The developmental basis of skeletal cell differentiation and the molecular basis of major skeletal defects

Biological Reviews

Volumn 83, Issue 4, 2008, Pages 401-415

  Blair, Harry C ^a   Zaidi, Mone ^b   Huang, Christopher L H ^c   Sun, Li ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

catenin; BMP; Chondrocyte; Frizzled; Osteoblast; Osteoclast; Parathyroid hormone; PTH rP; TGF

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; BONE MORPHOGENETIC PROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; GLYCOPROTEIN; PROTEIN C FOS; PROTEIN C JUN; PROTEOGLYCAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DLX3; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR FRA 2; TRANSCRIPTION FACTOR JUND; TRANSCRIPTION FACTOR MSX1; TRANSCRIPTION FACTOR MSX2; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT2; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; WNT PROTEIN;

ALBERS SCHOENBERG DISEASE; BONE CELL; BONE DEFECT; BONE DEVELOPMENT; BONE MASS; BONE METABOLISM; BONE MINERAL; BONE TURNOVER; CALCIUM HOMEOSTASIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CIRCADIAN RHYTHM; COLLAGEN SYNTHESIS; EMBRYO DEVELOPMENT; GENE EXPRESSION; HOMEOBOX; HUMAN; MESENCHYMAL STEM CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BONE AND BONES; BONE DEVELOPMENT; BONE RESORPTION; CELL DIFFERENTIATION; HUMANS; OSTEOBLASTS; OSTEOCLASTS;

MAMMALIA; OSTEICHTHYES; VERTEBRATA;

EID: 54949085828     PISSN: 14647931     EISSN: 1469185X     Source Type: Journal    
DOI: 10.1111/j.1469-185X.2008.00048.x     Document Type: Review

References (99)

1. Abe, E., Marians, R., Wu, X-B., Iqbal, J., Ando, T., Blair, H. C., Davies, T. F. Zaidi, M 2003). TSH is a negative regulator of bone remodeling. Cell 175, 151 162.
2. 2+ sensing in the regulation of osteoclastic bone resorption. Journal of Cell Biology 142, 1347 1356.
3. Akiyama, T., Bouillet, P., Miyazaki, T., Kadono, Y., Chikuda, H., Chung, U. I., Fukuda, A., Hikita, A., Seto, H., Okada, T., Inaba, T., Sanjay, A., Baron, R., Kawaguchi, H., Oda, H., Nakamura, K., Strasser, A. Tanaka, S 2003). Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO Journal 22, 6653 6664.
4. Almeida, M., Han, L., Bellido, T., Manolagas, S. C. Kousteni, S 2005). Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. Journal of Biological Chemistry 280, 41342 41351.
5. Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E. F., Mak, T. W., Serfling, E. Takayanagi, H 2005). Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. Journal of Experimental Medicine 202, 1261 1269.
6. Aulehla, A. Herrmann, B. G 2004). Segmentation in vertebrates: clock and gradient finally joined. Genes and Development 18, 2060 2067.
7. Baldock, P. A., Sainsbury, A., Couzens, M., Enriquea, R. F., Thomas, G. P., Gardiner, E. M. Herzog, H 2002). Hypothalamic Y2 receptors regulate bone formation. Journal of Clinical Investigation 109, 915 921.
8. Bialek, P., Kern, B., Yang, X., Schrock, M., Sosic, D., Hong, N., Wu, H., Yu, K., Ornitz, D. M., Olson, E. N., Justice, M. J. Karsenty, G 2004). A twist code determines the onset of osteoblast differentiation. Developmental Cell 6, 423 435.
9. Blair, H. C., Wells, A. Isales, C. M 2007). Pituitary glycoprotein hormone receptors in non-endocrine organs. Trends in Endocrinology and Metabolism 18, 227 33.
10. Bodine, P. V., Zhao, W., Kharode, Y. P., Bex, F. J., Lambert, A. J., Goad, M. B., Gaur, T., Stein, G. S., Lian, J. B. Komm, B. S 2004). The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Molecular Endocrinology 18, 1222 1237.
