메뉴 건너뛰기




Volumn 232, Issue 3, 2008, Pages 359-368

How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review

Author keywords

Arsenic; Modeling; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ARSENIC;

EID: 53449101872     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.06.023     Document Type: Conference Paper
Times cited : (14)

References (77)
  • 1
    • 22944459513 scopus 로고    scopus 로고
    • CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water
    • Adonis M., Martinez V., Marin P., and Gil L. CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water. Xenobiotica 35 (2005) 519-530
    • (2005) Xenobiotica , vol.35 , pp. 519-530
    • Adonis, M.1    Martinez, V.2    Marin, P.3    Gil, L.4
  • 5
    • 3242801408 scopus 로고    scopus 로고
    • A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species
    • Aposhian H.V., Zakharyan R.A., Avram M.D., Sampayo-Reyes A., and Wollenberg M.L. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicol. Appl. Pharmacol. 198 (2004) 327-335
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 327-335
    • Aposhian, H.V.1    Zakharyan, R.A.2    Avram, M.D.3    Sampayo-Reyes, A.4    Wollenberg, M.L.5
  • 6
    • 44649085807 scopus 로고    scopus 로고
    • Effect of treatment with sodium arsenate (AsV) or sodium arsenite (AsIII) in the drinking water on the bladder urothelium of male and female F344 rats and C57BL/6 mice
    • Charlotte, NC
    • Arnold L.L., Clark N.M., He J., Ohnishi T., and Cohen S.M. Effect of treatment with sodium arsenate (AsV) or sodium arsenite (AsIII) in the drinking water on the bladder urothelium of male and female F344 rats and C57BL/6 mice. In Society of Toxicology Annual Meeting (2007) Charlotte, NC
    • (2007) In Society of Toxicology Annual Meeting
    • Arnold, L.L.1    Clark, N.M.2    He, J.3    Ohnishi, T.4    Cohen, S.M.5
  • 7
    • 0033065466 scopus 로고    scopus 로고
    • Arsenic speciation in human organs following fatal arsenic trioxide poisoning-a case report
    • Benramdane L., Accominotti M., Fanton L., Malicier D., and Vallon J.J. Arsenic speciation in human organs following fatal arsenic trioxide poisoning-a case report. Clin. Chem. 45 (1999) 301-306
    • (1999) Clin. Chem. , vol.45 , pp. 301-306
    • Benramdane, L.1    Accominotti, M.2    Fanton, L.3    Malicier, D.4    Vallon, J.J.5
  • 8
    • 0019461078 scopus 로고
    • Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man
    • Buchet J.P., Lauwerys R., and Roels H. Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man. Int. Arch. Occup. Environ. Health 48 (1981) 71-79
    • (1981) Int. Arch. Occup. Environ. Health , vol.48 , pp. 71-79
    • Buchet, J.P.1    Lauwerys, R.2    Roels, H.3
  • 11
    • 11944259878 scopus 로고    scopus 로고
    • Polymorphisms in GSTT1 and p53 and urinary transitional cell carcinoma in South-western Taiwan: a preliminary study
    • Chen Y.C., Xu L., Guo Y.L., Su H.J., Smith T.J., Ryan L.M., Lee M.S., and Christiani D.C. Polymorphisms in GSTT1 and p53 and urinary transitional cell carcinoma in South-western Taiwan: a preliminary study. Biomarkers 9 (2004) 386-394
    • (2004) Biomarkers , vol.9 , pp. 386-394
    • Chen, Y.C.1    Xu, L.2    Guo, Y.L.3    Su, H.J.4    Smith, T.J.5    Ryan, L.M.6    Lee, M.S.7    Christiani, D.C.8
  • 13
    • 34547592376 scopus 로고    scopus 로고
    • Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report
