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Volumn 68, Issue 3, 2008, Pages 197-211

Pancreatic cancer: From molecular signature to target therapy

Author keywords

Angiogenesis; Bevacizumab; Epidermal growth factor receptor; Erlotinib; Pancreatic cancer

Indexed keywords

ALKALINE PHOSPHATASE; AMINOTRANSFERASE; BEVACIZUMAB; BILIRUBIN; CAPECITABINE; CELECOXIB; CETUXIMAB; CISPLATIN; DOCETAXEL; ERLOTINIB; FLUOROURACIL; GAMMA GLUTAMYLTRANSFERASE; GEFITINIB; GEMCITABINE; MARIMASTAT; MATUZUMAB; NIMESULIDE; NIMOTUZUMAB; OXALIPLATIN; PACLITAXEL; PLACEBO; PLATINUM COMPLEX; TANOMASTAT; THALIDOMIDE; TIPIFARNIB; TRASTUZUMAB; VASCULOTROPIN;

EID: 54349110130     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2008.03.003     Document Type: Review
Times cited : (35)

References (109)
  • 1
    • 35148834395 scopus 로고    scopus 로고
    • The management of pancreatic cancer. Current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006
    • Verslype C., Van Cutsem E., Dicato M., Cascinu S., Cunningham D., Diaz-Rubio E., et al. The management of pancreatic cancer. Current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006. Ann Oncol 18 Suppl. 7 (2007) vii1-vii10
    • (2007) Ann Oncol , vol.18 , Issue.SUPPL. 7
    • Verslype, C.1    Van Cutsem, E.2    Dicato, M.3    Cascinu, S.4    Cunningham, D.5    Diaz-Rubio, E.6
  • 3
    • 0033953188 scopus 로고    scopus 로고
    • Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective
    • Sakorafas G.H., Tsiotou A.G., and Tsiotos G.G. Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective. Cancer Treat Rev 26 (2000) 29-52
    • (2000) Cancer Treat Rev , vol.26 , pp. 29-52
    • Sakorafas, G.H.1    Tsiotou, A.G.2    Tsiotos, G.G.3
  • 4
    • 0035841631 scopus 로고    scopus 로고
    • Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer. A randomized controlled trial
    • Neoptolemos J.P., Dunn J.A., Stocken D.D., Almond J., Link K., Beger H., et al. Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer. A randomized controlled trial. Lancet 358 (2001) 1576-1585
    • (2001) Lancet , vol.358 , pp. 1576-1585
    • Neoptolemos, J.P.1    Dunn, J.A.2    Stocken, D.D.3    Almond, J.4    Link, K.5    Beger, H.6
  • 5
    • 0037103069 scopus 로고    scopus 로고
    • New applications of gemcitabine and future directions in the management of pancreatic cancer
    • Abbruzzese J.L. New applications of gemcitabine and future directions in the management of pancreatic cancer. Cancer 95 (2002) 941-945
    • (2002) Cancer , vol.95 , pp. 941-945
    • Abbruzzese, J.L.1
  • 6
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • Burris H.A., Moore M.J., Andersen J., Green M.R., Rothenberg M.L., Modiano M.R., et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15 (1997) 2403-2413
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3    Green, M.R.4    Rothenberg, M.L.5    Modiano, M.R.6
  • 7
    • 12144287320 scopus 로고    scopus 로고
    • A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    • Neoptolemos J.P., Stocken D.D., Friess H., Bassi C., Dunn J.A., Hickey H., et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350 (2004) 1200-1210
    • (2004) N Engl J Med , vol.350 , pp. 1200-1210
    • Neoptolemos, J.P.1    Stocken, D.D.2    Friess, H.3    Bassi, C.4    Dunn, J.A.5    Hickey, H.6
  • 8
    • 33846405332 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with gemcitabine vs. observation in patients undergoing curative-intent resection of pancreatic cancer
    • Oettle H., Post S., Neuhaus P., Gellert K., Langrehr J., Ridwelski K., et al. Adjuvant chemotherapy with gemcitabine vs. observation in patients undergoing curative-intent resection of pancreatic cancer. JAMA 297 (2007) 267-277
    • (2007) JAMA , vol.297 , pp. 267-277
    • Oettle, H.1    Post, S.2    Neuhaus, P.3    Gellert, K.4    Langrehr, J.5    Ridwelski, K.6
  • 9
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • Rocha Lima C.M., Green M.R., Rotche R., Miller Jr. W.H., Jeffrey G.M., Cisar L.A., et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol 22 (2004) 3776-3783
    • (2004) J Clin Oncol , vol.22 , pp. 3776-3783
    • Rocha Lima, C.M.1    Green, M.R.2    Rotche, R.3    Miller Jr., W.H.4    Jeffrey, G.M.5    Cisar, L.A.6
  • 10
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial
    • Louvet C., Labianca R., Hammel P., Lledo G., Zampino M.G., André T., et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 23 (2005) 3509-3516
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3    Lledo, G.4    Zampino, M.G.5    André, T.6
  • 12
    • 0033872039 scopus 로고    scopus 로고
    • Genetic progression in the pancreatic ducts
    • Hruban R.H., Wilentz R.E., and Kern S.E. Genetic progression in the pancreatic ducts. Am J Pathol 156 (2000) 1821-1825
    • (2000) Am J Pathol , vol.156 , pp. 1821-1825
    • Hruban, R.H.1    Wilentz, R.E.2    Kern, S.E.3
  • 13
    • 0030932869 scopus 로고    scopus 로고
    • Cancer-susceptibility genes: gate-keepers and caretakers
    • Kinzler K.W., and Vogelstein B. Cancer-susceptibility genes: gate-keepers and caretakers. Nature 386 (1997) 761-763
    • (1997) Nature , vol.386 , pp. 761-763
    • Kinzler, K.W.1    Vogelstein, B.2
  • 14
    • 0344061528 scopus 로고    scopus 로고
    • The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic and metaplastic ductal epithelium
