Folate and arsenic metabolism: A double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh

American Journal of Clinical Nutrition

Volumn 84, Issue 5, 2006, Pages 1093-1101

  Gamble, Mary V ^a   Liu, Xinhua ^a   Ahsan, Habibul ^a   Pilsner, J Richard ^a   Ilievski, Vesna ^a   Slavkovich, Vesna ^a   Parvez, Faruque ^a   Chen, Yu ^a   Levy, Diane ^a   Factor Litvak, Pam ^a   Graziano, Joseph H ^a,b  

^a Columbia University ^*  (United States)

^b NONE   (United States)

Author keywords

Arsenic; Bangladesh; Creatine; Creatinine; Dimethylarsinic acid; Folate; Folate deficiency; Folic acid; Homocysteine; Hyperhomocysteinemia; Monomethylarsonic acid; One carbon metabolism; S adenosylmethionine; Vitamin B 12

Indexed keywords

ARSENIC; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO;

AGED; ARSENIC POISONING; ARTICLE; BANGLADESH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLATE METABOLISM; FOLIC ACID BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; METHYLATION; RANDOMIZED CONTROLLED TRIAL; URINARY EXCRETION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 33750899094     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/84.5.1093     Document Type: Article

References (53)

1. The World Bank. Towards a more effective operational response. Washington, DC: The World Bank, 2005.
2. Kinniburgh DG, Smedley PL. Arsenic contamination of groundwater in Bangladesh. Final report, BGS Technical Report WC/00/19. Keyworth, United Kingdom: British Geological Survey, 2001.
3. Chiou HY, Huang WI, Su CL, Chang SF, Hsu YH, Chen CJ. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 1997;28:1717-23.
4. Tseng CH, Chong CK, Tseng CP, et al. Long-term arsenic exposure and ischemic heart disease in arseniasis-hyperendemic villages in Taiwan. Toxicol Lett 2003;137:15-21.
5. Feldman RG, Niles CA, Kelly-Hayes M, et al. Peripheral neuropathy in arsenic smelter workers. Neurology 1979;29:939-44.
6. Wasserman GA, Liu X, Parvez F, et al. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004;112:1329-33.
7. Shalat SL, Walker DB, Finnell RH. Role of arsenic as a reproductive toxin with particular attention to neural tube defects. J Toxicol Environ Health 1996;48:253-72.
8. Wlodarczyk B, Spiegelstein O, Gelineau-van Waes J, et al. Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. Toxicol Appl Pharmacol 2001;177:238-46.
9. Hopenhayn-Rich C, Biggs ML, Smith AH, Kalman DA, Moore LE. Methylation study of a population environmentally exposed to arsenic in drinking water. Environ Health Perspect 1996;104:620-8.
10. Vahter M, Marafante E. Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit. Toxicol Lett 1987;37:41-6.
11. Gamble MV, Liu X, Ahsan H, et al. Folate, homocysteine and arsenic metabolism in Bangladesh. Environ Health Perspect 2005;113:1683-8.
12. Lin S, Shi Q, Nix FB, et al. A novel S-adenosyl-L-methionine: arsenic(III) methyltransferase from rat liver cytosol. J Biol Chem 2002;277:10795-803.
13. Zakharyan R, Wu Y, Bogdan GM, Aposhian HV. Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. Chem Res Toxicol 1995;8:1029-38.
14. Zakharyan RA, Sampayo-Reyes A, Healy SM, et al. Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. Chem Res Toxicol 2001;14:1051-7.
15. Tice RR, Yager JW, Andrews P, Crecelius E. Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite. Mutat Res 1997;386:315-34.
16. Spiegelstein O, Lu X, Le CX, et al. Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice. Environ Toxicol Pharmacol 2005;19:1-7.
17. Buchet JP, Lauwerys R, Roels H. Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man. Int Arch Occup Environ Health 1981;48:71-9.
18. Vahter M, Concha G. Role of metabolism in arsenic toxicity. Pharmacol Toxicol 2001;89:1-5.
19. Chen YC, Guo YL, Su HJ, et al. Arsenic methylation and skin cancer risk in southwestern Taiwan. J Occup Environ Med 2003;45:241-8.
20. Chen YC, Su HJ, Guo YL, et al. Arsenic methylation and bladder cancer risk in Taiwan. Cancer Causes Control 2003;14:303-10.
21. Hsueh YM, Chiou HY, Huang YL, et al. Serum beta-carotene level, arsenic methylation capability, and incidence of skin cancer. Cancer Epidemiol Biomarkers Prev 1997;6:589-96.
22. Yu RC, Hsu KH, Chen CJ, Froines JR. Arsenic methylation capacity and skin cancer. Cancer Epidemiol Biomarkers Prev 2000;9:1259-62.
23. Tseng CH, Huang YK, Huang YL, et al. Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan. Toxicol Appl Pharmacol 2005;206:299-308.
