메뉴 건너뛰기




Volumn 198, Issue 3, 2004, Pages 327-335

A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species

Author keywords

Arsenic; Detoxication; DMA; generic term including DMA III and DMA V; generic term including MMA III and MMA V; Hydrogen peroxide; MMA; MMA III; MMA V; monomethylarsonic acid; monomethylarsonous acid

Indexed keywords

ARSENIC; ARSENIC DERIVATIVE; ARSENIC METHYLTRANSFERASE; ARSENIC TRIOXIDE; CACODYLIC ACID; DIMETHYLARSENOUS ACID; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; METHANEARSONIC ACID; METHYLTRANSFERASE; MONOMETHYLARSONOUS ACID; UNCLASSIFIED DRUG;

EID: 3242801408     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.10.027     Document Type: Review
Times cited : (204)

References (63)
  • 1
    • 0034667885 scopus 로고    scopus 로고
    • Arsenic species that cause release of iron from ferritin and generation of activated oxygen
    • Ahmad K., Kitchin K.T., Cullen W.R. Arsenic species that cause release of iron from ferritin and generation of activated oxygen. Arch. Biochem. Biophys. 382:2000;195-202
    • (2000) Arch. Biochem. Biophys. , vol.382 , pp. 195-202
    • Ahmad, K.1    Kitchin, K.T.2    Cullen, W.R.3
  • 2
    • 0008517022 scopus 로고    scopus 로고
    • Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity
    • Aposhian H.V. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu. Rev. Pharmacol. Toxicol. 37:1997;397-419
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 397-419
    • Aposhian, H.V.1
  • 6
    • 0033429247 scopus 로고    scopus 로고
    • Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite
    • Barchowsky A., Klei L.R., Dudek E.J., Swartz H.M., James P.E. Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite. Free Radic. Biol. Med. 27:1999;1405-1412
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 1405-1412
    • Barchowsky, A.1    Klei, L.R.2    Dudek, E.J.3    Swartz, H.M.4    James, P.E.5
  • 8
    • 0021866517 scopus 로고
    • Study of inorganic arsenic methylation by rat liver in vitro: Relevance for the interpretation of observations in man
    • Buchet J.P., Lauwerys R. Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in man. Arch. Toxicol. 57:1985;125-129
    • (1985) Arch. Toxicol. , vol.57 , pp. 125-129
    • Buchet, J.P.1    Lauwerys, R.2
  • 10
    • 33845184777 scopus 로고
    • Arsenic speciation in the environment
    • Cullen W.R., Reimer K.J. Arsenic speciation in the environment. Chem. Rev. 89:1989;713-764
    • (1989) Chem. Rev. , vol.89 , pp. 713-764
    • Cullen, W.R.1    Reimer, K.J.2
  • 11
    • 50849152175 scopus 로고
    • The reaction of methylarsenicals with thiols: Some biological implications
    • Cullen W.R., McBride B.C., Reglinski J. The reaction of methylarsenicals with thiols: some biological implications. J. Inorg. Biochem. 21:1984;179-194
    • (1984) J. Inorg. Biochem. , vol.21 , pp. 179-194
    • Cullen, W.R.1    McBride, B.C.2    Reglinski, J.3
  • 13
    • 0035793617 scopus 로고    scopus 로고
    • The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator
    • Dulhunty A., Gage P., Curtis S., Chelvanayagam G., Board P. The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. J. Biol. Chem. 276:2001;3319-3323
    • (2001) J. Biol. Chem. , vol.276 , pp. 3319-3323
    • Dulhunty, A.1    Gage, P.2    Curtis, S.3    Chelvanayagam, G.4    Board, P.5
  • 14
    • 0034718556 scopus 로고    scopus 로고
    • Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
    • Enroth C., Eger B.T., Okamoto K., Nishino T., Nishino T., Pai E.F. Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc. Natl. Acad. Sci. U.S.A. 97:2000;10723-10728
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 10723-10728
    • Enroth, C.1    Eger, B.T.2    Okamoto, K.3    Nishino, T.4    Nishino, T.5    Pai, E.F.6
  • 15
    • 0035543718 scopus 로고    scopus 로고
    • Unstable trivalent arsenic metabolites, monomethylarsonous acid and dimethylarsinous acid
    • Gong Z., Lu X., Cullen W.R., Le X.C. Unstable trivalent arsenic metabolites, monomethylarsonous acid and dimethylarsinous acid. J. Anal. At. Spectrom. 16:2001;1409-1413
    • (2001) J. Anal. At. Spectrom. , vol.16 , pp. 1409-1413
    • Gong, Z.1    Lu, X.2    Cullen, W.R.3    Le X., C.4
  • 16
    • 0036848202 scopus 로고    scopus 로고
    • Purine nucleoside phosphorylase as a cytosolic arsenate reductase
    • Gregus Z., Németi B. Purine nucleoside phosphorylase as a cytosolic arsenate reductase. Toxicol. Sci. 70:2002;13-19
    • (2002) Toxicol. Sci. , vol.70 , pp. 13-19
    • Gregus, Z.1    Németi, B.2
  • 17
    • 0030793517 scopus 로고    scopus 로고
    • Enzymatic methylation of arsenic compounds: IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig
    • Healy S.M., Zakharyan R.A., Aposhian H.V. Enzymatic methylation of arsenic compounds: IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig. Mutat. Res. 386:1997;229-239
    • (1997) Mutat. Res. , vol.386 , pp. 229-239
    • Healy, S.M.1    Zakharyan, R.A.2    Aposhian, H.V.3
  • 18
    • 0000273676 scopus 로고    scopus 로고
    • The mononuclear molybdenum enzymes
    • Hille R. The mononuclear molybdenum enzymes. Chem. Rev. 96:1996;2757-2816
    • (1996) Chem. Rev. , vol.96 , pp. 2757-2816
    • Hille, R.1
  • 19
    • 0029347181 scopus 로고
    • Xanthine oxidase and xanthine dehydrogenase
    • Hille R., Nishino T. Xanthine oxidase and xanthine dehydrogenase. FASEB J. 9:1995;995-1003
    • (1995) FASEB J. , vol.9 , pp. 995-1003
    • Hille, R.1    Nishino, T.2
  • 20
    • 0037036578 scopus 로고    scopus 로고
    • Arsenic toxicity and potential mechanisms of action
    • Hughes M.F. Arsenic toxicity and potential mechanisms of action. Toxicol. Lett. 133:2002;1-16
    • (2002) Toxicol. Lett. , vol.133 , pp. 1-16
    • Hughes, M.F.1
  • 21
    • 0001113823 scopus 로고
    • Radioactive tracer studies on arsenic injected as potassium arsenite
    • Hunter F.T., Kip A.F., Irvine J.W. Jr. Radioactive tracer studies on arsenic injected as potassium arsenite. J. Pharmacol. Exp. Ther. 76:1942;207-220
    • (1942) J. Pharmacol. Exp. Ther. , vol.76 , pp. 207-220
    • Hunter, F.T.1    Kip, A.F.2    Irvine Jr., J.W.3
  • 22
    • 0034721764 scopus 로고    scopus 로고
    • The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic
    • Kala S.V., Neely M.W., Kala G., Prater C.I., Atwood D.W., Rice J.S., Lieberman M.W. The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic. J. Biol. Chem. 275:2000;33404-33408
    • (2000) J. Biol. Chem. , vol.275 , pp. 33404-33408
    • Kala, S.V.1    Neely, M.W.2    Kala, G.3    Prater, C.I.4    Atwood, D.W.5    Rice, J.S.6    Lieberman, M.W.7
  • 23
    • 0016287777 scopus 로고
    • Biliary excretion of arsenic in rats, rabbits and dogs
    • Klaasen C.D. Biliary excretion of arsenic in rats, rabbits and dogs. Toxicol. Appl. Pharmacol. 29:1974;447-457
    • (1974) Toxicol. Appl. Pharmacol. , vol.29 , pp. 447-457
    • Klaasen, C.D.1
  • 25
    • 0034329575 scopus 로고    scopus 로고
    • Speciation of key arsenic metabolic intermediates in human urine
    • Le X.C., Lu X., Ma M., Cullen W.R., Aposhian H.V., Zheng B. Speciation of key arsenic metabolic intermediates in human urine. Anal. Chem. 72:2000;5172-5177
    • (2000) Anal. Chem. , vol.72 , pp. 5172-5177
    • Le X., C.1    Lu, X.2    Ma, M.3    Cullen, W.R.4    Aposhian, H.V.5    Zheng, B.6
  • 26
    • 0033675692 scopus 로고    scopus 로고
    • Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine
    • Le X.C., Ma M., Lu X., Cullen W.R., Aposhian H.V., Zheng B. Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. Environ. Health Perspect. 108:2000;1015-1018
    • (2000) Environ. Health Perspect. , vol.108 , pp. 1015-1018
    • Le X., C.1    Ma, M.2    Lu, X.3    Cullen, W.R.4    Aposhian, H.V.5    Zheng, B.6
  • 30
    • 0035056158 scopus 로고    scopus 로고
    • Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India
    • Mandal B.K., Ogra Y., Suzuki K.T. Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India. Chem. Res. Toxicol. 14:2001;371-378
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 371-378
    • Mandal, B.K.1    Ogra, Y.2    Suzuki, K.T.3
  • 32
    • 0024501676 scopus 로고
    • L-pipecolic acid oxidation in the rabbit and cynomolgus monkey. Evidence for differing organellar locations and cofactor requirements in each species
