Targeting the epidermal growth factor receptor in radiotherapy: Radiobiological mechanisms, preclinical and clinical results

Radiotherapy and Oncology

Volumn 72, Issue 3, 2004, Pages 257-266

  Baumann, Michael ^a   Krause, Mechthild ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

BIBX1382BS; Cetuximab; EGFR; Gefitinib; Local tumour control; Molecular targeting; Radiotherapy; Randomised clinical trial; Translational research; Tumour growth delay; Tumour response

Indexed keywords

ANTINEOPLASTIC AGENT; BIBX 1382 BS; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; GEFITINIB; UNCLASSIFIED DRUG;

CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER SURVIVAL; CELL HETEROGENEITY; CLINICAL TRIAL; COLORECTAL CANCER; CONFERENCE PAPER; CORRELATION ANALYSIS; HEAD AND NECK CANCER; HUMAN; LABORATORY; LUNG NON SMALL CELL CANCER; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; SKIN MANIFESTATION; TUMOR GROWTH; UTERINE CERVIX CARCINOMA;

COMBINED MODALITY THERAPY; HUMANS; NEOPLASMS; RADIOTHERAPY; RANDOMIZED CONTROLLED TRIALS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 4644335081     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.07.007     Document Type: Conference Paper

References (74)

1. F.G. Barker, M.L. Simmons, and S.M. Chang EGFR overexpression and radiation response in glioblastoma multiforme Int J Radiat Oncol Biol Phys 51 2001 410 418
2. T. Akimoto, N.R. Hunter, and L. Buchmiller Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas Clin Cancer Res 5 1999 2884 2890
3. M.K. Gibson, S.C. Abraham, and T.T. Wu Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy Clin Cancer Res 9 2003 6461 6468
4. R.K. Schmidt-Ullrich, K. Valerie, P.B. Fogleman, and J. Walters Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells Radiat Res 145 1996 81 85
5. R.S. Herbst Review of epidermal growth factor receptor biology Int J Radiat Oncol Biol Phys 59 2004 21 26
6. J. Mendelsohn, and J. Baselga The EGF receptor family as targets for cancer therapy Oncogene 19 2000 6550 6565
7. M.D. Marmor, K.B. Skaria, and Y. Yarden Signal transduction and oncogenesis by ErbB/HER receptors Int J Radiat Oncol Biol Phys 58 2004 903 913
8. S.Y. Lin, K. Makino, and W. Xia Nuclear localization of EGF receptor and its potential new role as a transcription factor Nat Cell Biol 3 2001 802 808
9. M.G. Waugh, and J.J. Hsuan EGF receptors as transcription factors: ridiculous or sublime? Nat Cell Biol 3 2001 E209 E211
10. M.P. Oksvold, H.S. Huitfeldt, E. Stang, and I. Madshus Localizing the EGF receptor Nat Cell Biol 4 2002 22
11. S.M. Thomas, and J.R. Grandis Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation Cancer Treat Rev 30 2004 255 268
12. G. Lammering, P.S. Lin, and J.N. Contessa Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells Int J Radiat Oncol Biol Phys 51 2001 775 784
13. M.R. Pillai, P.G. Jayaprakash, and M.K. Nair Tumour-proliferative fraction and growth factor expression as markers of tumour response to radiotherapy in cancer of the uterine cervix J Cancer Res Clin Oncol 124 1998 456 461
14. K. Ang, B.A. Berkey, and X. Tu Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma Cancer Res 62 2002 7350 7356
15. D.T. Chua, J.M. Nicholls, J.S. Sham, and G.K. Au Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy Int J Radiat Oncol Biol Phys 59 2004 11 20
16. J.G. Eriksen, T. Steiniche, and J. Askaa The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck Int J Radiat Oncol Biol Phys 58 2004 561 566
17. B.M. Atasoy, S.M. Bentzen, and K.R. Trott The epidermal growth factor receptor is involved in accelerated repopulation in squamous cell carcinoma of the head and neck Exp Strahlenther Klin Strahlenbiol 13 2004 39 41
18. M. Baumann, W. Dubois, and H.D. Suit Response of human squamous cell carcinoma xenografts of different sizes to irradiation: relationship of clonogenic cells, cellular radiation sensitivity in vivo, and tumor rescuing units Radiat Res 123 1990 325 330
19. C. Petersen, W. Eicheler, and A. Frömmel Proliferation and micromilieu during fractionated irradiation of human FaDu squamous cell carcinoma in nude mice Int J Radiat Biol 79 2003 469 477
20. M. Baumann, M. Krause, and D. Zips Molecular targeting in radiotherapy of lung cancer Lung Cancer 2004 in press
