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Volumn 50, Issue 11, 2007, Pages 2323-2331

Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis

Author keywords

Apoptosis; Beta cell replication; Human; Islet degeneration and damage; Islets; Ketoacidosis; Prediction of type 1 diabetes; Prevention of type 1 diabetes; Recent onset type 1 diabetes

Indexed keywords

ACIDOSIS; APOPTOSIS; ARTICLE; AUTOPSY; CAUSE OF DEATH; CONTROLLED STUDY; DIABETIC KETOACIDOSIS; GLUCOSE BLOOD LEVEL; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MORPHOMETRICS; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 34848851427     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0794-x     Document Type: Article
Times cited : (96)

References (28)
  • 1
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • Atkinson MA, Eisenbarth GS (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358:221-229
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 2
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619-633
    • (1965) Diabetes , vol.14 , pp. 619-633
    • Gepts, W.1
  • 3
    • 0017698017 scopus 로고
    • An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus
    • Junker K, Egeberg J, Kromann H et al (1977) An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus. Acta Pathol Microbiol Scand A 85:699-706
    • (1977) Acta Pathol Microbiol Scand a , vol.85 , pp. 699-706
    • Junker, K.1    Egeberg, J.2    Kromann, H.3
  • 4
    • 0018183984 scopus 로고
    • Islet cell survival determined by morphology. An immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus
    • Suppl 1
    • Gepts W, De Mey J (1978) Islet cell survival determined by morphology. An immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus. Diabetes 27(Suppl 1):251-261
    • (1978) Diabetes , vol.27 , pp. 251-261
    • Gepts, W.1    De Mey, J.2
  • 5
    • 0021141234 scopus 로고
    • Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes
    • Kloppel G, Drenck CR, Oberholzer M et al (1984) Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes. Virchows Arch A Pathol Anat Histopathol 403:441-452
    • (1984) Virchows Arch a Pathol Anat Histopathol , vol.403 , pp. 441-452
    • Kloppel, G.1    Drenck, C.R.2    Oberholzer, M.3
  • 6
    • 0021252607 scopus 로고
    • The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: Insulin content of islets, insulitis and associated changes in the exocrine acinar tissue
    • Foulis AK, Stewart JA (1984) The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue. Diabetologia 26:456-461
    • (1984) Diabetologia , vol.26 , pp. 456-461
    • Foulis, A.K.1    Stewart, J.A.2
  • 7
    • 0028929393 scopus 로고
    • Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus
    • Lernmark A, Kloppel G, Stenger D et al (1995) Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus. Virchows Arch 425:631-640
    • (1995) Virchows Arch , vol.425 , pp. 631-640
    • Lernmark, A.1    Kloppel, G.2    Stenger, D.3
  • 8
    • 0023618080 scopus 로고
    • Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy
    • Lohr M, Kloppel G (1987) Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy. Diabetologia 30:757-762
    • (1987) Diabetologia , vol.30 , pp. 757-762
    • Lohr, M.1    Kloppel, G.2
  • 9
    • 27744603796 scopus 로고    scopus 로고
    • Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: Indirect evidence for islet regeneration?
    • Meier JJ, Bhushan A, Butler AE et al (2005) Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48:2221-2228
    • (2005) Diabetologia , vol.48 , pp. 2221-2228
    • Meier, J.J.1    Bhushan, A.2    Butler, A.E.3
  • 10
    • 33745788583 scopus 로고    scopus 로고
    • Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes
    • Meier JJ, Lin JC, Butler AE et al (2006) Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49:1838-1844
    • (2006) Diabetologia , vol.49 , pp. 1838-1844
    • Meier, J.J.1    Lin, J.C.2    Butler, A.E.3
  • 11
    • 0344971498 scopus 로고
    • Hydropic degeneration of islands of Langerhans after partial pancretectomy
    • Allen FM (1922) Hydropic degeneration of islands of Langerhans after partial pancretectomy. J Metab Res 1:5-41
    • (1922) J Metab Res , vol.1 , pp. 5-41
    • Allen, F.M.1
  • 12
    • 34548397755 scopus 로고    scopus 로고
    • Screening for insulitis in adult autoantibody-positive organ donors
    • DOI 10.2337/db07-0416
    • In't Veld P, Lievens D, De Grijse J et al (2007) Screening for insulitis in adult autoantibody-positive organ donors. Diabetes DOI 10.2337/db07-0416
    • (2007) Diabetes
    • In't Veld, P.1    Lievens, D.2    De Grijse, J.3
  • 13
    • 9144268894 scopus 로고    scopus 로고
    • C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: Report of an ADA workshop, 21-22 October 2001
    • Palmer JP, Fleming GA, Greenbaum CJ et al (2004) C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 53:250-264
    • (2004) Diabetes , vol.53 , pp. 250-264
    • Palmer, J.P.1    Fleming, G.A.2    Greenbaum, C.J.3
  • 14
    • 31844443761 scopus 로고    scopus 로고
    • The rise and fall of insulin secretion in type 1 diabetes mellitus
    • Tsai EB, Sherry NA, Palmer JP et al (2006) The rise and fall of insulin secretion in type 1 diabetes mellitus. Diabetologia 49:261-270
    • (2006) Diabetologia , vol.49 , pp. 261-270