11. Bodmer, J. L., Schneider, P. Tschopp, J 2002). The molecular architecture of the TNF superfamily. Trends in Biochemical Science 27, 19 26.
12. Bruzzaniti, A., Neff, L., Sanjay, A., Horne, W. C., De Camilli, P. Baron, R 2005). Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Molecular Biology of the Cell 16, 3301 3313.
13. Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Divieti, P., Bringhurst, F. R., Milner, L. A., Kronenberg, H. M. Scadden, D. T 2003). Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841 846.
14. Curtis, J. R., Patkar, N., Xie, A., Martin, C., Allison, J. J., Saag, M., Shatin, D. Saag, K. G 2007). Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor alpha antagonists. Arthritis & Rheumatism 56, 1125 1133.
15. Dacquin, R., Davey, R. A., Laplace, C., Levasseur, R., Morris, H. A., Goldring, S. R., Gebre-Medhin, S., Galson, D. L., Zajac, J. D. Karsenty, G 2004). Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. Journal of Cell Biology 164, 509 514.
16. Datta, H. K., Zaidi, M., Wimalawansa, S. J., Ghatei, M. A., Beacham, J. L., Bloom, S. R. MacIntyre, I 1989). In vitro and in vivo effects of amylin and amylin-amide on calcium metabolism in the rat and rabbit. Biochemical and Biophysical Research Communications 162, 876 881.
17. de Vries F., Souverein P. C., Cooper C., Leufkens H. G. van Staa T. P 2007) Use of beta-blockers and the risk of hip/femur fracture in the United Kingdom and The Netherlands. Calcified Tissue International 80, 69 75.
18. Diewald, L., Rupp, J., Dreger, M., Hucho, F., Gillen, C. Nawrath, H 2002). Activation by acidic pH of CLC-7 expressed in oocytes from Xenopus laevis. Biochemical and Biophysical Research Communications 291, 421 424.
19. Doecke, J. D., Day, C. J., Stephens, A. S., Carter, S. L., van Daal, A., Kotowicz, M. A., Nicholson, G. C. Morrison, N. A 2006). Association of functionally different RUNX2 P2 promoter alleles with BMD. Journal of Bone and Mineral Research 21, 265 273.
20. Doffinger, R., Smahi, A., Bessia, C., Geissmann, F., Feinberg, J., Durandy, A., Bodemer, C., Kenwrick, S., Dupuis-Girod, S., Blanche, S., Wood, P., Rabia, S. H., Headon, D. J., Overbeek, P. A., Le Deist, F., Holland, S. M., Belani, K., Kumararatne, D. S., Fischer, A., Shapiro, R., Conley, M. E., Reimund, E., Kalhoff, H., Abinum, M., Munnich, A., Israel, A., Curtois, G. Casanova, J. L 2001). X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kB signaling. Nature Genetics 27, 277 285.
21. Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M. Karsenty, G 2000). Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100, 197 207.
22. Eberhardt, A. W., Yeager-Jones A. Blair, H. C 2001). Regional trabecular bone matrix degeneration and osteocyte death in femora of glucocorticoid treated rabbits. Endocrinology 142, 1333 1340.
23. Elefteriou, F., Ahn, J. D., Takeda, S., Starbuck, M., Yang, X., Liu, X., Kondo, H., Richards, W. G., Bannon, T. W., Noda, M., Clement, K., Vaisse, C. Karsenty, G 2005). Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434, 514 520.
24. Elefteriou, F., Takeda, S., Liu, X., Armstrong, D. Karsenty, G 2003). Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass. Endocrinology 144, 3842 3847.
25. Emery, J. G., McDonnell, P., Burke, M. B., Deen, K. C., Lyn, S., Silverman, C., Dul, E., Appelbaum, E. R., Eichman, C., DiPrinzio, R., Dodds, R. A., James, I. E., Rosenberg, M., Lee, J. C. Young, P. R 1998). Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. Journal of Biological Chemistry 273, 14363 14367.
26. Epstein, S., Inzerillo, A. M., Caminis, J. Zaidi, M 2003). Disorders associated with acute rapid and severe bone loss. Journal of Bone and Mineral Research 18, 2083 2094.
