Tryptophan-containing dipeptide derivatives as potent PPARγ antagonists: Design, synthesis, biological evaluation, and molecular modeling

European Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2008, Pages 2699-2716

  Deng, Guanghui ^a   Liu, Zhiguo ^a   Ye, Fei ^a   Luo, Xiaomin ^a   Zhu, Weiliang ^a   Shen, Xu ^a,b   Liu, Hong ^a   Jiang, Hualiang ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Difficult sequence; Dipeptide; PPAR; SAR; Tryptophan

Indexed keywords

2 CHLORO 5 NITRO N (4 PYRIDYL)BENZAMIDE; ARGININE DERIVATIVE; ASPARTIC ACID; BADGE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIPEPTIDE DERIVATIVE; G 3335; GLUTAMINE; GW 6992; HALOFENATE; METAGLIDASEN; MIFOBATE; PD 068253; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PHENYLALANINE DERIVATIVE; PHENYLALANYLASPARTIC ACID; PHENYLALANYLGLUTAMIC ACID; ROSIGLITAZONE; TRYPTOPHAN; TRYPTOPHAN 2 AMINOADIPIC ACID; TRYPTOPHAN DERIVATIVE; TRYPTOPHYLARGININE; TRYPTOPHYLASPARTATE DIBENZYL ESTER; TRYPTOPHYLASPARTIC ACID; TRYPTOPHYLGLUTAMIC ACID; TRYPTOPHYLGLUTAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DIABETES MELLITUS; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; IC 50; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; OBESITY; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; TWO HYBRID SYSTEM;

COMPUTER SIMULATION; DIPEPTIDES; DRUG DESIGN; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PPAR GAMMA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 57049115023     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.01.032     Document Type: Article

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