    • Lüttges J., Schlehe B., Menke M.A., Vogel I., Henne-Bruns D., Klöppel G., et al. The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic and metaplastic ductal epithelium. Cancer 85 (1999) 1703-1710
    • (1999) Cancer , vol.85 , pp. 1703-1710
    • Lüttges, J.1    Schlehe, B.2    Menke, M.A.3    Vogel, I.4    Henne-Bruns, D.5    Klöppel, G.6
  • 15
    • 0030050945 scopus 로고    scopus 로고
    • Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
    • Tada M., Ohashi M., Stiratori Y., Okudaira T., Komatsu Y., Kawabe T., et al. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology 110 (1996) 227-231
    • (1996) Gastroenterology , vol.110 , pp. 227-231
    • Tada, M.1    Ohashi, M.2    Stiratori, Y.3    Okudaira, T.4    Komatsu, Y.5    Kawabe, T.6
  • 16
    • 0035893388 scopus 로고    scopus 로고
    • Overexpression of p21WAF/CIP1 is an early event in the development of pancreatic intraepithelial neoplasia
    • Biankin A.V., Kench J.G., Morey A.L., Lee C.S., Biankin S.A., Head D.R., et al. Overexpression of p21WAF/CIP1 is an early event in the development of pancreatic intraepithelial neoplasia. Cancer Res 61 (2001) 8830-8837
    • (2001) Cancer Res , vol.61 , pp. 8830-8837
    • Biankin, A.V.1    Kench, J.G.2    Morey, A.L.3    Lee, C.S.4    Biankin, S.A.5    Head, D.R.6
  • 17
    • 0032532379 scopus 로고    scopus 로고
    • Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression
    • Wilentz R.E., Geradts J., Maynard R., Offerhaus G.J., Kang M., Goggins M., et al. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res 58 (1998) 4740-4744
    • (1998) Cancer Res , vol.58 , pp. 4740-4744
    • Wilentz, R.E.1    Geradts, J.2    Maynard, R.3    Offerhaus, G.J.4    Kang, M.5    Goggins, M.6
  • 18
    • 0030988302 scopus 로고    scopus 로고
    • p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
    • Moskaluk C.A., Hruban R.H., and Kern S.E. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 84 (1997) 2140-2143
    • (1997) Cancer Res , vol.84 , pp. 2140-2143
    • Moskaluk, C.A.1    Hruban, R.H.2    Kern, S.E.3
  • 21
    • 0033871565 scopus 로고    scopus 로고
    • Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma
    • Heinmoller E., Dietmaier W., Zirngibl H., Heinmöller P., Scaringe W., Jauch K.W., et al. Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma. Am J Pathol 157 (2000) 83-92
    • (2000) Am J Pathol , vol.157 , pp. 83-92
    • Heinmoller, E.1    Dietmaier, W.2    Zirngibl, H.3    Heinmöller, P.4    Scaringe, W.5    Jauch, K.W.6
  • 22
    • 0035004797 scopus 로고    scopus 로고
    • Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis
    • Luttges J., Galehdari H., Brocker V., Schwarte-Waldhoff I., Henne-Bruns D., Klöppel G., et al. Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am J Pathol 158 (2001) 1677-1683
    • (2001) Am J Pathol , vol.158 , pp. 1677-1683
    • Luttges, J.1    Galehdari, H.2    Brocker, V.3    Schwarte-Waldhoff, I.4    Henne-Bruns, D.5    Klöppel, G.6
  • 25
    • 0141742113 scopus 로고    scopus 로고
    • Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    • Maitra A., Adsay N.V., Argani P., Iacobuzio-Donahue C., De Marzo A., Cameron J.L., et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol 16 (2003) 902-912
    • (2003) Mod Pathol , vol.16 , pp. 902-912
    • Maitra, A.1    Adsay, N.V.2    Argani, P.3    Iacobuzio-Donahue, C.4    De Marzo, A.5    Cameron, J.L.6
  • 26
    • 0034946542 scopus 로고    scopus 로고
    • Immunohistochemical study of genetic alterations in intraductal and invasive ductal tumors of the pancreas
    • Islam H.K., Fujioka Y., Tomidokoro T., Sugiura H., Takahashi T., Kondo S., et al. Immunohistochemical study of genetic alterations in intraductal and invasive ductal tumors of the pancreas. Hepatogastroenterology 48 (2001) 879-883
    • (2001) Hepatogastroenterology , vol.48 , pp. 879-883
    • Islam, H.K.1    Fujioka, Y.2    Tomidokoro, T.3    Sugiura, H.4    Takahashi, T.5    Kondo, S.6
  • 27
    • 0347478156 scopus 로고    scopus 로고
    • Clinicopathological significance of hypoxia-inducible factor-1a expression in human pancreatic carcinoma
    • Kitada T., Seki S., Sakaguchi H., Sawada T., Hirakawa K., and Wakasa K. Clinicopathological significance of hypoxia-inducible factor-1a expression in human pancreatic carcinoma. Histopathology 43 (2003) 550-555
    • (2003) Histopathology , vol.43 , pp. 550-555
    • Kitada, T.1    Seki, S.2    Sakaguchi, H.3    Sawada, T.4    Hirakawa, K.5    Wakasa, K.6
  • 28
    • 2942615346 scopus 로고    scopus 로고
    • Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer
    • Duffy J.P., Eibl G., Reber H.A., and Hines O.J. Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Mol Cancer 2 (2003) 12
    • (2003) Mol Cancer , vol.2 , pp. 12
    • Duffy, J.P.1    Eibl, G.2    Reber, H.A.3    Hines, O.J.4
  • 29
    • 0000153299 scopus 로고    scopus 로고
    • Tumor cell motility and metastasis autocrine motility factor as an example of ecto/exoenzyme cytokines
    • Silletti S., Paku S., and Raz A. Tumor cell motility and metastasis autocrine motility factor as an example of ecto/exoenzyme cytokines. Pathol Oncol Res 3 (1997) 230-254
    • (1997) Pathol Oncol Res , vol.3 , pp. 230-254
    • Silletti, S.1    Paku, S.2    Raz, A.3
  • 30
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3 (2003) 721-732
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 31
    • 0038068122 scopus 로고    scopus 로고
