메뉴 건너뛰기




Volumn 22, Issue 5-6, 2002, Pages 425-437

Immunological effects of thalidomide and its chemical and functional analogs

Author keywords

Analogs; Costimulation; Cytokine; Immunomodulatory; Thalidomide; Tumor

Indexed keywords

3 (4 AMINO 1,3 DIHYDRO 1,3 DIOXO 2H ISOINDOL 2 YL)GLUTARIMIDE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CDC 801; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 5; LENALIDOMIDE; PHOSPHODIESTERASE IV; THALIDOMIDE; THALIDOMIDE DERIVATIVE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 0037992779     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (54)

References (82)
  • 1
    • 72949126604 scopus 로고
    • Neuropathy after intake of thalidomide
    • Fullerton PM, Kremer M. Neuropathy after intake of thalidomide. Br Med J 1961; 2:855-858.
    • (1961) Br Med J , vol.2 , pp. 855-858
    • Fullerton, P.M.1    Kremer, M.2
  • 2
    • 47349113508 scopus 로고
    • Thalidomide and congenital abnormalities
    • McBride WG. Thalidomide and congenital abnormalities. Lancet 1961; 2:1358.
    • (1961) Lancet , vol.2 , pp. 1358
    • McBride, W.G.1
  • 3
    • 0013805310 scopus 로고
    • Further observation with thalidomide in lepra reactions
    • Sheskin J. Further observation with thalidomide in lepra reactions. Lepr Rev 1965; 36:183-187.
    • (1965) Lepr Rev , vol.36 , pp. 183-187
    • Sheskin, J.1
  • 5
    • 0027304271 scopus 로고
    • The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum
    • Sampaio EP, Kaplan G, Miranda A, Nery JA, Miguel CP, Viana SM, Sarno EN. The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum. J Infect Dis 1993; 168:408-414.
    • (1993) J Infect Dis , vol.168 , pp. 408-414
    • Sampaio, E.P.1    Kaplan, G.2    Miranda, A.3    Nery, J.A.4    Miguel, C.P.5    Viana, S.M.6    Sarno, E.N.7
  • 6
    • 0033485968 scopus 로고    scopus 로고
    • Thalidomide as an emerging immunotherapeutic agent
    • Marriott JB, Muller G, Dalgleish AG. Thalidomide as an emerging immunotherapeutic agent. Immunol Today 1999; 583:538-540.
    • (1999) Immunol Today , vol.583 , pp. 538-540
    • Marriott, J.B.1    Muller, G.2    Dalgleish, A.G.3
  • 7
    • 0032708238 scopus 로고    scopus 로고
    • Thalidomide - A revival story
    • Raje N, Anderson K. Thalidomide-a revival story. N Engl J Med 1999; 341:1606-1609.
    • (1999) N Engl J Med , vol.341 , pp. 1606-1609
    • Raje, N.1    Anderson, K.2
  • 8
    • 0032895650 scopus 로고    scopus 로고
    • Thalidomide on the comeback trail
    • Hales B. Thalidomide on the comeback trail. Nat Med 1999; 5:489-490.
    • (1999) Nat Med , vol.5 , pp. 489-490
    • Hales, B.1
  • 9
    • 0032922147 scopus 로고    scopus 로고
    • S.T.E.P.S: A comprehensive program for controlling and monitoring access to thalidomide
    • Zeldis JB, Williams BA, Thomas SD, Elsayed ME. S.T.E.P.S: a comprehensive program for controlling and monitoring access to thalidomide. Clin Ther 1999; 21:319-330.
    • (1999) Clin Ther , vol.21 , pp. 319-330
    • Zeldis, J.B.1    Williams, B.A.2    Thomas, S.D.3    Elsayed, M.E.4
  • 11
    • 0035557940 scopus 로고    scopus 로고
    • Thalidomide in the treatment of multiple myeloma
    • Rajikumar SV. Thalidomide in the treatment of multiple myeloma. Expert Rev Anticancer Ther 2002; 1:20-28.
    • (2002) Expert Rev Anticancer Ther , vol.1 , pp. 20-28
    • Rajikumar, S.V.1
  • 15
    • 0034444007 scopus 로고    scopus 로고
    • Durable clinical response of refractory hepatocellular carcinoma to orally administered thalidomide
    • Patt YZ, Hassan MM, Lozano RD, Ellis LM, Peterson JA, Waugh KA. Durable clinical response of refractory hepatocellular carcinoma to orally administered thalidomide. Am J Clin Oncol 2000; 23:319-321.
    • (2000) Am J Clin Oncol , vol.23 , pp. 319-321
    • Patt, Y.Z.1    Hassan, M.M.2    Lozano, R.D.3    Ellis, L.M.4    Peterson, J.A.5    Waugh, K.A.6
  • 16
    • 0033772376 scopus 로고    scopus 로고
    • Thalidomide therapy in refractory solid tumor patients
    • Gutheil J, Finucane D. Thalidomide therapy in refractory solid tumor patients. Br J Haematol 2000; 110:754.
    • (2000) Br J Haematol , vol.110 , pp. 754
    • Gutheil, J.1    Finucane, D.2
  • 18
    • 0036036662 scopus 로고    scopus 로고
    • Recent advances in the treatment of AIDS-related Kaposi's sarcoma
    • Cattelan AM, Trevenzoli M, Aversa SM. Recent advances in the treatment of AIDS-related Kaposi's sarcoma. Am J Clin Dermatol 2002; 3(7):451-462.
    • (2002) Am J Clin Dermatol , vol.3 , Issue.7 , pp. 451-462
    • Cattelan, A.M.1    Trevenzoli, M.2    Aversa, S.M.3
  • 19
    • 0036708877 scopus 로고    scopus 로고
    • Thalidomide: Focus on its employment in rheumatologic diseases
    • Ossandon A, Cassara EA, Priori R, Valesini G. Thalidomide: focus on its employment in rheumatologic diseases. Clin Exp Rheumatol 2002; 20(5):709-718.
    • (2002) Clin Exp Rheumatol , vol.20 , Issue.5 , pp. 709-718
    • Ossandon, A.1    Cassara, E.A.2    Priori, R.3    Valesini, G.4
  • 20
    • 0036943402 scopus 로고    scopus 로고
    • Thalidomide therapy of cutaneous lupus erythematosus
    • Bohmeyer J, Achenbach A, Westenberger M, Stadler R. Thalidomide therapy of cutaneous lupus erythematosus. Hautarzt 2002; 53(11):744-748.
    • (2002) Hautarzt , vol.53 , Issue.11 , pp. 744-748
    • Bohmeyer, J.1    Achenbach, A.2    Westenberger, M.3    Stadler, R.4
  • 22
    • 0036634077 scopus 로고    scopus 로고
    • Thalidomide and tuberculosis
    • Fu LM, Fu-Liu CS. Thalidomide and tuberculosis. Int J Tuberc Lung Dis 2002; 6(7):569-572.
    • (2002) Int J Tuberc Lung Dis , vol.6 , Issue.7 , pp. 569-572
    • Fu, L.M.1    Fu-Liu, C.S.2
  • 24
    • 0029073894 scopus 로고
    • Thalidomide: Rationale for renewed use in immunological disorders
    • Schuler U, Ehninger G. Thalidomide: rationale for renewed use in immunological disorders. Drug Safety 1995; 12:364-369.
    • (1995) Drug Safety , vol.12 , pp. 364-369
    • Schuler, U.1    Ehninger, G.2
  • 25
    • 0026080801 scopus 로고
    • Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes
    • Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G. Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J Exp Med 1991; 173:699-703.
    • (1991) J Exp Med , vol.173 , pp. 699-703
    • Sampaio, E.P.1    Sarno, E.N.2    Galilly, R.3    Cohn, Z.A.4    Kaplan, G.5
  • 26
    • 0030798465 scopus 로고    scopus 로고
    • The therapeutic potential of TNF-α inhibitors old and new
    • Marriott JB, Westby M, Dalgleish AG. The therapeutic potential of TNF-α inhibitors old and new. Drug Discov Today 1997; 2:273-282.
    • (1997) Drug Discov Today , vol.2 , pp. 273-282
    • Marriott, J.B.1    Westby, M.2    Dalgleish, A.G.3
  • 27
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-κB activity by thalidomide through suppression of IκB activity
    • Keifer JA, Guttridge DC, Ashburner BP, Baldwin AS. Inhibition of NF-κB activity by thalidomide through suppression of IκB activity. J Biol Chem 2001; 276(25):22382-22387.
    • (2001) J Biol Chem , vol.276 , Issue.25 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3    Baldwin, A.S.4
  • 28
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappa B: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ, Karin M. Nuclear factor-kappa B: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336(15):1066-1071.
    • (1997) N Engl J Med , vol.336 , Issue.15 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 29
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998; 281(5383):1680-1683.
    • (1998) Science , vol.281 , Issue.5383 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin, A.S.5
  • 30
    • 0032588186 scopus 로고    scopus 로고
    • NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 1999; 19(8):5785-5799.
    • (1999) Mol Cell Biol , vol.19 , Issue.8 , pp. 5785-5799
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin, A.S.5
  • 31
    • 0034719680 scopus 로고    scopus 로고
    • The transcriptional factor NF-kappaB: Control of oncogenesis and cancer therapy resistance
    • Mayo MW, Baldwin AS. The transcriptional factor NF-kappaB: control of oncogenesis and cancer therapy resistance. Biochim Biophys Acta 2000; 1470(2): M55-62.
    • (2000) Biochim Biophys Acta , vol.1470 , Issue.2
    • Mayo, M.W.1    Baldwin, A.S.2
  • 33
    • 0033984493 scopus 로고    scopus 로고
    • The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease
    • O'Byrne KJ, Dalgleish AG, Browning MJ, Stewart WP, Harris AL. The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease. Eur J Cancer 2000; 36:151-169.
    • (2000) Eur J Cancer , vol.36 , pp. 151-169
    • O'Byrne, K.J.1    Dalgleish, A.G.2    Browning, M.J.3    Stewart, W.P.4    Harris, A.L.5
  • 34
    • 0040887215 scopus 로고    scopus 로고
    • Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
    • Ruegg C, Yilmaz A, Bieler G, Bamat J, Chaubert P, Lejeune FJ. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma. Nat Med 1998; 4:408-414.
    • (1998) Nat Med , vol.4 , pp. 408-414
    • Ruegg, C.1    Yilmaz, A.2    Bieler, G.3    Bamat, J.4    Chaubert, P.5    Lejeune, F.J.6
  • 35
    • 0028928143 scopus 로고
    • The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures
    • McHugh SM, Rifkin IR, Deighton J, Wilson AB, Lacmann PJ, Lockwood CM, Ewan PW. The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures. Clin Exp Immunol 1995; 99:160-167.
    • (1995) Clin Exp Immunol , vol.99 , pp. 160-167
    • McHugh, S.M.1    Rifkin, I.R.2    Deighton, J.3    Wilson, A.B.4    Lacmann, P.J.5    Lockwood, C.M.6    Ewan, P.W.7
  • 37
    • 0032100486 scopus 로고    scopus 로고
    • Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset
    • Haslett PA, Corral LG, Albert M, Kaplan G. Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset. J Exp Med 1998; 187:1885-1892.
    • (1998) J Exp Med , vol.187 , pp. 1885-1892
    • Haslett, P.A.1    Corral, L.G.2    Albert, M.3    Kaplan, G.4
  • 42
    • 0037103198 scopus 로고    scopus 로고
    • Efficacy of a low dose of thalidomide in advanced multiple myeloma
    • Leleu X, Magro L, Fawaz A, Bauters F, Facon T, Yakoub-Agha I. Efficacy of a low dose of thalidomide in advanced multiple myeloma. Blood 2002; 100(4):1519-1520.
    • (2002) Blood , vol.100 , Issue.4 , pp. 1519-1520
    • Leleu, X.1    Magro, L.2    Fawaz, A.3    Bauters, F.4    Facon, T.5    Yakoub-Agha, I.6
  • 43
  • 44
    • 0035990841 scopus 로고    scopus 로고
    • Consolidation therapy of multiple myeloma with thalidomide-dexamethasone after intensive chemotherapy
    • Alexanian R, Weber D, Giralt S, Delasalle K. Consolidation therapy of multiple myeloma with thalidomide-dexamethasone after intensive chemotherapy. Ann Oncol 2002; 13(7):1116-1119.
