3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-β signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 20, 1999, Pages 11525-11530

  Park, Ho Jin ^a   Galper, Jonas B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PRAVASTATIN; RHO FACTOR; SIMVASTATIN; TETRYLAMMONIUM BROMIDE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHICKEN; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; GROWTH REGULATION; HEART DISEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; CHICK EMBRYO; CHOLESTEROL; GTP-BINDING PROTEINS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MYOCARDIUM; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROMOTER REGIONS (GENETICS); PROTEIN ISOPRENYLATION; RECEPTORS, LDL; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RHOA GTP-BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

ANIMALIA; GALLUS GALLUS;

EID: 0033613098     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.20.11525     Document Type: Article

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