메뉴 건너뛰기




Volumn 7, Issue 19, 2008, Pages 2949-2955

The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors

Author keywords

GISTs; Imatinib mesylate; Insulin growth factor; NYP AEW541; Tyrosine kinase inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; CP 751871; IMATINIB; IMC A 12; NVP AEW 541; OSI 906; R 1507; SOMATOMEDIN; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN C RECEPTOR; SUNITINIB; UNCLASSIFIED DRUG;

EID: 53649108514     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.19.6760     Document Type: Review
Times cited : (30)

References (63)
  • 1
    • 53649088795 scopus 로고    scopus 로고
    • Molecular Pathobiology of Gastrointestinal Stromal Sarcomas
    • Corless CL, Heinrich MC. Molecular Pathobiology of Gastrointestinal Stromal Sarcomas. Annu Rev Pathol 2007.
    • (2007) Annu Rev Pathol
    • Corless, C.L.1    Heinrich, M.C.2
  • 2
    • 39049181396 scopus 로고    scopus 로고
    • The molecular pathogenesis of gastrointestinal stromal tumors
    • Tarn C, Godwin AK. The molecular pathogenesis of gastrointestinal stromal tumors. Clin Colorectal Cancer 2006; 6:7-17.
    • (2006) Clin Colorectal Cancer , vol.6 , pp. 7-17
    • Tarn, C.1    Godwin, A.K.2
  • 4
    • 0036092268 scopus 로고    scopus 로고
    • KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size
    • Corless CL, McGreevey L, Haley A, Town A, Heinrich MC. KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am J Pathol 2002; 160:1567-72.
    • (2002) Am J Pathol , vol.160 , pp. 1567-1572
    • Corless, C.L.1    McGreevey, L.2    Haley, A.3    Town, A.4    Heinrich, M.C.5
  • 8
    • 49749122255 scopus 로고    scopus 로고
    • Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours
    • Lasota J, Miettinen M. Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours. Histopathology 2008.
    • (2008) Histopathology
    • Lasota, J.1    Miettinen, M.2
  • 11
    • 0035852765 scopus 로고    scopus 로고
    • Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
    • Shen Y, Devgan G, Darnell JE Jr, Bromberg JF. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci USA 2001; 98:1543-8.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1543-1548
    • Shen, Y.1    Devgan, G.2    Darnell Jr, J.E.3    Bromberg, J.F.4
  • 13
    • 0028559163 scopus 로고
    • A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells
    • Kabarowski JH, Allen PB, Wiedemann LM. A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells. Embo J 1994; 13:5887-95.
    • (1994) Embo J , vol.13 , pp. 5887-5895
    • Kabarowski, J.H.1    Allen, P.B.2    Wiedemann, L.M.3
  • 19
    • 35148813515 scopus 로고    scopus 로고
    • Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors
    • Janeway KA, Liegl B, Harlow A, Le C, Perez-Atayde A, Kozakewich H, Corless CL, Heinrich MC, Fletcher JA. Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors. Cancer Res 2007; 67:9084-8.
    • (2007) Cancer Res , vol.67 , pp. 9084-9088
    • Janeway, K.A.1    Liegl, B.2    Harlow, A.3    Le, C.4    Perez-Atayde, A.5    Kozakewich, H.6    Corless, C.L.7    Heinrich, M.C.8    Fletcher, J.A.9
  • 20
    • 33750076675 scopus 로고    scopus 로고
    • Early effects of imatinib mesylate on the expression of insulin-like growth factor binding protein-3 and positron emission tomography in patients with gastrointestinal stromal tumor
    • Trent JC, Ramdas L, Dupart J, Hunt K, Macapinlac H, Taylor E, Hu L, Salvado A, Abbruzzese JL, Pollock R, Benjamin RS, Zhang W. Early effects of imatinib mesylate on the expression of insulin-like growth factor binding protein-3 and positron emission tomography in patients with gastrointestinal stromal tumor. Cancer 2006; 107:1898-908.
    • (2006) Cancer , vol.107 , pp. 1898-1908
    • Trent, J.C.1    Ramdas, L.2    Dupart, J.3    Hunt, K.4    Macapinlac, H.5    Taylor, E.6    Hu, L.7    Salvado, A.8    Abbruzzese, J.L.9    Pollock, R.10    Benjamin, R.S.11    Zhang, W.12
  • 24
    • 38849088141 scopus 로고    scopus 로고
    • The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer
    • Ryan PD, Goss PE. The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer. Oncologist 2008; 13:16-24.
    • (2008) Oncologist , vol.13 , pp. 16-24
    • Ryan, P.D.1    Goss, P.E.2
  • 25
    • 0034788985 scopus 로고    scopus 로고
    • The IGF system and breast cancer
    • Sachdev D, Yee D. The IGF system and breast cancer. Endocr Relat Cancer 2001; 8:197-209.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 197-209
    • Sachdev, D.1    Yee, D.2
  • 26
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: Overview and recent insights
    • Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007; 28:20-47.
    • (2007) Endocr Rev , vol.28 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    LeRoith, D.3    Brodt, P.4
  • 27
    • 28544444712 scopus 로고    scopus 로고
    • Type I insulin-like growth factor receptor as a therapeutic target in cancer
    • Miller BS, Yee D. Type I insulin-like growth factor receptor as a therapeutic target in cancer. Cancer Res 2005; 65:10123-7.
    • (2005) Cancer Res , vol.65 , pp. 10123-10127
    • Miller, B.S.1    Yee, D.2
  • 29
    • 0028229910 scopus 로고
    • Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma
    • Zhan S, Shapiro DN, Helman LJ. Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma. J Clin Invest 1994; 94:445-8.
    • (1994) J Clin Invest , vol.94 , pp. 445-448
    • Zhan, S.1    Shapiro, D.N.2    Helman, L.J.3
  • 30
    • 33745947934 scopus 로고    scopus 로고
    • Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1
    • Ueda S, Tsuda H, Sato K, Takeuchi H, Shigekawa T, Matsubara O, Hiraide H, Mochizuki H. Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1. Cancer Sci 2006; 97:597-604.
    • (2006) Cancer Sci , vol.97 , pp. 597-604
    • Ueda, S.1    Tsuda, H.2    Sato, K.3    Takeuchi, H.4    Shigekawa, T.5    Matsubara, O.6    Hiraide, H.7    Mochizuki, H.8
  • 31
    • 0028233617 scopus 로고
    • The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients
    • Railo MJ, von Smitten K, Pekonen F. The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients. Eur J Cancer 1994; 30:307-11.
    • (1994) Eur J Cancer , vol.30 , pp. 307-311
    • Railo, M.J.1    von Smitten, K.2    Pekonen, F.3
  • 34
    • 24744449559 scopus 로고    scopus 로고
    • Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice
    • Bauer TW, Liu W, Fan F, Camp ER, Yang A, Somcio RJ, Bucana CD, Callahan J, Parry GC, Evans DB, Boyd DD, Mazar AP, Ellis LM. Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice. Cancer Res 2005; 65:7775-81.
    • (2005) Cancer Res , vol.65 , pp. 7775-7781
    • Bauer, T.W.1    Liu, W.2    Fan, F.3    Camp, E.R.4    Yang, A.5    Somcio, R.J.6    Bucana, C.D.7    Callahan, J.8    Parry, G.C.9    Evans, D.B.10    Boyd, D.D.11    Mazar, A.P.12    Ellis, L.M.13
  • 35
    • 0033951758 scopus 로고    scopus 로고
    • The insulin-like growth factor-1 elevates urokinase-type plasminogen activator-1 in human breast cancer cells: A new avenue for breast cancer therapy
    • Dunn SE, Torres JV, Nihei N, Barrett JC. The insulin-like growth factor-1 elevates urokinase-type plasminogen activator-1 in human breast cancer cells: a new avenue for breast cancer therapy. Mol Carcinog 2000; 27:10-7.
    • (2000) Mol Carcinog , vol.27 , pp. 10-17
    • Dunn, S.E.1    Torres, J.V.2    Nihei, N.3    Barrett, J.C.4
  • 36
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    • Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 1999; 59:3915-8.
    • (1999) Cancer Res , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Ferreira, G.5    Semenza, G.L.6
  • 37
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002; 277:38205-11.
    • (2002) J Biol Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 38
    • 0033053127 scopus 로고    scopus 로고
    • Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9
    • Mira E, Manes S, Lacalle RA, Marquez G, Martinez AC. Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9. Endocrinology 1999; 140:1657-64.
    • (1999) Endocrinology , vol.140 , pp. 1657-1664
    • Mira, E.1    Manes, S.2    Lacalle, R.A.3    Marquez, G.4    Martinez, A.C.5
  • 39
    • 0037455716 scopus 로고    scopus 로고
    • Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI3-kinase/Akt signaling
    • Zhang D, Brodt P. Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI3-kinase/Akt signaling. Oncogene 2003; 22:974-82.
    • (2003) Oncogene , vol.22 , pp. 974-982
    • Zhang, D.1    Brodt, P.2
  • 41
    • 0032525021 scopus 로고    scopus 로고
    • Sex hormone-induced prostatic carcinogenesis in the noble rat: The role of insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in the development of prostate cancer
    • Wang YZ, Wong YC. Sex hormone-induced prostatic carcinogenesis in the noble rat: the role of insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in the development of prostate cancer. Prostate 1998; 35:165-77.
    • (1998) Prostate , vol.35 , pp. 165-177
    • Wang, Y.Z.1    Wong, Y.C.2
  • 42
    • 0029976435 scopus 로고    scopus 로고
    • Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation
    • Yang XF, Beamer WG, Huynh H, Pollak M. Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation. Cancer Res 1996; 56:1509-11.