    • Clewell H.J., Thomas R.S., Gentry P.R., Crump K.S., Kenyon E.M., El-Masri H.A., and Yager J.W. Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report. Toxicol. Appl. Pharmacol. 222 (2007) 388-398
    • (2007) Toxicol. Appl. Pharmacol. , vol.222 , pp. 388-398
    • Clewell, H.J.1    Thomas, R.S.2    Gentry, P.R.3    Crump, K.S.4    Kenyon, E.M.5    El-Masri, H.A.6    Yager, J.W.7
  • 14
    • 33644977000 scopus 로고    scopus 로고
    • Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment
    • Cohen S.M., Arnold L.L., Eldan M., Lewis A.S., and Beck B.D. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit. Rev. Toxicol. 36 (2006) 99-133
    • (2006) Crit. Rev. Toxicol. , vol.36 , pp. 99-133
    • Cohen, S.M.1    Arnold, L.L.2    Eldan, M.3    Lewis, A.S.4    Beck, B.D.5
  • 15
    • 0036736824 scopus 로고    scopus 로고
    • Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat
    • Cohen S.M., Arnold L.L., Uzvolgyi E., Cano M., St John M., Yamamoto S., Lu X., and Le X.C. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Chem. Res. Toxicol. 15 (2002) 1150-1157
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 1150-1157
    • Cohen, S.M.1    Arnold, L.L.2    Uzvolgyi, E.3    Cano, M.4    St John, M.5    Yamamoto, S.6    Lu, X.7    Le, X.C.8
  • 18
    • 8444227400 scopus 로고    scopus 로고
    • Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset
    • Conolly R.B., Kimbell J.S., Janszen D.J., Schlosser P.M., Kalisak D., Preston J., and Miller F.J. Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset. Toxicol. Sci. 82 (2004) 279-296
    • (2004) Toxicol. Sci. , vol.82 , pp. 279-296
    • Conolly, R.B.1    Kimbell, J.S.2    Janszen, D.J.3    Schlosser, P.M.4    Kalisak, D.5    Preston, J.6    Miller, F.J.7
  • 19
    • 0035419866 scopus 로고    scopus 로고
    • Determination of trivalent methylated arsenicals in biological matrices
    • Del Razo L.M., Styblo M., Cullen W.R., and Thomas D.J. Determination of trivalent methylated arsenicals in biological matrices. Toxicol Appl Pharmacol 174 (2001) 282-293
    • (2001) Toxicol Appl Pharmacol , vol.174 , pp. 282-293
    • Del Razo, L.M.1    Styblo, M.2    Cullen, W.R.3    Thomas, D.J.4
  • 20
    • 44649149026 scopus 로고    scopus 로고
    • [Relationship between 5,10-methylenetetrahydrofolate reductase genetic polymorphism and arsenic metabolism]
    • Deng F.R., Guo X.B., Chen L., Wang Z.Q., and Zhang K. [Relationship between 5,10-methylenetetrahydrofolate reductase genetic polymorphism and arsenic metabolism]. Beijing Da Xue Xue Bao 39 (2007) 149-152
    • (2007) Beijing Da Xue Xue Bao , vol.39 , pp. 149-152
    • Deng, F.R.1    Guo, X.B.2    Chen, L.3    Wang, Z.Q.4    Zhang, K.5
  • 22
    • 41049110206 scopus 로고    scopus 로고
    • Development of a human physiologically based pharmacokinetic (PBPK) model for inorganic arsenic and its mono- and di-methylated metabolites
    • El-Masri H.A., and Kenyon E.M. Development of a human physiologically based pharmacokinetic (PBPK) model for inorganic arsenic and its mono- and di-methylated metabolites. J. Pharmacokinet. Pharmacodyn. 35 (2008) 31-68
    • (2008) J. Pharmacokinet. Pharmacodyn. , vol.35 , pp. 31-68
    • El-Masri, H.A.1    Kenyon, E.M.2
  • 28
    • 33645633348 scopus 로고    scopus 로고
    • How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma
    • Gilmour M.I., Jaakkola M.S., London S.J., Nel A.E., and Rogers C.A. How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ. Health Perspect. 114 (2006) 627-633
    • (2006) Environ. Health Perspect. , vol.114 , pp. 627-633
    • Gilmour, M.I.1    Jaakkola, M.S.2    London, S.J.3    Nel, A.E.4    Rogers, C.A.5
  • 29
    • 0035543718 scopus 로고    scopus 로고
    • Unstable trivalent arsenic metabolites, monomethylarsonous acid and dimethylarsinous acid
    • Gong Z., Lu X., Cullen W.R., and Le X.C. Unstable trivalent arsenic metabolites, monomethylarsonous acid and dimethylarsinous acid. J. Anal. Atom. Spectrom. 16 (2001) 1409-1413
    • (2001) J. Anal. Atom. Spectrom. , vol.16 , pp. 1409-1413
    • Gong, Z.1    Lu, X.2    Cullen, W.R.3    Le, X.C.4
  • 30
    • 4243063986 scopus 로고    scopus 로고
    • Sulfur-containing arsenical mistaken for dimethylarsinous acid [DMA(III)] and identified as a natural metabolite in urine: major implications for studies on arsenic metabolism and toxicity
    • Hansen H., Raab A., Jaspars M., Milne B., and Feldman J. Sulfur-containing arsenical mistaken for dimethylarsinous acid [DMA(III)] and identified as a natural metabolite in urine: major implications for studies on arsenic metabolism and toxicity. Chem. Res. Toxicol. 17 (2004) 1086-1091
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 1086-1091
    • Hansen, H.1    Raab, A.2    Jaspars, M.3    Milne, B.4    Feldman, J.5
  • 31
    • 18044372615 scopus 로고    scopus 로고
    • A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19
    • Hayakawa T., Kobayashi Y., Cui X., and Hirano S. A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19. Arch. Toxicol. 79 (2005) 183-191
    • (2005) Arch. Toxicol. , vol.79 , pp. 183-191
    • Hayakawa, T.1    Kobayashi, Y.2    Cui, X.3    Hirano, S.4
  • 33
    • 33846620625 scopus 로고    scopus 로고
    • Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in Southwestern Taiwan
    • Huang Y.K., Tseng C.H., Huang Y.L., Yang M.H., Chen C.J., and Hsueh Y.M. Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in Southwestern Taiwan. Toxicol. Appl. Pharmacol. 218 (2007) 135-142
    • (2007) Toxicol. Appl. Pharmacol. , vol.218 , pp. 135-142
    • Huang, Y.K.1    Tseng, C.H.2    Huang, Y.L.3    Yang, M.H.4    Chen, C.J.5    Hsueh, Y.M.6
  • 34
    • 0033980631 scopus 로고    scopus 로고
    • Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration
    • Hughes M.F., Del Razo L.M., and Kenyon E.M. Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration. Toxicology 143 (2000) 155-166
    • (2000) Toxicology , vol.143 , pp. 155-166
    • Hughes, M.F.1    Del Razo, L.M.2    Kenyon, E.M.3
  • 35
    • 0032559282 scopus 로고    scopus 로고
    • Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration
    • Hughes M.F., and Kenyon E.M. Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration. J. Toxicol. Environ. Health A 53 (1998) 95-112
    • (1998) J. Toxicol. Environ. Health A , vol.53 , pp. 95-112
    • Hughes, M.F.1    Kenyon, E.M.2
  • 37
    • 0037714542 scopus 로고    scopus 로고
    • Magnitude of arsenic toxicity in tube-well drinking water in Bangladesh and its adverse effects on human health including cancer: evidence from a review of the literature
    • Khan M.M., Sakauchi F., Sonoda T., Washio M., and Mori M. Magnitude of arsenic toxicity in tube-well drinking water in Bangladesh and its adverse effects on human health including cancer: evidence from a review of the literature. Asian Pac. J. Cancer Prev. 4 (2003) 7-14
    • (2003) Asian Pac. J. Cancer Prev. , vol.4 , pp. 7-14