    • Expression of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival
    • Kuwahara K., Sasaki T., Kuwada Y., Murakami M., Yamasaki S., and Chayama K. Expression of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. Pancreas 26 (2003) 344-349
    • (2003) Pancreas , vol.26 , pp. 344-349
    • Kuwahara, K.1    Sasaki, T.2    Kuwada, Y.3    Murakami, M.4    Yamasaki, S.5    Chayama, K.6
  • 32
    • 0037389803 scopus 로고    scopus 로고
    • Clinical significance of aminopeptide N/CD13 expression in human pancreatic carcinoma
    • Ikeda N., Nakajima Y., Tokuhara T., Hattori N., Sho M., Kanehiro H., et al. Clinical significance of aminopeptide N/CD13 expression in human pancreatic carcinoma. Clin Cancer Res 9 (2003) 1503-1508
    • (2003) Clin Cancer Res , vol.9 , pp. 1503-1508
    • Ikeda, N.1    Nakajima, Y.2    Tokuhara, T.3    Hattori, N.4    Sho, M.5    Kanehiro, H.6
  • 33
    • 2442644244 scopus 로고    scopus 로고
    • Expression of pigment epithelium-derived factor decreases liver metastasis and correlates with favorable prognosis for patients with ductal pancreatic adenocarcinoma
    • Uehara H., Miyamoto M., Kato K., Ebihara Y., Kaneko H., Hashimoto H., et al. Expression of pigment epithelium-derived factor decreases liver metastasis and correlates with favorable prognosis for patients with ductal pancreatic adenocarcinoma. Cancer Res 64 (2004) 3533-3537
    • (2004) Cancer Res , vol.64 , pp. 3533-3537
    • Uehara, H.1    Miyamoto, M.2    Kato, K.3    Ebihara, Y.4    Kaneko, H.5    Hashimoto, H.6
  • 34
    • 0037010091 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted therapy for pancreatic cancer
    • Xiong H.Q., and Abbruzzese J.L. Epidermal growth factor receptor-targeted therapy for pancreatic cancer. Semin Oncol 29 5 Suppl. 14 (2002) 31-37
    • (2002) Semin Oncol , vol.29 , Issue.5 SUPPL. 14 , pp. 31-37
    • Xiong, H.Q.1    Abbruzzese, J.L.2
  • 35
    • 0027293748 scopus 로고
    • Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
    • Yamanaka Y., Friess H., Kobrin M.S., Buchler M., Beger H.G., and Korc M. Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 13 (1993) 565-569
    • (1993) Anticancer Res , vol.13 , pp. 565-569
    • Yamanaka, Y.1    Friess, H.2    Kobrin, M.S.3    Buchler, M.4    Beger, H.G.5    Korc, M.6
  • 36
    • 6044241807 scopus 로고    scopus 로고
    • The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma
    • Ueda S., Ogata S., Tsuda H., Kawarabayashi N., Kimura M., Sugiura Y., et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 29 (2004) e1-e8
    • (2004) Pancreas , vol.29
    • Ueda, S.1    Ogata, S.2    Tsuda, H.3    Kawarabayashi, N.4    Kimura, M.5    Sugiura, Y.6
  • 37
    • 0242522859 scopus 로고    scopus 로고
    • Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas
    • Kim S.G., Wu T.T., Lee J.H., Yun Y.K., Issa J.P., Hamilton S.R., et al. Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas. Mod Pathol 16 (2003) 1086-1094
    • (2003) Mod Pathol , vol.16 , pp. 1086-1094
    • Kim, S.G.1    Wu, T.T.2    Lee, J.H.3    Yun, Y.K.4    Issa, J.P.5    Hamilton, S.R.6
  • 38
    • 0036105502 scopus 로고    scopus 로고
    • Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor β-catenin mutations
    • Abraham S.C., Klimstra D.S., Wilentz R.E., Yeo C.J., Conlon K., Brennan M., et al. Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor β-catenin mutations. Am J Pathol 160 (2002) 1361-1369
    • (2002) Am J Pathol , vol.160 , pp. 1361-1369
    • Abraham, S.C.1    Klimstra, D.S.2    Wilentz, R.E.3    Yeo, C.J.4    Conlon, K.5    Brennan, M.6
  • 39
    • 0033582099 scopus 로고    scopus 로고
    • Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group
    • Porta M., Malats N., Jariod M., Grimalt J.O., Rifà J., Carrato A., et al. Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group. Lancet 354 (1999) 2125-2129
    • (1999) Lancet , vol.354 , pp. 2125-2129
    • Porta, M.1    Malats, N.2    Jariod, M.3    Grimalt, J.O.4    Rifà, J.5    Carrato, A.6
  • 40
    • 0037102434 scopus 로고    scopus 로고
    • A population-based study of the Arg399Gln polymorphism in X-ray repair cross-complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma
    • Duell E.J., Holly E.A., Bracci P.M., Wiencke J.K., and Kelsey K.T. A population-based study of the Arg399Gln polymorphism in X-ray repair cross-complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. Cancer Res 62 (2002) 4630-4636
    • (2002) Cancer Res , vol.62 , pp. 4630-4636
    • Duell, E.J.1    Holly, E.A.2    Bracci, P.M.3    Wiencke, J.K.4    Kelsey, K.T.5
  • 41
    • 23844540043 scopus 로고    scopus 로고
    • Mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in Japanese patients with pancreatitis
    • Kume K., Masamune A., Mizutamari H., Kaneko K., Kikuta K., Satoh M., et al. Mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in Japanese patients with pancreatitis. Pancreatology 5 (2005) 354-360
    • (2005) Pancreatology , vol.5 , pp. 354-360
    • Kume, K.1    Masamune, A.2    Mizutamari, H.3    Kaneko, K.4    Kikuta, K.5    Satoh, M.6
  • 42
    • 22444434462 scopus 로고    scopus 로고
    • Overview of linkage analysis: application to pancreatic cancer
    • Klein A.P. Overview of linkage analysis: application to pancreatic cancer. Methods Mol Med 103 (2005) 329-341
    • (2005) Methods Mol Med , vol.103 , pp. 329-341
    • Klein, A.P.1
  • 43
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers A.F., and Matrisian L.M. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 89 (1997) 1260-1270
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 44
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall S.R., Schulz J., Nemunaitis J., Brown P.D., Baillet M., and Buckels J.A. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 87 (2002) 161-167
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 45
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat Pancreatic Cancer Study Group. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial
    • Bramhall S.R., Rosemurgy A., Brown P.D., Bowry C., and Buckels J.A. Marimastat Pancreatic Cancer Study Group. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J Clin Oncol 19 (2001) 3447-3455
    • (2001) J Clin Oncol , vol.19 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3    Bowry, C.4    Buckels, J.A.5
  • 46
    • 0032710567 scopus 로고    scopus 로고
    • BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity
    • Gatto C., Rieppi M., Borsotti P., Innocenti S., Ceruti R., Drudis T., et al. BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity. Clin Cancer Res 5 (1999) 3603-3607
    • (1999) Clin Cancer Res , vol.5 , pp. 3603-3607
    • Gatto, C.1    Rieppi, M.2    Borsotti, P.3    Innocenti, S.4    Ceruti, R.5    Drudis, T.6
  • 49
    • 0034489694 scopus 로고    scopus 로고
    • A phase I dose escalation study of the matrix metalloproteinase inhibitor BAY 12-9566 administered orally in patients with advanced solid tumours
    • Hirte H., Goel R., Major P., Seymour L., Huan S., Stewart D., et al. A phase I dose escalation study of the matrix metalloproteinase inhibitor BAY 12-9566 administered orally in patients with advanced solid tumours. Ann Oncol 11 (2000) 1579-1584
    • (2000) Ann Oncol , vol.11 , pp. 1579-1584
    • Hirte, H.1    Goel, R.2    Major, P.3    Seymour, L.4    Huan, S.5    Stewart, D.6
  • 50
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore M.J., Hamm J., Dancey J., Eisenberg P.D., Dagenais M., Fields A., et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 21 (2003) 3296-3302
    • (2003) J Clin Oncol , vol.21 , pp. 3296-3302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3    Eisenberg, P.D.4    Dagenais, M.5    Fields, A.6
  • 51
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y., Baba H., Fukuda T., Takashima M., and Sugimachi K. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 88 (2000) 2239-2245
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3    Takashima, M.4    Sugimachi, K.5
  • 52
    • 0036311535 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas
    • Niedergethmann M., Hildenbrand R., Wostbrock B., Hartel M., Sturm J.W., Richter A., et al. High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas. Pancreas 25 (2002) 122-129
    • (2002) Pancreas , vol.25 , pp. 122-129
    • Niedergethmann, M.1    Hildenbrand, R.2    Wostbrock, B.3    Hartel, M.4    Sturm, J.W.5    Richter, A.6
  • 53
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler H.L., Friberg G., Singh D.A., Locker G., Nattam S., Kozloff M., et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 23 31 (2005) 8033-8040
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3    Locker, G.4    Nattam, S.5    Kozloff, M.6
  • 54
    • 0033635935 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer
    • Heinemann V., Wilke H., Mergenthaler H.G., Clemens M., König H., Illiger H.J., et al. Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer. Ann Oncol 11 (2000) 1399-1403
    • (2000) Ann Oncol , vol.11 , pp. 1399-1403
    • Heinemann, V.1    Wilke, H.2    Mergenthaler, H.G.3    Clemens, M.4    König, H.5    Illiger, H.J.6
  • 55
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial
    • Louvet C., Labianca R., Hammel P., Lledo G., Zampino M.G., Andre T., et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 23 (2005) 3509-3516
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3    Lledo, G.4    Zampino, M.G.5    Andre, T.6
  • 56
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., Cartwright T., Hainsworth J., Heim W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 (2004) 2335-2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 57
    • 0034700438 scopus 로고    scopus 로고
    • Prognosis of cancers associated with venous thromboembolism
    • Sorensen H.T., Mellemkjaer L., Olsen J.H., and Baron J.A. Prognosis of cancers associated with venous thromboembolism. N Engl J Med 343 (2000) 1846-1850
    • (2000) N Engl J Med , vol.343 , pp. 1846-1850
    • Sorensen, H.T.1    Mellemkjaer, L.2    Olsen, J.H.3    Baron, J.A.4
  • 58
    • 35548941394 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): a preliminary analysis of Cancer and Leukemia Group B (CALGB)
    • 2007 ASCO Annual Meeting Proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Kindler H.L., Niedzwiecki D., Hollis D., Oraef E., Schrag D., Hurwitz H., et al. A double-blind, placebo-controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): a preliminary analysis of Cancer and Leukemia Group B (CALGB). 2007 ASCO Annual Meeting Proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 4508
    • (2007) J Clin Oncol , pp. 4508
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3    Oraef, E.4    Schrag, D.5    Hurwitz, H.6
  • 59
    • 39149129574 scopus 로고    scopus 로고
