메뉴 건너뛰기




Volumn 17, Issue 9, 2008, Pages 2260-2267

Promoter hypermethylation of the p16 gene is associated with poor prognosis in recurrent early-stage hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; PROTEIN P53;

EID: 53349156591     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-08-0236     Document Type: Article
Times cited : (26)

References (36)
  • 3
    • 0029741643 scopus 로고    scopus 로고
    • Recurrence of hepatocellular carcinoma after surgery
    • Yamamoto J, Kosuge T, Takayama T, et al. Recurrence of hepatocellular carcinoma after surgery. Br J Surg 1996;83:1219-22.
    • (1996) Br J Surg , vol.83 , pp. 1219-1222
    • Yamamoto, J.1    Kosuge, T.2    Takayama, T.3
  • 4
    • 0033947630 scopus 로고    scopus 로고
    • Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma
    • Tung-Ping Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg 2000;232:10-24.
    • (2000) Ann Surg , vol.232 , pp. 10-24
    • Tung-Ping Poon, R.1    Fan, S.T.2    Wong, J.3
  • 5
    • 34548090762 scopus 로고    scopus 로고
    • Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma
    • Su PF, Lee TC, Lin PJ, et al. Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma. Int J Cancer 2007;121:1257-64.
    • (2007) Int J Cancer , vol.121 , pp. 1257-1264
    • Su, P.F.1    Lee, T.C.2    Lin, P.J.3
  • 6
    • 21644473614 scopus 로고    scopus 로고
    • p16INK4A hypermethylation is associated with hepatitis virus infection, age and gender in hepatocellular carcinoma
    • Li X, Hui AM, Sun L, et al. p16INK4A hypermethylation is associated with hepatitis virus infection, age and gender in hepatocellular carcinoma. Clin Cancer Res 2004;10:7484-9.
    • (2004) Clin Cancer Res , vol.10 , pp. 7484-7489
    • Li, X.1    Hui, A.M.2    Sun, L.3
  • 7
    • 2342578084 scopus 로고    scopus 로고
    • p16INK4A Gene alterations are not a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy
    • Anzola M, Cuevas N, Lopex-Martinez M, DePancorbo MM, Burgos JJ. p16INK4A Gene alterations are not a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy. J Gastroenterol Hepatol 2004;19:397-405.
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 397-405
    • Anzola, M.1    Cuevas, N.2    Lopex-Martinez, M.3    DePancorbo, M.M.4    Burgos, J.J.5
  • 8
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz J, Schreiber-Agus N, Liégeois NJ, et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998;92:713-23.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1    Schreiber-Agus, N.2    Liégeois, N.J.3
  • 9
    • 0030779215 scopus 로고    scopus 로고
    • E-Cadherin/catenin/cytoskeleton complex: A regulator of cancer invasion
    • Mareel M, Boterberg T, Noe V, et al. E-Cadherin/catenin/cytoskeleton complex: a regulator of cancer invasion. J Cell Physiol 1997;173:271-4.
    • (1997) J Cell Physiol , vol.173 , pp. 271-274
    • Mareel, M.1    Boterberg, T.2    Noe, V.3
  • 10
    • 0036554834 scopus 로고    scopus 로고
    • Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinoma
    • Zhong S, Tang MW, Yeo W, Liu C, Dennis Lo YM, Johnson PJ. Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinoma. Clin Cancer Res 2002;8:1087-92.
    • (2002) Clin Cancer Res , vol.8 , pp. 1087-1092
    • Zhong, S.1    Tang, M.W.2    Yeo, W.3    Liu, C.4    Dennis Lo, Y.M.5    Johnson, P.J.6
  • 11
    • 18844482200 scopus 로고    scopus 로고
    • GSTP1 CpG island DNA hypermethylation in hepatocellular carcinoma
    • Tchou JC, Lin X, Freije D, et al. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinoma. Int J Oncol 2000;16:663-7.
    • (2000) Int J Oncol , vol.16 , pp. 663-667
    • Tchou, J.C.1    Lin, X.2    Freije, D.3
  • 12
    • 0035879017 scopus 로고    scopus 로고
    • Hypermethylation leads to silencing of the SYK gene in human breast cancer
    • Yuan Y, Mendez R, Sahin A, Dai JL. Hypermethylation leads to silencing of the SYK gene in human breast cancer. Cancer Res 2001;61:5558-61.
    • (2001) Cancer Res , vol.61 , pp. 5558-5561
    • Yuan, Y.1    Mendez, R.2    Sahin, A.3    Dai, J.L.4
  • 13
    • 0038707589 scopus 로고    scopus 로고
    • Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia
    • Goodman PA, Burkhardt N, Juran B, Tibbles HE, Uckun FM. Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia. Oncogene 2003;22:2504-14.