    • (1996) Cancer Res , vol.56 , pp. 1509-1511
    • Yang, X.F.1    Beamer, W.G.2    Huynh, H.3    Pollak, M.4
  • 43
    • 0042090507 scopus 로고    scopus 로고
    • Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors
    • Wu Y, Cui K, Miyoshi K, Hennighausen L, Green JE, Setser J, LeRoith D, Yakar S. Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res 2003; 63:4384-8.
    • (2003) Cancer Res , vol.63 , pp. 4384-4388
    • Wu, Y.1    Cui, K.2    Miyoshi, K.3    Hennighausen, L.4    Green, J.E.5    Setser, J.6    LeRoith, D.7    Yakar, S.8
  • 46
    • 33646685694 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of the jejunum and ileum: A clinicopathologic, immunohistochemical and molecular genetic study of 906 cases before imatinib with long-term follow-up
    • Miettinen M, Makhlouf H, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical and molecular genetic study of 906 cases before imatinib with long-term follow-up. Am J Surg Pathol 2006; 30:477-89.
    • (2006) Am J Surg Pathol , vol.30 , pp. 477-489
    • Miettinen, M.1    Makhlouf, H.2    Sobin, L.H.3    Lasota, J.4
  • 47
    • 33646040417 scopus 로고    scopus 로고
    • Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells
    • Hopfner M, Huether A, Sutter AP, Baradari V, Schuppan D, Scherubl H. Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells. Biochem Pharmacol 2006; 71:1435-48.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1435-1448
    • Hopfner, M.1    Huether, A.2    Sutter, A.P.3    Baradari, V.4    Schuppan, D.5    Scherubl, H.6
  • 48
    • 33744903660 scopus 로고    scopus 로고
    • Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms
    • Tarn C, Skorobogatko YV, Taguchi T, Eisenberg B, von Mehren M, Godwin AK. Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer Res 2006; 66:5477-86.
    • (2006) Cancer Res , vol.66 , pp. 5477-5486
    • Tarn, C.1    Skorobogatko, Y.V.2    Taguchi, T.3    Eisenberg, B.4    von Mehren, M.5    Godwin, A.K.6
  • 54
    • 33745220580 scopus 로고    scopus 로고
    • Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells
    • Bertrand FE, Steelman LS, Chappell WH, Abrams SL, Shelton JG, White ER, Ludwig DL, McCubrey JA. Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells. Leukemia 2006; 20:1254-60.
    • (2006) Leukemia , vol.20 , pp. 1254-1260
    • Bertrand, F.E.1    Steelman, L.S.2    Chappell, W.H.3    Abrams, S.L.4    Shelton, J.G.5    White, E.R.6    Ludwig, D.L.7    McCubrey, J.A.8
  • 55
    • 0028053410 scopus 로고
    • In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and downregulates p34cdc2
    • Kalebic T, Tsokos M, Helman LJ. In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and downregulates p34cdc2. Cancer Res 1994; 54:5531-4.
    • (1994) Cancer Res , vol.54 , pp. 5531-5534
    • Kalebic, T.1    Tsokos, M.2    Helman, L.J.3
  • 56
    • 0032513524 scopus 로고    scopus 로고
    • Expression of a kinase-deficient IGF-I-R suppresses tumorigenicity of rhabdomyosarcoma cells constitutively expressing a wild type IGF-I-R
    • Kalebic T, Blakesley V, Slade C, Plasschaert S, Leroith D, Helman LJ. Expression of a kinase-deficient IGF-I-R suppresses tumorigenicity of rhabdomyosarcoma cells constitutively expressing a wild type IGF-I-R. International journal of cancer 1998; 76:223-7.
    • (1998) International journal of cancer , vol.76 , pp. 223-227
    • Kalebic, T.1    Blakesley, V.2    Slade, C.3    Plasschaert, S.4    Leroith, D.5    Helman, L.J.6
  • 58
    • 47249106539 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor 1 receptor in sarcomas
    • Scotlandi K, Picci P. Targeting insulin-like growth factor 1 receptor in sarcomas. Current opinion in oncology 2008; 20:419-27.
    • (2008) Current opinion in oncology , vol.20 , pp. 419-427
    • Scotlandi, K.1    Picci, P.2
  • 60
    • 29844446138 scopus 로고    scopus 로고
    • Molecular research directions in the management of gastrointestinal stromal tumors
    • Tarn C, Godwin AK. Molecular research directions in the management of gastrointestinal stromal tumors. Curr Treat Options Oncol 2005; 6:473-86.
    • (2005) Curr Treat Options Oncol , vol.6 , pp. 473-486
    • Tarn, C.1    Godwin, A.K.2
  • 61
    • 29844433168 scopus 로고    scopus 로고
    • Imatinib-refractory gastrointestinal stromal tumors: The clinical problem and therapeutic strategies
    • von Mehren M. Imatinib-refractory gastrointestinal stromal tumors: the clinical problem and therapeutic strategies. Curr Oncol Rep 2006; 8:192-7.
    • (2006) Curr Oncol Rep , vol.8 , pp. 192-197
    • von Mehren, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.