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Volumn 38, Issue 2, 1998, Pages 189-199

Mining the NCI anticancer drug discovery databases: Genetic function approximation for the QSAR study of anticancer ellipticine analogues

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ELLIPTICINE DERIVATIVE;

EID: 0032015070     PISSN: 00952338     EISSN: None     Source Type: Journal    
DOI: 10.1021/ci970085w     Document Type: Article
Times cited : (112)

References (63)
  • 1
    • 84867184644 scopus 로고
    • DeVita, V. T.; Hellman, S.; Rosenberg, S. A.; Eds.; J. B. Lippicott: Philadelphia
    • Boyd, M. R. In Cancer: Principles and Practice of Oncology Update; DeVita, V. T.; Hellman, S.; Rosenberg, S. A.; Eds.; J. B. Lippicott: Philadelphia, 1989; Vol. 3.
    • (1989) Cancer: Principles and Practice of Oncology Update , vol.3
    • Boyd, M.R.1
  • 4
    • 0028906786 scopus 로고
    • Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen
    • Boyd, M. R.; Paull, K. D. Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Devel. Res. 1995, 34, 91-109.
    • (1995) Drug Devel. Res. , vol.34 , pp. 91-109
    • Boyd, M.R.1    Paull, K.D.2
  • 6
    • 0024312538 scopus 로고
    • Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development of mean graph and COMPARE algorithm
    • Paull, K. D.; Shoemaker, R. H.; Hodes, L.; Monks, A.; Scudiero, D. A.; Rubinstein, L.; Plowman, J.; Boyd, M. R. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J. Natl. Cancer Inst. 1989, 81, 1088-1092.
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 1088-1092
    • Paull, K.D.1    Shoemaker, R.H.2    Hodes, L.3    Monks, A.4    Scudiero, D.A.5    Rubinstein, L.6    Plowman, J.7    Boyd, M.R.8
  • 11
    • 0028576841 scopus 로고
    • Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents
    • van Osdol, W. W.; Myers, T. G.; Paull, K. D.; Kohn, K. W.; Weinstein, J. N. Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents. J. Natl. Cancer Inst. 1994, 86, 1853-1859.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 1853-1859
    • Van Osdol, W.W.1    Myers, T.G.2    Paull, K.D.3    Kohn, K.W.4    Weinstein, J.N.5
  • 17
    • 0022812770 scopus 로고
    • The NCI Drug Information System. 1. System overview
    • Milne, G. W. A.; Miller, J. A. The NCI Drug Information System. 1. System overview. J. Chem. Inf. Comput. Sci. 1986, 26, 154-159.
    • (1986) J. Chem. Inf. Comput. Sci. , vol.26 , pp. 154-159
    • Milne, G.W.A.1    Miller, J.A.2
  • 20
    • 0022812775 scopus 로고
    • The NCI Drug Information System. 4. Inventory and shipping modules
    • Milne, G. W. A.; Miller, J. A.; Hoover, J. R. The NCI Drug Information System. 4. Inventory and shipping modules. J. Chem. Inf. Comput. Sci. 1986, 26, 179-185.
    • (1986) J. Chem. Inf. Comput. Sci. , vol.26 , pp. 179-185
    • Milne, G.W.A.1    Miller, J.A.2    Hoover, J.R.3
  • 21
    • 0030800078 scopus 로고    scopus 로고
    • Quantitative structure-activity relationship of multidrug resistance reversal agents
    • Klopman, G.; Shi, L. M.; Ramu, A. Quantitative structure-activity relationship of multidrug resistance reversal agents. Mol. Pharmacol. 1997, 52, 323-334.
    • (1997) Mol. Pharmacol. , vol.52 , pp. 323-334
    • Klopman, G.1    Shi, L.M.2    Ramu, A.3
  • 22
    • 0021529312 scopus 로고
    • Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules
    • Klopman, G. Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules. J. Am. Chem. Soc. 1984, 106, 7315-7320.