    • (2003) Oncogene , vol.22 , pp. 2504-2514
    • Goodman, P.A.1    Burkhardt, N.2    Juran, B.3    Tibbles, H.E.4    Uckun, F.M.5
  • 14
    • 33845303143 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma
    • Yuan Y, Wang J, Li J, et al. Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. Clin Cancer Res 2006;12:6687-95.
    • (2006) Clin Cancer Res , vol.12 , pp. 6687-6695
    • Yuan, Y.1    Wang, J.2    Li, J.3
  • 17
    • 33645321637 scopus 로고    scopus 로고
    • Promoter methylation of helicase-like transcription factor is associated with the early stage of gastric cancer with family history
    • Kim JJ, Chung SW, Kim JH, et al. Promoter methylation of helicase-like transcription factor is associated with the early stage of gastric cancer with family history. Ann Oncol 2006;17:657-62.
    • (2006) Ann Oncol , vol.17 , pp. 657-662
    • Kim, J.J.1    Chung, S.W.2    Kim, J.H.3
  • 19
    • 0035870282 scopus 로고    scopus 로고
    • p16INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    • Kim DH, Nelson HH, Wiencke JK, et al. p16INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res 2001;61:3419-24.
    • (2001) Cancer Res , vol.61 , pp. 3419-3424
    • Kim, D.H.1    Nelson, H.H.2    Wiencke, J.K.3
  • 20
    • 0345854731 scopus 로고    scopus 로고
    • Correlation of mutation and immunohistochemistry of p53 in hepatocellular carcinoma in Korean people
    • Lee SN, Park CK, Sung CO, et al. Correlation of mutation and immunohistochemistry of p53 in hepatocellular carcinoma in Korean people. J Korean Med Sci 2002;17:801-5.
    • (2002) J Korean Med Sci , vol.17 , pp. 801-805
    • Lee, S.N.1    Park, C.K.2    Sung, C.O.3
  • 21
    • 0033652599 scopus 로고    scopus 로고
    • Risk factors for recurring hepatocellular carcinoma differ according to infected hepatitis virus - an analysis of 236 consecutive patients with a single lesion
    • Koike Y, Shiratori Y, Sato S, et al. Risk factors for recurring hepatocellular carcinoma differ according to infected hepatitis virus - an analysis of 236 consecutive patients with a single lesion. Hepatology 2000;32:1216-23.
    • (2000) Hepatology , vol.32 , pp. 1216-1223
    • Koike, Y.1    Shiratori, Y.2    Sato, S.3
  • 22
    • 34547474116 scopus 로고    scopus 로고
    • Analysis of prognostic factors affecting survival after initial recurrence and treatment efficacy for recurrence in patients undergoing potentially curative hepatectomy for hepatocellular carcinoma
    • Shimada K, Sakamoto Y, Esaki M, et al. Analysis of prognostic factors affecting survival after initial recurrence and treatment efficacy for recurrence in patients undergoing potentially curative hepatectomy for hepatocellular carcinoma. Ann Surg Oncol 2007;14:2337-47.
    • (2007) Ann Surg Oncol , vol.14 , pp. 2337-2347
    • Shimada, K.1    Sakamoto, Y.2    Esaki, M.3
  • 23
    • 0034255520 scopus 로고    scopus 로고
    • Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma
    • Poon RT, Fan ST, Ng IO, Lo CM, Liu CL, Wong J. Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma. Cancer 2000;89:500-7.
    • (2000) Cancer , vol.89 , pp. 500-507
    • Poon, R.T.1    Fan, S.T.2    Ng, I.O.3    Lo, C.M.4    Liu, C.L.5    Wong, J.6
  • 24
    • 0141648473 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    • Lee S, Lee HJ, Kim JH, Lee HS, Jang JJ, Kang GH. Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 2003;163:1371-8.
    • (2003) Am J Pathol , vol.163 , pp. 1371-1378
    • Lee, S.1    Lee, H.J.2    Kim, J.H.3    Lee, H.S.4    Jang, J.J.5    Kang, G.H.6
  • 25
    • 0142029430 scopus 로고    scopus 로고
    • No association between GSTP1 gene aberrant promoter methylation and prognosis in surgically resected hepatocellular carcinoma patients from the Basque Country (Northern Spain)
    • Anzola M, Cuevas N, López-Martínez M, Saiz A, Burgos JJ, de Pancorbo MM. No association between GSTP1 gene aberrant promoter methylation and prognosis in surgically resected hepatocellular carcinoma patients from the Basque Country (Northern Spain). Liver Int 2003;23:249-54.
    • (2003) Liver Int , vol.23 , pp. 249-254
    • Anzola, M.1    Cuevas, N.2    López-Martínez, M.3    Saiz, A.4    Burgos, J.J.5    de Pancorbo, M.M.6
  • 26
    • 0033818628 scopus 로고    scopus 로고
    • Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients
    • Wong IHN, Lo YMD, Yeo W, Lau WY, Johnson PJ. Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients. Clin Cancer Res 2000;6:3516-21.