27. Ermakov, S., Malkin, I., Kobyliansky, E. Livshits, G 2006) Variation in femoral length is associated with polymorphisms in RUNX2 gene. Bone 38, 199 205.
28. Faccio, R., Teitelbaum, S. L., Fujikawa, K., Chappel, J., Zallone, A., Tybulewicz, V. L., Ross, F. P. Swat, W 2005). Vav3 regulates osteoclast function and bone mass. Nature Medicine 11, 284 290.
29. Fitz, R., Alsberg, C. L. Henderson, L. J 1907). Concerning the excretion of phosphoric acid during experimental acidosis in rabbits. American Journal of Physiology 18, 113 122.
30. Fu, L., Patel, M. S., Bradley, A., Wagner, E. F. Karsenty, G 2005). The molecular clock mediates leptin-regulated bone formation. Cell 122, 803 815.
31. Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A. Karsenty, G 2005). Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Developmental Cell 8, 751 764.
32. Glass, D. A. Karsenty, G 2006). Canonocal Wnt signaling in osteoblasts is required for osteoclast differentiation. Annals of the New York Academy of Sciences 1068, 117 130.
33. Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S. Inoue, J 2005). RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO Journal 24, 790 799.
34. Grey A., Bolland M., Gamble G., Wattie D., Horne A., Davidson J. Reid I. R 2007). The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: a randomized, controlled trial. Journal of Clinical Endocrinology and Metabolism 92, 1305 1310.
35. Guo, J., Chung, U. I., Yang, D., Karsenty, G., Bringhurst, F. R. Kronenberg, H. M 2006). PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Developmental Biology 292, 116 128.
36. Han, Y., Cowin, S. C., Schaffler, M. B. Weinbaum, S 2005). Mechanotransduction and strain amplification in osteocyte cell processes. Proceedings of the National Academy of Sciences (USA) 101, 16689 16694.
37. Hartikka, H., Makitie, O., Mannikko, M., Doria, A. S., Daneman, A., Cole, W. G., Ala-Kokko, L. Sochett, E. B 2005). Heterozygous mutations in the LDL receptor-related protein 5 (LRP5) gene are associated with primary osteoporosis in children. Journal of Bone and Mineral Research 20, 783 789.
38. Hase, H., Ando, T., Eldeiry, L., Brebene, A., Peng, Y., Liu, L., Amano, H., Davies, T. F., Sun, L., Zaidi, M. Abe, E 2006). TNFα mediates the skeletal effects of thyroid-stimulating hormone. Proceedings of the National Academy of Sciences (USA) 103, 12849 12854.
39. Hassan, M. Q., Javed, A., Morasso, M. I., Karlin, J., Montecino, M., van Wijnen, A. J., Stein, G. S., Stein, J. L. Lian, J. B 2004). Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Molecular Cell Biology 24, 9248 9261.
40. Hoff, A. O., Catala-Lehnen, P., Thomas, P. M., Priemel, M., Rueger, J. M., Nasonkin, I., Bradley, A., Hughes, M. R., Ordonez, N., Cote, G. J., Amling, M. Gagel, R. F 2002). Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. Journal of Clinical Investigation 110, 1849 1857.
41. Huang, J. C., Sakata, T., Pfleger, L. L., Bencsik, M., Halloran, B. P., Bikle, D. D. Nissenson, R. A 2004). PTH differentially regulates expression of RANKL and OPG. Journal of Bone and Mineral Research 19, 235 244.
42. Iqbal, J., Kumar, K., Sun, L. Zaidi, M 2006a). Selective upregulation of ADP-ribosyl cyclases CD38 and CD157 by TNF but not by RANK-L reveals differences in downstream signaling. Neuroendocrine. Journal of Physiology 291, F557 F566.
43. Iqbal, J., Sun, L., Kumar, T. R., Blair, H. C. Zaidi, M 2006b). Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proceedings of the National Academy of Sciences (USA) 103, 14925 114930.
44. Irwin, R., Lin, H. V., Motyl, K. J. McCabe, L. R 2006). Normal bone density obtained in the absence of insulin receptor expression in bone. Endocrinology 147, 5760 5767.
