Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 7, 2006, Pages 2209-2224

  Li, Jian ^a   Chen, Jing ^a   Gui, Chunshan ^a   Zhang, Li ^b   Qin, Yu ^b   Xu, Qiang ^b   Zhang, Jian ^a   Liu, Hong ^a   Shen, Xu ^a,c   Jiang, Hualiang ^a,c  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b NANJING UNIVERSITY   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cyclophilin A; Drug design; Inhibitor; Virtual screening

Indexed keywords

4 (2 (3 BROMOPHENYL) PYRIDINE 4 CARBOXAMIDO) N (3,4 DIMETHYLISOXAZOL 5 YL)BENZENESULFONAMIDE; 4 (2 (3 CHLOROPHENYL) QUINOLINE 4 CARBOXAMIDO) N (3,4,DIMETHYLISOXAZOL 5 YL)BENZENESULFONAMIDE; 4 (2 NAPHTHALEN 2 YLQUINOLINE 4 CARBOXAMIDO) N (3,4 DIMETHYLISOXAZOL 5 YL)BENZENESULFONAMIDE; 6,6' BIS BENZYLAMINO 3,3' METHANEDIYL DI BENZOIC ACID DIMETHYLESTER; CYCLOPHILIN A; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL ASSAY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; SCREENING; SPLEEN CELL;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; CYCLOPHILIN A; DATABASES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FEMALE; HUMANS; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PREDICTIVE VALUE OF TESTS; PROTEIN CONFORMATION; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 32844458547     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.11.006     Document Type: Article

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