    • Khan, M.M.1    Sakauchi, F.2    Sonoda, T.3    Washio, M.4    Mori, M.5
  • 38
    • 0030955550 scopus 로고    scopus 로고
    • Effects of acute and chronic arsenic exposure of human-derived keratinocytes in an in vitro human skin equivalent system: a novel model of human arsenicism
    • Klimecki W.T., Borchers A.H., Egbert R.E., Nagle R.B., Carter D.E., and Bowden G.T. Effects of acute and chronic arsenic exposure of human-derived keratinocytes in an in vitro human skin equivalent system: a novel model of human arsenicism. Toxicology In vitro 11 (1997) 89-98
    • (1997) Toxicology In vitro , vol.11 , pp. 89-98
    • Klimecki, W.T.1    Borchers, A.H.2    Egbert, R.E.3    Nagle, R.B.4    Carter, D.E.5    Bowden, G.T.6
  • 39
    • 53449087445 scopus 로고    scopus 로고
    • Lee, E. (1999). A Physiologically Based Pharmacokinetic Model for the Ingestion of Arsenic in Humans. In Ph.D. Dissertation in Environmental Toxicology. University of California Irvine.
    • Lee, E. (1999). A Physiologically Based Pharmacokinetic Model for the Ingestion of Arsenic in Humans. In Ph.D. Dissertation in Environmental Toxicology. University of California Irvine.
  • 40
    • 15944422921 scopus 로고    scopus 로고
    • Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype
    • Li J., Waters S.B., Drobna Z., Devesa V., Styblo M., and Thomas D.J. Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype. Toxicol. Appl. Pharmacol. 204 (2005) 164-169
    • (2005) Toxicol. Appl. Pharmacol. , vol.204 , pp. 164-169
    • Li, J.1    Waters, S.B.2    Drobna, Z.3    Devesa, V.4    Styblo, M.5    Thomas, D.J.6
  • 41
    • 36248949683 scopus 로고    scopus 로고
    • Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh
    • Lindberg A.L., Ekstrom E.C., Nermell B., Rahman M., Lonnerdal B., Persson L.A., and Vahter M. Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh. Environ. Res. 106 (2008) 110-120
    • (2008) Environ. Res. , vol.106 , pp. 110-120
    • Lindberg, A.L.1    Ekstrom, E.C.2    Nermell, B.3    Rahman, M.4    Lonnerdal, B.5    Persson, L.A.6    Vahter, M.7
  • 43
    • 33846854172 scopus 로고    scopus 로고
    • Binding of dimethylarsinous acid to cys-13alpha of rat hemoglobin is responsible for the retention of arsenic in rat blood
    • Lu M., Wang H., Li X.F., Arnold L.L., Cohen S.M., and Le X.C. Binding of dimethylarsinous acid to cys-13alpha of rat hemoglobin is responsible for the retention of arsenic in rat blood. Chem. Res. Toxicol. 20 (2007) 27-37
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 27-37
    • Lu, M.1    Wang, H.2    Li, X.F.3    Arnold, L.L.4    Cohen, S.M.5    Le, X.C.6
  • 47
    • 20844433563 scopus 로고    scopus 로고
    • Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children
    • Meza M.M., Yu L., Rodriguez Y.Y., Guild M., Thompson D., Gandolfi A.J., and Klimecki W.T. Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children. Environ. Health Perspect. 113 (2005) 775-781
    • (2005) Environ. Health Perspect. , vol.113 , pp. 775-781
    • Meza, M.M.1    Yu, L.2    Rodriguez, Y.Y.3    Guild, M.4    Thompson, D.5    Gandolfi, A.J.6    Klimecki, W.T.7
  • 48
    • 0030749513 scopus 로고    scopus 로고
    • Relative genotoxic potency of arsenic and its methylated metabolites
    • Moore M.M., Harrington-Brock K., and Doerr C.L. Relative genotoxic potency of arsenic and its methylated metabolites. Mutat. Res. 386 (1997) 279-290
    • (1997) Mutat. Res. , vol.386 , pp. 279-290
