Exploring three-dimensional quantitative structural activity relationship (3D-QSAR) analysis of SCH 66336 (Sarasar) analogues of farnesyltransferase inhibitors

European Journal of Medicinal Chemistry

Volumn 43, Issue 1, 2008, Pages 204-209

  Equbal, Tabish ^a   Silakari, Om ^a   Ravikumar, Muttineni ^b  

^a PUNJABI UNIVERSITY   (India)

^b GVK BIOSCIENCES PVT LTD   (India)

Author keywords

Anti cancer; Farnesyltransferase inhibitors; Genetic partial least squares (G PLS) method; Molecular field analysis; QSAR

Indexed keywords

LONAFARNIB; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ARTICLE; DRUG DESIGN; DRUG RECEPTOR BINDING; IC 50; MOLECULAR MODEL; PARTIAL LEAST SQUARES REGRESSION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS; STEREOCHEMISTRY; VALIDATION PROCESS;

DRUG EVALUATION, PRECLINICAL; FARNESYLTRANSTRANSFERASE; LEAST-SQUARES ANALYSIS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERIDINES; PYRIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS;

EID: 38349008696     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.02.013     Document Type: Article

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