Quantitative structure-activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity using variable selections

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 4, 2007, Pages 1082-1090

  Jung, Mankil ^a   Tak, Jungae ^a   Lee, Yongnam ^a   Jung, Youngae ^a  

^a Yonsei University   (South Korea)

Author keywords

Acetylcholinesterase (AChE); Multiple linear regression (MLR); Quantitative structure activity relationship (QSAR); RV criterion; Tacrine

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; RIVASTIGMINE; TACRINE; TACRINE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; ENZYME ACTIVITY; GENETIC ALGORITHM; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; MULTIPLE LINEAR REGRESSION ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ALGORITHMS; ARTIFICIAL INTELLIGENCE; CHEMISTRY, PHYSICAL; CHOLINESTERASE INHIBITORS; LINEAR MODELS; MOLECULAR CONFORMATION; MONTE CARLO METHOD; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 33846608151     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.022     Document Type: Article

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