    • Moore, M.M.1    Harrington-Brock, K.2    Doerr, C.L.3
  • 49
    • 0036189962 scopus 로고    scopus 로고
    • Quantitation of molecular endpoints for the dose-response component of cancer risk assessment
    • Preston R.J. Quantitation of molecular endpoints for the dose-response component of cancer risk assessment. Toxicol. Pathol. 30 (2002) 112-116
    • (2002) Toxicol. Pathol. , vol.30 , pp. 112-116
    • Preston, R.J.1
  • 51
    • 0345276611 scopus 로고    scopus 로고
    • Mechanism of arsenic carcinogenesis: an integrated approach
    • Rossman T.G. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat. Res. 533 (2003) 37-65
    • (2003) Mutat. Res. , vol.533 , pp. 37-65
    • Rossman, T.G.1
  • 52
    • 0024432311 scopus 로고
    • Estimation of the body burden of arsenic in a child fatally poisoned by arsenite weedkiller
    • Saady J.J., Blanke R.V., and Poklis A. Estimation of the body burden of arsenic in a child fatally poisoned by arsenite weedkiller. J. Anal. Toxicol. 13 (1989) 310-312
    • (1989) J. Anal. Toxicol. , vol.13 , pp. 310-312
    • Saady, J.J.1    Blanke, R.V.2    Poklis, A.3
  • 54
    • 3242813017 scopus 로고    scopus 로고
    • Arsenic toxicity at low doses: epidemiological and mode of action considerations
    • Schoen A., Beck B., Sharma R., and Dube E. Arsenic toxicity at low doses: epidemiological and mode of action considerations. Toxicol. Appl. Pharmacol. 198 (2004) 253-267
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 253-267
    • Schoen, A.1    Beck, B.2    Sharma, R.3    Dube, E.4
  • 55
    • 0345724836 scopus 로고    scopus 로고
    • Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg
    • Schwerdtle T., Walter I., and Hartwig A. Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg. DNA Repair (Amst) 2 (2003) 1449-1463
    • (2003) DNA Repair (Amst) , vol.2 , pp. 1449-1463
    • Schwerdtle, T.1    Walter, I.2    Hartwig, A.3
  • 56
    • 24644459501 scopus 로고    scopus 로고
    • Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk?
    • Snow E.T., Sykora P., Durham T.R., and Klein C.B. Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk?. Toxicol. Appl. Pharmacol. 207 (2005) 557-564
    • (2005) Toxicol. Appl. Pharmacol. , vol.207 , pp. 557-564
    • Snow, E.T.1    Sykora, P.2    Durham, T.R.3    Klein, C.B.4
  • 59
    • 36849031357 scopus 로고    scopus 로고
    • Uncertainties in the CIIT model for formaldehyde-induced carcinogenicity in the rat: a limited sensitivity analysis - 1
    • Subramaniam R.P., Crump K.S., Van Landingham C., White P., Chen C., and Schlosser P.M. Uncertainties in the CIIT model for formaldehyde-induced carcinogenicity in the rat: a limited sensitivity analysis - 1. Risk Anal. 27 (2007) 1237-1254
    • (2007) Risk Anal. , vol.27 , pp. 1237-1254
    • Subramaniam, R.P.1    Crump, K.S.2    Van Landingham, C.3    White, P.4    Chen, C.5    Schlosser, P.M.6
  • 60
    • 33646776352 scopus 로고    scopus 로고
    • Arsenic in the aetiology of cancer
    • Tapio S., and Grosche B. Arsenic in the aetiology of cancer. Mutat Res 612 (2006) 215-246
    • (2006) Mutat Res , vol.612 , pp. 215-246
    • Tapio, S.1    Grosche, B.2
  • 63
    • 33947116993 scopus 로고    scopus 로고
    • Arsenic methylation, urinary arsenic metabolites and human diseases: current perspective
    • Tseng C.H. Arsenic methylation, urinary arsenic metabolites and human diseases: current perspective. J. Environ. Sci. Health, Part C 25 (2007) 1-22