45. Kaneki, H., Guo, R., Chen, D., Yao, Z., Schwarz, E. M., Zhang, Y. E., Boyce, B. F. Xing, L 2006). TNF promotes RUNX2 degradation through up-regulation of SMURF1 and SMURF2 in osteoblasts. Journal of Biological Chemistry 281, 4326 4333.
46. Katayama, Y., Battista, M., Kao, W. -M., Hidalgo, A., Peired, A., Thomas, S. Frenette, P 2006). Signals from the sympathetic nervous system regulate hematopoetic stem cell egress from bone marrow. Cell 124, 407 421.
47. Kieslinger, M., Folberth, S., Dobreva. G., Dorn, T., Croci, L., Erben, R., Consalez, G. G. Grosschedl, R 2005). EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Developmental Cell 9, 757 767.
48. Kim, Y., Sato, K., Asagiri, M., Morita, I., Soma, K. Takayanagi, H 2005). Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor, but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. Journal of Biological Chemistry 280, 32905 32913.
49. Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., Taniguchi, T., Takayanagi, H. Takai, T 2004) Co-stimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428, 758 763.
50. Koga, T., Matsui, Y., Asagiri, M., Kodama, T., de Crombrugghe, B., Nakashima, K. Takayanagi, H 2005). NFAT and Osterix cooperatively regulate bone formation. Nature Medicine 11, 880 885.
51. Komori, T 2006). Regulation of osteoblast differentiation by transcription factors. Journal of Cellular Biochemistry 99, 1233 1239.
52. Kornak, U., Kasper, D., Bosl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G. Jentsch, T. J 2001). Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell 104, 205 15.
53. Kronenberg, H. M 2006). PTHrP and skeletal development. Annals of the New York Academy of Sciences 1068, 1 13.
54. Kudo, O., Fujikawa, Y., Itonaga, I., Sabokbar, A., Torisu, T. Athanasou, N. A 2002 Proinflammatory cytokine (TNFα/IL-1a) induction of human osteoclast formation. Journal of Pathology 198, 220 227.
55. Lee N. K., Sowa H., Hinoi E., Ferron M., Ahn J. D., Confavreux C., Dacquin R., Mee P. J., McKee M. D., Jung D. Y., Zhang Z., Kim J. K., Mauvais-Jarvis F., Ducy P. Karsenty G 2007). Endocrine regulation of energy metabolism by the skeleton. Cell 130, 456 469.
56. Li, C., Jepsen, K., Majeska, R. J., Zhang, J., Rujing, N., Gelb, B. D. Schaffler, M. B 2006). Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass. Journal of Bone and Mineral Research 21, 865 875.
57. Li, X., Liu, P., Liu, W., Maye, P., Zhang, J., Zhang, Y., Hurley, M., Guo, C., Boskey, A., Sun, L., Harris, S. E., Rowe, D. W., Ke, H. Z. Wu, D 2005). Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nature Genetics 37, 945 952.
58. Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q. Boskey, A. L 2005). DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. Journal of Bone and Mineral Research 20, 2169 2177.
59. MacIntyre, I., Zaidi, M., Alam, A. S., Datta, H. K., Moonga, B. S., Lidbury, P. K., Hecker, M. Vane, J. R 1991). Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP. Proceedings of the National Academy of Sciences (USA) 88, 2936 2940.
60. Matsuo, K., Galson, D. L., Zhao, C., Peng, L., Laplace, C., Wang, K. Z., Bachler, M. A., Amano, H., Aburatani, H., Ishikawa, H. Wagner, E. F 2004). Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. Journal of Biological Chemistry 279, 26475 26480.
61. Miller, J., Horner, A., Stacy, T., Lowrey, C., Lian, J. B., Stein, G., Nuckolls, G. H. Speck, N. A 2002). The core-binding factor beta subunit is required for bone formation and hematopoetic maturation. Nature Genetics 32, 645 649.
