Hypermethylation leads to silencing of the SYK gene in human breast cancer

Cancer Research

Volumn 61, Issue 14, 2001, Pages 5558-5561

  Yuan, Y ^a   Mendez, R ^a   Sahin, A ^a   Dai, J L ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE; GENE EXPRESSION; GENE SILENCING; GENE SYK; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BREAST NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; ENZYME PRECURSORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN-TYROSINE KINASES; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0035879017     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. The Syk family of protein tyrosine kinases in T-cell activation and development
2. Molecular mechanisms in B cell antigen receptor signaling
3. Molecular characterization of the murine SYK protein tyrosine kinase cDNA, transcripts and protein
4. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells
5. Cancer epigenetics comes of age
6. DNA hypermethylation in tumorigenesis, epigenetics joins genetics
7. DNA methylation in early development
8. Aging and DNA methylation in colorectal mucosa and cancer
9. Aging, DNA methylation and cancer
10. DNA methylation errors and cancer
11. Alterations in DNA methylation: A fundamental aspect of neoplasia
12. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
13. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
14. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
15. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
16. Aberrant methylation of the estrogen receptor and E-cadherin 5′ CpG islands increase with malignant progression in human breast cancer
17. Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer
18. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
19. High frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer
20. Allele-specific hypermethylation of the retinohlastoma tumor-suppressor gene
21. Methylation and silencing of the Thrombospondin-1 promoter in human cancer
22. Methylation of the BRCA1 gene in sporadic breast cancer
23. Methylation-specific PCR, a novel PCR assay for methylation status of CpG islands
24. Altering gene expression with 5-azacytidine
25. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
26. Transcriptional repression by the methyl-CpG-hinding protein MeCP2 involves a histone deacetylase complex
27. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
28. Transcriptional activation of estrogen receptor α in human breast cancer cells by histone deacetylase inhibition
29. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
30. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
31. INK4BI
32. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation