-
1
-
-
0035020826
-
Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence
-
Alexander, K., and P. W. Hinds. 2001. Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence. Mol. Cell. Biol. 21:3616-3631.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 3616-3631
-
-
Alexander, K.1
Hinds, P.W.2
-
2
-
-
33846004477
-
PTEN enters the nuclear age
-
Baker, S. J. 2007. PTEN enters the nuclear age. Cell 128:25-28.
-
(2007)
Cell
, vol.128
, pp. 25-28
-
-
Baker, S.J.1
-
3
-
-
0000522160
-
Human skin fibroblasts in vitro differentiate along a terminal cell lineage
-
Bayreuther, K., H. P. Rodemann, R. Hommel, K. Dittmann, M. Albiez, and P. I. Francz. 1988. Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc. Natl. Acad. Sci. USA 85:5112-5116.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 5112-5116
-
-
Bayreuther, K.1
Rodemann, H.P.2
Hommel, R.3
Dittmann, K.4
Albiez, M.5
Francz, P.I.6
-
4
-
-
0034028836
-
Tumor suppressors and oncogenes in cellular senescence
-
Bringold, F., and M. Serrano. 2000. Tumor suppressors and oncogenes in cellular senescence. Exp. Gerontol. 35:317-329.
-
(2000)
Exp. Gerontol
, vol.35
, pp. 317-329
-
-
Bringold, F.1
Serrano, M.2
-
5
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi, J. 2001. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11:S27-S31.
-
(2001)
Trends Cell Biol
, vol.11
-
-
Campisi, J.1
-
6
-
-
0035059672
-
From cells to organisms: Can we learn about aging from cells in culture?
-
Campisi, J. 2001. From cells to organisms: can we learn about aging from cells in culture? Exp. Gerontol. 36:607-618.
-
(2001)
Exp. Gerontol
, vol.36
, pp. 607-618
-
-
Campisi, J.1
-
7
-
-
0030964277
-
The biology of replicative senescence
-
Campisi, J. 1997. The biology of replicative senescence. Eur. J. Cancer 33:703-709.
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 703-709
-
-
Campisi, J.1
-
8
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi, J. 2005. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120:513-522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
9
-
-
24944568790
-
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis
-
Chung, J. H., and C. Eng. 2005. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res. 65:8096-8100.
-
(2005)
Cancer Res
, vol.65
, pp. 8096-8100
-
-
Chung, J.H.1
Eng, C.2
-
10
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri, G. P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacocke, and J. Campisi. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92:9363-9367.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
Peacocke, M.11
Campisi, J.12
-
12
-
-
33746257209
-
The evolution of phospha-tidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman, J. A., J. Luo, and L. C. Cantley. 2006. The evolution of phospha-tidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7:606-619.
-
(2006)
Nat. Rev. Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
13
-
-
0036237039
-
Oncogenic ras and p53 cooperate to induce cellular senescence
-
Ferbeyre, G., E. de Stanchina, A. W. Lin, E. Querido, M. E. McCurrach, G. J. Hannon, and S. W. Lowe. 2002. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol. Cell. Biol. 22:3497-3508.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 3497-3508
-
-
Ferbeyre, G.1
de Stanchina, E.2
Lin, A.W.3
Querido, E.4
McCurrach, M.E.5
Hannon, G.J.6
Lowe, S.W.7
-
14
-
-
0041450058
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
-
Freeman, D. J., A. G. Li, G. Wei, H. H. Li, N. Kertesz, R. Lesche, A. D. Whale, H. Martinez-Diaz, N. Rozengurt, R. D. Cardiff, X. Liu, and H. Wu. 2003. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell 3:117-130.