    • (2007) J. Environ. Sci. Health, Part C , vol.25 , pp. 1-22
    • Tseng, C.H.1
  • 64
    • 22544460259 scopus 로고    scopus 로고
    • Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan
    • Tseng C.H., Huang Y.K., Huang Y.L., Chung C.J., Yang M.H., Chen C.J., and Hsueh Y.M. Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan. Toxicol. Appl. Pharmacol. 206 (2005) 299-308
    • (2005) Toxicol. Appl. Pharmacol. , vol.206 , pp. 299-308
    • Tseng, C.H.1    Huang, Y.K.2    Huang, Y.L.3    Chung, C.J.4    Yang, M.H.5    Chen, C.J.6    Hsueh, Y.M.7
  • 65
    • 0000013015 scopus 로고    scopus 로고
    • National primary drinking water regulations; arsenic and clarification to compliance and new source contaminants monitoring: final rule
    • USEPA. National primary drinking water regulations; arsenic and clarification to compliance and new source contaminants monitoring: final rule. Federal Register 66 (2001) 6975-7066
    • (2001) Federal Register , vol.66 , pp. 6975-7066
    • USEPA1
  • 67
    • 53449102599 scopus 로고    scopus 로고
    • Revised science issue paper: mode of carcinogenic action for cacodylic acid (dimethylarsinic acid, DMAV) and recommendations for dose response extrapolation
    • USEPA. Revised science issue paper: mode of carcinogenic action for cacodylic acid (dimethylarsinic acid, DMAV) and recommendations for dose response extrapolation. Health Effects Division, Office of Pesticide Programs (2006) 182
    • (2006) Health Effects Division, Office of Pesticide Programs , pp. 182
    • USEPA1
  • 68
    • 0037184792 scopus 로고    scopus 로고
    • Vahter, M. (2002). Mechanisms of arsenic biotransformation. Toxicology 181-182, 211-217.
    • Vahter, M. (2002). Mechanisms of arsenic biotransformation. Toxicology 181-182, 211-217.
  • 71
    • 0036053457 scopus 로고    scopus 로고
    • Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors
    • Wei M., Wanibuchi H., Morimura K., Iwai S., Yoshida K., Endo G., Nakae D., and Fukushima S. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis 23 (2002) 1387-1397
    • (2002) Carcinogenesis , vol.23 , pp. 1387-1397
    • Wei, M.1    Wanibuchi, H.2    Morimura, K.3    Iwai, S.4    Yoshida, K.5    Endo, G.6    Nakae, D.7    Fukushima, S.8
  • 72
    • 32944463739 scopus 로고    scopus 로고
    • Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal
    • West J.D., and Marnett L.J. Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal. Chem. Res. Toxicol. 18 (2005) 1642-1653
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1642-1653
    • West, J.D.1    Marnett, L.J.2
  • 75
    • 3242761550 scopus 로고    scopus 로고
    • Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review
    • Yoshida T., Yamauchi H., and Fan Sun G. Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol. Appl. Pharmacol. 198 (2004) 243-252
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 243-252
    • Yoshida, T.1    Yamauchi, H.2    Fan Sun, G.3
  • 76
    • 0041351906 scopus 로고    scopus 로고
    • Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans
    • Yu L., Kalla K., Guthrie E., Vidrine A., and Klimecki W.T. Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans. Environ. Health Perspect. 111 (2003) 1421-1427
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1421-1427
    • Yu, L.1    Kalla, K.2    Guthrie, E.3    Vidrine, A.4    Klimecki, W.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.