The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells

Free Radical Biology and Medicine

Volumn 37, Issue 10, 2004, Pages 1648-1655

  Samuni, Ayelet M ^a   DeGraff, William ^a   Cook, John A ^a   Krishna, Murali C ^a   Russo, Angelo ^a   Mitchell, James B ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Center for Cancer Research   (United States)

Author keywords

Apoptosis; Caspase; Free radicals; Ionizing radiation; L NAC; Nitroxides; PARP

Indexed keywords

4 TRIMETHYLAMMONIUM 2,2,6,6 TETRAMETHYLPIPERIDINE 1 OXYL IODIDE; ANTIOXIDANT; TEMPOL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; PRIORITY JOURNAL; RADIATION DOSE; RADIOBIOLOGY;

ACETYLCYSTEINE; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASES; CELL SURVIVAL; COLLAGEN TYPE XI; CYCLIC N-OXIDES; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; RADIATION; SPIN LABELS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 5344268094     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.08.006     Document Type: Article

References (61)

1. T.P. Garrington, and G.L. Johnson Organization and regulation of mitogen-activated protein kinase signaling pathways Curr. Opin. Cell Biol. 11 1999 211 218
2. J.M. Kyriakis, and J. Avruch Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation Physiol. Rev. 81 2001 807 869
3. M. Benhar, D. Engelberg, and A. Levitzki ROS, stress-activated kinases and stress signaling in cancer EMBO Rep. 3 2002 420 425
4. T. Finkel Reactive oxygen species and signal transduction IUBMB Life 52 2001 3 6
5. J.L. Martindale, and N.J. Holbrook Cellular response to oxidative stress: signaling for suicide and survival J. Cell. Physiol. 192 2002 1 15
6. S. Suy, J.B. Mitchell, D. Ehleiter, F.A. Haimovitz, and U. Kasid Nitroxides tempol and tempo induce divergent signal transduction pathways in MDA-MB 231 breast cancer cells J. Biol. Chem. 273 1998 17871 17878
7. D. Gelvan, P. Saltman, and S.R. Powell Cardiac reperfusion damage prevented by a nitroxide free radical Proc. Natl. Acad. Sci. USA 88 1991 4680 4684
8. Y. Miura, H. Utsumi, and A. Hamada Antioxidant activity of nitroxide radicals in lipid peroxidation of rat liver microsomes Arch. Biochem. Biophys. 300 1993 148 156
9. M.C. Krishna, R.F. Halevy, R. Zhang, P.L. Gutierrez, and A. Samuni Modulation of streptonigrin cytotoxicity by nitroxide SOD mimics Free Radic. Biol. Med. 17 1994 379 388
10. M.C. Krishna, W. DeGraff, O.H. Hankovszky, C.P. Sar, T. Kalai, J. Jeko, A. Russo, J.B. Mitchell, and K. Hideg Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage J. Med. Chem. 41 1998 3477 3492
11. H. Sasaki, L.R. Lin, T. Yokoyama, M.D. Sevilla, V.N. Reddy, F.J. Giblin, TEMPOL protects against lens DNA strand breaks and cataract in the X-rayed rabbit39 (1998) 544-552
12. 2-induced damage and their protection by nitroxides Biochim. Biophys. Acta 1525 2001 70 76
13. W.G. DeGraff, M.C. Krishna, D. Kaufman, and J.B. Mitchell Nitroxide-mediated protection against X-ray- and neocarzinostatin-induced DNA damage Free Radic. Biol. Med. 13 1992 479 487
14. S.M. Hahn, L. Wilson, C.M. Krishna, J. Liebmann, W. DeGraff, J. Gamson, A. Samuni, D. Venzon, and J.B. Mitchell Identification of nitroxide radioprotectors Radiat. Res. 132 1992 87 93
15. S.M. Hahn, Z. Tochner, C.M. Krishna, J. Glass, L. Wilson, A. Samuni, M. Sprague, D. Venzon, E. Glatstein, and J.B. Mitchell Tempol, a stable free radical, is a novel murine radiation protector Cancer Res. 52 1992 1750 1753
16. A.M. Samuni, Y. Barenholz, D.J. Crommelin, and N.J. Zuidam Gamma-irradiation damage to liposomes differing in composition and their protection by nitroxides Free Radic. Biol. Med. 23 1997 972 979
17. A.M. Samuni, and Y. Barenholz Stable nitroxide radicals protect lipid acyl chains from radiation damage Free Radic. Biol. Med. 22 1997 1165 1174