    • (1984) J. Am. Chem. Soc. , vol.106 , pp. 7315-7320
    • Klopman, G.1
  • 23
    • 0026778110 scopus 로고
    • MULTICASE: A hierarchical computer automated structure evaluation program
    • Klopman, G. MULTICASE: a hierarchical computer automated structure evaluation program. QSAR 1992, 11, 176-184.
    • (1992) QSAR , vol.11 , pp. 176-184
    • Klopman, G.1
  • 25
    • 0028568707 scopus 로고
    • The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database search. Molecular modeling studies
    • Wang, S.; Zaharevitz, D. W.; Sharma, R.; Marquez, V. E.; Lewin, N. E.; Du, L.; Blumberg, P. M.; Milne, G. W. A. The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database search. Molecular modeling studies. J. Med. Chem. 1994, 37, 4479-4489.
    • (1994) J. Med. Chem. , vol.37 , pp. 4479-4489
    • Wang, S.1    Zaharevitz, D.W.2    Sharma, R.3    Marquez, V.E.4    Lewin, N.E.5    Du, L.6    Blumberg, P.M.7    Milne, G.W.A.8
  • 26
    • 0029984203 scopus 로고    scopus 로고
    • Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching
    • Wang, S.; Milne, G. W. A.; Yan, X.; Posey, I.; Nicklaus, M. C.; Graham, L.; Rice, W. G. Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching. J. Med. Chem. 1996, 39, 2047-2054.
    • (1996) J. Med. Chem. , vol.39 , pp. 2047-2054
    • Wang, S.1    Milne, G.W.A.2    Yan, X.3    Posey, I.4    Nicklaus, M.C.5    Graham, L.6    Rice, W.G.7
  • 31
    • 0029922621 scopus 로고    scopus 로고
    • p53 tumor suppressor gene: From the basic research laboratory to the clinic - An abridged historical perspective
    • Harris, C. C. p53 tumor suppressor gene: from the basic research laboratory to the clinic - an abridged historical perspective. Carcinogenesis 1996, 17, 1187-1198.
    • (1996) Carcinogenesis , vol.17 , pp. 1187-1198
    • Harris, C.C.1
  • 33
    • 0030865104 scopus 로고    scopus 로고
    • Characterization of the p53-tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
    • O'Connor, P. M.; Jackman, J.; Bae, I.; Myers, T. G.; Fan, S.; Mutoh, M.; Scudiero, D. A.; Monks, A.; Sausville, E. A.; Weinstein, J. N.; Friend, S.; Fornance, J., A. J.; Kohn, K. W. Characterization of the p53-tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res. 1997, 57, 4285-4300.
    • (1997) Cancer Res. , vol.57 , pp. 4285-4300
    • O'Connor, P.M.1    Jackman, J.2    Bae, I.3    Myers, T.G.4    Fan, S.5    Mutoh, M.6    Scudiero, D.A.7    Monks, A.8    Sausville, E.A.9    Weinstein, J.N.10    Friend, S.11    Fornance, J.A.J.12    Kohn, K.W.13
  • 34
    • 0030035584 scopus 로고    scopus 로고
    • p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas
    • Benhattar, J.; Cerottini, J. P.; Saraga, E.; Metthez, G.; Givel, J. C. p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas. Int. J. Cancer (Pred. Oncol.) 1996, 69, 190-2.
    • (1996) Int. J. Cancer (Pred. Oncol.) , vol.69 , pp. 190-192
    • Benhattar, J.1    Cerottini, J.P.2    Saraga, E.3    Metthez, G.4    Givel, J.C.5
  • 35
    • 85034295667 scopus 로고    scopus 로고
    • Mining the NCI anticancer drug discovery database: Cluster analysis of ellipticine analogs with p53-inverse and CNS-selective patterns of activity
    • Shi, L. M.; Myers, T. G.; Fan, Y.; O'Conner, P. M.; Paull, K. D.; Friend, S. H.; Weinstein, J. N. Mining the NCI anticancer drug discovery database: cluster analysis of ellipticine analogs with p53-inverse and CNS-selective patterns of activity. Mol. Pharmacol. in press.
