Synthesis and in vitro chemical and enzymatic stability of glycosyl 3′-azido-3′-deoxythymidine derivatives as potential anti-HIV agents

European Journal of Pharmaceutical Sciences

Volumn 16, Issue 3, 2002, Pages 167-174

  Bonina, Francesco ^a   Puglia, Carmelo ^a   Rimoli, Maria Grazia ^b   Avallone, Lucia ^b   Abignente, Enrico ^b   Boatto, Giampiero ^c   Nieddu, Maria ^c   Meli, Rosaria ^b   Amorena, Michele ^d   De Caprariis, Paolo ^c  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

^d UNIVERSITY OF TERAMO   (Italy)

Author keywords

Azidodeoxythymidine; Chemical stability; Enzymatic stability; Sustained release

Indexed keywords

BLOOD; DERIVATIVES; ENZYMES; ESTERS; PHARMACOKINETICS;

ENZYMATIC STABILITY;

SYNTHESIS (CHEMICAL);

ANTIVIRUS AGENT; DEOXYRIBONUCLEOSIDE; DEOXYRIBONUCLEOSIDE DEXTRO GALACTOSE 6' O SUCCINYL ESTER; DEOXYRIBONUCLEOSIDE DEXTRO GLUCOSE 3 O SUCCINYL ESTER; ESTER DERIVATIVE; ESTERASE; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DRUG DERIVATIVE; PRODRUG; ZIDOVUDINE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG RETENTION; DRUG STABILITY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; ANIMAL; AREA UNDER THE CURVE; BLOOD; CHEMISTRY; ENZYME STABILITY; GLYCOSYLATION; METABOLISM; SWINE; SYNTHESIS; WISTAR RAT;

ANIMAL; ANTI-HIV AGENTS; AREA UNDER CURVE; ENZYME STABILITY; ESTERASES; GLYCOSYLATION; MALE; PRODRUGS; RATS; RATS, WISTAR; SWINE; ZIDOVUDINE; ANIMALS;

EID: 0035997046     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00080-5     Document Type: Article

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