Indoleamine 2,3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines

Cell Research

Volumn 15, Issue 3, 2005, Pages 167-175

  Hwang, Shih Ling ^a   Chung, Nancy Pei Yee ^b   Chan, Jacqueline Kwai Yi ^b   Lin, Chen Lung Steve ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Activation; Chemokine; Dendritic cells; Indoleamine 2,3 dioxygenase (IDO); T cell; Tryptophan

Indexed keywords

1 METHYL TRYPTOPHAN; 1-METHYL-TRYPTOPHAN; BLR1 PROTEIN, HUMAN; CD40 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR4; CYTOKINE RECEPTOR; DRUG DERIVATIVE; INDOLEAMINE 2,3 DIOXYGENASE; LIPOPOLYSACCHARIDE; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL PROLIFERATION; CHEMOTAXIS; DENDRITIC CELL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; PHYSIOLOGY; T LYMPHOCYTE;

ANTIGENS, CD40; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINES; CHEMOTAXIS; DENDRITIC CELLS; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; LIPOPOLYSACCHARIDES; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4; RECEPTORS, CYTOKINE; T-LYMPHOCYTES; TRYPTOPHAN; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 27844576217     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cr.7290282     Document Type: Article

References (35)

1. Taylor MW, Feng GS. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. Faseb J 1991; 5:2516-22.
2. Pfefferkorn ER. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci USA 1984; 81:908-12.
3. Gupta SL, Carlin JM, Pyati P, et al. Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts. Infect Immun 1994; 2:2277-84.
4. Aune TM, Pogue SL. Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. J Clin Invest 1989; 84:863-75.
5. Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980; 303:782-7.
6. Belongia EA, Hedberg CW, Gleich GJ, et al. An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use. N Engl J Med 1990; 323:357-65.
7. Mayeno AN, Lin F, Foote CS, et al. Characterization of "peak E" a novel amino acid associated with eosinophilia-myalgia syndrome. Science 1990; 250:1707-8.
8. Uyttenhove C, Pilotte L, Theate I, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003; 9:1269-74.
9. Lee JR, Dalton RR, Messina JL, et al. Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma. Lab Invest 2003; 83:1457-66.
10. Moffett JR, Espey MG, Namboodiri MA. Antibodies to quinolinic acid and the determination of its cellular distribution within the rat immune system. Cell Tissue Res 1994; 278:461-9.
11. Espey MG, Tang Y, Morse HC 3rd, Moffett JR, Namboodiri MA. Localization of quinolinic acid in the murine AIDS model of retrovirus-induced immunodeficiency: implications for neurotoxicity and dendritic cell immunopathogenesis. Aids 1996; 10:151-8.
12. Yoshida R, NukiwaT, Watanabe Y, et al. Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice. Arch Biochem Biophys 1980; 203:343-51.
13. Yoshida R, Urade Y, Nakata K, Watanabe Y, Hayaishi O. Specific induction of indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide in the mouse lung. Arch Biochem Biophys 1981; 212:629-37.
14. Malina HZ, Martin XD. Indoleamine 2,3-dioxygenase: antioxidant enzyme in the human eye. Graefes Arch Clin Exp Ophthalmol 1996; 234:457-62.
15. Munn D.H, Shafizadeh E, Attwood JT, et al. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999; 189:1363-72.
16. Munn DH, Sharma MD, Lee JR, et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 2002; 297:1867-70.
17. Hwu P, Du MX, Lapointe R, et al. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 2000; 164:3596-9.
18. Munn DH, Zhou M, Attwood JT, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281:1191-3.
19. Mellor AL, Sivakumar J, Chandler P, et al. Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat Immunol 2001; 2:64-8.
20. Miki T, Sun H, Lee Y, et al. Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts. Transplant Proc 2001; 33:129-30.
21. Sakurai K, Zou JP, Tschetter JR, Ward JM, Shearer GM. Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis. J Neuroimmunol 2002; 129:186-96.
22. Friberg M, Jennings R, Alsarraj M, et al. Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection. Int J Cancer 2002; 101:151-5.
23. Grohmann U, Fallarino F, Bianchi R, et al. IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase. J Immunol 2001; 167:708-14.
24. Munn DH, Mellor AL. IDO and tolerance to tumors. Trends Mol Med 2004; 10:15-8.
25. Chung NP, Chen Y, Chan VS, Tam PK, Lin CL. Dendritic cells: sentinels against pathogens. Histol Histopathol 2004; 19:317-24.
26. Rissoan MC, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283:1183-6.
27. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392:245-52.
28. Munn DH, Sharma MD, Mellor AL. Ligation of B7-1/B7-2 by human CD4(+) T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J Immunol 2004; 172:4100-10.
29. Lin CL, Sewell AK, Gao GF, et al. Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis. J Exp Med 2000; 192:587-94.
30. Lin CL, Suri RM, Rahdon RA, Austyn JM, Roake JA. Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation. Eur J Immunol 1998; 28:4114-22.
31. Fallarino F, Grohmann U, Vacca C, et al. T cell apoptosis by tryptophan catabolism. Cell Death Differ 2002; 9:1069-77.
32. Bodaghi B, Goureau O, Zipeto D, et al. Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells. J Immunol 1999; 162:957-64.
33. Nagineni CN, Pardhasaradhi K, Martins MC, Detrick B, Hooks JJ. Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells. Infect Immun 1996; 64:4188-96.
34. Byrne GI, Lehmann LK, Landry GJ. Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells. Infect Immun 1986; 53:347-51.
35. Terness P, Bauer TM, Rose L, et al. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 2002; 196:447-57.