    • Mihalik S.J., Rhead W.J. L-pipecolic acid oxidation in the rabbit and cynomolgus monkey. Evidence for differing organellar locations and cofactor requirements in each species. J. Biol. Chem. 264:1989;2509-2517
    • (1989) J. Biol. Chem. , vol.264 , pp. 2509-2517
    • Mihalik, S.J.1    Rhead, W.J.2
  • 34
    • 0346445197 scopus 로고    scopus 로고
    • National Research Council Report, Subcommittee to update the 1999 arsenic in drinking water report, Committee on Toxicology, Board on Environmental Studies and Toxicology.
    • National Research Council Report, 2001. Arsenic in Drinking Water: 2001 Update. Subcommittee to update the 1999 arsenic in drinking water report, Committee on Toxicology, Board on Environmental Studies and Toxicology.
    • (2001) Arsenic in Drinking Water: 2001 Update
  • 35
    • 0036849298 scopus 로고    scopus 로고
    • Reduction of arsenate to arsenite in hepatic cytosol
    • Németi B., Gregus Z. Reduction of arsenate to arsenite in hepatic cytosol. Toxicol. Sci. 70:2002;4-12
    • (2002) Toxicol. Sci. , vol.70 , pp. 4-12
    • Németi, B.1    Gregus, Z.2
  • 36
    • 0037817843 scopus 로고    scopus 로고
    • Arsenate reduction in human erythrocytes and rats - Testing the role of purine nucleoside phosphorylase
    • Németi B., Csanaky I., Gregus Z. Arsenate reduction in human erythrocytes and rats - Testing the role of purine nucleoside phosphorylase. Toxicol. Sci. 74:2003;22-31
    • (2003) Toxicol. Sci. , vol.74 , pp. 22-31
    • Németi, B.1    Csanaky, I.2    Gregus, Z.3
  • 38
    • 0037150531 scopus 로고    scopus 로고
    • Worldwide occurrences of arsenic in ground water
    • Nordstrom D.K. Worldwide occurrences of arsenic in ground water. Science. 296:2002;2143-2145
    • (2002) Science , vol.296 , pp. 2143-2145
    • Nordstrom, D.K.1
  • 39
    • 0022502428 scopus 로고
    • Xanthine oxidase: Biochemistry distribution and physiology
    • Parks D.A., Granger D.N. Xanthine oxidase: biochemistry distribution and physiology. Acta Physiol. Scand. 548:1986;87-99
    • (1986) Acta Physiol. Scand. , vol.548 , pp. 87-99
    • Parks, D.A.1    Granger, D.N.2
  • 40
    • 0347629020 scopus 로고    scopus 로고
    • Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes
    • Patterson T.J., Ngo M., Aronov P.A., Reznikova T.V., Green P.G., Rice R.H. Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes. Chem. Res. Toxicol. 16:2003;1624-1631
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 1624-1631
    • Patterson, T.J.1    Ngo, M.2    Aronov, P.A.3    Reznikova, T.V.4    Green, P.G.5    Rice, R.H.6
  • 43
    • 0033958512 scopus 로고    scopus 로고
    • Enzymatic reduction of arsenic compounds in mammalian systems: Reduction of arsenate to arsenite by human liver arsenate reductase
    • Radabaugh T.R., Aposhian H.V. Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. Chem. Res. Toxicol. 13:2000;26-30
    • (2000) Chem. Res. Toxicol. , vol.13 , pp. 26-30
    • Radabaugh, T.R.1    Aposhian, H.V.2
  • 44
    • 0036093079 scopus 로고    scopus 로고
    • Arsenate reductase: II. Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems
    • Radabaugh T.R., Sampayo-Reyes A., Zakharyan R.A., Aposhian H.V. Arsenate reductase: II. Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. Chem. Res. Toxicol. 15:2002;692-698
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 692-698
    • Radabaugh, T.R.1    Sampayo-Reyes, A.2    Zakharyan, R.A.3    Aposhian, H.V.4
  • 45
    • 0035473801 scopus 로고    scopus 로고
    • Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: An animal model for arsenic carcinogenesis
    • Rossman T.G., Uddin A.N., Burns F.J., Bosland M.C. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol. Appl. Pharmacol. 176:2001;64-71
    • (2001) Toxicol. Appl. Pharmacol. , vol.176 , pp. 64-71
    • Rossman, T.G.1    Uddin, A.N.2    Burns, F.J.3    Bosland, M.C.4
  • 48
  • 50
    • 0025024869 scopus 로고
    • Long-term effects of peroxisome proliferators on the balance between hydrogen peroxide-generating and scavenging capacities in the liver of Fisher-344 rats
    • Tamura H., Iida T., Watanabe T., Suga T. Long-term effects of peroxisome proliferators on the balance between hydrogen peroxide-generating and scavenging capacities in the liver of Fisher-344 rats. Toxicology. 63:1990;199-213
