Quantitative structure-activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agents

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5381-5386

  Chen, Ke xian ^a   Xie, Hai ying ^a   Li, Zu guang ^a   Gao, Jian rong ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

1 Aryl tetrahydroisoquinoline analogs; Anti HIV activities; Quantitative structure activity relationship

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPATHOGENIC EFFECT; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENETIC ALGORITHM; GENETIC FUNCTION APPROXIMATION; HUMAN; HUMAN CELL; METHODOLOGY; MOLECULAR FIELD ANALYSIS; MULTIPLE LINEAR REGRESSION ANALYSIS; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL ANALYSIS; THERMODYNAMICS; THREE DIMENSIONAL IMAGING;

ANTI-HIV AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV REVERSE TRANSCRIPTASE; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MODELS, STATISTICAL; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 53349167179     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.056     Document Type: Article

References (39)

1. Menéndez-Arias L., and Tözsér J. Trends Pharmacol. 29 (2007) 42
2. Thakur A., Thakur M., Bharadwaj A., and Thakur S. Eur. J. Med. Chem. 43 (2008) 471
3. Walgate R., Degett J., and Eagles N. Biotechnology 25 (2008) 29
4. Andersen, J. L.; Le Rouzic, E.; Planelles, V. Exp. Mol. Pathol. 2008. doi:10.1016/j.yexmp.2008.03.015.
5. Ravichandran V., and Agrawal R.K. Bioorg. Med. Chem. Lett. 17 (2007) 2197
6. Vangelista L., Secchi M., and Lusso P. Vaccine 26 (2008) 3008
7. Dessalew N. QSAR Comb. Sci. 27 (2008) 901
8. Yuan H., and Parrill A.L. THEOCHEM 529 (2000) 273
9. Chen X., Tsiang M., Yu F., Hung M., Jones G.S., Zeynalzadegan A., Qi X., Jin H., Kim C.U., Swaminathan S., and Chen J.M. J. Mol. Biol. 380 (2008) 504
10. Bonina F., Puglia C., Rimoli M.G., Avallone L., Abignente E., Boatto G., Nieddu M., Meli R., Amorena M., and de Caprariis P. Eur. J. Pharm. Sci. 16 (2002) 167
11. Vicini, P.; Incerti, M.; La Cola, P.; Loddo, R. Eur. J. Med. Chem. 2008. doi: 10.1016/j.ejmech.2008.05.030.
12. Jochmans D. Virus Res. 134 (2008) 171
13. Dubey S., Satyanarayana Y.D., and Lavania H. Eur. J. Med. Chem. 42 (2007) 1159
14. Martinez-Picado J., and Martínez M.A. Virus Res. 134 (2008) 104
15. Alterman M., Sjöbom H., Säfsten P., Markgren P.O., Danielson U.H., Hämäläinen M., Löfås S., Hultén J., Classon B., Samuelsson B., and Hallberg A. Eur. J. Pharm. Sci. 13 (2001) 203
16. Leonard J.T., and Roy K. Bioorg. Med. Chem. Lett. 16 (2006) 4467
17. Leonard J.T., and Roy K. Bioorg. Med. Chem. 14 (2006) 1039
18. Dureja H., Gupta S., and Madan A.K. J. Mol. Graphics Modell. 26 (2008) 1020
19. Musah R.A. Curr. Med. Chem. 4 (2004) 1605
20. Cheng P., Huang N., Jiang Z.-Y., Zhang Q., Zheng Y.-T., Chen J.-J., Zhang X.-M., and Ma Y.-B. Bioorg. Med. Chem. Lett. 18 (2008) 2475
21. Oprea T.J., Waller G.L., and Marshall G.R. J. Med. Chem. 37 (1994) 2206
22. 2, version 4.10, A. San Diego, Inc.: CA, USA, 2005.
23. Rappe A.K., Casewit C.J., Colwell K.S., Goddard W.A., and Skiff W.M. J. Am. Chem. Soc. 114 (1992) 10024
24. Gasteiger J., and Marsili M. Tetrahedron 36 (1980) 3291
25. Kadam R.U., and Roy N. Bioorg. Med. Chem. Lett. 16 (2006) 5136
26. Rogers D., and Hopfinger A.J. J. Chem. Inf. Comput. Sci. 34 (1994) 854
27. Shi L.M., Yi F., Myers T.G., O'Connor P.M., Paull K.D., Friend S.H., and Weinstein J.N. J. Chem. Inf. Comput. Sci. 38 (1998) 189
28. Leonard J.T., and Roy K. Eur. J. Med. Chem. 43 (2008) 81
29. Ramar S., Bag S., Tawari N.R., and Degani M.S. QSAR Comb. Sci. 26 (2007) 608
30. Nair P.C., and Sobhia M.E. Eur. J. Med. Chem. 43 (2008) 293
31. Jung M., Tak J., Lee Y., and Jung Y. Bioorg. Med. Chem. Lett. 17 (2007) 1082
32. Sivakumar P.M., Seenivasan S.P., Kumar V., and Doble M. Bioorg. Med. Chem. Lett. 17 (2007) 1695
33. Deswal S., and Roy N. Eur. J. Med. Chem. 41 (2006) 1339
34. Equbal T., Silakari O., and Ravikumar M. Eur. J. Med. Chem. 43 (2008) 204
35. Hirashima A., Eiraku T., Kuwano E., and Eto M. Internet Electron. J. Mol. Des. 2 (2003) 511
36. Vijayan, R. S. K.; Ghoshal, N. J. Mol. Graphics Modell. 2008. doi:10.1016/j.jmgm.2008.05.003.
37. Yuan H., and Parrill A. J. Mol. Graphics Modell. 23 (2005) 317
38. Hirashima A., Morimoto M., Kuwanoa E., and Eto M. Bioorg. Med. Chem. 11 (2003) 3753
39. Shaikh A.R., Ismael M., Del Carpio C.A., Tsuboi H., Koyama M., Endou A., Kubo M., Broclawik E., and Miyamoto A. Bioorg. Med. Chem. Lett. 16 (2006) 5917