-
(2003)
Cancer Cell
, vol.3
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
Li, H.H.4
Kertesz, N.5
Lesche, R.6
Whale, A.D.7
Martinez-Diaz, H.8
Rozengurt, N.9
Cardiff, R.D.10
Liu, X.11
Wu, H.12
-
15
-
-
3242707579
-
Cloning and characterization of cellular senescence-associated genes in human fibroblasts by suppression subtractive hybridization
-
Guo, S. Z., Z. Y. Zhang, and T. J. Tong. 2004. Cloning and characterization of cellular senescence-associated genes in human fibroblasts by suppression subtractive hybridization. Exp. Cell Res. 298:465-472.
-
(2004)
Exp. Cell Res
, vol.298
, pp. 465-472
-
-
Guo, S.Z.1
Zhang, Z.Y.2
Tong, T.J.3
-
16
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick, L., and P. S. Moorhead. 1961. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:585-621.
-
(1961)
Exp. Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
17
-
-
0034682469
-
Sustained activation of Ras/Raf/mitogen-activated protein kinase cas-cade by the tumor suppressor p53
-
Lee, S. W., L. Fang, M. Igarashi, T. Ouchi, K. P. Lu, and S. A. Aaronson. 2000. Sustained activation of Ras/Raf/mitogen-activated protein kinase cas-cade by the tumor suppressor p53. Proc. Natl. Acad. Sci. USA 97:8302-8305.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8302-8305
-
-
Lee, S.W.1
Fang, L.2
Igarashi, M.3
Ouchi, T.4
Lu, K.P.5
Aaronson, S.A.6
-
18
-
-
33746990186
-
Mechanistic insights into maintenance of high p53 acetylation by PTEN
-
Li, A. G., L. G. Piluso, X. Cai, G. Wei, W. R. Sellers, and X. Liu. 2006. Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol. Cell 23:575-587.
-
(2006)
Mol. Cell
, vol.23
, pp. 575-587
-
-
Li, A.G.1
Piluso, L.G.2
Cai, X.3
Wei, G.4
Sellers, W.R.5
Liu, X.6
-
19
-
-
0032431028
-
PTEN/MMAC1/TEP1 suppresses the tumori-genicity and induces G(l) cell cycle arrest in human glioblastoma cells
-
Li, D. M., and H. Sun. 1998. PTEN/MMAC1/TEP1 suppresses the tumori-genicity and induces G(l) cell cycle arrest in human glioblastoma cells. Proc. Natl. Acad. Sci. USA 95:15406-15411.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15406-15411
-
-
Li, D.M.1
Sun, H.2
-
20
-
-
0029003790
-
The proliferative response and anti-oncogene expression in old 2BS cells after growth factor stimulation
-
Li, J., Z. Zhang, and T. Tong. 1995. The proliferative response and anti-oncogene expression in old 2BS cells after growth factor stimulation. Mech. Ageing Dev. 80:25-34.
-
(1995)
Mech. Ageing Dev
, vol.80
, pp. 25-34
-
-
Li, J.1
Zhang, Z.2
Tong, T.3
-
21
-
-
21744441932
-
Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation
-
Liu, J. L., X. Sheng, Z. K. Hortobagyi, Z. Mao, G. E. Gallick, and W. K. Yung. 2005. Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol. Cell. Biol. 25:6211-6224.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 6211-6224
-
-
Liu, J.L.1
Sheng, X.2
Hortobagyi, Z.K.3
Mao, Z.4
Gallick, G.E.5
Yung, W.K.6
-
22
-
-
0034737456
-
Mitotic misregulation and human aging
-
Ly, D. H., D. J. Lockhart, R. A. Lerner, and P. G. Schultz. 2000. Mitotic misregulation and human aging. Science 287:2486-2492.
-
(2000)
Science
, vol.287
, pp. 2486-2492
-
-
Ly, D.H.1
Lockhart, D.J.2
Lerner, R.A.3
Schultz, P.G.4
-
24
-
-
0038153919
-
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
-
Mazan-Mamczarz, K., S. Galban, I. Lopez-de-Silanes, J. Martindale, U. Atasoy, J. Keene, and M. Gorospe. 2003. RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc. Natl. Acad. Sci. USA 100:8354-8359.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8354-8359
-
-
Mazan-Mamczarz, K.1
Galban, S.2
Lopez-de-Silanes, I.3
Martindale, J.4
Atasoy, U.5
Keene, J.6
Gorospe, M.7
-
25
-
-
33846122599
-
Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm
-
Meng, L., H. Yasumoto, and R. Y. Tsai. 2006. Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm. J. Cell Sci. 119:5124-5136.
