Therapy. 2008;13(Suppl 3):A99 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Moores, A.1    Thielen, A.2    Dong, W.3
  • 75
    • 55049133759 scopus 로고    scopus 로고
    • Minority quasispecies of drug-resistant HIV-1 leading to early therapy failure in treatment-naïve and adherent patients
    • abstract
    • Giulieri S, Knoepfel S, Rauch P, Gunthard H, Cavassini M, Metzner K. Minority quasispecies of drug-resistant HIV-1 leading to early therapy failure in treatment-naïve and adherent patients. Antiviral Therapy. 2008;13(Suppl 3):A116 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Giulieri, S.1    Knoepfel, S.2    Rauch, P.3    Gunthard, H.4    Cavassini, M.5    Metzner, K.6
  • 76
    • 55049126431 scopus 로고    scopus 로고
    • A combination of bioinformatics tools can be accurately used for the screening of coreceptor usage in clinical samples
    • abstract
    • Chueca N, Martin L, Alvarez M, et al. A combination of bioinformatics tools can be accurately used for the screening of coreceptor usage in clinical samples. Antiviral Therapy. 2008;13(Suppl 3):A106 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Chueca, N.1    Martin, L.2    Alvarez, M.3
  • 77
    • 55049140228 scopus 로고    scopus 로고
    • Determination of HIV-1 coreceptor usage in German patients - comparison of genotypic methods with the TROFILE phenotypic assay
    • abstract
    • Obermeier M, Sichtig N, Braun P, et al. Determination of HIV-1 coreceptor usage in German patients - comparison of genotypic methods with the TROFILE phenotypic assay. Antiviral Therapy. 2008;13(Suppl 3): A112 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Obermeier, M.1    Sichtig, N.2    Braun, P.3
  • 78
    • 55049110142 scopus 로고    scopus 로고
    • Evaluation of the genotypic prediction of HIV-1 coreceptor tropism in a clinical setting
    • abstract
    • Recordon-Pinson P, Soule C, Anies G, et al. Evaluation of the genotypic prediction of HIV-1 coreceptor tropism in a clinical setting. Antiviral Therapy. 2008;13(Suppl 3):A113 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Recordon-Pinson, P.1    Soule, C.2    Anies, G.3
  • 79
    • 34047202703 scopus 로고    scopus 로고
    • Structural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usage
    • Sander O, Sing T, Sommer I, et al, Structural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usage. PLoS Comput Biol. 2007;3:e58.
    • (2007) PLoS Comput Biol , vol.3
    • Sander, O.1    Sing, T.2    Sommer, I.3
  • 80
    • 58149500107 scopus 로고    scopus 로고
    • Improved prediction of HIV-1 coreceptor usage by incorporating V2 loop sequence variation
    • abstract
    • Thelen A, Harrigan P, Low A, et al. Improved prediction of HIV-1 coreceptor usage by incorporating V2 loop sequence variation. Antiviral Therapy. 2008;13(Suppl 3:A113 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Thelen, A.1    Harrigan, P.2    Low, A.3
  • 81
    • 55049126129 scopus 로고    scopus 로고
    • Inferring viral tropism from genotype with massively parallel sequencing: Qualitative and quantitative analysis
    • abstract
    • Daumer M, Kaiser R, Klein R, Lengauer T, Thiele B, Thelen A. Inferring viral tropism from genotype with massively parallel sequencing: qualitative and quantitative analysis. Antiviral Therapy. 2008;13(Suppl 3):A101 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Daumer, M.1    Kaiser, R.2    Klein, R.3    Lengauer, T.4    Thiele, B.5    Thelen, A.6
  • 82
    • 55049137395 scopus 로고    scopus 로고
    • Dynamic HIV-1 escape from vicriviroc therapy in vivo
    • abstract
    • Tsibris A, Arnaout R, Korber B, et al. Dynamic HIV-1 escape from vicriviroc therapy in vivo, Antiviral Therapy. 2008;13(Suppl 3):A97 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Tsibris, A.1    Arnaout, R.2    Korber, B.3
  • 83
    • 16644381659 scopus 로고    scopus 로고
    • The current status of and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection
    • Maeda K, Nakata H, Ogata H, Koh Y, Myakawa T, Mitsuya H. The current status of and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection. Curr Opin Pharmacol. 2004; 4:447-52.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 447-452
    • Maeda, K.1    Nakata, H.2    Ogata, H.3    Koh, Y.4    Myakawa, T.5    Mitsuya, H.6
  • 84
    • 3042595910 scopus 로고    scopus 로고
    • Small-molecule antagonists of CCR5 and CXCR4: A promising new class of anti-HIV-1 drugs
    • Seibert C, Sakmar T. Small-molecule antagonists of CCR5 and CXCR4: A promising new class of anti-HIV-1 drugs. Curr Pharm Des. 2004; 10:2041-62.