    • (1990) Toxicology , vol.63 , pp. 199-213
    • Tamura, H.1    Iida, T.2    Watanabe, T.3    Suga, T.4
  • 51
    • 0029417335 scopus 로고
    • 2-generating NADH oxidase in human lung fibroblasts by transforming growth factor β1
    • 2-generating NADH oxidase in human lung fibroblasts by transforming growth factor β1. J. Biol. Chem. 270:1995;30334-30338
    • (1995) J. Biol. Chem. , vol.270 , pp. 30334-30338
    • Thannickal, V.J.1    Fanburg, B.L.2
  • 52
    • 0034759637 scopus 로고    scopus 로고
    • The cellular metabolism and systemic toxicity of arsenic
    • Thomas D.J., Styblo M., Lin S. The cellular metabolism and systemic toxicity of arsenic. Toxicol. Appl. Pharmacol. 176:2001;127-144
    • (2001) Toxicol. Appl. Pharmacol. , vol.176 , pp. 127-144
    • Thomas, D.J.1    Styblo, M.2    Lin, S.3
  • 53
    • 84989576535 scopus 로고
    • Species differences in the metabolism of arsenic compounds
    • Vahter M. Species differences in the metabolism of arsenic compounds. Appl. Organomet. Chem. 8:1994;175-182
    • (1994) Appl. Organomet. Chem. , vol.8 , pp. 175-182
    • Vahter, M.1
  • 56
    • 0035976392 scopus 로고    scopus 로고
    • Enzymatic methylation of arsenic compounds: IX. Liver arsenite methyltransferase and arsenate reductase activities in primates
    • Wildfang E., Radabaugh T.R., Aposhian H.V. Enzymatic methylation of arsenic compounds: IX. Liver arsenite methyltransferase and arsenate reductase activities in primates. Toxicology. 168:2001;213-221
    • (2001) Toxicology , vol.168 , pp. 213-221
    • Wildfang, E.1    Radabaugh, T.R.2    Aposhian, H.V.3
  • 57
  • 58
    • 0033372040 scopus 로고    scopus 로고
    • Enzymatic reduction of arsenic compounds in mammalian systems: The rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase
    • Zakharyan R.A., Aposhian H.V. Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. Chem. Res. Toxicol. 12:1999;1278-1283
    • (1999) Chem. Res. Toxicol. , vol.12 , pp. 1278-1283
    • Zakharyan, R.A.1    Aposhian, H.V.2
  • 59
    • 0028861888 scopus 로고
    • Enzymatic methylation of arsenic compounds: Assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver
    • Zakharyan R.A., Wu Y., Bogdan G.M., Aposhian H.V. Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. Chem. Res. Toxicol. 8:1995;1029-1038
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 1029-1038
    • Zakharyan, R.A.1    Wu, Y.2    Bogdan, G.M.3    Aposhian, H.V.4
  • 60
    • 0030247067 scopus 로고    scopus 로고
    • Enzymatic methylation of arsenic compounds: III. The marmoset and tamarin, but not the rhesus monkey, are deficient in methyltransferase that methylate inorganic arsenic
    • Zakharyan R.A., Wildfang E., Aposhian H.V. Enzymatic methylation of arsenic compounds: III. The marmoset and tamarin, but not the rhesus monkey, are deficient in methyltransferase that methylate inorganic arsenic. Toxicol. Appl. Pharmacol. 140:1996;77-84
    • (1996) Toxicol. Appl. Pharmacol. , vol.140 , pp. 77-84
    • Zakharyan, R.A.1    Wildfang, E.2    Aposhian, H.V.3
  • 61
    • 0033168039 scopus 로고    scopus 로고
    • Enzymatic methylation of arsenic compounds: VII. Monomethylarsonous acid [MMA(III)] is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes
    • Zakharyan R.A., Ayala-Fierro F., Cullen W.R, Carter D.M., Aposhian H.V. Enzymatic methylation of arsenic compounds: VII. Monomethylarsonous acid [MMA(III)] is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes. Toxicol. Appl. Pharmacol. 158:1999;9-15
    • (1999) Toxicol. Appl. Pharmacol. , vol.158 , pp. 9-15
    • Zakharyan, R.A.1    Ayala-Fierro, F.2    Cullen, W.R.3    Carter, D.M.4    Aposhian, H.V.5
  • 63
    • 0030885707 scopus 로고    scopus 로고
    • Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression
    • Zhao C.Q., Young M.R., Diwan B.A., Coogan T.P., Waalkes M.P. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc. Natl. Acad. Sci. U.S.A. 94:1997;10907-10912
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 10907-10912
    • Zhao, C.Q.1    Young, M.R.2    Diwan, B.A.3    Coogan, T.P.4    Waalkes, M.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.