-
(2006)
J. Cell Sci
, vol.119
, pp. 5124-5136
-
-
Meng, L.1
Yasumoto, H.2
Tsai, R.Y.3
-
26
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
Narita, M., S. Nunez, E. Heard, M. Narita, A. W. Lin, S. A. Hearn, D. L. Spector, G. J. Hannon, and S. W. Lowe. 2003. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113:703-716.
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
Nunez, S.2
Heard, E.3
Narita, M.4
Lin, A.W.5
Hearn, S.A.6
Spector, D.L.7
Hannon, G.J.8
Lowe, S.W.9
-
27
-
-
0029024015
-
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
-
Pagano, M., S. W. Tam, A. M. Theodoras, P. Beer-Romero, S. G. Del, V. Chau, P. R. Yew, G. F. Draetta, and M. Rolfe. 1995. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682-685.
-
(1995)
Science
, vol.269
, pp. 682-685
-
-
Pagano, M.1
Tam, S.W.2
Theodoras, A.M.3
Beer-Romero, P.4
Del, S.G.5
Chau, V.6
Yew, P.R.7
Draetta, G.F.8
Rolfe, M.9
-
28
-
-
0000299214
-
Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo
-
Rohme, D. 1981. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc. Natl. Acad. Sci. USA 78:5009-5013.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 5009-5013
-
-
Rohme, D.1
-
29
-
-
0033561655
-
Differential expression of MMAC/PTEN in glioblastoma multiforme: Relationship to localization and prognosis
-
Sano, T., H. Lin, X. S. Chen, L. A. Langford, D. Koul, M. L. Bondy, K. R. Hess, J. N. Myers, Y. K. Hong, W. K. Yung, and P. A. Steck. 1999. Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. Cancer Res. 59:1820-1824.
-
(1999)
Cancer Res
, vol.59
, pp. 1820-1824
-
-
Sano, T.1
Lin, H.2
Chen, X.S.3
Langford, L.A.4
Koul, D.5
Bondy, M.L.6
Hess, K.R.7
Myers, J.N.8
Hong, Y.K.9
Yung, W.K.10
Steck, P.A.11
-
30
-
-
12344271156
-
Heterochromatin focuses on senescence
-
Schulz, L., and J. Tyler. 2005. Heterochromatin focuses on senescence. Mol. Cell 17:168-170.
-
(2005)
Mol. Cell
, vol.17
, pp. 168-170
-
-
Schulz, L.1
Tyler, J.2
-
31
-
-
0030038104
-
Replicative senescence: Implications for in vivo aging and tumor suppression
-
Smith, J. R., and O. M. Pereira-Smith. 1996. Replicative senescence: implications for in vivo aging and tumor suppression. Science 273:63-67.
-
(1996)
Science
, vol.273
, pp. 63-67
-
-
Smith, J.R.1
Pereira-Smith, O.M.2
-
32
-
-
13044305289
-
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-trisphosphate and Akt/protein kinase B signaling pathway
-
Sun, H., R. Lesche, D. M. Li, J. Liliental, H. Zhang, J. Gao, N. Gavrilova, B. Mueller, X. Liu, and H. Wu. 1999. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-trisphosphate and Akt/protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 96:6199-6204.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6199-6204
-
-
Sun, H.1
Lesche, R.2
Li, D.M.3
Liliental, J.4
Zhang, H.5
Gao, J.6
Gavrilova, N.7
Mueller, B.8
Liu, X.9
Wu, H.10
-
33
-
-
0028202945
-
Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in Her-2 expression
-
Tang, Z., Z. Zhang, Y. Zheng, M. J. Corbley, and T. Tong. 1994. Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in Her-2 expression. Mech. Ageing Dev. 73:57-67.