    • (2004) Curr Pharm Des , vol.10 , pp. 2041-2062
    • Seibert, C.1    Sakmar, T.2
  • 85
    • 28544434492 scopus 로고    scopus 로고
    • CCR5 antagonists: Host-targeted antivirals for the treatment of HIV infection
    • Westloy M. van der Ryst E, CCR5 antagonists: Host-targeted antivirals for the treatment of HIV infection. Antivir Chem Chernother. 2005; 16:339-54.
    • (2005) Antivir Chem Chernother , vol.16 , pp. 339-354
    • Westloy, M.1    van der2    Ryst, E.3
  • 86
    • 28944454412 scopus 로고    scopus 로고
    • Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against HIV-1
    • Strizki J, Tremblay C, Xu S, et al. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against HIV-1. Antimicrob Agents Chemother. 2005;49:4911-19.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4911-4919
    • Strizki, J.1    Tremblay, C.2    Xu, S.3
  • 87
    • 0027916595 scopus 로고
    • Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing
    • Larder B, Kohli A, Kellam P, Kemp S, Kronick M, Henfrey R. Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing. Nature. 1993;365:671-3.
    • (1993) Nature , vol.365 , pp. 671-673
    • Larder, B.1    Kohli, A.2    Kellam, P.3    Kemp, S.4    Kronick, M.5    Henfrey, R.6
  • 88
    • 0027265082 scopus 로고
    • Analysis of heterogeneous viral populations by direct DNA sequencing
    • Leitner T, Halapi E, Scarlatti G, et al. Analysis of heterogeneous viral populations by direct DNA sequencing. BioTechniques. 1993; 15:120-7.
    • (1993) BioTechniques , vol.15 , pp. 120-127
    • Leitner, T.1    Halapi, E.2    Scarlatti, G.3
  • 89
    • 0033037358 scopus 로고    scopus 로고
    • Worldwide evaluation of DNA sequencing approaches for identification of drug resistance mutations in the HIV-1 reverse transcriptase
    • Schuurman R, Demeter L, Reichelderfer P, Tijnagel J, de Groot T, Boucher C. Worldwide evaluation of DNA sequencing approaches for identification of drug resistance mutations in the HIV-1 reverse transcriptase. J Clin Microbiol. 1999;37:2291-6.
    • (1999) J Clin Microbiol , vol.37 , pp. 2291-2296
    • Schuurman, R.1    Demeter, L.2    Reichelderfer, P.3    Tijnagel, J.4    de Groot, T.5    Boucher, C.6
  • 90
    • 0032733696 scopus 로고    scopus 로고
    • Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations
    • Van Laethem K, Van Vaerenbergh K, Schmit J, et al. Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations. J Acquir Immune Defic Syndr. 1999;22:107-18.
    • (1999) J Acquir Immune Defic Syndr , vol.22 , pp. 107-118
    • Van Laethem, K.1    Van Vaerenbergh, K.2    Schmit, J.3
  • 92
    • 55049116661 scopus 로고    scopus 로고
    • Pathway Diagnostics. Pathway Diagnostics Announces Commercial Availability of SensiTrop™ HIV Co-receptor Tropism Assay. Malibu, California: Pathway Diagnostics, 2007.