21. H.R. Withers The four R's of radiotherapy J.T. Lett H. Adler Advances in radiation biology 1975 Academic New York 241 247
22. G.G. Steel Basic clinical radiobiology 3rd ed 2002 Arnold London
23. G.G. Steel Cell survival as a determinant of tumour response G.G. Steel Basic clinical radiobiology 3rd ed 2002 Arnold London 52 63
24. M. Krause, M. Baumann, and H.D. Thames In regard to Solomon et al. EGFR blockade with ZD1839 ('Iressa') potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma Int J Radiat Oncol Biol Phys 57 2003 300 301
25. M. Krause, M.C. Joiner, and M. Baumann Ultrafractionation in human malignant glioma xenografts Int J Cancer 107 2003 333
26. R.F. Kallman Rodent tumor models in experimental cancer therapy 1987 Pergamon New York
27. M. Baumann, M. Krause, and D. Zips Selective inhibition of the epidermal growth factor tyrosine kinase by BIBX1382BS improves growth delay but not local control after fractionated irradiation in human FaDu squamous cell carcinoma in nude mice Int J Radiat Biol 79 2003 547 559
28. M. Krause, F. Hilberg, and D. Zips Inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS as adjuvant treatment after fractionated radiotherapy in FaDu human squamous cell carcinoma in nude mice Radiother Oncol 72 2004 95 101
29. M. Krause, C. Schütze, and G. Ostermann Combination of fractionated irradiation and C225 anti-EGFR antibody Radiother Oncol 2004 in press
30. S. Nasu, K.K. Ang, Z. Fan, and L. Milas C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability Int J Radiat Oncol Biol Phys 51 2001 474 477
31. M.M. Wrann, and C.F. Fox Identification of epidermal growth factor receptors in a hyperproducing human epidermoid carcinoma cell line J Biol Chem 254 1979 8083 8086
32. B. Solomon, J. Hagekyriakou, and M.K. Trivett EGFR blockade with ZD1839 ('Iressa') potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma Int J Radiat Oncol Biol Phys 55 2003 713 723
33. M.N. Saleh, K.P. Raisch, and M.A. Stackhouse Combined modality therapy of A431 human epidermoid cancer using anti- EGFr antibody C225 and radiation Cancer Biother Radiopharm 14 1999 451 463
34. S.M. Huang, J.M. Bock, and P.M. Harari Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck Cancer Res 59 1999 1935 1940
35. S. Shintani, C. Li, and M. Mihara Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer Int J Cancer 107 2003 1030 1037
36. S.M. Huang, J. Li, E.A. Armstrong, and P.M. Harari Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa) Cancer Res 62 2002 4300 4306
37. M. Toulany, K. Dittmann, M. Baumann, and H.P. Rodemann Inhibition of AKT/ protein kinase b but not mitogen activated protein kinase/ ERK modulates radiation response by EGFR antagonist Radiother Oncol 67 2003 S20
38. J.G. Paez, P.A. Janne, and J.C. Lee EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 2004 1497 1500
39. T.J. Lynch, D.W. Bell, and R. Sordella Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2004 2129 2139
40. S.M. Huang, and P.M. Harari Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis Clin Cancer Res 6 2000 2166 2174
41. A.B. Schreiber, I. Lax, and Y. Yarden Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor Proc Natl Acad Sci USA 78 1981 7535 7539
42. H. Modjtahedi, K. Affleck, C. Stubberfield, and C. Dean EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5 Int J Oncol 13 1998 335 342
43. H. Masui, T. Kawamoto, and J.D. Sato Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies Cancer Res 44 1984 1002 1007
44. C. Bianco, G. Tortora, and R. Bianco Enhancement of antitumor activity of ionizing radiation by combined treatment with selective epidermal growth factor receptor - tyrosine kinase inhibitor ZD1839 (Iressa) Clin Cancer Res 8 2002 3250 3258
45. L. Milas, K. Mason, and N. Hunter In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody Clin Cancer Res 6 2000 701 708
46. Y. She, F. Lee, and J. Chen The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index Clin Cancer Res 9 2003 3773 3778
47. X.D. Yang, X.C. Jia, and J.R. Corvalan Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy Cancer Res 59 1999 1236 1243
48. K.J. Williams, B.A. Telfer, I.J. Stratford, and S.R. Wedge ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor- tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model Br J Cancer 86 2002 1157 1161