24. Ahmad S, Anderson WL, Kitchin KT. Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice. Cancer Lett 1999;139:129-35.
25. Lee TC, Tanaka N, Lamb PW, Gilmer TM, Barrett JC. Induction of gene amplification by arsenic. Science 1988;241:79-81.
26. Nesnow S, Roop BC, Lambert G, et al. DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem Res Toxicol 2002;15:1627-34.
27. Styblo M, Drobna Z, Jaspers I, Lin S, Thomas DJ. The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environ Health Perspect 2002;110(suppl):767-71.
28. Herbert V, Colman N. Folic acid and vitamin B12. In: Shils M, Young VR, eds. Modern nutrition in health and disease. 7th ed. Philadelphia, PA: Lea & Febiger; 1988:388-416.
29. Gamble MV, Ahsan H, Liu X, et al. Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh. Am J Clin Nutr 2005;81:1372-7.
30. Ahsan H, Chen Y, Parvez F, et al. Health Effects of Arsenic Longitudinal Study (HEALS): a description of a multidisciplinary epidemiologic investigation. J Expo Sci Environ Epidemiol 2006;16:191-205.
31. 2 area of Bangladesh. Water Resources Res 2003;39:1140-50.
32. Cheng Z, Zheng Y, Mortlock R, van Geen A. Rapid multi-element analysis of groundwater by high-resolution inductively coupled plasma mass spectrometry. Anal Bioanal Chem 2004;379:512-8.
33. Nixon D, Mussmann G, Eckdahl S, Moyer T. Total arsenic in urine: palladium-persulfate vs nickel as a matrix modifier for graphite furnace atomic absorption spectrophotometry. Clin Chem 1991;37:1575-9.
34. Slot C. Plasma creatinine determination. A new and specific Jaffe reaction method. Scand J Clin Lab Invest 1965;17:381-7.
35. Reuter W, Davidowski L, Neubauer K. Speciation of five arsenic compounds in urine by HPLC/ICP-MS. Perkin Elmer Application Notes 2003. Internet: http://las.perkinelmer.com/content/ApplicationNotes/d_6736_screen.pdf (accessed on 1 August 2003).
36. Pfeiffer CM, Huff DL, Gunter EW. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin Chem 1999;45:290-2.
37. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 2000;275:29318-23.
38. De Kimpe J, Cornelis R, Vanholder R. In vitro methylation of arsenite by rabbit liver cytosol: effect of metal ions, metal chelating agents, methyltransferase inhibitors and uremic toxins. Drug Chem Toxicol 1999;22:613-28.
39. Spiegelstein O, Lu X, Le XC, et al. Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice. Toxicol Lett 2003;145:167-74.
40. Spiegelstein O, Gould A, Wlodarczyk B, et al. Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. Toxicol Appl Pharmacol 2005;203:18-26.
41. Vahter M. Methylation of inorganic arsenic in different mammalian species and population groups. Sci Prog 1999;82:69-88.
42. Steinmaus C, Carrigan K, Kalman D, Atallah R, Yuan Y, Smith AH. Dietary intake and arsenic methylation in a U.S. population. Environ Health Perspect 2005;113:1153-9.
43. Mitra SR, Mazumder DN, Basu A, et al. Nutritional factors and susceptibility to arsenic-caused skin lesions in West Bengal, India. Environ Health Perspect 2004;112:1104-9.
44. Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ, Bailey LB. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr 2000;72:998-1003.
45. Gregory JF III, Williamson J, Liao JF, Bailey LB, Toth JP. Kinetic model of folate metabolism in nonpregnant women consuming [2H2]folic acid: isotopic labeling of urinary folate and the catabolite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover of folate pools. J Nutr 1998;128:1896-906.
46. Gamble MV, Liu X. Urinary creatinine and arsenic metabolism. Environ Health Perspect 2005;113:A442 (letter).
47. Mudd SH, Poole JR. Labile methyl balances for normal humans on various dietary regimens. Metabolism 1975;24:721-35.
48. Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 2001;281:E1095-100.
49. Korzun WJ. Oral creatine supplements lower plasma homocysteine concentrations in humans. Clin Lab Sci 2004;17:102-6.
50. Fatterpaker P, Marfatia U, Sreenivasan A. Influence of folic acid and vitamin B12 on formation of creatine in vitro and in vivo. Nature 1951;167:1067-8.
51. Stekol JA, Weiss S, Smith P, Weiss K. The synthesis of choline and creatine in rats under various dietary conditions. J Biol Chem 1953;201:299-316.
52. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000;80:1107-213.
53. Rauh M, Verwied S, Knerr I, Dorr HG, Sonnichsen A, Koletzko B. Homocysteine concentrations in a German cohort of 500 individuals: reference ranges and determinants of plasma levels in healthy children and their parents. Amino Acids 2001;20:409-18.