18. A. Gillissen, M. Jaworska, M. Orth, M. Coffiner, P. Maes, E.M. App, A.M. Cantin, and W.G. Schultze Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro Respir. Med. 91 1997 159 168
19. A.M. Nagy, F. Vanderbist, N. Parij, P. Maes, P. Fondu, and J. Neve Effect of the mucoactive drug nacystelyn on the respiratory burst of human blood polymorphonuclear neutrophils Pulm. Pharmacol. Ther. 10 1997 287 292
20. F. Vanderbist, P. Maes, and J. Neve In vitro comparative assessment of the antioxidant activity of nacystelyn against three reactive oxygen species Arzneimittelforschung 46 1996 783 788
21. A. Orzechowski, M. Lokociejewska, P. Muras, and J.F. Hocquette Preconditioning with millimolar concentrations of vitamin C or N-acetylcysteine protects L6 muscle cells insulin-stimulated viability and DNA synthesis under oxidative stress Life Sci. 71 2002 1793 1808
22. S.H. Pook, K. Esuvaranathan, and R. Mahendran N-acetylcysteine augments the cellular redox changes and cytotoxic activity of internalized Mycobacterium bovis in human bladder cancer cells J. Urol. 168 2002 780 785
23. V.M. Victor, and M. De la Fuente N-acetylcysteine improves in vitro the function of macrophages from mice with endotoxin-induced oxidative stress Free Radic. Res. 36 2002 33 45
24. M. Grootveld, C.J. Silwood, E.J. Lynch, I.Y. Patel, and D.R. Blake The role of N-acetylcysteine in protecting synovial fluid biomolecules against radiolytically-mediated oxidative damage: a high field proton NMR study Free Radic. Res. 30 1999 351 369
25. G. Abt, H. Vaghef, E. Gebhart, C.V. Dahlgren, and B. Hellman The role of N-acetylcysteine as a putative radioprotective agent on X-ray-induced DNA damage as evaluated by alkaline single-cell gel electrophoresis Mutat. Res. 384 1997 55 64
26. Y.Y. Chuang, Q. Chen, J.P. Brown, J.M. Sedivy, and H.L. Liber Radiation-induced mutations at the autosomal thymidine kinase locus are not elevated in p53-null cells Cancer Res. 59 1999 3073 3076
27. I. Nicoletti, G. Migliorati, M.C. Pagliacci, and F. Grignani Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry J. Immunol. Methods 139 1991 271 279
28. Y. Yu, C.Y. Li, and J.B. Little Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells Oncogene 14 1997 1661 1667
29. J. Schafer, J. Bachtler, A. Engling, J.B. Little, K.J. Weber, and F. Wenz Suppression of apoptosis and clonogenic survival in irradiated human lymphoblasts with different TP53 status Radiat. Res. 158 2002 699 706
30. T.T. Puck, and P.I. Marcus Action of X-rays on mammalian cells J. Exp. Med. 103 1956 653 666
31. C. von Sonntag The Chemical Basis of Radiation Biology 1987 Taylor & Francis London
32. M.N. Cornforth, and J.S. Bedford X-ray-induced breakage and rejoining of human interphase chromosomes Science 222 1983 1141 1143
33. J.F. Ward DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability Prog. Nucleic Acid Res. Mol. Biol. 35 1988 95 125
34. S. Xavier, K. Yamada, A.M. Samuni, A. Samuni, W. DeGraff, M.C. Krishna, and J.B. Mitchell Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage Biochim. Biophys. Acta 1573 2002 109 120
35. H.M. Lander An essential role for free radicals and derived species in signal transduction FASEB J. 11 1997 118 124
36. C.K. Sen, and L. Packer Antioxidant and redox regulation of gene transcription FASEB J. 10 1996 709 720
37. V.J. Thannickal, and B.L. Fanburg Reactive oxygen species in cell signaling Am. J. Physiol. Lung Cell. Mol. Physiol. 279 2000 L1005 L1028
38. H.M. Patt, E.B. Tyree, R.L. Staube, and D.E. Smith Cysteine protection against X-irradiation Science 110 1949 213 214
39. J.D. Chapman, A.P. Reuvers, J. Borsa, and C.L. Greenstock Chemical radioprotection and radiosensitization of mammalian cells growing in vitro Radiat. Res. 56 1973 291 306