    • A randomized phase II and coagulation study of bevacizumab alone or with docetaxel in patients with previously treated metastatic pancreatic adenocarcinoma
    • 2007 ASCO Annual Meeting Proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Astsaturov N.J., Meropol N.J., Alpaugh R.K., Cheng J.D., Lewis N.L., Beard A., et al. A randomized phase II and coagulation study of bevacizumab alone or with docetaxel in patients with previously treated metastatic pancreatic adenocarcinoma. 2007 ASCO Annual Meeting Proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 4556
    • (2007) J Clin Oncol , pp. 4556
    • Astsaturov, N.J.1    Meropol, N.J.2    Alpaugh, R.K.3    Cheng, J.D.4    Lewis, N.L.5    Beard, A.6
  • 60
    • 39149108326 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab, gemcitabine, oxaliplatin in patients with metastatic pancreatic adenocarcinoma
    • 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Kim G.P., Oberg A.L., Foster N.R., Jaslowski A., Flynn P.J., Campbell D., et al. Phase II trial of bevacizumab, gemcitabine, oxaliplatin in patients with metastatic pancreatic adenocarcinoma. 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 4553
    • (2007) J Clin Oncol , pp. 4553
    • Kim, G.P.1    Oberg, A.L.2    Foster, N.R.3    Jaslowski, A.4    Flynn, P.J.5    Campbell, D.6
  • 61
    • 33644974427 scopus 로고    scopus 로고
    • Phase I trial of bevacizumab (BV) with concurrent radiotherapy (RT) and capecitabine (CAP) in locally advanced pancreatic adenocarcinoma (PA)
    • Crane C.H., Ellis M., Abbruzzese J.L., Douglas E.B., Henry H., Ho L., et al. Phase I trial of bevacizumab (BV) with concurrent radiotherapy (RT) and capecitabine (CAP) in locally advanced pancreatic adenocarcinoma (PA). J Clin Oncol 23 Suppl. (2005) 4033
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL , pp. 4033
    • Crane, C.H.1    Ellis, M.2    Abbruzzese, J.L.3    Douglas, E.B.4    Henry, H.5    Ho, L.6
  • 62
    • 54349129045 scopus 로고    scopus 로고
    • A phase II trial of weekly gemcitabine and bevacizumab in combination with abdominal radiation therapy in patients with localized pancreatic cancer
    • 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Small W., Mulcahy M., Benson A., Gold S., Bredesen R., Rademaker F., et al. A phase II trial of weekly gemcitabine and bevacizumab in combination with abdominal radiation therapy in patients with localized pancreatic cancer. 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 15043
    • (2007) J Clin Oncol , pp. 15043
    • Small, W.1    Mulcahy, M.2    Benson, A.3    Gold, S.4    Bredesen, R.5    Rademaker, F.6
  • 63
    • 4043063784 scopus 로고    scopus 로고
    • Effects of rofecoxib on angiogenesis of pancreatic cancer xenograft in nude mice
    • Zhou X.C., Tang C.W., Liu C.L., and Wang C.H. Effects of rofecoxib on angiogenesis of pancreatic cancer xenograft in nude mice. Ai Zheng 23 4 (2004) 376-380
    • (2004) Ai Zheng , vol.23 , Issue.4 , pp. 376-380
    • Zhou, X.C.1    Tang, C.W.2    Liu, C.L.3    Wang, C.H.4
  • 64
    • 0642346111 scopus 로고    scopus 로고
    • Expression and significance of cyclooxygenase-2 in human pancreatic carcinomas
    • Wang H.X., and Chen Q.K. Expression and significance of cyclooxygenase-2 in human pancreatic carcinomas. Ai Zheng 22 6 (2003) 649-652
    • (2003) Ai Zheng , vol.22 , Issue.6 , pp. 649-652
    • Wang, H.X.1    Chen, Q.K.2
  • 65
    • 0042575268 scopus 로고    scopus 로고
    • Initial experience combining cyclooxygenase-2 inhibition with chemoradiation for locally advanced pancreatic cancer
    • Crane H., Mason K., Janjan N.A., and Milas L. Initial experience combining cyclooxygenase-2 inhibition with chemoradiation for locally advanced pancreatic cancer. Am J Clin Oncol 26 4 (2003) S81-S84
    • (2003) Am J Clin Oncol , vol.26 , Issue.4
    • Crane, H.1    Mason, K.2    Janjan, N.A.3    Milas, L.4
  • 66
    • 3042524200 scopus 로고    scopus 로고
    • Pilot study of celecoxib and infusional 5-fluorouracil as second-line treatment for advanced pancreatic carcinoma
    • Milella M., Gelibter A., Di Cosimo S., Bria E., Ruggeri E.M., Carlini P., et al. Pilot study of celecoxib and infusional 5-fluorouracil as second-line treatment for advanced pancreatic carcinoma. Cancer 101 1 (2004) 133-138
    • (2004) Cancer , vol.101 , Issue.1 , pp. 133-138
    • Milella, M.1    Gelibter, A.2    Di Cosimo, S.3    Bria, E.4    Ruggeri, E.M.5    Carlini, P.6
  • 67
    • 33644977480 scopus 로고    scopus 로고
    • A phase II trial of gemcitabine and celecoxib for metastatic pancreatic cancer
    • Xiong H.Q., Hess K.R., Kayaleh O.R., Goodwin W., Banerjee T., Sinclair S.S., et al. A phase II trial of gemcitabine and celecoxib for metastatic pancreatic cancer. J Clin Oncol 23 Suppl. (2005) 4174
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL , pp. 4174
    • Xiong, H.Q.1    Hess, K.R.2    Kayaleh, O.R.3    Goodwin, W.4    Banerjee, T.5    Sinclair, S.S.6
  • 68
    • 27944458919 scopus 로고    scopus 로고
    • Celecoxib and cardiovascular risks
    • Brophy J.M. Celecoxib and cardiovascular risks. Exp Opin Drug Saf 4 (2005) 1005-1015
    • (2005) Exp Opin Drug Saf , vol.4 , pp. 1005-1015
    • Brophy, J.M.1
  • 71
    • 0033199017 scopus 로고    scopus 로고
    • Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by non-steroidal anti-inflammatory drugs