-
(1994)
Mech. Ageing Dev
, vol.73
, pp. 57-67
-
-
Tang, Z.1
Zhang, Z.2
Zheng, Y.3
Corbley, M.J.4
Tong, T.5
-
34
-
-
0031984692
-
A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts
-
Tresini, M., M. Mawal-Dewan, V. J. Cristofalo, and C. Sell. 1998. A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts. Cancer Res. 58:1-4.
-
(1998)
Cancer Res
, vol.58
, pp. 1-4
-
-
Tresini, M.1
Mawal-Dewan, M.2
Cristofalo, V.J.3
Sell, C.4
-
35
-
-
33845977965
-
Ubiquitination regulates PTEN nuclear import and tumor suppression
-
Trotman, L. C., X. Wang, A. Alimonti, Z. Chen, J. Teruya-Feldstein, H. Yang, N. P. Pavletich, B. S. Carver, C. Cordon-Cardo, H. Erdjument-Bro-mage, P. Tempst, S. G. Chi, H. J. Kim, T. Misteli, X. Jiang, and P. P. Pandolfi. 2007. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128:141-156.
-
(2007)
Cell
, vol.128
, pp. 141-156
-
-
Trotman, L.C.1
Wang, X.2
Alimonti, A.3
Chen, Z.4
Teruya-Feldstein, J.5
Yang, H.6
Pavletich, N.P.7
Carver, B.S.8
Cordon-Cardo, C.9
Erdjument-Bro-mage, H.10
Tempst, P.11
Chi, S.G.12
Kim, H.J.13
Misteli, T.14
Jiang, X.15
Pandolfi, P.P.16
-
36
-
-
0035966101
-
INK4a that contribute to over-expression of p16 in senescent fibroblasts
-
INK4a that contribute to over-expression of p16 in senescent fibroblasts. J. Biol. Chem. 276:48655-48661.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 48655-48661
-
-
Wang, W.1
Wu, J.2
Zhang, Z.3
Tong, T.4
-
37
-
-
33845991111
-
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
-
Wang, X., L. C. Trotman, T. Koppie, A. Alimonti, Z. Chen, Z. Gao, J. Wang, H. Erdjument-Bromage, P. Tempst, C. Cordon-Cardo, P. P. Pandolfi, and X. Jiang. 2007. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128:129-139.
-
(2007)
Cell
, vol.128
, pp. 129-139
-
-
Wang, X.1
Trotman, L.C.2
Koppie, T.3
Alimonti, A.4
Chen, Z.5
Gao, Z.6
Wang, J.7
Erdjument-Bromage, H.8
Tempst, P.9
Cordon-Cardo, C.10
Pandolfi, P.P.11
Jiang, X.12
-
38
-
-
14644422293
-
Increased stability of the p16 mRNA with replicative senescence
-
Wang, W., J. L. Martindale, X. Yang, F. J. Chrest, and M. Gorospe. 2005. Increased stability of the p16 mRNA with replicative senescence. EMBO Rep. 6:158-164.
-
(2005)
EMBO Rep
, vol.6
, pp. 158-164
-
-
Wang, W.1
Martindale, J.L.2
Yang, X.3
Chrest, F.J.4
Gorospe, M.5
-
39
-
-
33745156635
-
p21(wafl/cipl) plays a critical role in modulating senescence through changes of DNA methylation
-
Zheng, Q. H., L. W. Ma, W. G. Zhu, Z. Y. Zhang, and T. J. Tong. 2006. p21(wafl/cipl) plays a critical role in modulating senescence through changes of DNA methylation. J. Cell. Biochem. 98:1230-1248.
-
(2006)
J. Cell. Biochem
, vol.98
, pp. 1230-1248
-
-
Zheng, Q.H.1
Ma, L.W.2
Zhu, W.G.3
Zhang, Z.Y.4
Tong, T.J.5
|