    • Tsai, E.B.1    Sherry, N.A.2    Palmer, J.P.3
  • 15
    • 0027459623 scopus 로고
    • Determinants of clinical remission in recent-onset IDDM
    • Hramiak IM, Dupre J, Finegood DT (1993) Determinants of clinical remission in recent-onset IDDM. Diabetes Care 16:125-132
    • (1993) Diabetes Care , vol.16 , pp. 125-132
    • Hramiak, I.M.1    Dupre, J.2    Finegood, D.T.3
  • 16
    • 2342569164 scopus 로고    scopus 로고
    • Complete long-term recovery of beta-cell function in autoimmune type 1 diabetes after insulin treatment
    • Karges B, Durinovic-Bello I, Heinze E et al (2004) Complete long-term recovery of beta-cell function in autoimmune type 1 diabetes after insulin treatment. Diabetes Care 27:1207-1208
    • (2004) Diabetes Care , vol.27 , pp. 1207-1208
    • Karges, B.1    Durinovic-Bello, I.2    Heinze, E.3
  • 17
    • 10344241985 scopus 로고    scopus 로고
    • Improved glycemic control in subjects with atypical diabetes results from restored insulin secretion, but not improved insulin sensitivity
    • Rasouli N, Elbein SC (2004) Improved glycemic control in subjects with atypical diabetes results from restored insulin secretion, but not improved insulin sensitivity. J Clin Endocrinol Metab 89:6331-6335
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 6331-6335
    • Rasouli, N.1    Elbein, S.C.2
  • 18
    • 0034894618 scopus 로고    scopus 로고
    • One-hour meal tolerance test to assess withdrawal of insulin therapy in overweight patients with type 2 diabetes
    • Kumar D, Luna-Lollie T, Madha S (2001) One-hour meal tolerance test to assess withdrawal of insulin therapy in overweight patients with type 2 diabetes. Endocr Pract 7:256-261
    • (2001) Endocr Pract , vol.7 , pp. 256-261
    • Kumar, D.1    Luna-Lollie, T.2    Madha, S.3
  • 19
    • 33749324476 scopus 로고    scopus 로고
    • Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy
    • Matveyenko AV, Veldhuis JD, Butler PC (2006) Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy. Diabetes 55:2347-2356
    • (2006) Diabetes , vol.55 , pp. 2347-2356
    • Matveyenko, A.V.1    Veldhuis, J.D.2    Butler, P.C.3
  • 20
    • 33744979065 scopus 로고    scopus 로고
    • Relationship between beta-cell mass and fasting blood glucose concentration in humans
    • Ritzel RA, Butler AE, Rizza RA et al (2006) Relationship between beta-cell mass and fasting blood glucose concentration in humans. Diabetes Care 29:717-718
    • (2006) Diabetes Care , vol.29 , pp. 717-718
    • Ritzel, R.A.1    Butler, A.E.2    Rizza, R.A.3
  • 21
    • 0034982387 scopus 로고    scopus 로고
    • High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: A potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
    • Federici M, Hribal M, Perego L et al (2001) High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50:1290-1301
    • (2001) Diabetes , vol.50 , pp. 1290-1301
    • Federici, M.1    Hribal, M.2    Perego, L.3
  • 22
    • 0036738398 scopus 로고    scopus 로고
    • Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    • Maedler K, Sergeev P, Ris F et al (2002) Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851-860
    • (2002) J Clin Invest , vol.110 , pp. 851-860
    • Maedler, K.1    Sergeev, P.2    Ris, F.3
  • 23
    • 0036315888 scopus 로고    scopus 로고
    • Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    • Lupi R, Dotta F, Marselli L et al (2002) Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51:1437-1442
    • (2002) Diabetes , vol.51 , pp. 1437-1442
    • Lupi, R.1    Dotta, F.2    Marselli, L.3
  • 24
    • 33749428116 scopus 로고    scopus 로고
    • Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans
    • Meier JJ, Butler AE, Galasso R et al (2006) Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans. Diabetologia 49:2689-2696
    • (2006) Diabetologia , vol.49 , pp. 2689-2696
    • Meier, J.J.1    Butler, A.E.2    Galasso, R.3
  • 25
    • 33644787064 scopus 로고    scopus 로고
    • Latent autoimmune diabetes in adults: Definition, prevalence, beta-cell function, and treatment
    • Suppl 2
    • Stenstrom G, Gottsater A, Bakhtadze E et al (2005) Latent autoimmune diabetes in adults: definition, prevalence, beta-cell function, and treatment. Diabetes 54(Suppl 2):S68-S72
    • (2005) Diabetes , vol.54
    • Stenstrom, G.1    Gottsater, A.2    Bakhtadze, E.3
  • 26
    • 33745234081 scopus 로고    scopus 로고
    • Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell
    • Robertson RP, Harmon JS (2006) Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell. Free Radic Biol Med 41:177-184
    • (2006) Free Radic Biol Med , vol.41 , pp. 177-184
    • Robertson, R.P.1    Harmon, J.S.2
  • 27
    • 0347949547 scopus 로고    scopus 로고
    • Regulation of cell cycle progression by calcium/calmodulin-dependent pathways
    • Kahl CR, Means AR (2003) Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. Endocr Rev 24:719-736
    • (2003) Endocr Rev , vol.24 , pp. 719-736
    • Kahl, C.R.1    Means, A.R.2
  • 28
    • 33644747390 scopus 로고    scopus 로고
    • Mechanisms of beta-cell death in type 2 diabetes
    • Suppl 2
    • Donath MY, Ehses JA, Maedler K et al (2005) Mechanisms of beta-cell death in type 2 diabetes. Diabetes 54(Suppl 2):S108-S113
    • (2005) Diabetes , vol.54
    • Donath, M.Y.1    Ehses, J.A.2    Maedler, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.