    • Mol. Pharmacol. in Press
    • Shi, L.M.1    Myers, T.G.2    Fan, Y.3    O'Conner, P.M.4    Paull, K.D.5    Friend, S.H.6    Weinstein, J.N.7
  • 37
    • 84970598798 scopus 로고
    • Synthesis of the tumor-inhibitory alkaloids, ellipticine, 9-methoxyellipticine, and related pyrido[4,3-b]carbazoles
    • Dalton, L. K.; Demerac, S.; Elmes, B. C.; Lorder, J. W.; Swan, J. M.; Teitel, T. Synthesis of the tumor-inhibitory alkaloids, ellipticine, 9-methoxyellipticine, and related pyrido[4,3-b]carbazoles. Aust. J. Chem. 1967, 20, 2715-2727.
    • (1967) Aust. J. Chem. , vol.20 , pp. 2715-2727
    • Dalton, L.K.1    Demerac, S.2    Elmes, B.C.3    Lorder, J.W.4    Swan, J.M.5    Teitel, T.6
  • 40
    • 0028100851 scopus 로고
    • Design, synthesis and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents
    • Anderson, W. K.; Gopalsamy, A.; Reddy, P. S. Design, synthesis and study of 9-substituted ellipticine and 2-methylellipticinium analogues as potential CNS-selective antitumor agents. J. Med. Chem. 1994, 37, 1955-1963.
    • (1994) J. Med. Chem. , vol.37 , pp. 1955-1963
    • Anderson, W.K.1    Gopalsamy, A.2    Reddy, P.S.3
  • 41
    • 0028283531 scopus 로고
    • Design and synthesis ellipticinium salts and 1,2-dihydroellipticines with high selectivities against human CNS cancers in vitro
    • Jurayi, J.; Haugwitz, D.; Varma, R. K.; Paull, K. D.; Barrett, J. F.; Cushman, M. Design and synthesis ellipticinium salts and 1,2-dihydroellipticines with high selectivities against human CNS cancers in vitro. J. Med. Chem. 1994, 37, 2190-2197.
    • (1994) J. Med. Chem. , vol.37 , pp. 2190-2197
    • Jurayi, J.1    Haugwitz, D.2    Varma, R.K.3    Paull, K.D.4    Barrett, J.F.5    Cushman, M.6
  • 42
    • 0030014417 scopus 로고    scopus 로고
    • Synthesis of a series of cytotoxic 2-acyl-1,2-dihydroellipticines which inhibit topoisomerase II
    • Devraj, R.; Jurayj, J.; Fernanden, J. A.; Barrett, J. F.; Cushman, M. Synthesis of a series of cytotoxic 2-acyl-1,2-dihydroellipticines which inhibit topoisomerase II. Anti-Cancer Drug Design 1996, 11, 311-324.
    • (1996) Anti-Cancer Drug Design , vol.11 , pp. 311-324
    • Devraj, R.1    Jurayj, J.2    Fernanden, J.A.3    Barrett, J.F.4    Cushman, M.5
  • 44
    • 0029892584 scopus 로고    scopus 로고
    • Structure-activity relationship study on N-glycosyl moieties through model building of DNA and ellipticine N-glycoside complex
    • Shimamoto, T.; Imajo, S.; Honda, T.; Yoshimura, S.; Ishiguro, M. Structure-activity relationship study on N-glycosyl moieties through model building of DNA and ellipticine N-glycoside complex. Bioorg. Med. Chem. Lett. 1996, 6, 1331-1334.
