Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomes

Chemico-Biological Interactions

Volumn 155, Issue 1-2, 2005, Pages 62-70

  Matthias, A ^a   Gillam, E M J ^a   Penman, K G ^a   Matovic, N J ^a   Bone, K M ^a,b   De Voss, J J ^a   Lehmann, R P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

Alkylamides; Cytochrome P450; Echinacea; Liver; Metabolism

Indexed keywords

ALKYNE; CYTOCHROME P450; ECHINACEA EXTRACT; N ISOBUTYL 2,4 DODECADIENAMIDE; N ISOBUTYL 2,4,8,10 DODECATETRAENAMIDE; N ISOBUTYLDODECA 2 ENE 8,10 DIYNAMIDE; N ISOBUTYLUNDECA 2 ENE 8,10 DIYNAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CYTOSOLIC FRACTION; DEALKYLATION; DRUG DEGRADATION; DRUG INHIBITION; DRUG METABOLISM; ECHINACEA; ENZYME INACTIVATION; ENZYME INHIBITION; EPOXIDATION; HUMAN; HUMAN TISSUE; HYDROXYLATION; INHIBITION KINETICS; LIVER MICROSOME; LIVER MICROSOME METABOLISM; NORMAL HUMAN;

AMIDES; BUTYLAMINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ECHINACEA; HUMANS; MICROSOMES, LIVER; PLANT EXTRACTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 20644447802     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.04.003     Document Type: Article

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