    • Pathway Diagnostics. Pathway Diagnostics Announces Commercial Availability of SensiTrop™ HIV Co-receptor Tropism Assay. Malibu, California: Pathway Diagnostics, 2007.
  • 93
    • 0031214224 scopus 로고    scopus 로고
    • Tracking changes in HIV-1 envelope quasispecies using DNA heteroduplex analysis
    • Delwart E, Gordon C. Tracking changes in HIV-1 envelope quasispecies using DNA heteroduplex analysis. Methods. 1997; 12:348-54.
    • (1997) Methods , vol.12 , pp. 348-354
    • Delwart, E.1    Gordon, C.2
  • 94
    • 0030812851 scopus 로고    scopus 로고
    • Evolutionary variants of the HIV-1 V3 region characterized by using a heteroduplex tracking assay
    • Nelson J, Fiscus S, Swanstrom R. Evolutionary variants of the HIV-1 V3 region characterized by using a heteroduplex tracking assay. J Virol. 1997;71:8750-8.
    • (1997) J Virol , vol.71 , pp. 8750-8758
    • Nelson, J.1    Fiscus, S.2    Swanstrom, R.3
  • 95
    • 0033865498 scopus 로고    scopus 로고
    • Patterns of changes in HIV-1 V3 sequence populations late in infection
    • Nelson J, Baribaud F, Edwards T, Swanstrom R. Patterns of changes in HIV-1 V3 sequence populations late in infection. J Virol. 2000; 74:8494-501.
    • (2000) J Virol , vol.74 , pp. 8494-8501
    • Nelson, J.1    Baribaud, F.2    Edwards, T.3    Swanstrom, R.4
  • 96
    • 33750979833 scopus 로고    scopus 로고
    • Genetic I characteristics of the V3 region associated with CXCR4 usage in HIV-1 subtype C isolates
    • Coetzer M, Cilliers T, Ping L, Swanstrom R, Morris L. Genetic I characteristics of the V3 region associated with CXCR4 usage in HIV-1 subtype C isolates. Virology. 2006;356:95-105.
    • (2006) Virology , vol.356 , pp. 95-105
    • Coetzer, M.1    Cilliers, T.2    Ping, L.3    Swanstrom, R.4    Morris, L.5
  • 98
    • 55049137681 scopus 로고    scopus 로고
    • Li W, Webb E, Nary L, Robins T. SensiTrop QT: A novel molecular diagnostic assay for the detection and quantification of HIV coreceptor tropism. 15th CROI, Boston, USA, Feb 2008 [abstract 919].
    • Li W, Webb E, Nary L, Robins T. SensiTrop QT: A novel molecular diagnostic assay for the detection and quantification of HIV coreceptor tropism. 15th CROI, Boston, USA, Feb 2008 [abstract 919].
  • 99
    • 55049098292 scopus 로고    scopus 로고
    • Comparison ol results from the SensiTrop vs. Trofile assays on 100 samples from the maraviroc expanded access program
    • Boston, USA, Feb, abstract 920
    • Tressler R. Valdex H, van der Ryst E, et al. Comparison ol results from the SensiTrop vs. Trofile assays on 100 samples from the maraviroc expanded access program. 15th CROI, Boston, USA, Feb 2008 [abstract 920].
    • (2008) 15th CROI
    • Tressler, R.1    Valdex, H.2    van der Ryst, E.3
  • 100
    • 55049102647 scopus 로고    scopus 로고
    • Merriweather A. Study Reaffirms Superiority of Trofile (TM) Assay . Accessed 01/13/2008, Reuters, UK.
    • Merriweather A. Study Reaffirms Superiority of Trofile (TM) Assay . Accessed 01/13/2008, Reuters, UK.
  • 101
    • 55049090868 scopus 로고    scopus 로고
    • Invirion Diagnostics. Virotect Tropism Assay for HIV-1 . Accessed 01/7/2008. Invirion Diagnostics, LLC, Oak Brook, IL, 2007.
    • Invirion Diagnostics. Virotect Tropism Assay for HIV-1 . Accessed 01/7/2008. Invirion Diagnostics, LLC, Oak Brook, IL, 2007.
  • 102
    • 15044339793 scopus 로고    scopus 로고
    • R5 to X4 switch of the predominant HIV-1 population in cellular reservoirs during effective HAART
    • Delobel P, Sandres-Sauné K, Cazabat M, et al. R5 to X4 switch of the predominant HIV-1 population in cellular reservoirs during effective HAART. J Acquir Immune Defic Syndr. 2005;38:382-92.
    • (2005) J Acquir Immune Defic Syndr , vol.38 , pp. 382-392
    • Delobel, P.1    Sandres-Sauné, K.2    Cazabat, M.3
  • 104
    • 0032924183 scopus 로고    scopus 로고
    • Highly potent RANTES analogues either prevent CCR5-using HIV-1 infection in vivo or rapidly select for CXCR4-using variants
    • Mosier D, Picchio G, Gulzia R. et al. Highly potent RANTES analogues either prevent CCR5-using HIV-1 infection in vivo or rapidly select for CXCR4-using variants. J Virol. 1999;73:3544-50.
    • (1999) J Virol , vol.73 , pp. 3544-3550
    • Mosier, D.1    Picchio, G.2    Gulzia, R.3
  • 105
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia growth and development study. multicenter AIDS cohort study, multicenter hemophilia cohort study, San Francisco city cohort, ALIVE study
    • Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia growth and development study. multicenter AIDS cohort study, multicenter hemophilia cohort study, San Francisco city cohort, ALIVE study. Science. 1996; 273:1856-62.
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3
  • 106
    • 8044258978 scopus 로고    scopus 로고
    • Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals
    • Eugen-Olsen J, Iversen A, Garred P, et al. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS. 1997;11:305-10.
    • (1997) AIDS , vol.11 , pp. 305-310
    • Eugen-Olsen, J.1    Iversen, A.2    Garred, P.3
  • 107
    • 0030987288 scopus 로고    scopus 로고
    • CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1 in vitro
    • Wu L, Paxton W, Kassam N, et al. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1 in vitro, J Exp Med. 1997;185:1681-91.
    • (1997) J Exp Med , vol.185 , pp. 1681-1691
    • Wu, L.1    Paxton, W.2    Kassam, N.3
  • 108
    • 0030712312 scopus 로고    scopus 로고
    • Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32
    • Benkirane M, Jin D, Chun R, Koup R, Jeang K. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J Biol Chem. 1997;272:30603-6.
    • (1997) J Biol Chem , vol.272 , pp. 30603-30606
    • Benkirane, M.1    Jin, D.2    Chun, R.3    Koup, R.4    Jeang, K.5
  • 109
    • 0031781607 scopus 로고    scopus 로고
    • D'Aquila R, Sutton L. Savara A, Hughes M, Johnson V. CCR5/delta(ccr5) heterozygosity: A selective pressure for the syncytium-inducing HIV-1 phenotype. NIAID AIDS clinical trials group protocol 241 virology team. J Infect Dis. 1998;177:1549-53.
    • D'Aquila R, Sutton L. Savara A, Hughes M, Johnson V. CCR5/delta(ccr5) heterozygosity: A selective pressure for the syncytium-inducing HIV-1 phenotype. NIAID AIDS clinical trials group protocol 241 virology team. J Infect Dis. 1998;177:1549-53.
  • 110
    • 0031684753 scopus 로고    scopus 로고
    • Chemokine coreceptor usage by diverse primary isolates of HIV-1
    • Zhang L, He T, Huang Y, et al. Chemokine coreceptor usage by diverse primary isolates of HIV-1. J Virol. 1998;72:9307-12.
    • (1998) J Virol , vol.72 , pp. 9307-9312
    • Zhang, L.1    He, T.2    Huang, Y.3
  • 112
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc; utilize inhibitor-bound receptor for entry
    • Westby M, Smith-Burchnell C, Mori J, et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc; utilize inhibitor-bound receptor for entry. J Virol. 2007;81:2359-71.
    • (2007) J Virol , vol.81 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3
  • 113
    • 12144289333 scopus 로고    scopus 로고
    • Genetic and phenotypic analyses of HIV-1 escape from a small-molecule CCR5 inhibitor
    • Kuhmann S, Pugach P, Kunstman K, et al. Genetic and phenotypic analyses of HIV-1 escape from a small-molecule CCR5 inhibitor. J Virol. 2004;78:2790-807.
    • (2004) J Virol , vol.78 , pp. 2790-2807
    • Kuhmann, S.1    Pugach, P.2    Kunstman, K.3
  • 114
    • 0037039380 scopus 로고    scopus 로고
    • HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use
    • Trkola A, Kuhmann S, Strizki J, et al. HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use. Proc Natl Acad Sci USA. 2002;99:395-400.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 395-400
    • Trkola, A.1    Kuhmann, S.2    Strizki, J.3
  • 115
    • 34047271098 scopus 로고    scopus 로고
    • HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry
    • Pugach P, Marozsan A, Ketas T, Landes E, Moore J, Kuhmann S. HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry. Virology. 2007;361:212-28.
    • (2007) Virology , vol.361 , pp. 212-228
    • Pugach, P.1    Marozsan, A.2    Ketas, T.3    Landes, E.4    Moore, J.5    Kuhmann, S.6
  • 116
    • 55049085299 scopus 로고    scopus 로고
    • In vitro selection and characterization of maraviroc-resistant HIV-1
    • abstract
    • Wei J, Hogan P, Paulman R. et al. In vitro selection and characterization of maraviroc-resistant HIV-1. Antiviral Therapy. 2008;13(Suppl3):A64 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL.3
    • Wei, J.1    Hogan, P.2    Paulman, R.3
  • 117
    • 55049095860 scopus 로고    scopus 로고
    • Defining the structural and functional roles of mutations in gp120 associated with the emergence of HIV-1 clinical resistance to the CCR5 antagonist vicriviroc
    • abstract
    • Howe J, Murgolo N, Hou Y, et al. Defining the structural and functional roles of mutations in gp120 associated with the emergence of HIV-1 clinical resistance to the CCR5 antagonist vicriviroc. Antiviral Therapy. 2008;13(Suppl 3):A36 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Howe, J.1    Murgolo, N.2    Hou, Y.3
  • 118
    • 34347363143 scopus 로고    scopus 로고
    • Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss
    • Anastassopoulou C, Marozsan A, Matet A, et al. Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss. PLoS Pathog. 2007;3:e79.
    • (2007) PLoS Pathog , vol.3
    • Anastassopoulou, C.1    Marozsan, A.2    Matet, A.3
  • 119
    • 55049122474 scopus 로고    scopus 로고
    • Escape of HIV-1 from a CCR5 antagonist can reduce envelope-mediated entry
    • abstract
    • Huang W, Wojcik L, Toma J, et al. Escape of HIV-1 from a CCR5 antagonist can reduce envelope-mediated entry. Antiviral Therapy. 2008;13(Suppl 3):A65 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • Huang, W.1    Wojcik, L.2    Toma, J.3
  • 120
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using HIV-1 variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
    • Westby M. Lewis M, Whitcomb J, et al. Emergence of CXCR4-using HIV-1 variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol. 2006;80:4909-20.
    • (2006) J Virol , vol.80 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3
  • 121
    • 55049086900 scopus 로고    scopus 로고
    • Dynamics of emergence of CXCR4-using HIV in clinical samples as detected by Trofile and MT-2 assays
    • abstract
    • van't Wout A, Coakley E, Reeves J, Petropoulos C, Schuitemaker H, Huang W. Dynamics of emergence of CXCR4-using HIV in clinical samples as detected by Trofile and MT-2 assays. Antiviral Therapy. 2008;13(Suppl 3):A93 [abstract].
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 3
    • van't Wout, A.1    Coakley, E.2    Reeves, J.3    Petropoulos, C.4    Schuitemaker, H.5    Huang, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.