Disruption of the LOV-Jα helix interaction activates phototropin kinase activity

Biochemistry

Volumn 43, Issue 51, 2004, Pages 16184-16192

  Harper, Shannon M ^a   Christie, John M ^b   Gardner, Kevin H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOCHEMISTRY; CHEMICAL BONDS; OXYGEN; PROTEINS;

FLAVIN MONONUCLEOTIDES (FMN); LIGHT-OXYGEN-VOLTAGE (LOV); PHOTORECEPTORS; PHOTOTROPINS;

LIGHT;

FLAVINE MONONUCLEOTIDE; OXYGEN; PHOTOTROPIN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; CRYPTOCHROME; FLAVOPROTEIN; PROTEIN KINASE;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; COVALENT BOND; ELECTRIC POTENTIAL; ENZYME ACTIVATION; ILLUMINATION; LIGHT; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OAT; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ARABIDOPSIS; ELECTRICITY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AVENA;

AMINO ACID SEQUENCE; ARABIDOPSIS; AVENA SATIVA; ELECTROSTATICS; FLAVOPROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 11144344967     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048092i     Document Type: Article

References (32)

1. Briggs, W. R., and Huala, E. (1999) Blue-light photoreceptors in higher plants, Annu. Rev. Cell Dev. Biol. 15, 33-62.
2. Christie, J. M., Reymond, P., Powell, G. K., Bernasconi, P., Raibekas, A. A., Liscum, E., and Briggs, W. R. (1998) Arabidopsis NPH1: a flavoprotein with the properties of a photoreceptor for phototropism, Science 282, 1698-1701.
3. Taylor, B. L., and Zhulin, I. B. (1999) PAS domains: internal sensors of oxygen, redox potential, and light, Microbiol. Mol. Biol. Rev. 63, 479-506.
4. Salomon, M., Christie, J. M., Knieb, E., Lempert, U., and Briggs, W. R. (2000) Photochemical and mutational analysis of the FMN-binding domains of the plant blue light photoreceptor, phototropin, Biochemistry 39, 9401-9410.
5. Swartz, T. E., Corchnoy, S. B., Christie, J. M., Lewis, J. W., Szundi, I., Briggs, W. R., and Bogomolni, R. A. (2001) The photocycle of a flavin-binding domain of the blue light photoreceptor phototropin, J. Biol. Chem. 276, 36493-36500.
6. Christie, J. M., Swartz, T. E., Bogomolni, R. A., and Briggs, W. R. (2002) Phototropin LOV domains exhibit distinct roles in regulating photoreceptor function, Plant J. 32, 205-219.
7. Crosson, S., and Moffat, K. (2001) Structure of a flavin-binding plant photoreceptor domain: insights into light-mediated signal transduction, Proc. Natl. Acad. Sci. U.S.A. 98, 2995-3000.
8. Fedorov, R., Schlichting, I., Hartmann, E., Domratcheva, T., Fuhrmann, M., and Hegemann, P. (2003) Crystal structures and molecular mechanism of a light-induced signaling switch: the Phot-LOV1 domain from Chlamydomonas reinhardtii, Biophys. J. 84, 2474-2482.
9. Crosson, S., and Moffat, K. (2002) Photoexcited structure of a plant photoreceptor domain reveals a light-driven molecular switch, Plant Cell 14, 1067-1075.
10. Crosson, S., Rajagopal, S., and Moffat, K. (2003) The LOV domain family: photoresponsive signaling modules coupled to diverse output domains, Biochemistry 42, 2-10.
11. Iwata, T., Nozaki, D., Tokutomi, S., Kagawa, T., Wada, M., and Kandori, H. (2003) Light-induced structural changes in the LOV2 domain of Adiantum phytochrome3 studied by low-temperature FTIR and UV-visible spectroscopy, Biochemistry 42, 8183-91.
12. Corchnoy, S. B., Swartz, T. E., Lewis, J. W., Szundi, I., Briggs, W. R., and Bogomolni, R. A. (2003) Intramolecular proton transfers and structural changes during the photocycle of the LOV2 domain of Phototropin 1, J. Biol. Chem. 278, 724-731.