62. Mocsai, A., Humphrey, M. B., Van Ziffle, J. A., Hu, Y., Burghardt, A., Spusta, S. C., Majumdar, S., Lanier, L. L., Lowell, C. A. Nakamura, M. C 2004). The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proceedings of the National Academy of Sciences (USA) 101, 6158 6163.
63. Mohan, S. Baylink, D. J 2005). Impaired skeletal growth in mice with insufficiency of IGF-1: genetic evidence that differences in IGF-1 expression could contribute to peak bone mass differences. Journal of Endocrinology 185, 415 420.
64. 2+ influx through the osteoclast plasma membrane ryanodine receptor. Neuroendocrine. Journal of Physiology 282, F921 F932.
65. Mundy, G. R. Guise, T. R 1999). Hormonal control of calcium homeostasis. Clinical Chemistry 45, 1347 1352.
66. Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R. de Crombrugghe, B 2002). The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17 29.
67. Ogata N., Chikazu D., Kubota N., Terauchi Y., Tobe K., Azuma Y., Ohta T., Kadowaki T., Nakamura K. Kawaguchi H 2000). Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. Journal of Clinical Investigation 105, 935 943.
68. Picollo, A. Pusch, M 2005). Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature 436, 420 423.
69. Qvist, P., Christgau, S., Pedersen, B. J., Schlemmer, A. Christiansen, C 2002). Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting. Bone 31, 57 61.
70. Reid I. R., Lucas J., Wattie D., Horne A., Bolland M., Gamble G. D., Davidson J. S. Grey A. B 2005) Effects of a beta-blocker on bone turnover in normal postmenopausal women: a randomized controlled trial. Journal of Clinical Endocrinology and Metabolism 90, 5212 5216.
71. Semenov, M., Tamai, K. He, X 2005). SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. Journal of Biological Chemistry 280, 26770 26775.
72. Shore, E. M., Xu, M., Feldman, G. J., Fenstermacher, D. A., FOP International Research Consortium, Brown, M. A. Kaplan, F. S. (2006). A recurrent mutation of BMP type 1 receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nature Genetics 38, 525 527.
73. Silver, I. A., Murrills, R. J. Etherington, D. J 1988). Microelectrode studies on acid beneath adherent macrophages and osteoclasts. Experimental Cell Research 175, 266 276.
74. Storm E. E. Kingsley D. M 1999). GDF5 coordinates bone and joint formation during digit development. Developmental Biology (Orlando) 209, 11 27.
75. + sensor. FASEB Journal 16, 302 314.
76. Sun, L., Blair, H. C., Peng, Y., Zaidi, N., Adebanjo, O. A., Wu, X. B., Wu, X. Y., Iqbal, J., Epstein, S., Abe, E., Moonga, B. S. Zaidi, M 2005). Calcineurin regulates bone formation by the osteoblast. Proceedings of the National Academy of Sciences (USA) 102, 17130 17135.
77. Sun, L., Iqbal, J., Dolgilevich, S., Yuen, T., Wu, X. -B., Moonga, B. S., Adebanjo, O. A., Bevis, P. J. R., Lund, F., Huang, C. L. -H., Blair, H. C., Abe, E. Zaidi, M 2003). Disordered osteoclast formation and function in CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption. FASEB Journal 17, 369 375.
78. Sun, L., Peng, Y., Sharrow, A., Iqbal, J., Zhang, Z., Papachristou, D. J., Zaidi, S., Zhu, L. -L., Yaroslavskiy, B. B., Zhao, H., Zallone, A., Sairam, M. R., Kumar, T. R., Bo, W., Braun, J., Cardoso-Landa, L., Schaffler, M., Moonga, B. S., Blair, H. C. Zaidi, M 2006). FSH directly regulates bone mass. Cell 125, 247 260.
79. Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E. F., Mak, T. W., Kodama, T. Taniguchi, T 2002). Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Developmental Cell 3, 889 901.
80. Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P. Karsenty, G 2002). Leptin regulates bone formation via the sympathetic nervous system. Cell 111, 305 317.
81. Takeshita, S., Namba, N., Zhao, J. J., Jiang, Y., Genant, H. K., Silva, M. J., Brodt, M. D., Helgason, C. D., Kalesnikoff, J., Rauh, M. J., Humphries, R. K., Krystal, G., Teitelbaum, S. L. Ross F. P 2002). SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nature Medicine 8, 943 949.