    • (2000) Clin Cancer Res , vol.6 , pp. 3516-3521
    • Wong, I.H.N.1    Lo, Y.M.D.2    Yeo, W.3    Lau, W.Y.4    Johnson, P.J.5
  • 27
    • 0042334830 scopus 로고    scopus 로고
    • Loss of p16 contributes to p27 sequestration by cyclin D1-cyclin-dependent kinase 4 complexes and poor prognosis in hepatocellular carcinoma
    • Matsuda Y, Ichida T, Genda T, Yamagiwa S, Aoyagi Y, Asakura H. Loss of p16 contributes to p27 sequestration by cyclin D1-cyclin-dependent kinase 4 complexes and poor prognosis in hepatocellular carcinoma. Clin Cancer Res 2003;9:3389-96.
    • (2003) Clin Cancer Res , vol.9 , pp. 3389-3396
    • Matsuda, Y.1    Ichida, T.2    Genda, T.3    Yamagiwa, S.4    Aoyagi, Y.5    Asakura, H.6
  • 28
    • 34249780403 scopus 로고    scopus 로고
    • Association of p16INK4A hypermethylation with hepatitis B virus X protein expression in the early stage of HBV-associated hepatocarcinogenesis
    • Zhu R, Li BZ, Li H, et al. Association of p16INK4A hypermethylation with hepatitis B virus X protein expression in the early stage of HBV-associated hepatocarcinogenesis. Pathol Int 2007;57:328-36.
    • (2007) Pathol Int , vol.57 , pp. 328-336
    • Zhu, R.1    Li, B.Z.2    Li, H.3
  • 29
    • 33745728247 scopus 로고    scopus 로고
    • Persistent infection of hepatitis B virus is involved in high rate of p16 methylation in hepatocellular carcinoma
    • Jicai Z, Zongtao Y, Jun L, Haiping L, Jianmin W, Lihua H. Persistent infection of hepatitis B virus is involved in high rate of p16 methylation in hepatocellular carcinoma. Mol Carcinog 2006;45:530-6.
    • (2006) Mol Carcinog , vol.45 , pp. 530-536
    • Jicai, Z.1    Zongtao, Y.2    Jun, L.3    Haiping, L.4    Jianmin, W.5    Lihua, H.6
  • 30
    • 18444369018 scopus 로고    scopus 로고
    • Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma
    • Roncalli M, Bianchi P, Bruni B, et al. Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. Hepatology 2002;36:427-32.
    • (2002) Hepatology , vol.36 , pp. 427-432
    • Roncalli, M.1    Bianchi, P.2    Bruni, B.3
  • 31
    • 0035056507 scopus 로고    scopus 로고
    • Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus
    • Kaneto H, Sasaki S, Yamamoto H, et al. Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut 2001;48:372-7.
    • (2001) Gut , vol.48 , pp. 372-377
    • Kaneto, H.1    Sasaki, S.2    Yamamoto, H.3
  • 32
    • 0037455979 scopus 로고    scopus 로고
    • p16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis
    • Shim YH, Yoon GS, Choi HJ, Chung YH, Yu E. p16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis. Cancer Lett 2003;190:213-9.
    • (2003) Cancer Lett , vol.190 , pp. 213-219
    • Shim, Y.H.1    Yoon, G.S.2    Choi, H.J.3    Chung, Y.H.4    Yu, E.5
  • 33
    • 13444278808 scopus 로고    scopus 로고
    • The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    • Lewis BC, Klimstra DS, Socci ND, Xu S, Koutcher JA, Varmus HE. The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol Cell Biol 2005;25:1228-37.
    • (2005) Mol Cell Biol , vol.25 , pp. 1228-1237
    • Lewis, B.C.1    Klimstra, D.S.2    Socci, N.D.3    Xu, S.4    Koutcher, J.A.5    Varmus, H.E.6
  • 34
    • 34548044683 scopus 로고    scopus 로고
    • Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells
    • Chen YW, Klimstra DS, Mongeau ME, Tatem JL, Boyartchuk V, Lewis BC. Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res 2007;67:7589-96.
    • (2007) Cancer Res , vol.67 , pp. 7589-7596
    • Chen, Y.W.1    Klimstra, D.S.2    Mongeau, M.E.3    Tatem, J.L.4    Boyartchuk, V.5    Lewis, B.C.6
  • 35
    • 0037816165 scopus 로고    scopus 로고
    • Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
    • Kato S, Han SY, Liu W, et al. Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci U S A 2003;100:8424-9.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8424-8429
    • Kato, S.1    Han, S.Y.2    Liu, W.3
  • 36
    • 34047216406 scopus 로고    scopus 로고
    • p53 Alterations in human cancer: More questions than answers
    • Soussi T. p53 Alterations in human cancer: more questions than answers. Oncogene 2007;26:2145-6.
    • (2007) Oncogene , vol.26 , pp. 2145-2146
    • Soussi, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.