    • Molina M.A., Sitja-Arnau M., Lemoine M.G., Frazier M.L., and Sinicrope F.A. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by non-steroidal anti-inflammatory drugs. Cancer Res 59 17 (1999) 4356-4362
    • (1999) Cancer Res , vol.59 , Issue.17 , pp. 4356-4362
    • Molina, M.A.1    Sitja-Arnau, M.2    Lemoine, M.G.3    Frazier, M.L.4    Sinicrope, F.A.5
  • 72
    • 13444260752 scopus 로고    scopus 로고
    • Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor
    • Eibl G., Takata Y., Boros L.G., Liu J., Okada Y., Reber H.A., et al. Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. Cancer Res 65 3 (2005) 982-990
    • (2005) Cancer Res , vol.65 , Issue.3 , pp. 982-990
    • Eibl, G.1    Takata, Y.2    Boros, L.G.3    Liu, J.4    Okada, Y.5    Reber, H.A.6
  • 73
    • 30344439138 scopus 로고    scopus 로고
    • Simultaneous targeting of epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy
    • Ali S., El-Rayes B.F., Sarkar F.H., and Philip P.A. Simultaneous targeting of epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Mol Cancer Ther 4 12 (2005) 1943-1951
    • (2005) Mol Cancer Ther , vol.4 , Issue.12 , pp. 1943-1951
    • Ali, S.1    El-Rayes, B.F.2    Sarkar, F.H.3    Philip, P.A.4
  • 74
    • 13844256192 scopus 로고    scopus 로고
    • Thalidomide as a novel therapeutic agent: new uses for an old product
    • Teo S.K., Stirling D.I., and Zeldis J.B. Thalidomide as a novel therapeutic agent: new uses for an old product. Drug Discov Today 10 (2005) 107-114
    • (2005) Drug Discov Today , vol.10 , pp. 107-114
    • Teo, S.K.1    Stirling, D.I.2    Zeldis, J.B.3
  • 75
    • 23944495120 scopus 로고    scopus 로고
    • Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma
    • Vacca A., Scavelli C., Montefusco V., Di Pietro G., Neri A., Mattioli M., et al. Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma. J Clin Oncol 23 (2005) 5334-5346
    • (2005) J Clin Oncol , vol.23 , pp. 5334-5346
    • Vacca, A.1    Scavelli, C.2    Montefusco, V.3    Di Pietro, G.4    Neri, A.5    Mattioli, M.6
  • 76
    • 33644978679 scopus 로고    scopus 로고
    • A phase I/II trial of weekly gemcitabine with celecoxib and thalidomide for patients with advanced pancreatic cancer
    • Densmore J.J., Fox J.R., Kannarkat G., Morgan J.K., Petroni G., Blount T., et al. A phase I/II trial of weekly gemcitabine with celecoxib and thalidomide for patients with advanced pancreatic cancer. J Clin Oncol 23 Suppl. (2005) 4241
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL , pp. 4241
    • Densmore, J.J.1    Fox, J.R.2    Kannarkat, G.3    Morgan, J.K.4    Petroni, G.5    Blount, T.6
  • 77
    • 0037992779 scopus 로고    scopus 로고
    • Immunological effects of thalidomide and its chemical and functional analogs
    • Dredge K., Marriott J.B., and Dalgleish A.G. Immunological effects of thalidomide and its chemical and functional analogs. Crit Rev Immunol 22 (2002) 425-437
    • (2002) Crit Rev Immunol , vol.22 , pp. 425-437
    • Dredge, K.1    Marriott, J.B.2    Dalgleish, A.G.3
  • 78
    • 15444379633 scopus 로고    scopus 로고
    • Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial
    • Gordon J.N., Trebble T.M., Ellis R.D., Duncan H.D., Johns T., and Goggin P.M. Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. Gut 54 (2005) 540-545
    • (2005) Gut , vol.54 , pp. 540-545
    • Gordon, J.N.1    Trebble, T.M.2    Ellis, R.D.3    Duncan, H.D.4    Johns, T.5    Goggin, P.M.6
  • 79
    • 0035884231 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
    • Arteaga C.L. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 19 (2001) 32s-40s
    • (2001) J Clin Oncol , vol.19
    • Arteaga, C.L.1
  • 80
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial
    • Xiong H.Q., Rosenberg A., LoBuglio A., Schmidt W., Wolff R.A., Deutsch J., et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J Clin Oncol 22 (2004) 2610-2616
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    LoBuglio, A.3    Schmidt, W.4    Wolff, R.A.5    Deutsch, J.6
  • 81
    • 36549083856 scopus 로고    scopus 로고
    • Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study
    • 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Philip P.A., Benedetti J., Fenoglio-Preiser C., Zalupski M., Lenz H., O'Reilly E., et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study. 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) LBA4509
    • (2007) J Clin Oncol
    • Philip, P.A.1    Benedetti, J.2    Fenoglio-Preiser, C.3    Zalupski, M.4    Lenz, H.5    O'Reilly, E.6
  • 82
    • 53949100602 scopus 로고    scopus 로고
    • The impact of cetuximab on the gemcitabine/cisplatin combination in first-line treatment of EGFR-positive advanced pancreatic cancer (APC): a randomized phase II trial of GISCAD
    • ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Cascinu S., Berardi R., Siena S., La bianca R., Falcone A., Aitini E., et al. The impact of cetuximab on the gemcitabine/cisplatin combination in first-line treatment of EGFR-positive advanced pancreatic cancer (APC): a randomized phase II trial of GISCAD. ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 4544
    • (2007) J Clin Oncol , pp. 4544
    • Cascinu, S.1    Berardi, R.2    Siena, S.3    La bianca, R.4    Falcone, A.5    Aitini, E.6
  • 83
    • 4644335081 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results
    • Baumann M., and Krause M. Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results. Radiother Oncol 72 (2004) 257-266