    • (2002) Ann Oncol , vol.13 , Issue.7 , pp. 1116-1119
    • Alexanian, R.1    Weber, D.2    Giralt, S.3    Delasalle, K.4
  • 47
    • 0037105593 scopus 로고    scopus 로고
    • Polymorphisms of the tumor necrosis factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma
    • Neben K, Mytilineos J, Moehler TM, Preiss A, Kraemer A, Ho AD, Opelz G, Goldschmidt H. Polymorphisms of the tumor necrosis factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma. Blood 2002; 100(6):2263-2265.
    • (2002) Blood , vol.100 , Issue.6 , pp. 2263-2265
    • Neben, K.1    Mytilineos, J.2    Moehler, T.M.3    Preiss, A.4    Kraemer, A.5    Ho, A.D.6    Opelz, G.7    Goldschmidt, H.8
  • 48
    • 0035672117 scopus 로고    scopus 로고
    • Response to thalidomide in progressive multiple myeloma is not mediated by inhibition of angiogenic cytokine secretion
    • Neben K, Moehler T, Kraemer A, Benner A, Egerer G, Ho AD, Goldschmidt H. Response to thalidomide in progressive multiple myeloma is not mediated by inhibition of angiogenic cytokine secretion. Br J Haematol 2001; 115:605-608.
    • (2001) Br J Haematol , vol.115 , pp. 605-608
    • Neben, K.1    Moehler, T.2    Kraemer, A.3    Benner, A.4    Egerer, G.5    Ho, A.D.6    Goldschmidt, H.7
  • 56
  • 57
    • 0029784855 scopus 로고    scopus 로고
    • Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity
    • Muller GW, Corral LG, Shire MG, Wang H, Moreira A, Kaplan G, Stirling DI. Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity. J Med Chem 1996; 39:3238-3240.
    • (1996) J Med Chem , vol.39 , pp. 3238-3240
    • Muller, G.W.1    Corral, L.G.2    Shire, M.G.3    Wang, H.4    Moreira, A.5    Kaplan, G.6    Stirling, D.I.7
  • 58
    • 0029742896 scopus 로고    scopus 로고
    • Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity
    • Corral LG, Muller GW, Moreira AL, Chen Y, Wu M, Stirling DI, Kaplan G. Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity. Mol Med 1996; 2:506-515.
    • (1996) Mol Med , vol.2 , pp. 506-515
    • Corral, L.G.1    Muller, G.W.2    Moreira, A.L.3    Chen, Y.4    Wu, M.5    Stirling, D.I.6    Kaplan, G.7
  • 61
    • 0033168605 scopus 로고    scopus 로고
    • Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogs that are potent inhibitors of TNF-α
    • Corral LG, Haslett PA, Muller GW, Chen R, Wong LM, Ocampo CJ, Patterson RT, Stirling DI, Kaplan G. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogs that are potent inhibitors of TNF-α. J Immunol 1999; 163:380-386.
    • (1999) J Immunol , vol.163 , pp. 380-386
    • Corral, L.G.1    Haslett, P.A.2    Muller, G.W.3    Chen, R.4    Wong, L.M.5    Ocampo, C.J.6    Patterson, R.T.7    Stirling, D.I.8    Kaplan, G.9
  • 62
    • 0037308584 scopus 로고    scopus 로고
    • A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase dependent apoptosis is associated with altered expression of bcl-2 family proteins
    • Marriott JB, Clarke IA, Czajka A, Dredge K, Childs K, Man HW, Schafer P, Govinda S, Muller GW, Stirling D, Dalgleish AG. A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase dependent apoptosis is associated with altered expression of bcl-2 family proteins. Cancer Res 2003; 63(3):593-599.
    • (2003) Cancer Res , vol.63 , Issue.3 , pp. 593-599
    • Marriott, J.B.1    Clarke, I.A.2    Czajka, A.3    Dredge, K.4    Childs, K.5    Man, H.W.6    Schafer, P.7    Govinda, S.8    Muller, G.W.9    Stirling, D.10    Dalgleish, A.G.11
  • 63
    • 0031921590 scopus 로고    scopus 로고
    • The effect of thalidomide and 2 analogs on collagen induced arthritis
    • Oliver SJ, Cheng TP, Banquerigo ML, Brahn E. The effect of thalidomide and 2 analogs on collagen induced arthritis. J Rheumatol 1998; 25:964-969.