    • (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 1331-1334
    • Shimamoto, T.1    Imajo, S.2    Honda, T.3    Yoshimura, S.4    Ishiguro, M.5
  • 45
    • 0028232102 scopus 로고
    • Cellular uptake as a determinant of cytotoxicity of quaternized ellipticines to human brain tumor cells
    • Vistica, D. T.; Kenney, S.; Hursey, M. L.; Boyd, M. R. Cellular uptake as a determinant of cytotoxicity of quaternized ellipticines to human brain tumor cells. Biochem. Biophys. Res. Commun. 1994, 200, 1762-1768.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 1762-1768
    • Vistica, D.T.1    Kenney, S.2    Hursey, M.L.3    Boyd, M.R.4
  • 46
    • 0028982937 scopus 로고
    • Uptake and cytotoxicity of 9-methoxy-N2-methylellipticinium acetate in human brain and non-brain tumor cell lines
    • Kenney, S.; Vistica, D. T.; Linden, H.; Boyd, M. R. Uptake and cytotoxicity of 9-methoxy-N2-methylellipticinium acetate in human brain and non-brain tumor cell lines. Biochem. Pharmacol. 1995, 49, 23-32.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 23-32
    • Kenney, S.1    Vistica, D.T.2    Linden, H.3    Boyd, M.R.4
  • 49
    • 0029015354 scopus 로고
    • Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy
    • Froelich, A. S.; Patchan, M. W.; Osheroff, N.; Thompson, R. B. Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy. J. Biol. Chem. 1995, 270, 14998-15004.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14998-15004
    • Froelich, A.S.1    Patchan, M.W.2    Osheroff, N.3    Thompson, R.B.4
  • 50
    • 0042041206 scopus 로고
    • UFF, a full periodic table force field for molecular mechanics and molecular dynamics simulations
    • Rappe, A. K.; Casewit, C. J.; Colwell, K. S.; Goddard, W. A.; Skiff, W. M. UFF, a full periodic table force field for molecular mechanics and molecular dynamics simulations. J. Am. Chem. Soc. 1992, 114, 10024-10035.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 10024-10035
    • Rappe, A.K.1    Casewit, C.J.2    Colwell, K.S.3    Goddard, W.A.4    Skiff, W.M.5
  • 55
    • 0003820293 scopus 로고    scopus 로고
    • van de Waterbeemd, H., Academic and R. G. Landes: San Diego
    • Structure-Property Correlations in Drug Research; van de Waterbeemd, H., Ed.; Academic and R. G. Landes: San Diego, 1996.
    • (1996) Structure-Property Correlations in Drug Research
  • 56
    • 0028467707 scopus 로고
    • Application of genetic function approximation to quantitative structure-activity relationships and quantitative structure-property relationships
    • Rogers, D.; Hopfinger, A. J. Application of genetic function approximation to quantitative structure-activity relationships and quantitative structure-property relationships. J. Chem. Inf. Comput. Sci. 1994, 34, 854-866.
    • (1994) J. Chem. Inf. Comput. Sci. , vol.34 , pp. 854-866
    • Rogers, D.1    Hopfinger, A.J.2
  • 58
    • 0003764428 scopus 로고
    • Technical Report No. 102, Nov/Rev.1990 Aug; Laboratory of Computational Statistics, Department of Statistics, Stanford University: Standford, CA
    • Friedman, J. H. Multivariate Adaptive Regression Splines, Technical Report No. 102, Nov/Rev.1990 Aug; Laboratory of Computational Statistics, Department of Statistics, Stanford University: Standford, CA, 1988.
    • (1988) Multivariate Adaptive Regression Splines
    • Friedman, J.H.1
  • 59
    • 0002432565 scopus 로고
    • Multivariate adaptive regression splines
    • Friedman, J. H. Multivariate adaptive regression splines (with discussion). Ann. Stat. 1991, 19, 1-141.
    • (1991) Ann. Stat. , vol.19 , pp. 1-141
    • Friedman, J.H.1


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