    • (2004) Radiother Oncol , vol.72 , pp. 257-266
    • Baumann, M.1    Krause, M.2
  • 84
    • 0035868359 scopus 로고    scopus 로고
    • The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells
    • Bowers G., Reardon D., Hewitt T., Dent P., Mikkelsen R.B., Valerie K., et al. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. Oncogene 20 (2001) 1388-1397
    • (2001) Oncogene , vol.20 , pp. 1388-1397
    • Bowers, G.1    Reardon, D.2    Hewitt, T.3    Dent, P.4    Mikkelsen, R.B.5    Valerie, K.6
  • 85
    • 0030772168 scopus 로고    scopus 로고
    • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
    • Schmidt-Ullrich R.K., Mikkelsen R.B., Dent P., Todd D.G., Valerie K., Kavanagh B.D., et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 15 (1997) 1191-1197
    • (1997) Oncogene , vol.15 , pp. 1191-1197
    • Schmidt-Ullrich, R.K.1    Mikkelsen, R.B.2    Dent, P.3    Todd, D.G.4    Valerie, K.5    Kavanagh, B.D.6
  • 86
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • Huang S.M., and Harari P.M. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 6 (2000) 2166-2174
    • (2000) Clin Cancer Res , vol.6 , pp. 2166-2174
    • Huang, S.M.1    Harari, P.M.2
  • 88
    • 36749004365 scopus 로고    scopus 로고
    • Cetuximab in combination with intensity modulated radiotherapy (IMRT) and gemcitabine for patients with locally advanced pancreatic cancer: a prospective phase II trial
    • 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Krempien R., Munter M.W., Timke C., Friess H., Hartung G., Herfarth K.K., et al. Cetuximab in combination with intensity modulated radiotherapy (IMRT) and gemcitabine for patients with locally advanced pancreatic cancer: a prospective phase II trial. 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 4573
    • (2007) J Clin Oncol , pp. 4573
    • Krempien, R.1    Munter, M.W.2    Timke, C.3    Friess, H.4    Hartung, G.5    Herfarth, K.K.6
  • 89
    • 33646504884 scopus 로고    scopus 로고
    • Phase I study of the humanised anti-EGFR monoclonal antibody matuzumab (EMD 72000) combined with gemcitabine in advanced pancreatic cancer
    • Graeven U., Kremer B., Sudhoff T., Killing B., Rojo F., Weber D., et al. Phase I study of the humanised anti-EGFR monoclonal antibody matuzumab (EMD 72000) combined with gemcitabine in advanced pancreatic cancer. Br J Cancer 94 (2006) 1293-1299
    • (2006) Br J Cancer , vol.94 , pp. 1293-1299
    • Graeven, U.1    Kremer, B.2    Sudhoff, T.3    Killing, B.4    Rojo, F.5    Weber, D.6
  • 90
    • 34548787224 scopus 로고    scopus 로고
    • Safety, efficacy and pharmacokinetics of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, as monotherapy in patients with locally advanced or metastatic pancreatic cancer (PC)
    • 2006 ASCO annual meeting proceedings. Part I. Vol. 24, no. 18S (June 20 supplement)
    • Strumberg D., Scheulen M.E., Hilger R.A., Krauss J., Marschner N., Lordick F., et al. Safety, efficacy and pharmacokinetics of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, as monotherapy in patients with locally advanced or metastatic pancreatic cancer (PC). 2006 ASCO annual meeting proceedings. Part I. Vol. 24, no. 18S (June 20 supplement). J Clin Oncol (2006) 12504
    • (2006) J Clin Oncol , pp. 12504
    • Strumberg, D.1    Scheulen, M.E.2    Hilger, R.A.3    Krauss, J.4    Marschner, N.5    Lordick, F.6
  • 91
    • 24144495254 scopus 로고    scopus 로고
    • Recent updates on the role of chemotherapy in pancreatic cancer
    • Burris III H.A. Recent updates on the role of chemotherapy in pancreatic cancer. Semin Oncol 32 4 Suppl. 6 (2005) S1-S3
    • (2005) Semin Oncol , vol.32 , Issue.4 SUPPL. 6
    • Burris III, H.A.1
  • 92
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore M.J., Goldstein D., Hamm J., Figer A., Hecht J.R., Gallinger S., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25 (2007) 1960-1966
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6
  • 93
    • 33144463315 scopus 로고    scopus 로고
    • A phase II study of erlotinib in combination with capecitabine in previously treated patients with metastatic pancreatic cancer
    • 2005 ASCO Annual Meeting Proceedings. Part I. Vol. 23, no. 16S (June 1 supplement)
    • Blaszkowsky L.S., Kulke K.H., Ryan D.P., Clark J.W., Meyerhardt J., Zhu A.X., et al. A phase II study of erlotinib in combination with capecitabine in previously treated patients with metastatic pancreatic cancer. 2005 ASCO Annual Meeting Proceedings. Part I. Vol. 23, no. 16S (June 1 supplement). J Clin Oncol (2005) 4099
    • (2005) J Clin Oncol , pp. 4099
    • Blaszkowsky, L.S.1    Kulke, K.H.2    Ryan, D.P.3    Clark, J.W.4    Meyerhardt, J.5    Zhu, A.X.6
  • 94
    • 40849128424 scopus 로고    scopus 로고
    • A phase I study of erlotinib, bevacizumab and gemcitabine in patients with advanced pancreatic cancer
    • 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Gomez-Martin C., Camara J.C., Cortes H., Jara C., Gravalos C., Rubio B., et al. A phase I study of erlotinib, bevacizumab and gemcitabine in patients with advanced pancreatic cancer. 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 4611
    • (2007) J Clin Oncol , pp. 4611
    • Gomez-Martin, C.1    Camara, J.C.2    Cortes, H.3    Jara, C.4    Gravalos, C.5    Rubio, B.6
  • 95
    • 54349094701 scopus 로고    scopus 로고