40. S. Zheng, G.L. Newton, G. Gonick, R.C. Fahey, and J.F. Ward Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA Radiat. Res. 114 1988 11 27
41. J.B. Mitchell, W. DeGraff, D. Kaufman, M.C. Krishna, A. Samuni, E. Finkelstein, M.S. Ahn, S.M. Hahn, and J. Gamson Russo, A. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol Arch. Biochem. Biophys. 289 1991 62 70
42. S.M. Hahn, F.J. Sullivan, A.M. DeLuca, C.M. Krishna, N. Wersto, D. Venzon, A. Russo, and J.B. Mitchell Evaluation of tempol radioprotection in a murine tumor model Free Radic. Biol. Med. 22 1997 1211 1216
43. J.B. Mitchell, A. Russo, P. Kuppusamy, and M.C. Krishna Radiation, radicals, and images Ann. N. Y. Acad. Sci. 899 2000 28 43
44. J.M. Vitolo, A.P. Cotrim, A.L. Sowers, A. Russo, R.B. Wellner, S.R. Pillemer, J.B. Mitchell, and B.J. Baum The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model Clin. Cancer Res. 10 2004 1807 1812
45. P.L. Olive, G. Frazer, and J.P. Banath Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay Radiat. Res. 136 1993 130 136
46. W. Zhen, and A.T. Vaughan Effect of caffeine on radiation-induced apoptosis in TK6 cells Radiat. Res. 141 1995 170 175
47. C.Q. Li, L.J. Trudel, and G.N. Wogan Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53 Proc. Natl. Acad. Sci. USA 99 2002 10364 10369
48. R. Aikawa, I. Komuro, T. Yamazaki, Y. Zou, S. Kudoh, M. Tanaka, I. Shiojima, Y. Hiroi, and Y. Yazaki Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats J. Clin. Invest. 100 1997 1813 1821
49. 2: role in cell survival following oxidant injury J. Biol. Chem. 271 1996 4138 4142
50. J.M. Muller, M.A. Cahill, R.A. Rupec, P.A. Baeuerle, and A. Nordheim Antioxidants as well as oxidants activate c-fos via Ras-dependent activation of extracellular-signal-regulated kinase 2 and Elk-1 Eur. J. Biochem. 244 1997 45 52
51. M.K. Abe, T.S. Chao, J. Solway, M.R. Rosner, and M.B. Hershenson Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease Am. J. Respir. Cell Mol. Biol. 11 1994 577 585
52. G.U. Bae, D.W. Seo, H.K. Kwon, H.Y. Lee, S. Hong, Z.W. Lee, K.S. Ha, H.W. Lee, and J.W. Han Hydrogen peroxide activates p70(S6k) signaling pathway J. Biol. Chem. 274 1999 32596 32602
53. S.A. Milligan, M.W. Owens, and M.B. Grisham Differential regulation of extracellular signal-regulated kinase and nuclear factor-kappa B signal transduction pathways by hydrogen peroxide and tumor necrosis factor Arch. Biochem. Biophys. 352 1998 255 262
54. J.C. Reed, T. Miyashita, S. Takayama, H.G. Wang, T. Sato, S. Krajewski, C. Aime-Sempe, S. Bodrug, S. Kitada, and M. Hanada BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy J. Cell. Biochem. 60 1996 23 32
55. C.M. Rudin, and C.B. Thompson Apoptosis and disease: regulation and clinical relevance of programmed cell death Annu. Rev. Med. 48 1997 267 281
56. J.M. Brown, and B.G. Wouters Apoptosis, p53, and tumor cell sensitivity to anticancer agents Cancer Res. 59 1999 1391 1399
57. D.R. Aldridge, M.J. Arends, and I.R. Radford Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response Br. J. Cancer 71 1995 571 577
58. R.B. Lock Stribinskiene, L. Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival Cancer Res. 56 1996 4006 4012
59. N. Kyprianou, E.D. King, D. Bradbury, and J.G. Rhee bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells Int. J. Cancer 70 1997 341 348
60. T. Waldman, Y. Zhang, L. Dillehay, J. Yu, K. Kinzler, B. Vogelstein, and J. Williams Cell-cycle arrest versus cell death in cancer therapy Nat. Med. 3 1997 1034 1036
61. B.G. Wouters, A.J. Giaccia, N.C. Denko, and J.M. Brown Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism Cancer Res. 57 1997 4703 4706