82. Thorndyke, M. C. Probert, L 1979). Calcitonin-like cells in the pharynx of the ascidian Styela clava. Cell and Tissue Research 203, 301 309.
83. Tian, E., Zhan, F., Walker, R., Rasmussen, E., Ma, Y., Barlogie, B. Shaughnessy, J. D. Jr. 2003). The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. New England Journal of Medicine 349, 2483 2494.
84. Towler, D. A., Shao, J. S., Cheng, S. L., Pingsterhaus, J. M. Loewy, A. P 2006). Osteogenic regulation of vascular calcification. Annals of the New York Academy of Sciences 1068, 327 333.
85. Varghese, S., Rydziel, S. Canalis, E 2000). Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Endocrinology 141, 2185 2191.
86. Visnjic, D., Kalajzic, Z., Rowe, D. W., Katavic, V., Lorenzo, J. Aguila, H. L 2004). Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood 103, 3258 3264.
87. Whyte, M. P 2006). Paget's disease of bone and genetic disorders of RANKL/OPG/NF-kappaB signaling. Annals of the New York Academy of Sciences 1068, 143 168.
88. Wu, X. -B., Li, Y., Schneider, A., Yu, W., Gopalan, R., Iqbal, J., Yamamoto, M., Alam, M., Brunet, L. J., Harland, R. M., Blair, H. C., Zaidi, M. Abe, E 2003). Impaired osteoblastic differentiation, reduced bone formation and severe osteoporosis in noggin-overexpressing mice. Journal of Clinical Investigation 112, 924 934.
89. Yakar, S., Rosen, C. J., Beamer, W. G., Ackert-Bicknell, C. L., Wu, Y., Liu, J. L., Ooi, G. T., Setser, J., Frystyk, J., Boisclair, Y. R. LeRoith, D 2002). Circulating levels of IGF-1 directly regulate bone growth and density. Journal of Clinical Investigation 110, 771 781.
90. Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone-Corsi, P., Townes, T. M., Hanauer, A. Karsenty, G 2004). ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: implication for Coffin-Lowry Syndrome. Cell 117, 387 398.
91. Zaidi, M 2005). Neural surveillance of skeletal homeostasis. Cell Metabolism 1, 219 221.
92. Zaidi, M., Datta, H. K., Patchell, A., Moonga, B. S. MacIntyre, I 1989). 'Calcium-activated' intracellular calcium elevation: a novel mechanism of osteoclast regulation. Biochemical and Biophysical Research Communications 163, 1461 1465.
93. Zaidi, M., Fuller, K., Bevis, P. J. R., Gaines Das, R. E., Chambers, T. J. MacIntyre, I 1987). Calcitonin gene-related peptode inhibits osteoclastic bone resorption: a comparative study. Calcified Tissue International 40, 149 154.
94. Zaidi, M., Moonga, B. S. Abe, E 2002). Calcitonin and bone formation: a knockout full of surprises. Journal of Clinical Investigation 110, 1769 1771.
95. Zaidi, M., Moonga, B. S. Huang, C. L. -H 2004). Calcium sensing and cell signaling processes in the local regulation of osteoclastic bone resorption. Biological Reviews 79, 79 100.
96. 2+ sensor. Journal of Clinical Investigation 96, 1582 1590.
97. Zaidi, M., Sun, L., Davies, T. F. Abe, E 2006). Low TSH triggers bone loss: fact or fiction? Thyroid 16, 1075 1076.
98. Zhang, J., Niu, C., Ye, L., Huang, H., He, X., Tong, W. G., Ross, J., Haug, J., Johnson, T., Feng, J. Q., Harris, S., Wiedemann, L. M., Mishina, Y. Li, L 2003). Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836 841.
99. Zhang, Y., Wang, Y., Li, X., Zhang, J., Mao, J., Li, Z., Zheng, J., Li, L., Harris, S. Wu, D 2004). The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Molecular Cell Biology 24, 4677 4684.