    • Phase II study of gefitinib and docetaxel as salvage therapy in patients (pts) with advanced pancreatic adenocarcinoma (APC)
    • 2006 ASCO Annual Meeting Proceedings. Part I. Vol. 24, no. 18S (June 20 supplement)
    • Shadad F., Matin K., Evans T., Volkin R.L., Kiefer G.J., Schlesselman J.J., et al. Phase II study of gefitinib and docetaxel as salvage therapy in patients (pts) with advanced pancreatic adenocarcinoma (APC). 2006 ASCO Annual Meeting Proceedings. Part I. Vol. 24, no. 18S (June 20 supplement). J Clin Oncol (2006) 4120
    • (2006) J Clin Oncol , pp. 4120
    • Shadad, F.1    Matin, K.2    Evans, T.3    Volkin, R.L.4    Kiefer, G.J.5    Schlesselman, J.J.6
  • 96
    • 51749091018 scopus 로고    scopus 로고
    • Gemcitabine (G) combined with gefitinib in patients with inoperable or metastatic pancreatic cancer. A phase II trial
    • ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Fountzilas G., Murray S., Xiros N., Karayannopoulou G., Dafni U., Linardou H., et al. Gemcitabine (G) combined with gefitinib in patients with inoperable or metastatic pancreatic cancer. A phase II trial. ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 15016
    • (2007) J Clin Oncol , pp. 15016
    • Fountzilas, G.1    Murray, S.2    Xiros, N.3    Karayannopoulou, G.4    Dafni, U.5    Linardou, H.6
  • 97
    • 39149143222 scopus 로고    scopus 로고
    • Phase II study of gefitinib and docetaxel for patients (pts) with advanced pancreatic adenocarcinoma (APC) progressing after first-line therapy. Final results
    • 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement)
    • Brell J.M., Matin K., Evans T., Volkin R.L., Keifer G.J., Schlesselman J.J., et al. Phase II study of gefitinib and docetaxel for patients (pts) with advanced pancreatic adenocarcinoma (APC) progressing after first-line therapy. Final results. 2007 ASCO annual meeting proceedings. Part I. Vol. 25, no. 18S (June 20 supplement). J Clin Oncol (2007) 4586
    • (2007) J Clin Oncol , pp. 4586
    • Brell, J.M.1    Matin, K.2    Evans, T.3    Volkin, R.L.4    Keifer, G.J.5    Schlesselman, J.J.6
  • 98
    • 33750903161 scopus 로고    scopus 로고
    • A randomized phase II study of bevacizumab and gemcitabine plus cetuximab or erlotinib in patients with advanced pancreatic cancer: a preliminary analysis
    • 2006 ASCO Annual Meeting Proceedings. Part I. Vol. 24, no. 18S (June 20 supplement)
    • Kindler H., Bylow K.A., Hochster H., Friberg G., Micetich H., Locker G., et al. A randomized phase II study of bevacizumab and gemcitabine plus cetuximab or erlotinib in patients with advanced pancreatic cancer: a preliminary analysis. 2006 ASCO Annual Meeting Proceedings. Part I. Vol. 24, no. 18S (June 20 supplement). J Clin Oncol (2006) 4040
    • (2006) J Clin Oncol , pp. 4040
    • Kindler, H.1    Bylow, K.A.2    Hochster, H.3    Friberg, G.4    Micetich, H.5    Locker, G.6
  • 99
    • 29044433659 scopus 로고    scopus 로고
    • Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a phase I study
    • Iannitti D., Dipetrillo T., Akerman P., Barnett J.M., Maia-Acuna C., Cruff D., et al. Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a phase I study. Am J Clin Oncol 28 (2005) 570-575
    • (2005) Am J Clin Oncol , vol.28 , pp. 570-575
    • Iannitti, D.1    Dipetrillo, T.2    Akerman, P.3    Barnett, J.M.4    Maia-Acuna, C.5    Cruff, D.6
  • 100
    • 0035132538 scopus 로고    scopus 로고
    • Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
    • End D.W., Smets G., Todd A.V., Applegate T.L., Fuery C.J., Angibaud P., et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res 61 (2001) 131-137
    • (2001) Cancer Res , vol.61 , pp. 131-137
    • End, D.W.1    Smets, G.2    Todd, A.V.3    Applegate, T.L.4    Fuery, C.J.5    Angibaud, P.6
  • 101
    • 0035893740 scopus 로고    scopus 로고
    • Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models
    • Lobell R.B., Omer C.A., Abrams M.T., Bhimnathwala H.G., Brucker M.J., Buser C.A., et al. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Res 61 (2001) 8758-8768
    • (2001) Cancer Res , vol.61 , pp. 8758-8768
    • Lobell, R.B.1    Omer, C.A.2    Abrams, M.T.3    Bhimnathwala, H.G.4    Brucker, M.J.5    Buser, C.A.6
  • 102
    • 0001120709 scopus 로고    scopus 로고
    • A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest Oncology Group (SWOG) study
    • Macdonald J.S., Chansky K., Whitehead R., Wade J., Giguere J., Abbruzzese J.L., et al. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest Oncology Group (SWOG) study. J Clin Oncol 21 (2003) 1301-1306
    • (2003) J Clin Oncol , vol.21 , pp. 1301-1306
    • Macdonald, J.S.1    Chansky, K.2    Whitehead, R.3    Wade, J.4    Giguere, J.5    Abbruzzese, J.L.6
  • 104
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E., van de Velde H., Karasek P., Oettle H., Vervenne V.V.L., Szawlowski A., et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 22 (2004) 1430-1438
    • (2004) J Clin Oncol , vol.22 , pp. 1430-1438
    • Van Cutsem, E.1    van de Velde, H.2    Karasek, P.3    Oettle, H.4    Vervenne, V.V.L.5    Szawlowski, A.6
  • 105
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D.J., Clark G.M., Wong S.G., Levin W.J., Ullrich A., and McGuire W.L. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235 (1987) 177-182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 108
  • 109


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