49. F.M. Sirotnak, M.F. Zakowski, and V.A. Miller Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase Clin Cancer Res 6 2000 4885 4892
50. M. Prewett, M. Rothman, and H. Waksal Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice Clin Cancer Res 4 1998 2957 2966
51. J.P. Overholser, M.C. Prewett, and A.T. Hooper Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice Cancer 89 2000 74 82
52. M.C. Gutowski, S.L. Briggs, and D.A. Johnson Epidermal growth factor receptor-reactive monoclonal antibodies: xenograft antitumor activity alone and as drug immunoconjugates Cancer Res 51 1991 5471 5475
53. C. Bianco, R. Bianco, and G. Tortora Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide Clin Cancer Res 6 2000 4343 4350
54. E. Aboud-Pirak, E. Hurwitz, and M.E. Pirak Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice J Nat Cancer Inst 80 1988 605 611
55. D.J. Buchsbaum, J.A. Bonner, and W.E. Grizzle Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation Int J Radiat Oncol Biol Phys 54 2002 1180 1193
56. M. Baumann, C. Petersen, and W. Eicheler Mechanisms of repopulation in experimental squamous cell carcinoma H.D. Kogelnik P. Lukas F. Sedlmayer Progress in radiation-oncology vol. 7 2002 Monduzzi Bologna 417 422
57. R.K. Schmidt-Ullrich, R.B. Mikkelsen, and P. Dent Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation Oncogene 15 1997 1191 1197
58. C. Petersen, D. Zips, and M. Krause Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation Int J Radiat Oncol Biol Phys 51 2001 483 493
59. F. Hessel, C. Petersen, and D. Zips Impact of increased cell loss on the repopulation rate during fractionated irradiation in human FaDu squamous cell carcinoma growing in nude mice Int J Radiat Biol 79 2003 479 486
60. D. Zips, and M. Baumann Anti-VEGF strategies in combination with radiotherapy C. Nieder L. Milas K. Ang Modification of radiation response 2003 Springer Berlin 179 188
61. C.J. Langer Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC Int J Radiat Oncol Biol Phys 58 2004 991 1002
62. D. Raben, C. Bianco, L. Milas, and K.K. Ang Targeted therapies and radiation for the treatment of head and neck cancer: are we making progress? Semin Radiat Oncol 14 2004 139 152
63. M. Kukuoka, S. Yano, and G. Giaccone Final results from a phase II trial of ZD1839 ('Iressa') for patients with advanced non-small-cell lung cancer (IDEAL 1) Proc Am Soc Clin Oncol 21 2002 abstract 292a
64. D.H. Johnson Gefitinib (Iressa) trials in non-small cell lung cancer Lung Cancer 41 2003 S23 S28
65. G. Giaccone, R.S. Herbst, and C. Manegold Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1 J Clin Oncol 22 2004 777 784
66. R.S. Herbst, G. Giaccone, and J.H. Schiller Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2 J Clin Oncol 22 2004 785 794
67. D.H. Johnson, and C.L. Arteaga Gefitinib in recurrent non-small-cell lung cancer: an IDEAL trial? J Clin Oncol 21 2003 2227 2229
68. J. Baselga Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer: how do we go from INTACT to impact? J Clin Oncol 22 2004 759 761
69. L.R. Bailey, M. Janas, and K. Schmidt Evaluation of epidermal growth factor receptor (EGFR) as a predictive marker in patients with non-small-cell lung cancer (NSCLC) receiving first-line gefitinib combined with platinum-based chemotherapy Proc Am Soc Clin Oncol 2004 abstract 7013
70. M. Janas, L.R. Bailey, and K. Schmidt Evaluation of epidermal growth factor receptor (EGFR) as a prognostic factor for survival in non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy as first-line treatment Proc Am Soc Clin Oncol,: abstract 2004 abstract 7024
71. P.A. Bunn Jr, F.A. Shepherd, and A. Sandler Ongoing and future trials of biologic therapies in lung cancer Lung Cancer 41 2003 S175 S186
72. E.E. Vokes, and H. Choy Targeted therapies for stage III non-small cell lung cancer: integration in the combined modality setting Lung Cancer 41 2003 S115 S121
73. F. Robert, M.P. Ezekiel, and S.A. Spencer Phase I study of anti-epidermal growth facto receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer J Clin Oncol 19 2001 3234 3243
74. J.A. Bonner, P.M. Harari, and J.L. Giralt Cetuximab (Erbitux TM) prolongs survival in patients with locally advanced squamous cell carcinoma of the head and neck: a phase III study of high dose radiation therapy with and without cetuximab Proc Am Soc Clin Oncol 2004 abstract 5507