13. Harper, S. M., Neil, L. C., and Gardner, K. H. (2003) Structural basis of a phototropin light switch, Science 301, 1541-1544.
14. Harper, S. M., Neil, L. C., Day, I. J., Hore, P. J., and Gardner, K. H. (2004) Conformational changes in a photosensory LOV domain monitored by time-resolved NMR spectroscopy, J. Am. Chem. Soc. 126, 3390-3391.
15. Bashford, D. (1997) in Scientific computing in object-oriented parallel environments (Ishikawa, Y., Oldehoeft, R. R., Reynders, J. V. W., and Tholburn, M., Eds.) pp 233-240, Springer, Berlin.
16. Lindahl, E., Hess, B., and van der Spoel, D. (2001) GROMACS 3.0: A package for molecular simulation and trajectory analysis, J. Mol. Mod. 7, 306-317.
17. DeLano, W. L. (2002) The PyMOL Molecular Graphics System.
18. + binding site on the MurB enzyme by NMR, Nat. Struct. Biol. 3, 995-997.
19. Clackson, T., and Wells, J. A. (1995) A hot spot of binding energy in a hormone-receptor interface, Science 267, 383-6.
20. Swartz, T. E., Wenzel, P. J., Corchnoy, S. B., Briggs, W. R., and Bogomolni, R. A. (2002) Vibration spectroscopy reveals light-induced chromophore and protein structural changes in the LOV2 domain of the plant blue-light receptor phototropin 1, Biochemistry 41, 7183-7189.
21. Kagawa, T., Kasahara, M., Abe, T., Yoshida, S., and Wada, M. (2004) Function analysis of phototropin2 using fern mutants deficient in blue light-induced chloroplast avoidance movement, Plant Cell Physiol. 45, 416-426.
22. Salomon, M., Lempert, U., and Rudiger, W. (2004) Dimerization of the plant photoreceptor phototropin is probably mediated by the LOV1 domain, FEBS Lett. 572, 8-10.
23. Nozaki, D., Iwata, T., Ishikawa, T., Todo, T., Tokutomi, S., and Kandori, H. (2004) Role of Gln1029 in the photoactivation processes of the LOV2 domain in Adiantum phytochrome3, Biochemistry 43, 8373-8379.
24. Huse, M., Chen, Y. G., Massague, J., and Kuriyan, J. (1999) Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12, Cell 96, 425-36.
25. Salomon, M., Knieb, E., Zeppelin, T., and Rudiger, W. (2003) Mapping of low- and high-fluence autophosphorylation sites in phototropin 1, Biochemistry 42, 4217-4225.
26. Yang, J., Cron, P., Thompson, V., Good, V. M., Hess, D., Hemmings, B. A., and Barford, D. (2002) Molecular mechanism for the regulation of protein kinase B/Akt by Hydrophobic motif phosphorylation, Mol. Cell 9, 1227-40.
27. Ballario, P., Talora, C., Galli, D., Linden, H., and Macino, G. (1998) Roles in dimerization and blue light photoresponse of the PAS and LOV domains of Neurospora crassa white collar proteins, Mol. Microbiol. 29, 719-729.
28. Bourne, Y., Watson, M. H., Mickey, M. J., Holmes, W., Rocque, W., Reed, S. I., and Tainer, J. A. (1996) Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1, Cell 84, 863-74.
29. Erbel, P. J., Card, P. B., Karakuzu, O., Bruick, R. K., and Gardner, K. H. (2003) Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor, Proc. Natl. Acad. Sci. U.S.A. 100, 15504-9.
30. Kurokawa, H., Lee, D. S., Watanabe, M., Sagami, I., Mikami, B., Raman, C. S., and Shimizu, T. (2004) A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor, J. Biol. Chem. 279, 20186-93.
31. Gong, W., Hao, B., Mansy, S. S., Gonzalez, G., Gilles-Gonzalez, M. A., and Chan, M. K. (1998) Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction, Proc. Natl. Acad. Sci. U.S.A. 95, 15177-82.
32. Corpet, F. (1988) Multiple sequence alignment with hierarchical clustering, Nucleic Acids Res. 16, 10881-10890.