Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5497-5502

  Deng, Guanghui ^a   Li, Weihua ^a   Shen, Jianhua ^a   Jiang, Hualiang ^a,b   Chen, Kaixian ^a   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Farnesoid X receptor; Pyrazolidine 3,5 dione; Virtual screening

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; FARNESOID X RECEPTOR; LUCIFERASE; PYRAZOLE DERIVATIVE; PYRAZOLIDINE 3,5 DIONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

BILE ACIDS AND SALTS; CHEMISTRY, PHARMACEUTICAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; HYDROGEN BONDING; LIGANDS; LUCIFERASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRAZOLES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

RHODOCOCCUS RHODOCHROUS;

EID: 53549132514     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.027     Document Type: Article

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