    • (1998) J Rheumatol , vol.25 , pp. 964-969
    • Oliver, S.J.1    Cheng, T.P.2    Banquerigo, M.L.3    Brahn, E.4
  • 64
    • 0034762335 scopus 로고    scopus 로고
    • Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogs
    • Prehn JL, Landers C, Muller GW, Man HW, Stirling DI, Targan SR. Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogs. J Clin Immunol 2001; 21(5):357-364.
    • (2001) J Clin Immunol , vol.21 , Issue.5 , pp. 357-364
    • Prehn, J.L.1    Landers, C.2    Muller, G.W.3    Man, H.W.4    Stirling, D.I.5    Targan, S.R.6
  • 67
    • 0037093854 scopus 로고    scopus 로고
    • Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole cell vaccination is mediated by increased Th1-type immunity
    • Dredge K, Marriott JB, Todryk SM, Muller GW, Chen R, Stirling DI, Dalgleish AG. Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole cell vaccination is mediated by increased Th1-type immunity. J Immunol 2002; 168:4914-4919.
    • (2002) J Immunol , vol.168 , pp. 4914-4919
    • Dredge, K.1    Marriott, J.B.2    Todryk, S.M.3    Muller, G.W.4    Chen, R.5    Stirling, D.I.6    Dalgleish, A.G.7
  • 70
    • 0033967978 scopus 로고    scopus 로고
    • The thalidomide analogue CC-3052 inhibits HIV-1 and tumor necrosis factor-alpha (TNF-alpha) expression in acutely and chronically infected cells in vitro
    • La Maestra L, Zaninoni A, Marriott JB, Lazzarin A, Dalgleish AG, Barcellini W. The thalidomide analogue CC-3052 inhibits HIV-1 and tumor necrosis factor-alpha (TNF-alpha) expression in acutely and chronically infected cells in vitro. Clin Exp Immunol 2000; 119:123-129.
    • (2000) Clin Exp Immunol , vol.119 , pp. 123-129
    • La Maestra, L.1    Zaninoni, A.2    Marriott, J.B.3    Lazzarin, A.4    Dalgleish, A.G.5    Barcellini, W.6
  • 71
    • 0036855805 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory drugs as cancer therapy
    • Raje N, Anderson KC. Thalidomide and immunomodulatory drugs as cancer therapy. Curr Opin Oncol 2002; 14:635-640.
    • (2002) Curr Opin Oncol , vol.14 , pp. 635-640
    • Raje, N.1    Anderson, K.C.2
  • 74
    • 0032865755 scopus 로고    scopus 로고
    • Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro
    • Moreira AL, Friedlander DR, Shif B, Kaplan G, Zagzag D. Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. J Neuro-Oncol 1999; 43:109-114.
    • (1999) J Neuro-Oncol , vol.43 , pp. 109-114
    • Moreira, A.L.1    Friedlander, D.R.2    Shif, B.3    Kaplan, G.4    Zagzag, D.5
  • 80
    • 0003234481 scopus 로고    scopus 로고
    • Results of Phase I study of CC-5013 for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT)
    • Zangari M, Tricot G, Zeldis J, Eddlemon P, Saghafifar F, Barlogie B. Results of Phase I study of CC-5013 for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT). Blood 2001; 98(Suppl. 1):775a.
    • (2001) Blood , vol.98 , Issue.SUPPL. 1
    • Zangari, M.1    Tricot, G.2    Zeldis, J.3    Eddlemon, P.4    Saghafifar, F.5    Barlogie, B.6
  • 82
    • 0037595174 scopus 로고    scopus 로고
    • Thalidomide analogue CDC-501 is safe and well tolerated by patients with end stage cancer and shows evidence of clinical responses and extensive immune activation
    • Marriott JB, Clarke IA, Dredge K, Pandha H, Kristaleit H, Polychronis A, Muller GW, Stirling D, Dalgleish AG. Thalidomide analogue CDC-501 is safe and well tolerated by patients with end stage cancer and shows evidence of clinical responses and extensive immune activation. Br J Cancer 2002; 86:S26.
    • (2002) Br J Cancer , vol.86
    • Marriott, J.B.1    Clarke, I.A.2    Dredge, K.3    Pandha, H.4    Kristaleit, H.5    Polychronis, A.6    Muller, G.W.7    Stirling, D.8    Dalgleish, A.G.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.